메뉴 건너뛰기




Volumn 18, Issue 3, 2005, Pages 211-215

Recent developments in tuberculosis vaccines

Author keywords

BCG; Booster vaccination; Tuberculosis vaccine

Indexed keywords

ADJUVANT; BCG VACCINE; DNA VACCINE; EARLY SECRETORY ANTIGENIC TARGET 6; EUROCINE; HEAT SHOCK PROTEIN 60; HYBRID PROTEIN; NEW DRUG; PROTEIN AG85B; PROTEIN MTB; PROTEIN MTB32; PROTEIN MTB39; RECOMBINANT BCG VACCINE 30; RECOMBINANT VACCINE; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 20044361834     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.qco.0000168380.08895.9a     Document Type: Review
Times cited : (45)

References (53)
  • 1
    • 0003699846 scopus 로고    scopus 로고
    • Issues relating to the use of BCG in immunization programmes: A discussion document
    • Fine PE, Carneiro AMI, Milstien BJ. Issues relating to the use of BCG in immunization programmes: a discussion document. WHO Bull 1999; 23.
    • (1999) WHO Bull , pp. 23
    • Fine, P.E.1    Carneiro, A.M.I.2    Milstien, B.J.3
  • 2
    • 0028153628 scopus 로고
    • Efficacy of BCG vaccine in the prevention of tuberculosis: Meta-analysis of the published literature
    • Colditz GA, Brewer TF, Berkey CS, et al. Efficacy of BCG vaccine in the prevention of tuberculosis: meta-analysis of the published literature. JAMA 1994; 271:698-702.
    • (1994) JAMA , vol.271 , pp. 698-702
    • Colditz, G.A.1    Brewer, T.F.2    Berkey, C.S.3
  • 3
    • 2342584774 scopus 로고    scopus 로고
    • Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study
    • Aronson NE, Santosham M, Comstock GW, et al. Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: a 60-year follow-up study. JAMA 2004; 291:2086-2091. The authors study the long-term efficacy of BCG. Women were significantly better protected than men. There are some important differences in the vaccine preparation procedures compared with a previous large-scale study in South India, where no protection was seen with the same vaccine. In this study the vaccine used was prepared freshly on site and not in a lyophilized form as in the study in South India. This correlates with the good efficacy seen in a MRC trial in the 1950s, which showed high efficacy with liquid vaccines.
    • (2004) JAMA , vol.291 , pp. 2086-2091
    • Aronson, N.E.1    Santosham, M.2    Comstock, G.W.3
  • 4
    • 0028872014 scopus 로고
    • Variation in protection by BCG: Implications of and for heterologous immunity
    • Fine PE. Variation in protection by BCG: implications of and for heterologous immunity. Lancet 1995; 346:1339-1345.
    • (1995) Lancet , vol.346 , pp. 1339-1345
    • Fine, P.E.1
  • 5
    • 0014199881 scopus 로고
    • Efficacy and applicability of mass BCG vaccination in tuberculosis control
    • Hart PD. Efficacy and applicability of mass BCG vaccination in tuberculosis control. BMJ 1967; 1:587-592.
    • (1967) BMJ , vol.1 , pp. 587-592
    • Hart, P.D.1
  • 6
    • 0033612136 scopus 로고    scopus 로고
    • Comparative genomics of BCG vaccines by wholegenome DNA microarray
    • Behr MA, Wilson MA, Gill WP, et al. Comparative genomics of BCG vaccines by wholegenome DNA microarray. Science 1999; 284:1520-1523.
    • (1999) Science , vol.284 , pp. 1520-1523
    • Behr, M.A.1    Wilson, M.A.2    Gill, W.P.3
  • 7
    • 0032862386 scopus 로고    scopus 로고
    • Development of diagnostic reagents to differentiate between Mycobacterium bovis BCG vaccination and M. bovis infection in cattle
    • Vordermeier HM, Cockle PC, Whelan A, et al. Development of diagnostic reagents to differentiate between Mycobacterium bovis BCG vaccination and M. bovis infection in cattle. Clin Diagn Lab Immunol 1999; 6:675-682.
