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Volumn 21, Issue 1, 2013, Pages 131-138

Minicircle DNA vectors achieve sustained expression reflected by active chromatin and transcriptional level

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MINICIRCLE DNA; PLASMID DNA; RNA POLYMERASE II;

EID: 84871919467     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.244     Document Type: Article
Times cited : (100)

References (50)
  • 1
    • 79954650563 scopus 로고    scopus 로고
    • State-of-the-art gene-based therapies: The road ahead
    • Kay, MA (2011). State-of-the-art gene-based therapies: the road ahead. Nat Rev Genet12: 316-328.
    • (2011) Nat Rev Genet , vol.12 , pp. 316-328
    • Ma, K.1
  • 2
    • 15944400651 scopus 로고    scopus 로고
    • Towards safe, non-viral therapeutic gene expression in humans
    • DOI 10.1038/nrg1577
    • Glover, DJ, Lipps, HJ and Jans, DA (2005). Towards safe, non-viral therapeutic geneexpression in humans. Nat Rev Genet 6: 299-310. (Pubitemid 40469049)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.4 , pp. 299-310
    • Glover, D.J.1    Lipps, H.J.2    Jans, D.A.3
  • 3
    • 0033166561 scopus 로고    scopus 로고
    • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
    • DOI 10.1089/10430349950017734
    • Zhang, G, Budker, V and Wolff, JA (1999). High levels of foreign gene expressionin hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 10:1735-1737. (Pubitemid 29328217)
    • (1999) Human Gene Therapy , vol.10 , Issue.10 , pp. 1735-1737
    • Zhang, G.1    Budker, V.2    Wolff, J.A.3
  • 4
    • 0034103009 scopus 로고    scopus 로고
    • Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system
    • DOI 10.1038/75568
    • Yant, SR, Meuse, L, Chiu, W, Ivics, Z, Izsvak, Z and Kay, MA (2000). Somaticintegration and long-term transgene expression in normal and haemophilic miceusing a DNA transposon system. Nat Genet 25: 35-41. (Pubitemid 30257033)
    • (2000) Nature Genetics , vol.25 , Issue.1 , pp. 35-41
    • Yant, S.R.1    Meuse, L.2    Chiu, W.3    Ivics, Z.4    Izsvak, Z.5    Kay, M.A.6
  • 5
    • 60449098993 scopus 로고    scopus 로고
    • Progress and prospects: The design andproduction of plasmid vectors
    • Gill, DR, Pringle, IA and Hyde, SC (2009). Progress and prospects: the design andproduction of plasmid vectors. Gene Ther 16: 165-171.
    • (2009) Gene Ther , vol.16 , pp. 165-171
    • Gill, D.R.1    Pringle, I.A.2    Hyde, S.C.3
  • 6
    • 77955407609 scopus 로고    scopus 로고
    • An invitro-identified high-affinity nucleosome-positioning signal is capable of transientlypositioning a nucleosome in vivo
    • Gracey, LE, Chen, ZY, Maniar, JM, Valouev, A, Sidow, A, Kay, MA et al. (2010). An invitro-identified high-affinity nucleosome-positioning signal is capable of transientlypositioning a nucleosome in vivo. Epigenetics Chromatin 3: 13.
    • (2010) Epigenetics Chromatin , vol.3 , pp. 13
    • Gracey, L.E.1    Chen, Z.Y.2    Maniar, J.M.3    Valouev, A.4    Sidow, A.5    Kay, M.A.6
  • 7
    • 0037271797 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Alpha-1 antitrypsin
    • DOI 10.1038/sj.gt.3301947
    • Stecenko, AA and Brigham, KL (2003). Gene therapy progress and prospects: alpha-1antitrypsin. Gene Ther 10: 95-99. (Pubitemid 36582580)
    • (2003) Gene Therapy , vol.10 , Issue.2 , pp. 95-99
    • Stecenko, A.A.1    Brigham, K.L.2
  • 8
    • 79960649903 scopus 로고    scopus 로고
    • Gene therapy for haemophilia: A long and winding road
    • High, KA (2011). Gene therapy for haemophilia: a long and winding road. J ThrombHaemost 9 Suppl 1: 2-11.
    • (2011) J ThrombHaemost , vol.9 , Issue.SUPPL. 1 , pp. 2-11
    • High, K.A.1
  • 9
    • 0028899573 scopus 로고
    • Therapeutic serum concentrationsof human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mousehepatocytes
    • Kay, MA, Graham, F, Leland, F and Woo, SL (1995). Therapeutic serum concentrationsof human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mousehepatocytes. Hepatology 21: 815-819.
