Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide

Journal of Leukocyte Biology

Volumn 71, Issue 5, 2002, Pages 813-820

  Gürsel, Mayda ^a   Verthelyi, Daniela ^a   Gürsel, Ihsan ^a   Ishii, Ken J ^a   Klinman, Dennis M ^a,b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

B cells; CpG DNA; Monocytes; NK cells

Indexed keywords

ALLERGEN; CD83 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN M; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE;

ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CPG ISLAND; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; B-LYMPHOCYTES; CELLS, CULTURED; ENDOCYTOSIS; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MONOCYTES; OLIGODEOXYRIBONUCLEOTIDES;

EID: 0036587573     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Yamamoto, S., Yamamoto, T., Katoaka, T., Kuramoto, E., Yano, O., Tokunaga, T. (1992) Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148, 4072-4076.
2. Krieg, A. M., Yi, A., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., Klinman, D. M. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546-548.
3. Klinman, D. M., Yi, A., Beaucage, S. L., Conover, J., Krieg, A. M. (1996) CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN γ. Proc. Natl. Acad. Sci. USA 93, 2879-2883.
4. Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M., Carson, D. A., Raz, E. (1996) Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352-354.
5. Yamamoto, S., Yamamoto, T., Shimada, S., Kuramoto, E., Yano, O., Kataoka, T., Tokunaga, T. (1992) DNA from bacteria, but not vertebrates, induces interferons, activates NK cells and inhibits tumor growth. Microbiol. Immunol. 36, 983-997.
6. Yi, A., Klinman, D. M., Martin, T. L., Matson, S., Krieg, A. M. (1996) Rapid immune activation by CpG motifs in bacterial DNA. J. Immunol. 157, 5394-5402.
7. Ballas, Z. D., Rasmussen, W. L., Krieg, A. M. (1996) Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157, 1840-1847.
8. Verthelyi, D., Ishii, K. J., Gursel, M., Takeshita, F., Klinman, D. M. (2001) Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166, 2372-2377.
9. Sparwasser, T., Miethke, T., Lipford, G., Erdmann, A., Hacker, H., Heeg, K., Wagner, H. (1997) Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27, 1671-1679.
10. Stacey, K. J., Sweet, M. J., Hume, D. A. (1996) Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157, 2116-2120.
11. Sparwasser, T., Koch, E., Vabulas, R. M., Heeg, K., Lipford, G. B., Ellwart, J. W., Wager, H. (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28, 2045-2054.
12. Behboudi, S., Chao, D., Klenerman, P., Austyn, J. (2000) The effects of DNA containing CpG motif on dendritic cells. Immunology 99, 361-366.
13. Klinman, D. M., Barnhart, K. M., Conover, J. (1999) CpG motifs as immune adjuvants. Vaccine 17, 19-25.
14. Lipford, G. B., Bauer, M., Blank, C., Reiter, R., Wagner, H., Heeg, K. (1997) CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27, 2340-2344.
15. Kline, J. N., Waldschmidt, T. J., Businga, T. R., Lemish, J. E., Weinstock, J. V., Thorne, P. S., Krieg, A. M. (1998) Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 160, 2555-2559.
16. Sur, S., Wild, J. S., Choudhury, B. K., Alam, R., Sur, N., Klinman, D. M. (1999) Long-term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J. Immunol. 162, 6284-6291.
17. Elkins, K. L., Rhinehart-Jones, T. R., Stibitz, S., Conover, J. S., Klinman, D. M. (1999) Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162, 2291-2298.
18. Krug, A., Rothenfusser, S., Hornung, V., Jahrsdorfer, B., Blackwell, S., Ballas, Z. K., Endres, S., Krieg, A. M., Hartmann, G. (2001) Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur. J. Immunol. 31, 2154-2163.
19. Ballas, Z. K., Krieg, A. M., Warren, T., Weiner, G. L. (2001) Divergent therapeutic and immunological effects of oligonucleotides with distinct CpG motifs. J. Immunol. 167, 4878-4886.