    • (1999) Clin Diagn Lab Immunol , vol.6 , pp. 675-682
    • Vordermeier, H.M.1    Cockle, P.C.2    Whelan, A.3
  • 8
    • 0019041173 scopus 로고
    • Tuberculosis prevention trial, Madras
    • Baily GV. Tuberculosis prevention trial, Madras. Indian J Med Res 1980; 72(Suppl):1-74.
    • (1980) Indian J Med Res , vol.72 , Issue.SUPPL. , pp. 1-74
    • Baily, G.V.1
  • 9
    • 0021331179 scopus 로고
    • Efficacy of Mycobacterium bovis BCG vaccination in mice undergoing prior pulmonary infection with atypical mycobacteria
    • Orme IM, Collins FM. Efficacy of Mycobacterium bovis BCG vaccination in mice undergoing prior pulmonary infection with atypical mycobacteria. Infect Immun 1984; 44:28-32.
    • (1984) Infect Immun , vol.44 , pp. 28-32
    • Orme, I.M.1    Collins, F.M.2
  • 10
    • 0013963959 scopus 로고
    • Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis
    • Palmer CE, Long MW. Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis. Am Rev Respir Dis 1966; 94:553-568.
    • (1966) Am Rev Respir Dis , vol.94 , pp. 553-568
    • Palmer, C.E.1    Long, M.W.2
  • 11
    • 0024634219 scopus 로고
    • The BCG story: Lessons from the past and implications for the future
    • Fine PE. The BCG story: lessons from the past and implications for the future. Rev Infect Dis 1989; 11(Suppl 2):S353-S359.
    • (1989) Rev Infect Dis , vol.11 , Issue.SUPPL. 2
    • Fine, P.E.1
  • 12
    • 0019365845 scopus 로고
    • The effect of two distinct forms of cell-mediated response to mycobacteria on the protective efficacy of BCG
    • Rook GA, Bahr GM, Stanford JL. The effect of two distinct forms of cell-mediated response to mycobacteria on the protective efficacy of BCG. Tubercle 1981; 62:63-68.
    • (1981) Tubercle , vol.62 , pp. 63-68
    • Rook, G.A.1    Bahr, G.M.2    Stanford, J.L.3
  • 13
    • 0036153758 scopus 로고    scopus 로고
    • Failure of the Mycobacterium bovis BCG vaccine: Some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis
    • Brandt L, Feino Cunha J, Weinreich Olsen A, et al. Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis. Infect Immun 2002; 70:672-678.
    • (2002) Infect Immun , vol.70 , pp. 672-678
    • Brandt, L.1    Feino Cunha, J.2    Weinreich Olsen, A.3
  • 14
    • 0037081384 scopus 로고    scopus 로고
    • Influence of sensitisation to environmental mycobacteria on subsequent vaccination against bovine tuberculosis
    • Buddle BM, Wards BJ, Aldwell FE, et al. Influence of sensitisation to environmental mycobacteria on subsequent vaccination against bovine tuberculosis. Vaccine 2002; 20:1126-1133.
    • (2002) Vaccine , vol.20 , pp. 1126-1133
    • Buddle, B.M.1    Wards, B.J.2    Aldwell, F.E.3
  • 15
    • 15944385974 scopus 로고    scopus 로고
    • The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium
    • de Lisle GW, Wards BJ, Buddle BM, Collins DM. The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium. Tuberculosis (Edinb) 2005; 85:73-79. In this study the authors evaluated the protective efficacy of live attenuated M. bovis strains as a vaccine after presensitization with environmental mycobacteria (M. avium containing or not the IS901 DNA insertion) in guinea pigs. Different inoculation routes of the vaccine, as well as the level of protective efficacy, are evaluated.
    • (2005) Tuberculosis (Edinb) , vol.85 , pp. 73-79
    • De Lisle, G.W.1    Wards, B.J.2    Buddle, B.M.3    Collins, D.M.4
  • 16
    • 0033152035 scopus 로고    scopus 로고
    • Helminth- and Bacillus Calmette-Guérin induced immunity in children sensitized in utero to filariasis and schistosomiasis
    • Malhotra I, Mungai P, Wamachi A, et al. Helminth- and Bacillus Calmette-Guérin induced immunity in children sensitized in utero to filariasis and schistosomiasis. J Immunol 1999; 162:6843-6848.
