-
1
-
-
84880580320
-
HIV integrase inhibitors:20-year landmark and challenges
-
Métifiot M, Marchand C, Pommier Y. 2013. HIV integrase inhibitors:20-year landmark and challenges. Adv Pharmacol 67:75-105.
-
(2013)
Adv Pharmacol
, vol.67
, pp. 75-105
-
-
Métifiot, M.1
Marchand, C.2
Pommier, Y.3
-
2
-
-
84886782112
-
An integrated overview of HIV-1 latency
-
Ruelas DS, Greene WC. 2013. An integrated overview of HIV-1 latency. Cell 155:519-529.
-
(2013)
Cell
, vol.155
, pp. 519-529
-
-
Ruelas, D.S.1
Greene, W.C.2
-
3
-
-
0342452981
-
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration
-
Donehower LA, Varmus HE. 1984. A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc Natl Acad Sci USA 81:6461-6465.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 6461-6465
-
-
Donehower, L.A.1
Varmus, H.E.2
-
4
-
-
0342466800
-
The retrovirus pol gene encodes a product required for DNA integration: Identification of a retrovirus int locus
-
Panganiban AT, Temin HM. 1984. The retrovirus pol gene encodes a product required for DNA integration: Identification of a retrovirus int locus. Proc Natl Acad Sci USA 81:7885-7889.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 7885-7889
-
-
Panganiban, A.T.1
Temin, H.M.2
-
5
-
-
0021729809
-
Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: A new viral function required for productive infection
-
Schwartzberg P, Colicelli J, GoffSP. 1984. Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: A new viral function required for productive infection. Cell 37:1043-1052.
-
(1984)
Cell
, vol.37
, pp. 1043-1052
-
-
Schwartzberg, P.1
Colicelli, J.2
Goff, S.P.3
-
6
-
-
0032883917
-
Characterization of intracellular reverse transcription complexes of Moloney murine leukemia virus
-
Fassati A, GoffSP. 1999. Characterization of intracellular reverse transcription complexes of Moloney murine leukemia virus. J Virol 73:8919-8925.
-
(1999)
J Virol
, vol.73
, pp. 8919-8925
-
-
Fassati, A.1
Goff, S.P.2
-
7
-
-
0035078745
-
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1
-
Fassati A, GoffSP. 2001. Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1. J Virol 75:3626-3635.
-
(2001)
J Virol
, vol.75
, pp. 3626-3635
-
-
Fassati, A.1
Goff, S.P.2
-
8
-
-
0021022185
-
The terminal nucleotides of retrovirus DNA are required for integration but not virus production
-
Panganiban AT, Temin HM. 1983. The terminal nucleotides of retrovirus DNA are required for integration but not virus production. Nature 306:155-160.
-
(1983)
Nature
, vol.306
, pp. 155-160
-
-
Panganiban, A.T.1
Temin, H.M.2
-
9
-
-
0022318818
-
Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site
-
Colicelli J, GoffSP. 1985. Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site. Cell 42:573-580.
-
(1985)
Cell
, vol.42
, pp. 573-580
-
-
Colicelli, J.1
Goff, S.P.2
-
10
-
-
0024278041
-
Sequence and spacing requirements of a retrovirus integration site
-
Colicelli J, GoffSP. 1988. Sequence and spacing requirements of a retrovirus integration site. J Mol Biol 199:47-59.
-
(1988)
J Mol Biol
, vol.199
, pp. 47-59
-
-
Colicelli, J.1
Goff, S.P.2
-
11
-
-
0031682564
-
Specific and independent recognition of U3 and U5 att sites by human immunodeficiency virus type 1 integrase in vivo
-
Masuda T, Kuroda MJ, Harada S. 1998. Specific and independent recognition of U3 and U5 att sites by human immunodeficiency virus type 1 integrase in vivo. J Virol 72:8396-8402.
-
(1998)
J Virol
, vol.72
, pp. 8396-8402
-
-
Masuda, T.1
Kuroda, M.J.2
Harada, S.3
-
12
-
-
0032846188
-
Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis
-
Brown HEV, Chen H, Engelman A. 1999. Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis. J Virol 73:9011-9020.
-
(1999)
J Virol
, vol.73
, pp. 9011-9020
-
-
Brown, H.E.V.1
Chen, H.2
Engelman, A.3
-
13
-
-
0024340289
-
Structure of the termini of DNA intermediates in the integration of retroviral DNA: Dependence on IN function and terminal DNA sequence
-
Roth MJ, Schwartzberg PL, GoffSP. 1989. Structure of the termini of DNA intermediates in the integration of retroviral DNA: Dependence on IN function and terminal DNA sequence. Cell 58:47-54.
-
(1989)
Cell
, vol.58
, pp. 47-54
-
-
Roth, M.J.1
Schwartzberg, P.L.2
Goff, S.P.3
-
14
-
-
0023687763
-
Retroviral DNA integration: structure of an integration intermediate
-
Fujiwara T, Mizuuchi K. 1988. Retroviral DNA integration: structure of an integration intermediate. Cell 54:497-504.
-
(1988)
Cell
, vol.54
, pp. 497-504
-
-
Fujiwara, T.1
Mizuuchi, K.2
-
15
-
-
0040896601
-
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein
-
Brown PO, Bowerman B, Varmus HE, Bishop JM. 1989. Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci USA 86:2525-2529.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 2525-2529
-
-
Brown, P.O.1
Bowerman, B.2
Varmus, H.E.3
Bishop, J.M.4
-
16
-
-
0025225368
-
Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombination
-
Pauza CD. 1990. Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombination. Virology 179:886-889.
-
(1990)
Virology
, vol.179
, pp. 886-889
-
-
Pauza, C.D.1
-
17
-
-
0026030093
-
Relationship of avian retrovirus DNA synthesis to integration in vitro
-
Lee YM, Coffin JM. 1991. Relationship of avian retrovirus DNA synthesis to integration in vitro. Mol. Cell Biol. 11:1419-1430.
-
(1991)
Mol. Cell Biol.
, vol.11
, pp. 1419-1430
-
-
Lee, Y.M.1
Coffin, J.M.2
-
19
-
-
0025221829
-
Efficient autointegration of avian retrovirus DNA in vitro
-
Lee YM, Coffin JM. 1990. Efficient autointegration of avian retrovirus DNA in vitro. J Virol 64:5958-5965.