20. Britigan, B. E., Lewis, T. S., Waldschmidt, M., McCormick, M. L., Krieg, A. M. (2001) Lactoferrin binds CpG-containing oligonucleotides and inhibits their immunostimulatory effects on human B cells. J. Immunol. 167, 2921-2928.
21. Bohle, B., Orel, L., Kraft, D., Ebner, C. (2001) Oligodeoxynucleotides containing CpG motifs induce low levels of TNF-alpha in human B lymphocytes: possible adjuvants for Th1 responses. J. Immunol. 166, 3743-3748.
22. Liang, H., Reich, C. F., Pisetsky, D. S., Lipsky, P. E. (2000) The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides. J. Immunol. 165, 1438-1445.
23. Hartmann, G., Krieg, A. M. (2000) Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164, 944-952.
24. Hasbold, J., Gett, A. V., Rush, J. S., Deenick, E., Avery, D., Jun, J., Hodgkin, P. D. (1999) Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester. Immunol. Cell Biol. 77, 516-522.
25. Warren, T. L., Bhattia, S. K., Acosta, A. M., Dahle, C. E., Ratliff, T. L., Krieg, A. M., Weiner, G. J. (2000) APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells. J. Immunol. 165, 6244-6251.
26. Vabulas, R. M., Pircher, H., Lipford, G. B., Hacker, H., Wagner, H. (2000) CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J. Immunol. 164, 2372-2378.
27. Tascon, R. E., Ragno, S., Lowrie, D. B., Colston, M. J. (2000) Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells. Immunology 99, 1-7.
28. Liu, H. M., Newbrough, S. E., Bhatia, S. K., Dahle, C. E., Krieg, A. M., Weiner, G. J. (1998) Immunostimulatory CpG oligodeoxynucleotides enhanced the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor. Blood 92, 3730-3736.
29. Weiner, G. J., Liu, H. M., Wooldridge, J. E., Dahle, C. E., Krieg, A. M. (1997) Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA 94, 10833-10837.
30. Bauer, M., Heeg, K., Wagner, H., Lipford, G. B. (1999) DNA activates human immune cells through a CpG sequence-dependent manner. Immunology 97, 699-705.
31. Roman, M., Martin-Orozco, E., Goodman, J. S., Nguyen, M., Sato, Y., Ronaghy, A., Kornbluth, R. S., Richman, D. D., Carson, D. A., Raz, E. (1997) Immunostimulatory DNA sequences function as T helper-1 promoting adjuvants. Nat. Med. 3, 849-854.
32. Bohle, B., Jahn-Schmid, B., Maurer, D., Kraft, D., Ebner, C. (1999) Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur. J. Immunol. 29, 2344-2353.
33. Chomarat, P., Banchereau, J., Davoust, J., Palucka, A. K. (2000) Interleukin-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat. Immunol. 1, 510-514.
34. Palucka, K. A., Taquet, N., Sanchez-Chapuis, F, Gluckman, J. C. (1999) Lipopolysaccharide can block the potential of monocytes to differentiate into dendritic cells. J. Leukoc. Biol. 65, 232-240.
35. Mitani, H., Katayama, N., Araki, H., Ohishi, K., Kobayashi, K., Suzuki, H., Nishii, K., Masuyama, M., Yasukawa, K., Minami, N., Shiku, H. (2000) Activity of interleukin-6 in the differentiation of monocytes to macrophages and dendritic cells. Br. J. Haematol. 109, 288-295.
36. Takeshita, F., Leifer, C. A., Gursel, I., Ishii, K., Takeshita, S., Gursel, M., Klinman, D. M. (2001) Cutting edge: role of toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167, 3555-3558.
37. Bauer, S., Kirschning, C. J., Hacker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H., Lipford, G. B. (2001) Human TLR9 confers responsiveness to bacterial DNA via species specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98, 9237-9242.
38. Hacker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K., Lipford, G. B., Wagner, H. (1998) CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17, 6230-6240.
39. Yi, A. K., Krieg, A. M. (1998) Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. J. Immunol. 161, 4493-4497.
40. Lee, S. W., Song, M. K., Baek, K. H., Park, Y., Kim, J. K., Lee, C. H., Cheong, H. K, Cheong, C., Sung, Y. C. (2000) Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials. J. Immunol. 165, 3631-3639.