    • (1999) J Immunol , vol.162 , pp. 6843-6848
    • Malhotra, I.1    Mungai, P.2    Wamachi, A.3
  • 17
    • 12344254603 scopus 로고    scopus 로고
    • Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis
    • Elias D, Akuffo H, Pawlowski A, et al. Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis. Vaccine 2005; 23:1326-1334. In animal models of TB infection, prevaccination exposure of mice to chronic helminth infection reduces the protective efficacy of the ensuing BCG. The immune response is polarized towards a Th2 type.
    • (2005) Vaccine , vol.23 , pp. 1326-1334
    • Elias, D.1    Akuffo, H.2    Pawlowski, A.3
  • 18
    • 0035111178 scopus 로고    scopus 로고
    • Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guérin (BCG) vaccination
    • Elias D, Wolday D, Akuffo H, et al. Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guérin (BCG) vaccination. Clin Exp Immunol 2001; 123:219-225.
    • (2001) Clin Exp Immunol , vol.123 , pp. 219-225
    • Elias, D.1    Wolday, D.2    Akuffo, H.3
  • 19
    • 1842509011 scopus 로고    scopus 로고
    • Immunization with heat-killed Mycobacterium bovis bacille Calmette-Guérin (BCG) in Eurocine L3 adjuvant protects against tuberculosis
    • Haile M, Schroder U, Hamasur B, et al. Immunization with heat-killed Mycobacterium bovis bacille Calmette-Guérin (BCG) in Eurocine L3 adjuvant protects against tuberculosis. Vaccine 2004; 22:1498-1508. Vaccination of mice with a heat-killed BCG formulated in L3 adjuvant followed by booster with the same formulation by the intranasal route was found as protective as vaccination with live BCG in terms of prolonged long-term survival. Several formulations of the heat-killed BCG in L3 adjuvant were compared and their long-term efficacy and immunological responses were analysed and discussed.
    • (2004) Vaccine , vol.22 , pp. 1498-1508
    • Haile, M.1    Schroder, U.2    Hamasur, B.3
  • 20
    • 0242352546 scopus 로고    scopus 로고
    • Oral vaccination with Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in brushtail possums
    • Aldwell FE, Keen DL, Parlane NA, et al. Oral vaccination with Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in brushtail possums. Vaccine 2003; 22:70-76.
    • (2003) Vaccine , vol.22 , pp. 70-76
    • Aldwell, F.E.1    Keen, D.L.2    Parlane, N.A.3
  • 21
    • 0042346025 scopus 로고    scopus 로고
    • Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara
    • Goonetilleke NP, McShane H, Hannan CM, et al. Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara. J Immunol 2003; 171:1602-1609.
    • (2003) J Immunol , vol.171 , pp. 1602-1609
    • Goonetilleke, N.P.1    McShane, H.2    Hannan, C.M.3
  • 22
    • 0034782438 scopus 로고    scopus 로고
    • Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFNgamma in their lungs
    • Lyadova IV, Vordermeier HM, Eruslanov EB, et al. Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFNgamma in their lungs. Clin Exp Immunol 2001; 126:274-279.
    • (2001) Clin Exp Immunol , vol.126 , pp. 274-279
    • Lyadova, I.V.1    Vordermeier, H.M.2    Eruslanov, E.B.3
  • 23
    • 0036263333 scopus 로고    scopus 로고
    • Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosis
    • Doherty TM, Olsen AW, van Pinxteren L, Andersen P. Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosis. Infect Immun 2002; 70:3111-3121.
    • (2002) Infect Immun , vol.70 , pp. 3111-3121
    • Doherty, T.M.1    Olsen, A.W.2    Van Pinxteren, L.3    Andersen, P.4
  • 24
    • 0037264496 scopus 로고    scopus 로고
    • Mycobacterium vaccae immunotherapy for treating tuberculosis
    • CD001166
    • de Bruyn G, Garner P. Mycobacterium vaccae immunotherapy for treating tuberculosis. Cochrane Database Syst Rev 2003; 1:CD001166.