-
(1990)
J Virol
, vol.64
, pp. 5958-5965
-
-
Lee, Y.M.1
Coffin, J.M.2
-
20
-
-
0025337327
-
Human immunodeficiency virus integration in a cell-free system
-
Ellison V, Abrams H, Roe T, Lifson J, Brown P. 1990. Human immunodeficiency virus integration in a cell-free system. J Virol 64:2711-2715.
-
(1990)
J Virol
, vol.64
, pp. 2711-2715
-
-
Ellison, V.1
Abrams, H.2
Roe, T.3
Lifson, J.4
Brown, P.5
-
21
-
-
0025313138
-
Integration of human immunodeficiency virus type 1 DNA in vitro
-
Farnet CM, Haseltine WA. 1990. Integration of human immunodeficiency virus type 1 DNA in vitro. Proc Natl Acad Sci USA 87:4164-4168.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 4164-4168
-
-
Farnet, C.M.1
Haseltine, W.A.2
-
22
-
-
0024431589
-
The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration
-
Katzman M, Katz RA, Skalka AM, Leis J. 1989. The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol 63:5319-5327.
-
(1989)
J Virol
, vol.63
, pp. 5319-5327
-
-
Katzman, M.1
Katz, R.A.2
Skalka, A.M.3
Leis, J.4
-
23
-
-
0025031786
-
The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro
-
Craigie R, Fujiwara T, Bushman F. 1990. The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro. Cell 62:829-837.
-
(1990)
Cell
, vol.62
, pp. 829-837
-
-
Craigie, R.1
Fujiwara, T.2
Bushman, F.3
-
24
-
-
0025366844
-
Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity
-
Sherman PA, Fyfe JA. 1990. Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity. Proc Natl Acad Sci USA 87:5119-5123.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 5119-5123
-
-
Sherman, P.A.1
Fyfe, J.A.2
-
25
-
-
0025133394
-
Retroviral DNA integration directed by HIV integration protein in vitro
-
Bushman FD, Fujiwara T, Craigie R. 1990. Retroviral DNA integration directed by HIV integration protein in vitro. Science 249:1555-1558.
-
(1990)
Science
, vol.249
, pp. 1555-1558
-
-
Bushman, F.D.1
Fujiwara, T.2
Craigie, R.3
-
26
-
-
0026034790
-
Activities of human immunodeficiency virus (HIV) integration protein in vitro: Specific cleavage and integration of HIV DNA
-
Bushman FD, Craigie R. 1991. Activities of human immunodeficiency virus (HIV) integration protein in vitro: Specific cleavage and integration of HIV DNA. Proc Natl Acad Sci USA 88:1339-1343.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 1339-1343
-
-
Bushman, F.D.1
Craigie, R.2
-
27
-
-
0025011051
-
The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro
-
Katz RA, Merkel G, Kulkosky J, Leis J, Skalka AM. 1990. The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell 63:87-95.
-
(1990)
Cell
, vol.63
, pp. 87-95
-
-
Katz, R.A.1
Merkel, G.2
Kulkosky, J.3
Leis, J.4
Skalka, A.M.5
-
28
-
-
0025184912
-
Removal of 3'-OH-terminal nucleotides from blunt-ended long terminal repeat termini by the avian retrovirus integration protein
-
Vora AC, Fitzgerald ML, Grandgenett DP. 1990. Removal of 3'-OH-terminal nucleotides from blunt-ended long terminal repeat termini by the avian retrovirus integration protein. J Virol 64:5656-5659.
-
(1990)
J Virol
, vol.64
, pp. 5656-5659
-
-
Vora, A.C.1
Fitzgerald, M.L.2
Grandgenett, D.P.3
-
29
-
-
0026072804
-
Substrate specificity of recombinant human immunodeficiency virus integrase protein
-
LaFemina RL, Callahan PL, Cordingley MG. 1991. Substrate specificity of recombinant human immunodeficiency virus integrase protein. J Virol 65:5624-5630.
-
(1991)
J Virol
, vol.65
, pp. 5624-5630
-
-
LaFemina, R.L.1
Callahan, P.L.2
Cordingley, M.G.3
-
30
-
-
0027327513
-
Endonucleolytic cleavages and DNA-joining activities of the integration protein of human foamy virus
-
Pahl A, Flugel RM. 1993. Endonucleolytic cleavages and DNA-joining activities of the integration protein of human foamy virus. J Virol 67:5426-5434.
-
(1993)
J Virol
, vol.67
, pp. 5426-5434
-
-
Pahl, A.1
Flugel, R.M.2
-
31
-
-
0030972160
-
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition
-
Miller M, Farnet C, Bushman F. 1997. Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. J Virol 71:5382-5390.
-
(1997)
J Virol
, vol.71
, pp. 5382-5390
-
-
Miller, M.1
Farnet, C.2
Bushman, F.3
-
32
-
-
84883541122
-
Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle
-
Munir S, Thierry S, Subra F, Deprez E, Delelis O. 2013. Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle. Retrovirology 10:87.
-
(2013)
Retrovirology
, vol.10
, pp. 87
-
-
Munir, S.1
Thierry, S.2
Subra, F.3
Deprez, E.4
Delelis, O.5
-
33
-
-
0035025888
-
A quantitative assay for HIV DNA integration in vivo
-
Butler SL, Hansen MS, Bushman FD. 2001. A quantitative assay for HIV DNA integration in vivo. Nat Med 7:631-634.
-
(2001)
Nat Med
, vol.7
, pp. 631-634
-
-
Butler, S.L.1
Hansen, M.S.2
Bushman, F.D.3
-
34
-
-
0034760352
-
Kinetics of human immunodeficiency virus type 1 (HIV) DNA integration in acutely infected cells as determined using a novel assay for detection of integrated HIV DNA
-
VandegraaffN, Kumar R, Burrell CJ, Li P. 2001. Kinetics of human immunodeficiency virus type 1 (HIV) DNA integration in acutely infected cells as determined using a novel assay for detection of integrated HIV DNA. J Virol 75:11253-11260.
-
(2001)
J Virol
, vol.75
, pp. 11253-11260
-
-
Vandegraaff, N.1
Kumar, R.2
Burrell, C.J.3
Li, P.4
-
35
-
-
0026549933
-
Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus
-
Chow SA, Vincent KA, Ellison V, Brown PO. 1992. Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. Science 255:723-726.