    • (1995) Hepatology , vol.21 , pp. 815-819
    • Kay, M.A.1    Graham, F.2    Leland, F.3    Woo, S.L.4
  • 10
    • 67649390890 scopus 로고    scopus 로고
    • Clinical practice. Alpha1-antitrypsindeficiency
    • Silverman, EK and Sandhaus, RA (2009). Clinical practice. Alpha1-antitrypsindeficiency. N Engl J Med 360: 2749-2757.
    • (2009) N Engl J Med , vol.360 , pp. 2749-2757
    • Silverman, E.K.1    Sandhaus, R.A.2
  • 11
    • 80155145248 scopus 로고    scopus 로고
    • Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing a1-antitrypsin: Interim results
    • Flotte, TR, Trapnell, BC, Humphries, M, Carey, B, Calcedo, R, Rouhani, F et al. (2011).Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing a1-antitrypsin: interim results. Hum Gene Ther 22: 1239-1247.
    • (2011) Hum Gene Ther , vol.22 , pp. 1239-1247
    • Flotte, T.R.1    Trapnell, B.C.2    Humphries, M.3    Carey, B.4    Calcedo, R.5    Rouhani, F.6
  • 12
    • 79952187756 scopus 로고    scopus 로고
    • Minicircle DNA-based gene therapy coupled with immune modulation permits longtermexpression of a-L-iduronidase in mice with mucopolysaccharidosis type i
    • Osborn, MJ, McElmurry, RT, Lees, CJ, DeFeo, AP, Chen, ZY, Kay, MA et al. (2011).Minicircle DNA-based gene therapy coupled with immune modulation permits longtermexpression of a-L-iduronidase in mice with mucopolysaccharidosis type I. MolTher 19: 450-460.
    • (2011) Mol Ther , vol.19 , pp. 450-460
    • Osborn, M.J.1    McElmurry, R.T.2    Lees, C.J.3    Defeo, A.P.4    Chen, Z.Y.5    Kay, M.A.6
  • 13
    • 0041315884 scopus 로고    scopus 로고
    • Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo
    • DOI 10.1016/S1525-0016(03)00168-0
    • Chen, ZY, He, CY, Ehrhardt, A and Kay, MA (2003). Minicircle DNA vectors devoid ofbacterial DNA result in persistent and high-level transgene expression in vivo. Mol Ther8: 495-500. (Pubitemid 37161471)
    • (2003) Molecular Therapy , vol.8 , Issue.3 , pp. 495-500
    • Chen, Z.-Y.1    He, C.-Y.2    Ehrhardt, A.3    Kay, M.A.4
  • 14
    • 2642519089 scopus 로고    scopus 로고
    • Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo
    • DOI 10.1038/sj.gt.3302231
    • Chen, ZY, He, CY, Meuse, L and Kay, MA (2004). Silencing of episomal transgeneexpression by plasmid bacterial DNA elements in vivo. Gene Ther 11: 856-864. (Pubitemid 38714589)
    • (2004) Gene Therapy , vol.11 , Issue.10 , pp. 856-864
    • Chen, Z.Y.1    He, C.Y.2    Meuse, L.3    Kay, M.A.4
  • 15
    • 0034993252 scopus 로고    scopus 로고
    • Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver
    • DOI 10.1006/mthe.2001.0278
    • Chen, ZY, Yant, SR, He, CY, Meuse, L, Shen, S and Kay, MA (2001). Linear DNAsconcatemerize in vivo and result in sustained transgene expression in mouse liver. MolTher 3: 403-410. (Pubitemid 32514657)
    • (2001) Molecular Therapy , vol.3 , Issue.3 , pp. 403-410
    • Chen, Z.-Y.1    Yant, S.R.2    He, C.-Y.3    Meuse, L.4    Shen, S.5    Kay, M.A.6
  • 16
    • 78650028269 scopus 로고    scopus 로고
    • A robust system for production of minicircleDNA vectors
    • Kay, MA, He, CY and Chen, ZY (2010). A robust system for production of minicircleDNA vectors. Nat Biotechnol 28: 1287-1289.
