Skin electroporation for transdermal and topical delivery

Advanced Drug Delivery Reviews

Volumn 56, Issue 5, 2004, Pages 659-674

  Denet, Anne Rose ^a   Vanbever, Rita ^a   Préat, Véronique ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Electroporation; Mechanism; Safety; Skin permeability; Topical delivery; Transdermal delivery

Indexed keywords

DIFFUSION; ELECTRODES; ELECTROPHORESIS; MACROMOLECULES; MUSCLE; SKIN;

ELECTROPORATION; HIGH VOLTAGE PULSES;

DRUG THERAPY;

ALNIDITAN; ANTIGEN; ASCORBIC ACID; ATENOLOL; BUPRENORPHINE; CALCEIN; CYCLOSPORIN A; DEXTRAN SULFATE; DOMPERIDONE; ERYTHROSINE; FENTANYL; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; HEPARIN; LIDOCAINE; LUCIFER YELLOW; MANNITOL; METHYLENE BLUE; METOPROLOL; MICROSPHERE; NALBUPHINE; OLIGONUCLEOTIDE; OVALBUMIN; PLASMID DNA; SALCATONIN; SULFORHODAMINE B; TERAZOSIN; TETRACAINE; TIMOLOL; UNINDEXED DRUG;

DIFFUSION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG TRANSPORT; ELECTRIC POTENTIAL; ELECTRODE; ELECTROOSMOSIS; ELECTROPHORESIS; ELECTROPORATION; HUMAN; HYDROPHILICITY; IMPEDANCE; IONTOPHORESIS; LIPID BILAYER; LIPOPHILICITY; MACROMOLECULE; MOLECULAR WEIGHT; MUSCLE CONTRACTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PULSE WAVE; RADIATION SCATTERING; REVIEW; SKIN PERMEABILITY; ULTRASOUND;

EID: 1542328820     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2003.10.027     Document Type: Article

References (86)