-
(1992)
Science
, vol.255
, pp. 723-726
-
-
Chow, S.A.1
Vincent, K.A.2
Ellison, V.3
Brown, P.O.4
-
36
-
-
0026348879
-
Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein
-
Vink C, Yeheskiely E, van der Marel GA, Van Boom JH, Plasterk RHA. 1991. Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein. Nucleic Acids Res 19:6691-6698.
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 6691-6698
-
-
Vink, C.1
Yeheskiely, E.2
van der Marel, G.A.3
Van Boom, J.H.4
Plasterk, R.H.A.5
-
37
-
-
0029148615
-
Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases
-
Katzman M, Sudol M. 1995. Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases. J Virol 69:5687-5696.
-
(1995)
J Virol
, vol.69
, pp. 5687-5696
-
-
Katzman, M.1
Sudol, M.2
-
38
-
-
0026637325
-
Transpositional recombination:Mechanistic insights from studies of Mu and other elements
-
Mizuuchi K. 1992. Transpositional recombination:Mechanistic insights from studies of Mu and other elements. Annu Rev Biochem 61:1011-1051.
-
(1992)
Annu Rev Biochem
, vol.61
, pp. 1011-1051
-
-
Mizuuchi, K.1
-
39
-
-
0018881742
-
Enzyme-catalyzed phosphoryl transfer reactions
-
Knowles JR. 1980. Enzyme-catalyzed phosphoryl transfer reactions. Annu Rev Biochem 49:877-919.
-
(1980)
Annu Rev Biochem
, vol.49
, pp. 877-919
-
-
Knowles, J.R.1
-
40
-
-
0025899314
-
Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism
-
Mizuuchi K, Adzuma K. 1991. Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism. Cell 66:129-140.
-
(1991)
Cell
, vol.66
, pp. 129-140
-
-
Mizuuchi, K.1
Adzuma, K.2
-
41
-
-
0026330796
-
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
-
Engelman A, Mizuuchi K, Craigie R. 1991. HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer. Cell 67:1211-1221.
-
(1991)
Cell
, vol.67
, pp. 1211-1221
-
-
Engelman, A.1
Mizuuchi, K.2
Craigie, R.3
-
42
-
-
0029980485
-
A soluble active mutant of HIV-1 integrase: Involvement of both the core and the C-terminal domains in multimerization
-
Jenkins TM, Engelman A, Ghirlando R, Craigie R. 1996. A soluble active mutant of HIV-1 integrase: Involvement of both the core and the C-terminal domains in multimerization. J Biol Chem 271:7712-7718.
-
(1996)
J Biol Chem
, vol.271
, pp. 7712-7718
-
-
Jenkins, T.M.1
Engelman, A.2
Ghirlando, R.3
Craigie, R.4
-
43
-
-
0028584269
-
Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases
-
Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR. 1994. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science 266:1981-1986.
-
(1994)
Science
, vol.266
, pp. 1981-1986
-
-
Dyda, F.1
Hickman, A.B.2
Jenkins, T.M.3
Engelman, A.4
Craigie, R.5
Davies, D.R.6
-
44
-
-
4444302947
-
Crystal structure of Argonaute and its implications for RISC slicer activity
-
Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. 2004. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305:1434-1437.
-
(2004)
Science
, vol.305
, pp. 1434-1437
-
-
Song, J.J.1
Smith, S.K.2
Hannon, G.J.3
Joshua-Tor, L.4
-
45
-
-
0033380368
-
Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination
-
Landree MA, Wibbenmeyer JA, Roth DB. 1999. Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev 13:3059-3069.
-
(1999)
Genes Dev
, vol.13
, pp. 3059-3069
-
-
Landree, M.A.1
Wibbenmeyer, J.A.2
Roth, D.B.3
-
46
-
-
0000675571
-
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
-
Kim DR, Dai Y, Mundy CL, Yang W, Oettinger MA. 1999. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev 13:3070-3080.
-
(1999)
Genes Dev
, vol.13
, pp. 3070-3080
-
-
Kim, D.R.1
Dai, Y.2
Mundy, C.L.3
Yang, W.4
Oettinger, M.A.5
-
47
-
-
59649101866
-
Retroviral integrase superfamily: The structural perspective
-
Nowotny M. 2009. Retroviral integrase superfamily: The structural perspective. EMBO Rep 10:144-151.
-
(2009)
EMBO Rep
, vol.10
, pp. 144-151
-
-
Nowotny, M.1
-
48
-
-
0033528762
-
A new method for determining the stereochemistry of DNA cleavage reactions: Application to the SfiI and HpaII restriction endonucleases and to the MuA transposase
-
Mizuuchi K, Nobbs TJ, Halford SE, Adzuma K, Qin J. 1999. A new method for determining the stereochemistry of DNA cleavage reactions: Application to the SfiI and HpaII restriction endonucleases and to the MuA transposase. Biochemistry 38:4640-4648.
-
(1999)
Biochemistry
, vol.38
, pp. 4640-4648
-
-
Mizuuchi, K.1
Nobbs, T.J.2
Halford, S.E.3
Adzuma, K.4
Qin, J.5
-
49
-
-
0029967722
-
Similarities between initiation of V(D)J recombination and retroviral integration
-
van Gent DC, Mizuuchi K, Gellert M. 1996. Similarities between initiation of V(D)J recombination and retroviral integration. Science 271:1592-1594.
-
(1996)
Science
, vol.271
, pp. 1592-1594
-
-
van Gent, D.C.1
Mizuuchi, K.2
Gellert, M.3
-
50
-
-
0033584864
-
Stereospecificity of reactions catalyzed by HIV-1 integrase
-
Gerton JL, Herschlag D, Brown PO. 1999. Stereospecificity of reactions catalyzed by HIV-1 integrase. J Biol Chem 274:33480-33487.
-
(1999)
J Biol Chem
, vol.274
, pp. 33480-33487
-
-
Gerton, J.L.1
Herschlag, D.2
Brown, P.O.3
-
51
-
-
0034724557
-
Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity
-
Kennedy AK, Haniford DB, Mizuuchi K. 2000. Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity. Cell 101:295-305.