    • (2010) Nat Biotechnol , vol.28 , pp. 1287-1289
    • Kay, M.A.1    He, C.Y.2    Chen, Z.Y.3
  • 17
    • 67651102609 scopus 로고    scopus 로고
    • Gene transfer to mouse heart and skeletal muscles using a minicircle expressinghuman vascular endothelial growth factor
    • Stenler, S, Andersson, A, Simonson, OE, Lundin, KE, Chen, ZY, Kay, MA et al. (2009).Gene transfer to mouse heart and skeletal muscles using a minicircle expressinghuman vascular endothelial growth factor. J Cardiovasc Pharmacol 53: 18-23.
    • (2009) J Cardiovasc Pharmacol , vol.53 , pp. 18-23
    • Stenler, S.1    Andersson, A.2    Simonson, O.E.3    Lundin, K.E.4    Chen, Z.Y.5    Kay, M.A.6
  • 18
    • 78651108455 scopus 로고    scopus 로고
    • Generation of adult human induced pluripotent stem cells using nonviral minicircleDNA vectors
    • Narsinh, KH, Jia, F, Robbins, RC, Kay, MA, Longaker, MT and Wu, JC (2011).Generation of adult human induced pluripotent stem cells using nonviral minicircleDNA vectors. Nat Protoc 6: 78-88.
    • (2011) Nat Protoc , vol.6 , pp. 78-88
    • Narsinh, K.H.1    Jia, F.2    Robbins, R.C.3    Kay, M.A.4    Longaker, M.T.5    Wu, J.C.6
  • 19
    • 39849089752 scopus 로고    scopus 로고
    • Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation
    • DOI 10.1038/sj.mt.6300399, PII 6300399
    • Chen, ZY, Riu, E, He, CY, Xu, H and Kay, MA (2008). Silencing of episomal transgeneexpression in liver by plasmid bacterial backbone DNA is independent of CpGmethylation. Mol Ther 16: 548-556. (Pubitemid 351314995)
    • (2008) Molecular Therapy , vol.16 , Issue.3 , pp. 548-556
    • Chen, Z.-Y.1    Riu, E.2    He, C.-Y.3    Xu, H.4    Kay, M.A.5
  • 20
    • 34250739823 scopus 로고    scopus 로고
    • Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo
    • DOI 10.1038/sj.mt.6300177, PII 6300177
    • Riu, E, Chen, ZY, Xu, H, He, CY and Kay, MA (2007). Histone modifications areassociated with the persistence or silencing of vector-mediated transgene expressionin vivo. Mol Ther 15: 1348-1355. (Pubitemid 46965331)
    • (2007) Molecular Therapy , vol.15 , Issue.7 , pp. 1348-1355
    • Riu, E.1    Chen, Z.-Y.2    Xu, H.3    He, C.-Y.4    Kay, M.A.5
  • 21
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • DOI 10.1038/sj.gt.3300947
    • Liu, F, Song, Y and Liu, D (1999). Hydrodynamics-based transfection in animals bysystemic administration of plasmid DNA. Gene Ther 6: 1258-1266. (Pubitemid 29359019)
    • (1999) Gene Therapy , vol.6 , Issue.7 , pp. 1258-1266
    • Liu, F.1    Song, Y.K.2    Liu, D.3
  • 22
    • 46249106990 scopus 로고    scopus 로고
    • Mapping and quantifying mammalian transcriptomes by RNA-Seq
    • DOI 10.1038/nmeth.1226, PII NMETH.1226
    • Mortazavi, A, Williams, BA, McCue, K, Schaeffer, L and Wold, B (2008). Mappingand quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5:621-628. (Pubitemid 351911867)
    • (2008) Nature Methods , vol.5 , Issue.7 , pp. 621-628
    • Mortazavi, A.1    Williams, B.A.2    McCue, K.3    Schaeffer, L.4    Wold, B.5
  • 23
    • 0000245728 scopus 로고
    • Isolation of pure andunaltered liver nuclei morphology and biochemical composition
    • Chauveau, J, Moule, Y and Rouiller, C (1956). Isolation of pure andunaltered liver nuclei morphology and biochemical composition. Exp Cell Res 11:317-321.
    • (1956) Exp Cell Res , vol.11 , pp. 317-321
    • Chauveau, J.1    Moule, Y.2    Rouiller, C.3
  • 24
    • 67650711140 scopus 로고    scopus 로고
    • Genome-wide views of chromatin structure
    • Rando, OJ and Chang, HY (2009). Genome-wide views of chromatin structure. AnnuRev Biochem 78: 245-271.