    • (2003) Cochrane Database Syst Rev , vol.1
    • De Bruyn, G.1    Garner, P.2
  • 25
    • 1642539116 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine
    • Pinto R, Saunders BM, Camacho LR, et al. Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine. J Infect Dis 2004; 189:105-112. A mutant strain of M. tuberculosis, which is defective in translocating the capsular lipid phthiocerol dimycocerosate (DIM), was constructed using signature-tagged mutagenesis, and used as a vaccine. Improved and sustainable protection was seen when compared with BCG.
    • (2004) J Infect Dis , vol.189 , pp. 105-112
    • Pinto, R.1    Saunders, B.M.2    Camacho, L.R.3
  • 26
    • 0035145539 scopus 로고    scopus 로고
    • Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates
    • Smith DA, Parish T, Stoker NG, Bancroft GJ. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun 2001; 69:1142-1150.
    • (2001) Infect Immun , vol.69 , pp. 1142-1150
    • Smith, D.A.1    Parish, T.2    Stoker, N.G.3    Bancroft, G.J.4
  • 27
    • 0034610299 scopus 로고    scopus 로고
    • Recombinant bacillus Calmette-Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model
    • Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. Recombinant bacillus Calmette-Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl Acad Sci U S A 2000; 97:13853-13858.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13853-13858
    • Horwitz, M.A.1    Harth, G.2    Dillon, B.J.3    Maslesa-Galic, S.4
  • 28
    • 0038751936 scopus 로고    scopus 로고
    • Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
    • Pym AS, Brodin P, Majlessi L, et al. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat Med 2003; 9:533-539.
    • (2003) Nat Med , vol.9 , pp. 533-539
    • Pym, A.S.1    Brodin, P.2    Majlessi, L.3
  • 29
    • 0032967664 scopus 로고    scopus 로고
    • Live antigen carriers as tools for improved anti-tuberculosis vaccines
    • Hess J, Kaufmann SH. Live antigen carriers as tools for improved anti-tuberculosis vaccines. FEMS Immunol Med Microbiol 1999; 23:165-173.
    • (1999) FEMS Immunol Med Microbiol , vol.23 , pp. 165-173
    • Hess, J.1    Kaufmann, S.H.2
  • 30
    • 0033834505 scopus 로고    scopus 로고
    • Aerosol infection of mice with recombinant BCG secreting murine IFN-gamma partially reconstitutes local protective immunity
    • Moreira AL, Tsenova L, Murray PJ, et al. Aerosol infection of mice with recombinant BCG secreting murine IFN-gamma partially reconstitutes local protective immunity. Microb Pathog 2000; 29:175-185.
    • (2000) Microb Pathog , vol.29 , pp. 175-185
    • Moreira, A.L.1    Tsenova, L.2    Murray, P.J.3
  • 31
    • 0030034978 scopus 로고    scopus 로고
    • Manipulation and potentiation of anti-mycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines
    • Murray PJ, Aldovini A, Young RA. Manipulation and potentiation of anti-mycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines. Proc Natl Acad Sci U S A 1996; 93:934-939.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 934-939
    • Murray, P.J.1    Aldovini, A.2    Young, R.A.3
  • 32
    • 0035141937 scopus 로고    scopus 로고
    • Enhanced immunogenicity of CD4(+) T-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis
    • McShane H, Brookes R, Gilbert SC, Hill AV. Enhanced immunogenicity of CD4(+) T-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis. Infect Immun 2001; 69:681-686.
    • (2001) Infect Immun , vol.69 , pp. 681-686
    • McShane, H.1    Brookes, R.2    Gilbert, S.C.3    Hill, A.V.4
  • 33
    • 0035898950 scopus 로고    scopus 로고
    • Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA
    • Mollenkopf HJ, Groine-Triebkorn D, Andersen P, et al. Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA. Vaccine 2001; 19:4028-4035.