1. Hadgraft J., Guy R.H. Transdermal Drug Delivery: Development Issues and Research Initiatives. vol. 35:1989;Marcel Dekker, New York.
2. Guy R.H. Current status and future prospects of transdermal drug delivery. Pharm. Res. 13:1996;1765-1768.
3. Naik A., Kalia Y.N., Guy R.H. Transdermal drug delivery: overcoming the skin's barrier function. P.S.T.T. 3:2000;318-326.
4. Folvari M. Non-invasive administration of drugs through the skin: challenges in delivery system design. P.S.T.T. 3:2000;417-425.
5. Barry B.W. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur. J. Pharm. Sci. 14:2001;101-114.
6. Weaver J.C., Chizmadzhev Y.A. Theory of electroporation: a review. Bioelectrochem. Bioenerg. 41:1996;135-160.
7. Mir L., Orlowski S. Mechanisms of electrochemotherapy. Adv. Drug Deliv. Rev. 35:1999;107-118.
8. Heller R., Gilbert R., Jaroszeski M.J. Clinical applications of electrochemotherapy. Adv. Drug Deliv. Rev. 35:1999;119-129.
9. Prausnitz M.R., Bose V.G., Langer R., Weaver J.C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. USA. 90:1993;10504-10508.
10. Vanbever R., Lecouturier N., Préat V. Transdermal delivery of metoprolol by electroporation. Pharm. Res. 11:1994;1657-1662.
11. Pliquett U. Mechanistic studies of molecular transport due to skin electroporation. Adv. Drug Deliv. Rev. 35:1999;41-60.
12. Weaver J.C., Vaughan T.E., Chizmadzhev Y.A. Theory of electrical creation of aqueous pathways across skin transport barriers. Adv. Drug Deliv. Rev. 35:1999;21-39.
13. Banga A., Bose S., Ghosh T. Iontophoresis and electroporation: comparisons and contrasts. Int. J. Pharm. 179:1999;1-19.
14. Mitragotri S. Synergistic effect of enhancers for transdermal drug delivery. Pharm. Res. 17:2000;1354-1359.
15. Pliquett U., Langer R., Weaver J.C. Changes in the passive electrical properties of human stratum corneum due to electroporation. Biochim. Biophys. Acta. 1239:1995;111-121.
16. Chizmadzhev Y.A., Zarnytsin V.G., Weaver J.C., Potts R.O. Mechanism of electroinduced ionic species transport through a multilamellar lipid bilayer system. Biophys. J. 68:1995;749-765.
17. Vanbever R., De Morre N., Préat V. Transdermal delivery of fentanyl by electroporation: II. Mechanisms involved in drug transport. Pharm. Res. 13:1996;1359-1365.
18. Pliquett U., Gusbeth C. Perturbation of human skin due to application of high voltage. Bioelectrochemistry. 51:2000;41-51.
19. Weaver J.C. Electroporation: a general phenomenon for manipulating cells and tissues. J. Cell. Biochem. 51:1993;426-435.
20. Weaver J.C. Electroporation theory: concepts and mechanisms. Nickoloff J.A. Molecular Biology: Methods. vol. 55:1995;3-28 Humana Press, Totowa.
21. Prausnitz M.R. The effects of electric current applied to the skin: a review for transdermal drug delivery. Adv. Drug Deliv. Rev. 18:1996;395-425.
22. Pliquett U., Weaver J.C. Electroporation of human skin: simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties. Bioelectrochem. Bioenerg. 39:1996;1-12.
23. Vanbever R., Préat V. In vivo efficacy and safety of skin electroporation. Adv. Drug Deliv. Rev. 35:1999;77-88.
24. Pliquett U., Zewert T.E., Chen T., Langer R., Weaver J.C. Imaging of fluorescent molecule and small ion transport through human stratum corneum during high voltage pulsing: localized transport regions are involved. Biophys. Chem. 58:1996;185-204.
25. Pliquett U., Vanbever R., Préat V., Weaver J.C. Local transport regions in human stratum corneum due to short and long high-voltage pulses. Bioelectrochem. Bioenerg. 47:1998;151-161.
26. Vanbever R., Pliquett U.F., Préat V., Weaver J.C. Comparison of the effects of short, high-voltage and long medium voltage pulses on skin electrical and transport properties. J. Control. Release. 69:1999;35-47.
27. Chizmadzhev Y.A., Indenbom A.V., Kuzmin P.I., Galichenko S.V., Weaver J.C., Potts R.O. Electrical properties of skin at moderate voltages: contribution of appendageal macropores. Biophys. J. 74:1998;843-856.
28. Chizmadzhev Y.A., Kuzmin P.I., Weaver J.C., Potts R.O. Skin appendageal macropores as a possible pathway for electrical current. J. Invest. Dermatol. Symp. 3:1998;148-152.
29. Regnier V., Le Doan T., Preat V. Parameters controlling topical delivery of oligonucleotides by electroporation. J. Drug Targeting. 5:1998;275-289.
30. Lombry C., Dujardin N., Preat V. Transdermal delivery of macromolecules using skin electroporation. Pharm. Res. 17:2000;32-37.
31. Dujardin N., Van der Smissen P., Preat V. Topical gene transfer into rat skin using electroporation. Pharm. Res. 18:2001;61-66.
32. Martin G.T., Pliquett U.F., Weaver J.C. Theoretical analysis of localized heating in human skin subjected to high voltage pulses. Bioelectrochemistry. 57:2002;55-64.
33. Pliquett U.F., Martin G.T., Weaver J.C. Kinetics of the temperature rise within human stratum corneum during electroporation and pulsed high-voltage iontophoresis. Bioelectrochemistry. 57:2002;65-72.