-
(2000)
Cell
, vol.101
, pp. 295-305
-
-
Kennedy, A.K.1
Haniford, D.B.2
Mizuuchi, K.3
-
52
-
-
0028116161
-
Efficient concerted integration of retrovirus-like DNA in vitro by avian myeloblastosis virus integrase
-
Vora AC, McCord M, Fitzgerald ML, Inman RB, Grandgenett DP. 1994. Efficient concerted integration of retrovirus-like DNA in vitro by avian myeloblastosis virus integrase. Nucleic Acids Res 22:4454-4461.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4454-4461
-
-
Vora, A.C.1
McCord, M.2
Fitzgerald, M.L.3
Inman, R.B.4
Grandgenett, D.P.5
-
53
-
-
0034812084
-
Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase
-
Yang F, Roth MJ. 2001. Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase. J Virol 75:9561-9670.
-
(2001)
J Virol
, vol.75
, pp. 9561-9670
-
-
Yang, F.1
Roth, M.J.2
-
54
-
-
33846652601
-
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
-
Cherepanov P. 2007. LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro. Nucleic Acids Res 35:113-124.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 113-124
-
-
Cherepanov, P.1
-
55
-
-
84885052814
-
Biochemical characterization of novel retroviral integrase proteins
-
Ballandras-Colas A, Naraharisetty H, Li X, Serrao E, Engelman A. 2013. Biochemical characterization of novel retroviral integrase proteins. PLoS One 8:e76638.
-
(2013)
PLoS One
, vol.8
-
-
Ballandras-Colas, A.1
Naraharisetty, H.2
Li, X.3
Serrao, E.4
Engelman, A.5
-
56
-
-
58549092798
-
Functional and structural characterization of the integrase from the prototype foamy virus
-
Valkov E, Gupta SS, Hare S, Helander A, Roversi P, McClure M, Cherepanov P. 2009. Functional and structural characterization of the integrase from the prototype foamy virus. Nucleic Acids Res 37:243-255.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 243-255
-
-
Valkov, E.1
Gupta, S.S.2
Hare, S.3
Helander, A.4
Roversi, P.5
McClure, M.6
Cherepanov, P.7
-
57
-
-
0036118227
-
Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors
-
Sinha S, Pursley MH, Grandgenett DP. 2002. Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors. J Virol 76:3105-3113.
-
(2002)
J Virol
, vol.76
, pp. 3105-3113
-
-
Sinha, S.1
Pursley, M.H.2
Grandgenett, D.P.3
-
58
-
-
14244264128
-
HIV-1 integrase crosslinked oligomers are active in vitro
-
Faure A, Calmels C, Desjobert C, Castroviejo M, Caumont-Sarcos A, Tarrago-Litvak L, Litvak S, Parissi V. 2005. HIV-1 integrase crosslinked oligomers are active in vitro. Nucleic Acids Res 33:977-986.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 977-986
-
-
Faure, A.1
Calmels, C.2
Desjobert, C.3
Castroviejo, M.4
Caumont-Sarcos, A.5
Tarrago-Litvak, L.6
Litvak, S.7
Parissi, V.8
-
59
-
-
23844491860
-
Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration
-
Li M, Craigie R. 2005. Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration. J Biol Chem 280:29334-29339.
-
(2005)
J Biol Chem
, vol.280
, pp. 29334-29339
-
-
Li, M.1
Craigie, R.2
-
60
-
-
0032776165
-
Coupled integration of human immunodeficiency virus type 1 cDNA ends by purified integrase in vitro: Stimulation by the viral nucleocapsid protein
-
Carteau S, Gorelick RJ, Bushman FD. 1999. Coupled integration of human immunodeficiency virus type 1 cDNA ends by purified integrase in vitro: Stimulation by the viral nucleocapsid protein. J Virol 73:6670-6679.
-
(1999)
J Virol
, vol.73
, pp. 6670-6679
-
-
Carteau, S.1
Gorelick, R.J.2
Bushman, F.D.3
-
61
-
-
59249089461
-
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75
-
Hare S, Shun MC, Gupta SS, Valkov E, Engelman A, Cherepanov P. 2009. A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75. PLoS Pathog. 5:e1000259.
-
(2009)
PLoS Pathog.
, vol.5
-
-
Hare, S.1
Shun, M.C.2
Gupta, S.S.3
Valkov, E.4
Engelman, A.5
Cherepanov, P.6
-
62
-
-
80755156291
-
The HIV-1 integrase monomer induces a specific interaction with LTR DNA for concerted integration
-
Pandey KK, Bera S, Grandgenett DP. 2011. The HIV-1 integrase monomer induces a specific interaction with LTR DNA for concerted integration. Biochemistry 50:9788-9796.
-
(2011)
Biochemistry
, vol.50
, pp. 9788-9796
-
-
Pandey, K.K.1
Bera, S.2
Grandgenett, D.P.3
-
63
-
-
55549143334
-
Insight into the integrase-DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase
-
Delelis O, Carayon K, Guiot E, Leh H, Tauc P, Brochon JC, Mouscadet JF, Deprez E. 2008. Insight into the integrase-DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase. J Biol Chem 283:27838-27849.
-
(2008)
J Biol Chem
, vol.283
, pp. 27838-27849
-
-
Delelis, O.1
Carayon, K.2
Guiot, E.3
Leh, H.4
Tauc, P.5
Brochon, J.C.6
Mouscadet, J.F.7
Deprez, E.8
-
64
-
-
84868535547
-
Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA
-
Gupta K, Curtis JE, Krueger S, Hwang Y, Cherepanov P, Bushman FD, Van Duyne GD. 2012. Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA. Structure 20:1918-1928.
-
(2012)
Structure
, vol.20
, pp. 1918-1928
-
-
Gupta, K.1
Curtis, J.E.2
Krueger, S.3
Hwang, Y.4
Cherepanov, P.5
Bushman, F.D.6
Van Duyne, G.D.7
-
65
-
-
0029017919
-
Catalytic domain of human immunodeficiency virus type 1 integrase: Identification of a soluble mutant by systematic replacement of hydrophobic residues
-
Jenkins T, Hickman A, Dyda F, Ghirlando R, Davies D, Craigie R. 1995. Catalytic domain of human immunodeficiency virus type 1 integrase: Identification of a soluble mutant by systematic replacement of hydrophobic residues. Proc Natl Acad Sci USA 92:6057-6061.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 6057-6061
-
-
Jenkins, T.1
Hickman, A.2
Dyda, F.3
Ghirlando, R.4
Davies, D.5
Craigie, R.6
-
66
-
-
0034682511
-
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
-
Chen JC-H, Krucinski J, Miercke LJW, Finer-Moore JS, Tang AH, Leavitt AD, Stroud RM. 2000. Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding. Proc Natl Acad Sci USA 97:8233-8238.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8233-8238
-
-
Chen, J.C.-H.1
Krucinski, J.2
Miercke, L.J.W.3
Finer-Moore, J.S.4
Tang, A.H.5
Leavitt, A.D.6
Stroud, R.M.7
-
67
-
-
24044489892
-
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding
-
Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z. 2005. The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding. J Biol Chem 280:17841-17847.