    • (2001) Vaccine , vol.19 , pp. 4028-4035
    • Mollenkopf, H.J.1    Groine-Triebkorn, D.2    Andersen, P.3
  • 34
    • 9144267735 scopus 로고    scopus 로고
    • Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    • McShane H, Pathan AA, Sander CR, et al. Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nat Med 2004; 10:1240-1244. This is the first report on the results of the clinical evaluation of a new TB vaccine candidate. A subunit candidate vaccine, based on heterologous BCG/MVA85A vaccination, is shown to be safe and immunogenic. Preexisting antimycobacterial immune responses (induced either by environmental mycobacteria or BCG vaccination) are enhanced by this new vaccine.
    • (2004) Nat Med , vol.10 , pp. 1240-1244
    • McShane, H.1    Pathan, A.A.2    Sander, C.R.3
  • 35
    • 0032427179 scopus 로고    scopus 로고
    • DNA vaccines: Application to tuberculosis
    • Huygen K. DNA vaccines: application to tuberculosis. Int J Tuberc Lung Dis 1998; 2:971-978.
    • (1998) Int J Tuberc Lung Dis , vol.2 , pp. 971-978
    • Huygen, K.1
  • 36
    • 0033962642 scopus 로고    scopus 로고
    • Enhancement of immunocompetence in tuberculosis by DNA vaccination
    • Lowrie DB, Silva CL. Enhancement of immunocompetence in tuberculosis by DNA vaccination. Vaccine 2000; 18:1712-1716.
    • (2000) Vaccine , vol.18 , pp. 1712-1716
    • Lowrie, D.B.1    Silva, C.L.2
  • 37
    • 9244220647 scopus 로고    scopus 로고
    • A heterologous DNA priming-Mycobacterium bovis BCG boosting immunization strategy using mycobacterial Hsp70, Hsp65, and Apa antigens improves protection against tuberculosis in mice
    • Ferraz JC, Stavropoulos E, Yang M, et al. A heterologous DNA priming-Mycobacterium bovis BCG boosting immunization strategy using mycobacterial Hsp70, Hsp65, and Apa antigens improves protection against tuberculosis in mice. Infect Immun 2004; 72:6945-6950. Previous studies by the same authors using Hsp65 and Hsp70 as DNA vaccines have shown good protection against TB. In this study using the Mtb Apa (alanine-proline-rich antigen) and mycobacterial Hsp65 and Hsp70 antigens as DNA vaccine, followed by BCG vaccination, significant improvement in the protective efficacy was seen.
    • (2004) Infect Immun , vol.72 , pp. 6945-6950
    • Ferraz, J.C.1    Stavropoulos, E.2    Yang, M.3
  • 38
    • 0642280874 scopus 로고    scopus 로고
    • DNA vaccination: An update
    • Lowrie DB. DNA vaccination: an update. Methods Mol Med 2003; 87:377-390.
    • (2003) Methods Mol Med , vol.87 , pp. 377-390
    • Lowrie, D.B.1
  • 39
    • 0345734379 scopus 로고    scopus 로고
    • Anti-mycobacterial immunity induced by a single injection of M. leprae Hsp65-encoding plasmid DNA in biodegradable microparticles
    • Johansen P, Raynaud C, Yang M, et al. Anti-mycobacterial immunity induced by a single injection of M. leprae Hsp65-encoding plasmid DNA in biodegradable microparticles. Immunol Lett 2003; 90:81-85.
    • (2003) Immunol Lett , vol.90 , pp. 81-85
    • Johansen, P.1    Raynaud, C.2    Yang, M.3
  • 40
    • 2942596008 scopus 로고    scopus 로고
    • Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein
    • Skeiky YA, Alderson MR, Ovendale PJ, et al. Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein. J Immunol 2004; 172:7618-7628. Using serological and T cell expression cloning methods, several antigens were identified that stimulate CD4 and CD8 responses in cells derived from PPD+ donors and in mice infected with Mtb. The relevant antigens were then used to construct recombinant fusion protein or naked DNA vaccine, in combination with two adjuvant formulations, and tested in mice and guinea pigs.