    • (2009) Annu Rev Biochem , vol.78 , pp. 245-271
    • Rando, O.J.1    Chang, H.Y.2
  • 25
    • 34447098370 scopus 로고    scopus 로고
    • A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
    • DOI 10.1016/j.cell.2007.05.042, PII S0092867407006812
    • Guenther, MG, Levine, SS, Boyer, LA, Jaenisch, R and Young, RA (2007). A chromatinlandmark and transcription initiation at most promoters in human cells. Cell 130:77-88. (Pubitemid 47031323)
    • (2007) Cell , vol.130 , Issue.1 , pp. 77-88
    • Guenther, M.G.1    Levine, S.S.2    Boyer, L.A.3    Jaenisch, R.4    Young, R.A.5
  • 26
    • 84861857476 scopus 로고    scopus 로고
    • RNA polymerase II elongation control
    • Zhou, Q, Li, T and Price, DH (2012). RNA polymerase II elongation control. Annu RevBiochem 81: 119-143.
    • (2012) Annu RevBiochem , vol.81 , pp. 119-143
    • Zhou, Q.1    Li, T.2    Price, D.H.3
  • 27
    • 33746324216 scopus 로고    scopus 로고
    • Chromatin modifications by methylation and ubiquitination: Implications in the regulation of gene expression
    • DOI 10.1146/annurev.biochem.75.103004.142422
    • Shilatifard, A (2006). Chromatin modifications by methylation and ubiquitination:implications in the regulation of gene expression. Annu Rev Biochem 75: 243-269. (Pubitemid 44118033)
    • (2006) Annual Review of Biochemistry , vol.75 , pp. 243-269
    • Shilatifard, A.1
  • 28
    • 0344022572 scopus 로고    scopus 로고
    • Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity
    • DOI 10.1016/S1097-2765(03)00092-3
    • Ng, HH, Robert, F, Young, RA and Struhl, K (2003). Targeted recruitment of Set1histone methylase by elongating Pol II provides a localized mark and memory ofrecent transcriptional activity. Mol Cell 11: 709-719. (Pubitemid 36385124)
    • (2003) Molecular Cell , vol.11 , Issue.3 , pp. 709-719
    • Ng, H.H.1    Robert, F.2    Young, R.A.3    Struhl, K.4
  • 29
    • 39749145198 scopus 로고    scopus 로고
    • Dynamic Regulation of Nucleosome Positioning in the Human Genome
    • DOI 10.1016/j.cell.2008.02.022, PII S0092867408002705
    • Schones, DE, Cui, K, Cuddapah, S, Roh, TY, Barski, A, Wang, Z et al. (2008).Dynamic regulation of nucleosome positioning in the human genome. Cell 132:887-898. (Pubitemid 351312809)
    • (2008) Cell , vol.132 , Issue.5 , pp. 887-898
    • Schones, D.E.1    Cui, K.2    Cuddapah, S.3    Roh, T.-Y.4    Barski, A.5    Wang, Z.6    Wei, G.7    Zhao, K.8
  • 31
    • 73449096761 scopus 로고    scopus 로고
    • Investigating repetitively matchingshort sequencing reads: The enigmatic nature of H3K9me3
    • Rosenfeld, JA, Xuan, Z and DeSalle, R (2009). Investigating repetitively matchingshort sequencing reads: the enigmatic nature of H3K9me3. Epigenetics 4:476-486.
    • (2009) Epigenetics , vol.4 , pp. 476-486
    • Rosenfeld, J.A.1    Xuan, Z.2    Desalle, R.3
  • 32
    • 23044431656 scopus 로고    scopus 로고
    • Histone H3 lysine 9 methylation and HP1γ are associated with transcription elongation through mammalian chromatin
    • DOI 10.1016/j.molcel.2005.06.011, PII S1097276505013900
    • Vakoc, CR, Mandat, SA, Olenchock, BA and Blobel, GA (2005). Histone H3 lysine 9methylation and HP1gamma are associated with transcription elongation throughmammalian chromatin. Mol Cell 19: 381-391. (Pubitemid 41074893)
    • (2005) Molecular Cell , vol.19 , Issue.3 , pp. 381-391
    • Vakoc, C.R.1    Mandat, S.A.2    Olenchock, B.A.3    Blobel, G.A.4
  • 33
    • 77957776228 scopus 로고    scopus 로고
    • Systematic protein location mapping reveals five principal chromatin types inDrosophila cells
    • Filion, GJ, van Bemmel, JG, Braunschweig, U, Talhout, W, Kind, J, Ward, LD et al.(2010). Systematic protein location mapping reveals five principal chromatin types inDrosophila cells. Cell 143: 212-224.
