Enhancement of immune responses to an HBV DNA vaccine by electroporation

Vaccine

Volumn 24, Issue 21, 2006, Pages 4490-4493

  Luxembourg, A ^a   Hannaman, D ^a   Ellefsen, B ^a   Nakamura, G ^a   Bernard, R ^a  

^a Ichor Medical Systems Inc   (United States)

Author keywords

DNA vaccine; Electroporation; Hepatitis B virus

Indexed keywords

DNA VACCINE; HEPATITIS B VACCINE; PLASMID VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; ELECTROPORATION; HEPATITIS B; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ANTIBODIES, VIRAL; ELECTROPORATION; HEPATITIS B VACCINES; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, DNA;

EID: 33646849278     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2005.08.014     Document Type: Article

References (10)

1. Chisari F.V. Cytotoxic T cells and viral hepatitis. J Clin Invest 99 7 (1997) 1472-1477
2. Somiari S., Glasspool-Malone J., Drabick J.J., Gilbert R.A., Heller R., Jaroszeski M.J., et al. Theory and in vivo application of electroporative gene delivery. Mol Ther 2 3 (2000) 178-187
3. Widera G., Austin M., Rabussay D., Goldbeck C., Barnett S.W., Chen M., et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 164 9 (2000) 4635-4640
4. Michel M.L., Davis H.L., Schleef M., Mancini M., Tiollais P., and Whalen R.G. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc Natl Acad Sci USA 92 12 (1995) 5307-5311
5. Olsen C.H. Review of the use of statistics in infection and immunity. Infect Immun 71 12 (2003) 6689-6692
6. Schirmbeck R., Stober D., El-Kholy S., Riedl P., and Reimann J. The immunodominant, Ld-restricted T cell response to hepatitis B surface antigen (HBsAg) efficiently suppresses T cell priming to multiple Dd-, Kd-, and Kb-restricted HBsAg epitopes. J Immunol 168 12 (2002) 6253-6262
7. Guidotti L.G., Ando K., Hobbs M.V., Ishikawa T., Runkel L., Schreiber R.D., et al. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci USA 91 9 (1994) 3764-3768
8. Betts M.R., Brenchley J.M., Price D.A., De Rosa S.C., Douek D.C., Roederer M., et al. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281 1-2 (2003) 65-78
9. Tennant B.C., and Gerin J.L. The woodchuck model of hepatitis B virus infection. ILAR J 42 2 (2001) 89-102
10. van Drunen Littel-van den Hurk S., Loehr B.I., and Babiuk L.A. Immunization of livestock with DNA vaccines: current studies and future prospects. Vaccine 19 17-19 (2001) 2474-2479