Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration

Expert Opinion on Biological Therapy

Volumn 8, Issue 11, 2008, Pages 1645-1657

  Chiarella, Pieranna ^a,b   Massi, Emanuela ^a,b   De Robertis, Mariangela ^a,b   Sibilio, Annarita ^a,c   Parrella, Paola ^d   Fazio, Vito Michele ^a,d   Signori, Emanuela ^a,b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b CNR   (Italy)

^c Bio Ker srl   (Italy)

^d CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

Adjuvant; Antigen presentation; Dendritic cell; DNA vaccine; Electroporation

Indexed keywords

CYTOKINE; DNA VACCINE; HYALURONIDASE; MONOCLONAL ANTIBODY; PLASMID DNA;

ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL MIGRATION; CLINICAL ASSESSMENT; CLINICAL PROTOCOL; CYTOKINE RELEASE; DNA EXTRACTION; DNA IMMUNIZATION; ELECTROPORATION; ELECTROTRANSFORMATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; NONHUMAN; SKELETAL MUSCLE; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL MOVEMENT; CYTOKINES; ELECTROPORATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MICE; MICE, INBRED C3H; MUSCLE, SKELETAL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; VACCINES, DNA;

EID: 56249136280     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.8.11.1645     Document Type: Article

References (61)

1. Bojak A, Wild J, Deml L, Wagner R. Impact of codon usage modification on T cell immunogenicity and longevity of HIV-1 gag-specific DNA vaccines. Intervirology 2002;45(4-6):275-86
2. Yang NS, Burkholder J, Roberts B, et al. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 1990;87:9568-72
3. Bohm W, Mertens T, Schirmbeck R, Reimann J. Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses. Vaccine 1998;16:949-54
4. Wiendl H, Hohlfeld R, Kieseier BC. Immunobiology of muscle: advances in understanding an immunological microenvironment. Trends in Immunology 2005;267:373-80
5. Shirota H, Petrenko L, Hong C, Klinman DM. Potential of transfected muscle cells to contribute to DNA vaccine immunogenicity. J Immunol 2007;179(1):329-36
6. Heath WR, Belz GT, Behrens GM, et al. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev 2004;199:9-26
7. + T cells. J Immunol 2006;177(10):6626-33
8. Peng B, Zhao Y, Xu L, Xu Y. Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity. Vaccine 2007;25(11):2064-73
9. Scheerlinck JP, Karlis J, Tjelle TE, et al. In vivo electroporation improves immune responses to DNA vaccination in sheep. Vaccine 2004;22(13-14):1820-5
10. Babiuk S, Baca-Estrada ME, Foldvari M, et al. Electroporation improves the efficacy of DNA vaccines in large animals. Vaccine 2002;20(27-28):3399-408
11. Tollefsen S, Tjelle T, Schneider J, et al. Improved cellular and humoural immune responses against Mycobacterium tubercolosis antigens after intramuscular DNA immunisation combined with muscle electroporation. Vaccine 2002;20(27-28):3370-8
12. Dupuis M, Denis-Mize K, Woo C, et al. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol 2000;165(5):2850-8
13. Widera G, Austin M, Rabussay D, et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 2000;164(9):4635-40
14. Wang XD, Tang JG, Xie XL, et al. A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation. J Gene Med 2005;7(9):1235-45
15. McMahon JM, Signori E, Wells KE, et al. Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase increased expression with reduced muscle damage. Gene Ther 2001;8(16):1264-70
16. Mir LM, Bureau MF, Gehl J, et al. High-efficiency gene transfer into skeletal muscle mediated by electric pulses. Proc Natl Acad Sci USA 1999;96(8):4262-7
17. Long YC, Jaichandran S, Ho LP, et al. FVIII gene delivery by muscle electroporation corrects murine hemophilia A. J Gene Med 2005;7(4):494-505
18. + T cells. J Immunol 2007;179(7):4741-53
19. + T cells. J Immunol 2003;171(7):3379-84
20. Wells KE, McMahon J, Foster H, et al. Gene delivery to dystrophic muscle. Methods Mol Biol 2008;423:421-31
21. Ciafre' SA, Rinaldi M, Vespignani I, et al. A plasmid family containing two different expression cassettes suitable for immunomodulation and genetic immunization. Plasmid 1998;40(1):84-9
22. Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998;16(9):867-70
23. Harrison RL, Byrne BJ, Tung L. Electroporation-mediated gene transfer in cardiac tissue. FEBS Lett 1998;435(1):1-5
24. Buchan S, Grønevik E, Mathiesen I, et al. Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigen. J Immunol 2005;174(10):6292-8
25. Bachy M, Boudet F, Bureau M, et al. Electric pulses increase the immunogenicity of an influenza DNA vaccine injected intramuscularly in the mouse. Vaccine 2001;19(13-14):1688-93
26. Zucchelli S, Capone S, Fattori E, et al. Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J Virol 2000;74(24):11598-607
27. Otten G, Schaefer M, Doe B, et al. Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine 2004;22(19):2489-93
28. Babiuk S, Baca-Estrada ME, Foldvari M, et al. Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines. J Biotechnol 2004;110(1):1-10
