Toxicological safety evaluation of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar despite differing plasmid backbones or gene-inserts

Toxicological Sciences

Volumn 91, Issue 2, 2006, Pages 620-630

  Sheets, Rebecca L ^a   Stein, Judith ^a   Manetz, T Scott ^b   Andrews, Charla ^a   Bailer, Robert ^a   Rathmann, John ^a   Gomez, Phillip L ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b Gene Logic Inc   (United States)

Author keywords

DNA vaccine toxicology; DNA vaccines; Ebola; HIV AIDS; Plasmid vaccines; SARS; WNV

Indexed keywords

CYTOKINE; DNA VACCINE; EBOLA VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; PLASMID DNA; SEVERE ACUTE RESPIRATORY SYNDROME VACCINE; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS VACCINE; VRC 3900; WEST NILE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA STRUCTURE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DOSE REGIMEN; DRUG SAFETY; DRUG TISSUE LEVEL; EBOLA VIRUS; FEMALE; GENE EXPRESSION; GENE INSERTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGENICITY; IMMUNOREACTIVITY; INFECTION PREVENTION; MALE; NONHUMAN; PROMOTER REGION; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; TOXICITY TESTING; VIRUS INFECTION; VIRUS STRAIN; WEST NILE FLAVIVIRUS;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; EBOLAVIRUS; FEMALE; GENES, VIRAL; HEMORRHAGIC FEVER, EBOLA; HIV-1; INJECTIONS, INTRAMUSCULAR; MALE; PLASMIDS; PROMOTER REGIONS (GENETICS); RABBITS; SEVERE ACUTE RESPIRATORY SYNDROME; TISSUE DISTRIBUTION; VACCINES, DNA; VIRAL VACCINES; WEST NILE FEVER; WEST NILE VIRUS;

ANIMALIA; EBOLA VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SARS CORONAVIRUS; WEST NILE VIRUS;

EID: 33744792063     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj170     Document Type: Article

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