-
(2005)
J Biol Chem
, vol.280
, pp. 17841-17847
-
-
Busschots, K.1
Vercammen, J.2
Emiliani, S.3
Benarous, R.4
Engelborghs, Y.5
Christ, F.6
Debyser, Z.7
-
68
-
-
65449189123
-
Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor
-
Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, RuffM. 2009. Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor. EMBO J. 28:980-991.
-
(2009)
EMBO J.
, vol.28
, pp. 980-991
-
-
Michel, F.1
Crucifix, C.2
Granger, F.3
Eiler, S.4
Mouscadet, J.F.5
Korolev, S.6
Agapkina, J.7
Ziganshin, R.8
Gottikh, M.9
Nazabal, A.10
Emiliani, S.11
Benarous, R.12
Moras, D.13
Schultz, P.14
Ruff, M.15
-
69
-
-
28444445583
-
From the Cover: Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
-
Cherepanov P, Ambrosio ALB, Rahman S, Ellenberger T, Engelman A. 2005. From the Cover: Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proc Natl Acad Sci USA 102:17308-17313.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17308-17313
-
-
Cherepanov, P.1
Ambrosio, A.L.B.2
Rahman, S.3
Ellenberger, T.4
Engelman, A.5
-
70
-
-
70049117341
-
Structural basis for functional tetramerization of lentiviral integrase
-
Hare S, Di Nunzio F, Labeja A, Wang J, Engelman A, Cherepanov P. 2009. Structural basis for functional tetramerization of lentiviral integrase. PLoS Pathog. 5:e1000515.
-
(2009)
PLoS Pathog.
, vol.5
-
-
Hare, S.1
Di Nunzio, F.2
Labeja, A.3
Wang, J.4
Engelman, A.5
Cherepanov, P.6
-
71
-
-
0026035178
-
Retroviral integrase domains: DNA binding and the recognition of LTR sequences
-
Khan E, Mack JPG, Katz RA, Kulkosky J, Skalka AM. 1991. Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res 19:851-860.
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 851-860
-
-
Khan, E.1
Mack, J.P.G.2
Katz, R.A.3
Kulkosky, J.4
Skalka, A.M.5
-
72
-
-
0026655897
-
Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase
-
Burke CJ, Sanyal G, Bruner MW, Ryan JA, LaFemina RL, Robbins HL, Zeft AS, Middaugh CR, Cordingley MG. 1992. Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase. J Biol Chem 267:9639-9644.
-
(1992)
J Biol Chem
, vol.267
, pp. 9639-9644
-
-
Burke, C.J.1
Sanyal, G.2
Bruner, M.W.3
Ryan, J.A.4
LaFemina, R.L.5
Robbins, H.L.6
Zeft, A.S.7
Middaugh, C.R.8
Cordingley, M.G.9
-
73
-
-
0026649557
-
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro
-
Engelman A, Craigie R. 1992. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J Virol 66:6361-6369.
-
(1992)
J Virol
, vol.66
, pp. 6361-6369
-
-
Engelman, A.1
Craigie, R.2
-
74
-
-
0027456715
-
Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding
-
Bushman FD, Engelman A, Palmer I, Wingfield P, Craigie R. 1993. Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding. Proc Natl Acad Sci USA 90:3428-3432.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 3428-3432
-
-
Bushman, F.D.1
Engelman, A.2
Palmer, I.3
Wingfield, P.4
Craigie, R.5
-
76
-
-
0027210608
-
Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein
-
Vink C, Oude Groeneger AM, Plasterk RHA. 1993. Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Res 21:1419-1425.
-
(1993)
Nucleic Acids Res
, vol.21
, pp. 1419-1425
-
-
Vink, C.1
Oude Groeneger, A.M.2
Plasterk, R.H.A.3
-
78
-
-
0026719238
-
Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases
-
Kulkosky J, Jones KS, Katz RA, Mack JP, Skalka AM. 1992. Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases. Mol Cell Biol 12:2331-2338.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 2331-2338
-
-
Kulkosky, J.1
Jones, K.S.2
Katz, R.A.3
Mack, J.P.4
Skalka, A.M.5
-
79
-
-
0026740842
-
Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitro
-
Drelich M, Wilhelm R, Mous J. 1992. Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitro. Virology 188:459-468.
-
(1992)
Virology
, vol.188
, pp. 459-468
-
-
Drelich, M.1
Wilhelm, R.2
Mous, J.3
-
80
-
-
0027470432
-
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro
-
Leavitt AD, Shiue L, Varmus HE. 1993. Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. J Biol Chem 268:2113-2119.
-
(1993)
J Biol Chem
, vol.268
, pp. 2113-2119
-
-
Leavitt, A.D.1
Shiue, L.2
Varmus, H.E.3
-
81
-
-
0025053617
-
Functional similarities between retroviruses and the IS3 family of bacterial insertion sequences?
-
Fayet O, Ramond P, Polard P, Prère MF, Chandler M. 1990. Functional similarities between retroviruses and the IS3 family of bacterial insertion sequences? Mol Microbiol 4:1771-1777.
-
(1990)
Mol Microbiol
, vol.4
, pp. 1771-1777
-
-
Fayet, O.1
Ramond, P.2
Polard, P.3
Prère, M.F.4
Chandler, M.5
-
82
-
-
79956364806
-
The catalytic domain of all eukaryotic cut-and-paste transposase superfamilies
-
Yuan Y-W, Wessler SR. 2011. The catalytic domain of all eukaryotic cut-and-paste transposase superfamilies. Proc Natl Acad Sci USA 108:7884-7889.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 7884-7889
-
-
Yuan, Y.-W.1
Wessler, S.R.2
-
83
-
-
84879911640
-
A superfamily of DNA transposons targeting multicopy small RNA genes
-
Kojima KK, Jurka J. 2013. A superfamily of DNA transposons targeting multicopy small RNA genes. PLoS One 8:e68260.