29. Tsang G, Babiuk S, Van Drunen Little-Van Den Hurk S, et al. A single DNA immunization in combination with electroporation prolongs the primary immune response and maintains immune memory for six months. Vaccine 2007;25(30):5485-94
30. Selby M, Goldbeck C, Pertile T, et al. Enhancement of DNA vaccine potency by electroporation in vivo. J Biotechnol 2000;83(1-2):147-52
31. Capone S, Zampaglione I, Vitelli A, et al. Modulation of the immune response induced by gene elctrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates. J Immunol 2006;177(10):7462-71
32. Chiarella P, Massi E, De Robertis M, et al. Adjuvants in vaccines and for immunisation: current trends. Expert Opin Biol Ther 2007;7(10):1551-62
33. Ellis RW, Gerety RJ. Key issues in the selection of an expression system for vaccine antigens. J Med Virol 1990;31(1):54-8
34. Grønevik E, Mathiensen, Lømo T, et al. Early events of electroporation-mediated intramuscular DNA vaccination potentiate Th1-directed immune responses. J Gene Med 2005;7:1246-54
35. Tsang C, Babiuk S, Van Drunen Little-Van Den Hurk S, et al. A single DNA immunization in combination with electroporation prolongs the primary immune response and maintains immune memory for six months. Vaccine 2007;25:5485-94
36. Luxembourg A, Hannaman D, Nolan E, et al. Potentiation of an anthrax DNA vaccine with electroporation. Vaccine 2008 [Epub ahead of print]
37. Rinaldi M, Fioretti D, Iurescia S, et al. Anti-tumor immunity induced by CDR3-based DNA vaccination in a murine B-cell lymphoma model. Biochem Biophys Res Commun 2008;370(2):279-84
38. Peng B, Zhao Y, Lu H, et al. In vivo plasmid DNA electroporation resulted in transfection of satellite cells and lasting transgene expression in regenerated muscle fibers. Biochem Biophys Res Commun 2005;338(3):1490-8
39. Lefesvre P, Attema J, Van Bekkum D. A comparison of efficacy and toxicity between electroporation and adenoviral gene transfer. BMC Mol Biol 2002;3(12):1-13
40. Hojman P, Zibert JR, Gissel H, et al. Gene expression profiles in skeletal muscle after gene electrotransfer. BMC Mol Biol 2007;8(56):1-12
41. Luxembourg A, Evans CF, Hannaman D. Electroporation-based DNA immunisation: translation to the clinic. Expert Opin Biol Ther 2007;7(11):1647-64
42. Rice J, Ottensmeier CH, Stevenson FK. DNA vaccines: precision tools for activating effective immunity against cancer. Nat Rev Cancer 2008;8:108-20
43. Wang XD, Tang JG, Xie XL, et al. A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation. J Gene Med 2005;7:1235-45
44. Sumida SM, McKay PF, Truitt DM, et al. Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines. J Clin Invest 2004;114(9):1334-42
45. McKay PF, Barouch DH, Santra S, et al. Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte response. Eur J Immunol 2004;34(4):1011-20
46. Zepter K, Haffner A, Soohoo LF, et al. Induction of biologically active IL-1 beta-converting enzyme and mature IL-1 beta in human keratinocytes of inflammatory and immunologic stimuli. J Immunol 1997;159(2):6203-8
47. Azzawi M, Hasleton P. Tumor necrosis factor alpha and the cardiovascular system: its role in cardiac allograft rejection and heart disease. Cardiovasc Res 1999;43(4):850-9
48. Sallusto F, Palermo B, Lenig D, et al. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol 1999;29(5):1617-25
49. Luft T, Pang KC, Thomas E, et al. Type-I IFNs enhance the terminal differentiation of dendritic cells. J Immunol 1998;161(4):1947-53
50. Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997;9(1):10-6
51. Gallucci S, Matzinger P. Danger signals: SOS to the immune system. Curr Opin Immunol 2001;13(1):114-9
52. Brown BD, Lillicrap D. Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy. Blood 2002;100(4):1133-40
53. Tjelle TE, Rabussay D, Ottensmeier C, et al. Taking electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol. Methods Mol Biol 2008;423:497-507
54. Isaka Y, Imai E. Electroporation-mediated gene therapy. Expert Opin Drug Deliv 2007;4(5):561-71
55. Chiarella P, Massi E, De Robertis M, et al. Strategies for effective naked-DNA vaccination against infectious diseases. Recent Patents Antiinfect Drug Discov 2008;3(2):93-101
56. Draghia-Akli R, Khan AS, Brown PA, et al. Parameters for DNA vaccination using adaptive constant-current electroporation in mouse and pig models. Vaccine 2008 [Epub ahead of print]
57. Mir L. Application of electroporation gene therapy: past, current and future. Methods Mol Biol 2008;423:3-17
58. Brown PA, Khan AS, Draghia-Akli R. Delivery of DNA into skeletal muscle in large animals. Meth Mol Biol 2008;423:215-24
59. Li Z, Zhang H, Fan X, et al. DNA electroporation prime and protein boost strategy enhances humoural immunity of tubercolosis DNA vaccine in mice and non-human primates. Vaccine 2006;24:4565-8
60. Li S. Delivery of DNA into tumours. Methods Mol Biol 2008;423:311-8
61. Wells DJ. Gene therapy progress and prospects: electroporation and other physical methods. Gene Ther 2004;11(18):1363-9