    • (2004) J Immunol , vol.172 , pp. 7618-7628
    • Skeiky, Y.A.1    Alderson, M.R.2    Ovendale, P.J.3
  • 41
    • 2342474615 scopus 로고    scopus 로고
    • A single vaccination with protein-microspheres elicits a strong CD8 T-cell-mediated immune response against Mycobacterium tuberculosis antigen Mtb8.4
    • Evans JT, Ward JR, Kern J, Johnson ME. A single vaccination with protein-microspheres elicits a strong CD8 T-cell-mediated immune response against Mycobacterium tuberculosis antigen Mtb8.4. Vaccine 2004; 22:1964-1972. This paper highlights how a nonimmunogenic protein antigen when formulated in a microsphere-based vaccine could induce both humoral and T cell immune responses. Several adjuvant formulations were developed and evaluated. The benefits of using a microsphere formulation over other types of delivery systems are also discussed. Different routes of administration were compared to test if vaccination with this new vaccine candidate could stimulate CD8 immune response against TB.
    • (2004) Vaccine , vol.22 , pp. 1964-1972
    • Evans, J.T.1    Ward, J.R.2    Kern, J.3    Johnson, M.E.4
  • 42
    • 70449298186 scopus 로고
    • Vaccination against tuberculosis with nonliving vaccines. I: The problem and its historical background
    • Weiss DW. Vaccination against tuberculosis with nonliving vaccines. I: The problem and its historical background. Am Rev Respir Dis 1959; 80:676-688.
    • (1959) Am Rev Respir Dis , vol.80 , pp. 676-688
    • Weiss, D.W.1
  • 43
    • 20144387363 scopus 로고    scopus 로고
    • Nasal boost with adjuvanted heat-killed BCG or arabinomannan-protein conjugate improves primary BCG-induced protection in C57BL/6 mice
    • Haile M, Hamasur B, Jaxmar T, et al. Nasal boost with adjuvanted heat-killed BCG or arabinomannan-protein conjugate improves primary BCG-induced protection in C57BL/6 mice. Tuberculosis (Edinb) 2005; 85:107-114. Using the mouse model two new vaccine candidates which have shown good protection in a prophylactic mode of vaccination are tested for their efficacy as a booster vaccine given intranasally in mice vaccinated with BCG at a young age.
    • (2005) Tuberculosis (Edinb) , vol.85 , pp. 107-114
    • Haile, M.1    Hamasur, B.2    Jaxmar, T.3
  • 44
    • 1242270634 scopus 로고    scopus 로고
    • A single dose of killed Mycobacterium bovis BCG in a novel class of adjuvant (Novasome) protects guinea pigs from lethal tuberculosis
    • Chambers MA, Wright DC, Brisker J, et al. A single dose of killed Mycobacterium bovis BCG in a novel class of adjuvant (Novasome) protects guinea pigs from lethal tuberculosis. Vaccine 2004; 22:1063-1071. The killed, whole cell BCG, formulated together with a liposome adjuvant, was tested for its protective efficacy in guinea pig model. A single dose of the adjuvanted formalin-kilied BCG vaccine was shown to be protective in terms of reduced bacterial loads in lungs and spleens and the increased long-term survival.
    • (2004) Vaccine , vol.22 , pp. 1063-1071
    • Chambers, M.A.1    Wright, D.C.2    Brisker, J.3
  • 45
    • 3042829628 scopus 로고    scopus 로고
    • Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guérin
    • Vordermeier HM, Rhodes SG, Dean G, et al. Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guérin. Immunology 2004; 112:461-470. The main aim of this paper was to evaluate the cellular immune responses, in particular in-vitro IFN-γ responses in cattle vaccinated with recombinant MVA85A or FP85A in conjunction with BCG. The same vaccine has already gone through phase I clinical evaluation, and is being prepared for large-scale studies in endemic countries (Ref. [18]).