34. Vanbever R., Fouchard D., Jadoul A., De Morre N., Préat V., Marty J.-P. In vivo noninvasive evaluation of hairless rat skin after high-voltage pulse exposure. Skin Pharmacol. Appl. Skin Physiol. 11:1998;23-34.
35. Vanbever R., LeBoulenge E., Preat V. Transdermal delivery of fentanyl by electroporation: I. Influence of electrical factors. Pharm. Res. 13:1996;559-565.
36. Regnier V., Préat V. Mechanisms of a phosphorothioate oligonucleotide delivery by skin electroporation. Int. J. Pharm. 184:1999;147-156.
37. Vanbever R., Leroy M.-A., Préat V. Transdermal permeation of neutral molecules by electroporation. J. Control. Release. 54:1998;243-250.
38. Préat V., Vanbever R. Skin electroporation for transdermal and topical drug delivery. Guy R.H., Hadgraft J. Transdermal Drug Delivery. vol. 123:2002;227-254 Marcel Dekker, New York.
39. Pliquett U., Weaver J.C. Transport of a charged molecule across the human epidermis due to electroporation. J. Control. Release. 38:1996;1-10.
40. Denet A.R., Préat V. Transdermal delivery of timolol by electroporation through human skin. J. Control. Release. 88:2003;253-262.
41. Prausnitz M.R., Pliquett U., Langer R., Weaver J.C. Rapid temporal control of transdermal drug delivery by electroporation. Pharm. Res. 11:1994;1834-1837.
42. Jadoul A., Lecouturier N., Mesens J., Caers W., Préat V. Electrically enhanced transdermal delivery of alnitidan. J. Control. Release. 54:1998;265-272.
43. Sung K.C., Fang J.-Y., Wang J.-J., Hu O.Y. Transdermal delivery of nalbuphine and its prodrugs by electroporation. Eur. J. Pharm. Sci. 18:2003;63-70.
44. Zhang L., Rabussay D.P. Clinical evaluation of safety and human tolerance of electrical sensation induced by electric fields with non-invasive electrodes. Bioelectrochemistry. 56:2002;233-236.
45. Mori K., Hasegawa T., Sato S., Sugibayashi K. Effect of electric field on the enhanced skin permeation of drugs by electroporation. J. Control. Release. 90:2003;171-179.
46. Fukushima S., Kishimoto S., Horai S., Miyawaki K., Kamiyabu S., Kamata Y., Yamaoka Y., Takeuchi Y. Transdermal drug delivery by electroporation applied on the stratum corneum of rat using stamp-type electrode and frog-type electrode in vitro. Biol. Pharm. Bull. 24:2001;1027-1031.
47. Vanbever R., Preat V. Factors affecting transdermal delivery of metoprolol by electroporation. Bioelectrochem. Bioenerg. 38:1995;223-228.
48. Bommannan D.B., Tamada J., Leung L., Potts R.O. Effect of electroporation on transdermal iontophoretic delivery of luteinizing-hormone- releasing hormone (LHRH) in vitro. Pharm. Res. 11:1994;1809-1814.
49. Chang S.L., Hofmann G.A., Zhang L., Deftos L.J., Banga A.K. The effect of electroporation on iontophoretic transdermal delivery of calcium regulating hormones. J. Control. Release. 66:2000;127-133.
50. Prausnitz M.R., Edelman E.R., Gimm J.A., Langer R., Weaver J.C. Transdermal delivery of heparin by skin electroporation. Biol. Technol. 13:1995;1205-1209.
51. Denet A.-R., Ucakar B., Préat V. Transdermal delivery of timolol and atenolol using electroporation and iontophoresis in combination: a mechanistic approach. Pharm. Res. 20:2003;1946-1951.
52. Hu Q., Liang W., Bao J., Ping Q. Enhanced transdermal delivery of tetracaine by electroporation. Int. J. Pharm. 202:2000;121-124.
53. Johnson P.G., Gallo S.A., Hui S.W., Oseroff A. A pulsed electric field enhances cutaneous delivery of methylene blue in excised full-thickness porcine skin. J. Invest. Dermatol. 111:1998;457-463.
54. Fang J.Y., Hwang T.L., Huang Y.B., Tsai Y.H. Transdermal iontophoresis of sodium nonivamide acetate-V. Combined effect of physical enhancement methods. Int. J. Pharm. 235:2002;95-105.
55. Jadoul A., Préat V. Electrically-enhanced transdermal delivery of domperidone. Int. J. Pharm. 154:1997;229-234.
56. Chen T., Segall E.M., Langer R., Weaver J.C. Skin electroporation: rapid measurement of the transdermal voltage and flux of four fluorescent molecules show a transition to large fluxes near 50 V. J. Pharm. Sci. 37:1998;1368-1374.
57. Sharma A., Kara M., Smith F.R., Krishnan T.R. Transdermal drug delivery using electroporation: I. Factors influencing in vitro delivery of terazosin hydrochloride. J. Pharm. Sci. 89:2000;528-535.
58. Sharma A., Kara M., Smith F.R., Krishnan T.R. Transdermal drug delivery using electroporation: II. Factors influencing skin reversibility in electroporative delivery of terazosin hydrochloride in hairless rats. J. Pharm. Sci. 89:2000;536-544.
59. Bose S., Ravis W.R., Lin Y.J., Zhang L., Hofmann G.A., Banga A.K. Electrically-assisted transdermal delivery of buprenorphine. J. Control. Release. 73:2001;197-203.
60. Wang S., Kara M., Krishnan R.R. Transdermal delivery of cyclosporin-A using electroporation. J. Control. Release. 50:1998;61-70.