-
(2013)
PLoS One
, vol.8
-
-
Kojima, K.K.1
Jurka, J.2
-
84
-
-
84902952147
-
The diversity of prokaryotic DDE transposases of the mutator superfamily, insertion specificity, and association with conjugation machineries
-
Guérillot R, Siguier P, Gourbeyre E, Chandler M, Glaser P. 2014. The diversity of prokaryotic DDE transposases of the mutator superfamily, insertion specificity, and association with conjugation machineries. Genome Biol Evol 6:260-272.
-
(2014)
Genome Biol Evol
, vol.6
, pp. 260-272
-
-
Guérillot, R.1
Siguier, P.2
Gourbeyre, E.3
Chandler, M.4
Glaser, P.5
-
85
-
-
84863823336
-
3'-Processing and strand transfer catalysed by retroviral integrase in crystallo
-
Hare S, Maertens GN, Cherepanov P. 2012. 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo. EMBO J. 31:3020-3028.
-
(2012)
EMBO J
, vol.31
, pp. 3020-3028
-
-
Hare, S.1
Maertens, G.N.2
Cherepanov, P.3
-
86
-
-
0030828521
-
Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking
-
Jenkins TM, Esposito D, Engelman A, Craigie R. 1997. Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J. 16:6849-6859.
-
(1997)
EMBO J.
, vol.16
, pp. 6849-6859
-
-
Jenkins, T.M.1
Esposito, D.2
Engelman, A.3
Craigie, R.4
-
87
-
-
0032189652
-
Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction
-
Esposito D, Craigie R. 1998. Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction. EMBO J. 17:5832-5843.
-
(1998)
EMBO J.
, vol.17
, pp. 5832-5843
-
-
Esposito, D.1
Craigie, R.2
-
88
-
-
0030764902
-
The core domain of HIV-1 integrase recognizes key features of its DNA substrates
-
Gerton JL, Brown PO. 1997. The core domain of HIV-1 integrase recognizes key features of its DNA substrates. J Biol Chem 272:25809-25815.
-
(1997)
J Biol Chem
, vol.272
, pp. 25809-25815
-
-
Gerton, J.L.1
Brown, P.O.2
-
89
-
-
0031949592
-
Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzyme-substrate interactions
-
Gerton JL, Ohgi S, Olsen M, DeRisi J, Brown PO. 1998. Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzyme-substrate interactions. J Virol 72:5046-5055.
-
(1998)
J Virol
, vol.72
, pp. 5046-5055
-
-
Gerton, J.L.1
Ohgi, S.2
Olsen, M.3
DeRisi, J.4
Brown, P.O.5
-
90
-
-
0030875813
-
Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking
-
Heuer TS, Brown PO. 1997. Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking. Biochemistry 36:10655-10665.
-
(1997)
Biochemistry
, vol.36
, pp. 10655-10665
-
-
Heuer, T.S.1
Brown, P.O.2
-
91
-
-
33645216987
-
Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends
-
Chen A, Weber IT, Harrison RW, Leis J. 2006. Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends. J Biol Chem 281:4173-4182.
-
(2006)
J Biol Chem
, vol.281
, pp. 4173-4182
-
-
Chen, A.1
Weber, I.T.2
Harrison, R.W.3
Leis, J.4
-
92
-
-
33644861936
-
Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop
-
Johnson AA, Santos W, Pais GCG, Marchand C, Amin R, Burke TR, Jr., Verdine G, Pommier Y. 2006. Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop. J Biol Chem 281:461-467.
-
(2006)
J Biol Chem
, vol.281
, pp. 461-467
-
-
Johnson, A.A.1
Santos, W.2
Pais, G.C.G.3
Marchand, C.4
Amin, R.5
Burke, T.R.6
Verdine, G.7
Pommier, Y.8
-
93
-
-
75649146606
-
Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase a4 helix
-
Hobaika Z, Zargarian L, Boulard Y, Maroun RG, Mauffret O, Fermandjian S. 2009. Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase a4 helix. Nucleic Acids Res 37:7691-7700.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 7691-7700
-
-
Hobaika, Z.1
Zargarian, L.2
Boulard, Y.3
Maroun, R.G.4
Mauffret, O.5
Fermandjian, S.6
-
94
-
-
77949365510
-
Retroviral intasome assembly and inhibition of DNA strand transfer
-
Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P. 2010. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature 464:232-236.
-
(2010)
Nature
, vol.464
, pp. 232-236
-
-
Hare, S.1
Gupta, S.S.2
Valkov, E.3
Engelman, A.4
Cherepanov, P.5
-
95
-
-
0035824646
-
Role of the nonspecific DNA-binding region and alpha helices within the core domain of retroviral integrase in selecting target DNA sites for integration
-
Appa RS, Shin C-G, Lee P, Chow SA. 2001. Role of the nonspecific DNA-binding region and alpha helices within the core domain of retroviral integrase in selecting target DNA sites for integration. J Biol Chem 276:45848-45855.
-
(2001)
J Biol Chem
, vol.276
, pp. 45848-45855
-
-
Appa, R.S.1
Shin, C.-G.2
Lee, P.3
Chow, S.A.4
-
96
-
-
0034908087
-
Use of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selection
-
Harper AL, Skinner LM, Sudol M, Katzman M. 2001. Use of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selection. J Virol 75:7756-7762.
-
(2001)
J Virol
, vol.75
, pp. 7756-7762
-
-
Harper, A.L.1
Skinner, L.M.2
Sudol, M.3
Katzman, M.4
-
97
-
-
0037334017
-
An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA
-
Harper AL, Sudol M, Katzman M. 2003. An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA. J Virol 77:3838-3845.
-
(2003)
J Virol
, vol.77
, pp. 3838-3845
-
-
Harper, A.L.1
Sudol, M.2
Katzman, M.3
-
98
-
-
78149434355
-
The mechanism of retroviral integration through X-ray structures of its key intermediates
-
Maertens GN, Hare S, Cherepanov P. 2010. The mechanism of retroviral integration through X-ray structures of its key intermediates. Nature 468:326-329.
-
(2010)
Nature
, vol.468
, pp. 326-329
-
-
Maertens, G.N.1
Hare, S.2
Cherepanov, P.3
-
99
-
-
0030986376
-
Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
-
Cai M, Zheng R, Caffrey M, Craigie R, Clore GM, Gronenborn AM. 1997. Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nat Struct Biol 4:567-577.