    • (2004) Immunology , vol.112 , pp. 461-470
    • Vordermeier, H.M.1    Rhodes, S.G.2    Dean, G.3
  • 46
    • 15944388936 scopus 로고    scopus 로고
    • Boosting BCG with MVA85A: The first candidate subunit vaccine for tuberculosis in clinical trials
    • McShane H, Pathan AA, Sander CR, et al. Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials. Tuberculosis (Edinb) 2005; 85:47-52. The authors of this paper give a review on preclinical data from a BCG prime-recombinant MVA85A boost vaccine in the UK and Africa. Additionally, ethical and regulatory issues, different aims of TB vaccines, immune correlates of protection, as well as the Koch reaction, are discussed.
    • (2005) Tuberculosis (Edinb) , vol.85 , pp. 47-52
    • McShane, H.1    Pathan, A.A.2    Sander, C.R.3
  • 47
    • 0033989886 scopus 로고    scopus 로고
    • Immunogenicity and protective capacity of Mycobacterium bovis BCG after oral or intragastric administration in mice
    • Lagranderie M, Chavarot P, Balazuc AM, Marchai G. Immunogenicity and protective capacity of Mycobacterium bovis BCG after oral or intragastric administration in mice. Vaccine 2000; 18:1186-1195.
    • (2000) Vaccine , vol.18 , pp. 1186-1195
    • Lagranderie, M.1    Chavarot, P.2    Balazuc, A.M.3    Marchai, G.4
  • 48
    • 0037339779 scopus 로고    scopus 로고
    • Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production
    • Lagranderie M, Nahori MA, Balazuc AM, et al. Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production. Immunology 2003; 108:352-364.
    • (2003) Immunology , vol.108 , pp. 352-364
    • Lagranderie, M.1    Nahori, M.A.2    Balazuc, A.M.3
  • 49
    • 0034256992 scopus 로고    scopus 로고
    • Intranasal vaccination of mice against infection with Mycobacterium tuberculosis
    • Falero-Diaza G, Challacombea S, Banerjeeb D, et al. Intranasal vaccination of mice against infection with Mycobacterium tuberculosis. Vaccine 2000; 18:3223-3229.
    • (2000) Vaccine , vol.18 , pp. 3223-3229
    • Falero-Diaza, G.1    Challacombea, S.2    Banerjeeb, D.3
  • 50
    • 10744224166 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis arabinomannan-protein conjugates protect against tuberculosis
    • Hamasur B, Haile M, Pawlowski A, et al. Mycobacterium tuberculosis arabinomannan-protein conjugates protect against tuberculosis. Vaccine 2003; 21:4081-4093.
    • (2003) Vaccine , vol.21 , pp. 4081-4093
    • Hamasur, B.1    Haile, M.2    Pawlowski, A.3
  • 51
    • 8444222278 scopus 로고    scopus 로고
    • Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis
    • Wang J, Thorson L, Stokes RW, et al. Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis. J Immunol 2004; 173:6357-6365. In this paper, the recombinant replication-deficient, adenoviral vector expressing Mtb Ag85A (AdAgSSA) was tested as mucosal vaccine against TB. Single mucosal vaccination activated both CD4 and CD8 T cells, and enhanced protection more than cutaneous vaccination with BCG.
    • (2004) J Immunol , vol.173 , pp. 6357-6365
    • Wang, J.1    Thorson, L.2    Stokes, R.W.3
  • 52
    • 15944404248 scopus 로고    scopus 로고
    • Advancing TB vaccines to phase I clinical trials in the US: Regulatory/manufacturing/licensing issues
    • Rowland SS, Mayner RL, Barker L. Advancing TB vaccines to phase I clinical trials in the US: regulatory/manufacturing/licensing issues. Tuberculosis (Edinb) 2005; 85:39-46.
    • (2005) Tuberculosis (Edinb) , vol.85 , pp. 39-46
    • Rowland, S.S.1    Mayner, R.L.2    Barker, L.3
  • 53
    • 15944381546 scopus 로고    scopus 로고
    • NIH pre-clinical screening program: Overview and current status
    • Izzo A, Brandt L, Lasco T, et al. NIH pre-clinical screening program: overview and current status. Tuberculosis (Edinb) 2005; 85:25-28.
    • (2005) Tuberculosis (Edinb) , vol.85 , pp. 25-28
    • Izzo, A.1    Brandt, L.2    Lasco, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.