    • (2010) Cell , vol.143 , pp. 212-224
    • Filion, G.J.1    Van Bemmel, J.G.2    Braunschweig, U.3    Talhout, W.4    Kind, J.5    Ward, L.D.6
  • 34
    • 80052020631 scopus 로고    scopus 로고
    • Pre-mRNA splicing is adeterminant of histone H3K36 methylation
    • Kim, S, Kim, H, Fong, N, Erickson, B and Bentley, DL (2011). Pre-mRNA splicing is adeterminant of histone H3K36 methylation. Proc Natl Acad Sci USA 108: 13564-13569.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 13564-13569
    • Kim, S.1    Kim, H.2    Fong, N.3    Erickson, B.4    Bentley, D.L.5
  • 35
    • 80052445151 scopus 로고    scopus 로고
    • Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation ofhistone H3 Lys 36
    • de Almeida, SF, Grosso, AR, Koch, F, Fenouil, R, Carvalho, S, Andrade, J et al. (2011).Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation ofhistone H3 Lys36. Nat Struct Mol Biol 18: 977-983.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 977-983
    • De Almeida, S.F.1    Grosso, A.R.2    Koch, F.3    Fenouil, R.4    Carvalho, S.5    Andrade, J.6
  • 36
    • 0030742092 scopus 로고    scopus 로고
    • Epigenetic phenomena in filamentous fungi: Useful paradigms or repeat-induced confusion?
    • DOI 10.1016/S0168-9525(97)01201-8, PII S0168952597012018
    • Selker, EU (1997). Epigenetic phenomena in filamentous fungi: useful paradigms orrepeat-induced confusion? Trends Genet 13: 296-301. (Pubitemid 27309904)
    • (1997) Trends in Genetics , vol.13 , Issue.8 , pp. 296-301
    • Selker, E.U.1
  • 37
    • 0016008908 scopus 로고
    • DNA modification and restriction
    • Arber, W (1974). DNA modification and restriction. Prog Nucleic Acid Res Mol Biol 14:1-37.
    • (1974) Prog Nucleic Acid Res Mol Biol , vol.14 , pp. 1-37
    • Arber, W.1
  • 38
    • 0030907212 scopus 로고    scopus 로고
    • Mechanisms and applications of pathogen-derived resistance in transgenic plants
    • DOI 10.1016/S0958-1669(97)80105-X
    • Beachy, RN (1997). Mechanisms and applications of pathogen-derived resistance intransgenic plants. Curr Opin Biotechnol 8: 215-220. (Pubitemid 27154082)
    • (1997) Current Opinion in Biotechnology , vol.8 , Issue.2 , pp. 215-220
    • Beachy, R.N.1
  • 39
    • 0025947975 scopus 로고
    • Production of antisenseRNA leads to effective and specific inhibition of gene expression in C. elegans muscle
    • Fire, A, Albertson, D, Harrison, SW and Moerman, DG (1991). Production of antisenseRNA leads to effective and specific inhibition of gene expression in C. elegans muscle.Development 113: 503-514.
    • (1991) Development , vol.113 , pp. 503-514
    • Fire, A.1    Albertson, D.2    Harrison, S.W.3    Moerman, D.G.4
  • 40
    • 0026020992 scopus 로고
    • Inhibition of gene expression by a short sense fragment
    • Cameron, FH and Jennings, PA (1991). Inhibition of gene expression by a short sensefragment. Nucleic Acids Res 19: 469-475. (Pubitemid 21897028)
    • (1991) Nucleic Acids Research , vol.19 , Issue.3 , pp. 469-475
    • Cameron, F.H.1    Jennings, P.A.2
  • 42
    • 34249026300 scopus 로고    scopus 로고
    • High-Resolution Profiling of Histone Methylations in the Human Genome
    • DOI 10.1016/j.cell.2007.05.009, PII S0092867407006009
    • Barski, A, Cuddapah, S, Cui, K, Roh, TY, Schones, DE, Wang, Z et al. (2007).High-resolution profiling of histone methylations in the human genome. Cell 129:823-837. (Pubitemid 46802390)
    • (2007) Cell , vol.129 , Issue.4 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3    Roh, T.-Y.4    Schones, D.E.5    Wang, Z.6    Wei, G.7    Chepelev, I.8    Zhao, K.9
  • 43
    • 33646070846 scopus 로고    scopus 로고
    • Abivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein, BE, Mikkelsen, TS, Xie, X, Kamal, M, Huebert, DJ, Cuff, J et al. (2006). Abivalent chromatin structure marks key developmental genes in embryonic stem cells.Cell 125: 315-326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3    Kamal, M.4    Huebert, D.J.5    Cuff, J.6
  • 44
    • 79958077283 scopus 로고    scopus 로고
    • Nucleosome positioning in Saccharomycescerevisiae
    • Jansen, A and Verstrepen, KJ (2011). Nucleosome positioning in Saccharomycescerevisiae. Microbiol Mol Biol Rev 75: 301-320.