-
(1997)
Nat Struct Biol
, vol.4
, pp. 567-577
-
-
Cai, M.1
Zheng, R.2
Caffrey, M.3
Craigie, R.4
Clore, G.M.5
Gronenborn, A.M.6
-
100
-
-
0031260521
-
The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc
-
Eijkelenboom AP, van den Ent FM, Vos A, Doreleijers JF, Hard K, Tullius TD, Plasterk RH, Kaptein R, Boelens R. 1997. The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc. Curr Biol 7:739-746.
-
(1997)
Curr Biol
, vol.7
, pp. 739-746
-
-
Eijkelenboom, A.P.1
van den Ent, F.M.2
Vos, A.3
Doreleijers, J.F.4
Hard, K.5
Tullius, T.D.6
Plasterk, R.H.7
Kaptein, R.8
Boelens, R.9
-
101
-
-
0029670473
-
Zinc stimulates Mg2+-dependent 3'-processing activity of human immunodeficiency virus type 1 integrase in vitro
-
Lee SP, Han MK. 1996. Zinc stimulates Mg2+-dependent 3'-processing activity of human immunodeficiency virus type 1 integrase in vitro. Biochemistry 35:3837-3844.
-
(1996)
Biochemistry
, vol.35
, pp. 3837-3844
-
-
Lee, S.P.1
Han, M.K.2
-
102
-
-
0030478950
-
Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity
-
Zheng R, Jenkins TM, Craigie R. 1996. Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. Proc Natl Acad Sci USA 93:13659-13664.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13659-13664
-
-
Zheng, R.1
Jenkins, T.M.2
Craigie, R.3
-
103
-
-
0033050758
-
Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis
-
van den Ent FMI, Vos A, Plasterk RHA. 1999. Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis. J Virol 73:3176-3183.
-
(1999)
J Virol
, vol.73
, pp. 3176-3183
-
-
van den Ent, F.M.I.1
Vos, A.2
Plasterk, R.H.A.3
-
104
-
-
41949095115
-
Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 integrase during viral DNA binding
-
Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia M. 2008. Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 integrase during viral DNA binding. J Biol Chem 283:5632-5641.
-
(2008)
J Biol Chem
, vol.283
, pp. 5632-5641
-
-
Zhao, Z.1
McKee, C.J.2
Kessl, J.J.3
Santos, W.L.4
Daigle, J.E.5
Engelman, A.6
Verdine, G.7
Kvaratskhelia, M.8
-
105
-
-
77957670046
-
Structure-based modeling of the functional HIV-1 intasome and its inhibition
-
Krishnan L, Li X, Naraharisetty HL, Hare S, Cherepanov P, Engelman A. 2010. Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proc Natl Acad Sci USA 107:15010-15915.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 15010-15915
-
-
Krishnan, L.1
Li, X.2
Naraharisetty, H.L.3
Hare, S.4
Cherepanov, P.5
Engelman, A.6
-
106
-
-
0029655459
-
Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication
-
Cannon PM, Byles ED, Kingsman SM, Kingsman AJ. 1996. Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication. J Virol 70:651-657.
-
(1996)
J Virol
, vol.70
, pp. 651-657
-
-
Cannon, P.M.1
Byles, E.D.2
Kingsman, S.M.3
Kingsman, A.J.4
-
107
-
-
0028067324
-
The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding
-
Engelman A, Hickman AB, Craigie R. 1994. The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. J Virol 68:5911-5917.
-
(1994)
J Virol
, vol.68
, pp. 5911-5917
-
-
Engelman, A.1
Hickman, A.B.2
Craigie, R.3
-
108
-
-
0001166515
-
Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: Critical residues for protein oligomerization and DNA binding
-
Puras Lutzke RA, Plasterk RHA. 1998. Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: Critical residues for protein oligomerization and DNA binding. J Virol 72:4841-4848.
-
(1998)
J Virol
, vol.72
, pp. 4841-4848
-
-
Puras Lutzke, R.A.1
Plasterk, R.H.A.2
-
109
-
-
0028034050
-
Characterization of the minimal DNA-binding domain of the HIV integrase protein
-
Puras Lutzke RA, Vink C, Plasterk RHA. 1994. Characterization of the minimal DNA-binding domain of the HIV integrase protein. Nucleic Acids Res 22:4125-4131.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4125-4131
-
-
Puras Lutzke, R.A.1
Vink, C.2
Plasterk, R.H.A.3
-
110
-
-
0028863151
-
Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase
-
Andrake MD, Skalka AM. 1995. Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase. J Biol Chem 270:29299-29306.
-
(1995)
J Biol Chem
, vol.270
, pp. 29299-29306
-
-
Andrake, M.D.1
Skalka, A.M.2
-
111
-
-
0027179694
-
Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex
-
Engelman A, Bushman FD, Craigie R. 1993. Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J. 12:3269-3275.
-
(1993)
EMBO J.
, vol.12
, pp. 3269-3275
-
-
Engelman, A.1
Bushman, F.D.2
Craigie, R.3
-
112
-
-
0027179416
-
Identification of amino acids in HIV-2 integrase involved in site-specific hydrolysis and alcoholysis of viral DNA termini
-
van Gent DC, Oude Groeneger AAM, Plasterk RHA. 1993. Identification of amino acids in HIV-2 integrase involved in site-specific hydrolysis and alcoholysis of viral DNA termini. Nucleic Acids Res 21:3373-3377.
-
(1993)
Nucleic Acids Res
, vol.21
, pp. 3373-3377
-
-
van Gent, D.C.1
Oude Groeneger, A.A.M.2
Plasterk, R.H.A.3
-
113
-
-
0028205117
-
Rous sarcoma virus integrase protein: Mapping functions for catalysis and substrate binding
-
Bushman FD, Wang B. 1994. Rous sarcoma virus integrase protein: Mapping functions for catalysis and substrate binding. J Virol 68:2215-2223.
-
(1994)
J Virol
, vol.68
, pp. 2215-2223
-
-
Bushman, F.D.1
Wang, B.2
-
114
-
-
0028850802
-
Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase
-
Kulkosky J, Katz RA, Merkel G, Skalka AM. 1995. Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase. Virology 206:448-456.