61. Badkar A.V., Banga A.K. Electrically enhanced transdermal delivery of a macromolecule. J. Pharm. Pharmacol. 54:2002;907-912.
62. Zhao H.Y., Zheng J.M., Pan Y., Song J.D. Effect of electroporation and iontophoresis on skin permeation of Defibrase® - a purified thrombin-like enzyme from the venon of Agkistrodon halys ussuriensis Emelianov. Pharmazie. 57:2002;482-484.
63. Chen T., Langer R., Weaver J.C. Charged microbeads are not transported across the human stratum corneum in vitro by short high-voltage pulses. Bioelectrochem. Bioenerg. 48:1999;181-192.
64. Hofmann G.A., Rustrum W.V., Suder K.S. Electro-incorporation of microcarriers as a method for the transdermal delivery of large molecules. Bioelectrochem. Bioenerg. 38:1995;209-222.
65. Vanbever R., Langers G., Montmayeur S., Preat V. Transdermal delivery of fentanyl: rapid onset of analgesia using skin electroporation. J. Control. Release. 50:1998;225-235.
66. Zhang L., Lerner S., Rustrum W.V., Hofmann G.A. Electroporation mediated topical delivery of vitamin C for cosmetic applications. Bioelectrochem. Bioenerg. 48:1999;453-461.
67. Wallace M.S., Ridgeway B., Jun E., Schulteis G., Rabussay D., Zhang L. Topical delivery of lidocaine in healthy volunteers by electroporation, electroincorporation, or iontophoresis: an evaluation of skin anesthesia. Reg. Anesth. Pain Med. 26:2001;229-238.
68. Wang S., Kara M., Krishnan R.R. Topical delivery of cyclosporin-A coevaporate using electroporation. Tech. Drug Deliv. Ind. Pharm. 23:1998;657-998.
69. Regnier V., Préat V. Localisation of an FITC-labeled phosphorothioate oligodeoxynucleotide in the skin after topical delivery by iontophoresis and electroporation. Pharm. Res. 15:1998;1596-1602.
70. Regnier V., Tahiri A., André N., Lemaître M., Le Doan T., Préat V. Electroporation-mediated delivery of 3′-protected phosphodiester oligodeoxynucleotides to the skin. J. Control. Release. 67:2000;337-346.
71. Misra A., Ganga S., Upadhay P. Needle-free non-adjuvanted skin immunization by electroporation-enhanced transdermal delivery of diphtheria toxoid and a candidate peptide vaccine against hepatitis B virus. Vaccine. 18:1999;517-523.
72. Dujardin N., Staes E., Préat V. Needle free immunization using skin electroporation. Proc. Control. Release Bioactive Mater. 27:2000;7409.
73. Zhang L., Li L., An Z.L., Hoffman R.M., Hofmann G.A. In vivo transdermal delivery of large molecules by pressure-mediated electroincorporation and electroporation: a novel method for drug and gene therapy. Bioelectrochem. Bioenerg. 42:1997;283-292.
74. Glenn G.M., Matyas G.R., Alving C.R. Skin immunization made possible by cholera toxin. Nature. 391:1998;351.
75. Zewert T.E., Pliquett U.F., Vanbever R., Langer R., Weaver J.C. Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule. Bioelectrochem. Bioenerg. 49:1999;11-20.
76. Vanbever R., Prausnitz M.R., Preat V. Macromolecules as novel transdermal transport enhancers for skin electroporation. Pharm. Res. 14:1997;638-644.
77. Sen A., Zhao Y.L., Zhang L., Hui S.W. Saturated anionic phospholipids enhance transdermal transport by electroporation. Biophys. J. 83:2002;2064-2073.
78. Weaver J.C., Vanbever R., Vaughan T.E., Prausnitz M.R. Heparin alters transdermal transport associated with electroporation. Biochem. Biophys. Res. Commun. 234:1997;637-640.
79. Kost J., Pliquett U., Mitragotri S., Yamamoto A., Langer R., Weaver J. Synergistic effect of electric field and ultrasound on transdermal transport. Pharm. Res. 13:1996;633-638.
80. Jadoul A., Bouwstra J., Preat V. Effects of iontophoresis and electroporation on the stratum corneum - review of the biophysical studies. Adv. Drug Deliv. Rev. 35:1999;89-105.
81. Rivière J.E., Monteiro-Rivière N.A., Rogers R.A., Bommannan D., Tamada J.A., Potts R.O. Pulsatile transdermal delivery of LHRH using electroporation: drug delivery and skin toxicology. J. Control. Release. 36:1995;229-233.
82. Dujardin N., Staes E., Kalia Y., Clarys P., Guy R., Preat V. In vivo assessment of skin electroporation using square wave pulses. J. Control. Release. 79:2002;219-227.
83. Jadoul A., Regnier V., Doucet J., Durand D., Préat V. X-ray scattering analysis of the stratum corneum treated by high voltage pulses. Pharm. Res. 14:1997;1275-1277.
84. Jadoul A., Tanajo H., Préat V., Spies F., Boddé H. Electroperturbation of human stratum corneum fine structure by high voltage pulses: a freeze fracture electron microscopy and differential thermal analysis study. J. Invest. Dermatol. Symp. Proc. 3:1998;153-158.
85. Gallo S., Sen A., Hensen M., Hui S. Time-dependent ultrastructural changes to porcine stratum corneum following an electric pulse. Biophys. J. 76:1999;2824-2832.
86. Sersa G., Cemazar M., Rudolf Z. Electrochemotherapy: advantages and drawbacks in treatment of cancer patients. Cancer Ther. 1:2003;133-142.