    • (2011) Microbiol Mol Biol Rev , vol.75 , pp. 301-320
    • Jansen, A.1    Verstrepen, K.J.2
  • 45
    • 33749153628 scopus 로고    scopus 로고
    • Nucleosome positions predicted through comparative genomics
    • DOI 10.1038/ng1878, PII NG1878
    • Ioshikhes, IP, Albert, I, Zanton, SJ and Pugh, BF (2006). Nucleosome positionspredicted through comparative genomics. Nat Genet 38: 1210-1215. (Pubitemid 44470369)
    • (2006) Nature Genetics , vol.38 , Issue.10 , pp. 1210-1215
    • Ioshikhes, I.P.1    Albert, I.2    Zanton, S.J.3    Pugh, B.F.4
  • 46
    • 43749088127 scopus 로고    scopus 로고
    • Two strategies for gene regulation by promoter nucleosomes
    • DOI 10.1101/gr.076059.108
    • Tirosh, I and Barkai, N (2008). Two strategies for gene regulation by promoternucleosomes. Genome Res 18: 1084-1091. (Pubitemid 351931159)
    • (2008) Genome Research , vol.18 , Issue.7 , pp. 1084-1091
    • Tirosh, I.1    Barkai, N.2
  • 47
    • 54949100776 scopus 로고    scopus 로고
    • Reactivation of silenced transgene expression in mouse liver by rapid, large-volumeinjection of isotonic solution
    • Nishikawa, M, Nakayama, A, Takahashi, Y, Fukuhara, Y and Takakura, Y (2008).Reactivation of silenced transgene expression in mouse liver by rapid, large-volumeinjection of isotonic solution. Hum Gene Ther 19: 1009-1020.
    • (2008) Hum Gene Ther , vol.19 , pp. 1009-1020
    • Nishikawa, M.1    Nakayama, A.2    Takahashi, Y.3    Fukuhara, Y.4    Takakura, Y.5
  • 48
    • 79955579208 scopus 로고    scopus 로고
    • Positive correlation between the generation of reactive oxygen species andactivation/reactivation of transgene expression after hydrodynamic injections intomice
    • Takiguchi, N, Takahashi, Y, Nishikawa, M, Matsui, Y, Fukuhara, Y, Oushiki, D et al.(2011). Positive correlation between the generation of reactive oxygen species andactivation/reactivation of transgene expression after hydrodynamic injections intomice. Pharm Res 28: 702-711.
    • (2011) Pharm Res , vol.28 , pp. 702-711
    • Takiguchi, N.1    Takahashi, Y.2    Nishikawa, M.3    Matsui, Y.4    Fukuhara, Y.5    Oushiki, D.6
  • 49
    • 74149094362 scopus 로고    scopus 로고
    • Partitioning the C. elegans genome bynucleosome modification, occupancy, and positioning
    • Gu, SG and Fire, A (2010). Partitioning the C. elegans genome bynucleosome modification, occupancy, and positioning. Chromosoma 119:73-87.
    • (2010) Chromosoma , vol.119 , pp. 73-87
    • Gu, S.G.1    Fire, A.2
  • 50
    • 33845925394 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation andmicroarray-based analysis of protein location
    • Lee, TI, Johnstone, SE and Young, RA (2006). Chromatin immunoprecipitation andmicroarray-based analysis of protein location. Nat Protoc 1: 729-748.
    • (2006) Nat Protoc , vol.1 , pp. 729-748
    • Lee, T.I.1    Johnstone, S.E.2    Young, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.