-
(1995)
Virology
, vol.206
, pp. 448-456
-
-
Kulkosky, J.1
Katz, R.A.2
Merkel, G.3
Skalka, A.M.4
-
115
-
-
0028814535
-
Characterization of the human spuma retrovirus integrase by site-directed mutagenesis, by complementation analysis, and by swapping the zinc finger domain of HIV-1
-
Pahl A, Flügel RM. 1995. Characterization of the human spuma retrovirus integrase by site-directed mutagenesis, by complementation analysis, and by swapping the zinc finger domain of HIV-1. J Biol Chem 270:2957-2966.
-
(1995)
J Biol Chem
, vol.270
, pp. 2957-2966
-
-
Pahl, A.1
Flügel, R.M.2
-
116
-
-
0029934077
-
Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysis
-
Jonsson C, Donzella G, Gaucan E, Smith C, Roth M. 1996. Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysis. J Virol 70:4585-4597.
-
(1996)
J Virol
, vol.70
, pp. 4585-4597
-
-
Jonsson, C.1
Donzella, G.2
Gaucan, E.3
Smith, C.4
Roth, M.5
-
117
-
-
0026665238
-
Retroviral integrase functions as a multimer and can turn over catalytically
-
Jones KS, Coleman J, Merkel GW, Laue TM, Skalka AM. 1992. Retroviral integrase functions as a multimer and can turn over catalytically. J Biol Chem 267:16037-16040.
-
(1992)
J Biol Chem
, vol.267
, pp. 16037-16040
-
-
Jones, K.S.1
Coleman, J.2
Merkel, G.W.3
Laue, T.M.4
Skalka, A.M.5
-
118
-
-
0037428412
-
Functional oligomeric state of avian sarcoma virus integrase
-
Bao KK, Wang H, Miller JK, Erie DA, Skalka AM, Wong I. 2003. Functional oligomeric state of avian sarcoma virus integrase. J Biol Chem 278:1323-1327.
-
(2003)
J Biol Chem
, vol.278
, pp. 1323-1327
-
-
Bao, K.K.1
Wang, H.2
Miller, J.K.3
Erie, D.A.4
Skalka, A.M.5
Wong, I.6
-
119
-
-
0346036088
-
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
-
Cherepanov P, Maertens G, Proost P, Devreese B, Van Beeumen J, Engelborghs Y, De Clercq E, Debyser Z. 2003. HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J Biol Chem 278:372-381.
-
(2003)
J Biol Chem
, vol.278
, pp. 372-381
-
-
Cherepanov, P.1
Maertens, G.2
Proost, P.3
Devreese, B.4
Van Beeumen, J.5
Engelborghs, Y.6
De Clercq, E.7
Debyser, Z.8
-
120
-
-
33645285267
-
Retroviral DNA integration: Reaction pathway and critical intermediates
-
Li M, Mizuuchi M, Burke TRJ, Craigie R. 2006. Retroviral DNA integration: Reaction pathway and critical intermediates. EMBO J. 25:1295-1304.
-
(2006)
EMBO J.
, vol.25
, pp. 1295-1304
-
-
Li, M.1
Mizuuchi, M.2
Burke, T.R.J.3
Craigie, R.4
-
121
-
-
67349245812
-
Molecular interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration
-
Bera S, Pandey KK, Vora AC, Grandgenett DP. 2009. Molecular interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration. J Mol Biol 389:183-198.
-
(2009)
J Mol Biol
, vol.389
, pp. 183-198
-
-
Bera, S.1
Pandey, K.K.2
Vora, A.C.3
Grandgenett, D.P.4
-
122
-
-
0027246609
-
Complementation between HIV integrase proteins mutated in different domains
-
van Gent DC, Vink C, Groeneger AAMO, Plasterk RHA. 1993. Complementation between HIV integrase proteins mutated in different domains. EMBO J. 12:3261-3267.
-
(1993)
EMBO J.
, vol.12
, pp. 3261-3267
-
-
van Gent, D.C.1
Vink, C.2
Groeneger, A.A.M.O.3
Plasterk, R.H.A.4
-
123
-
-
0028888455
-
An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer
-
Ellison V, Gerton J, Vincent KA, Brown PO. 1995. An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer. J Biol Chem 270:3320-3326.
-
(1995)
J Biol Chem
, vol.270
, pp. 3320-3326
-
-
Ellison, V.1
Gerton, J.2
Vincent, K.A.3
Brown, P.O.4
-
124
-
-
0026095906
-
Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage
-
Vink C, van Gent DC, Elgersma Y, Plasterk RH. 1991. Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage. J Virol 65:4636-4644.
-
(1991)
J Virol
, vol.65
, pp. 4636-4644
-
-
Vink, C.1
van Gent, D.C.2
Elgersma, Y.3
Plasterk, R.H.4
-
125
-
-
0026537415
-
Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae
-
Leavitt AD, Rose RB, Varmus HE. 1992. Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae. J Virol 66:2359-2368.
-
(1992)
J Virol
, vol.66
, pp. 2359-2368
-
-
Leavitt, A.D.1
Rose, R.B.2
Varmus, H.E.3
-
126
-
-
0026693410
-
Human immunodeficiency virus type 1 integration protein: DNA sequence requirements for cleaving and joining reactions
-
Sherman PA, Dickson ML, Fyfe JA. 1992. Human immunodeficiency virus type 1 integration protein: DNA sequence requirements for cleaving and joining reactions. J Virol 66:3593-3601.
-
(1992)
J Virol
, vol.66
, pp. 3593-3601
-
-
Sherman, P.A.1
Dickson, M.L.2
Fyfe, J.A.3
-
127
-
-
0028871705
-
Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype ofmutants in the zinc finger-like domain
-
Masuda T, Planelles V, Krogstad P, Chen IS. 1995. Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype ofmutants in the zinc finger-like domain. J Virol 69:6687-6696.
-
(1995)
J Virol
, vol.69
, pp. 6687-6696
-
-
Masuda, T.1
Planelles, V.2
Krogstad, P.3
Chen, I.S.4
-
128
-
-
33749474353
-
Alternate polypurine tracts affect Rous sarcoma virus integration in vivo
-
Oh J, Chang KW, Alvord WG, Hughes SH. 2006. Alternate polypurine tracts affect Rous sarcoma virus integration in vivo. J Virol 80:10281-10284.
-
(2006)
J Virol
, vol.80
, pp. 10281-10284
-
-
Oh, J.1
Chang, K.W.2
Alvord, W.G.3
Hughes, S.H.4
-
129
-
-
33645965892
-
Mutations in the U5 sequences adjacent to the primer binding site do not affect tRNA cleavage by Rous sarcoma virus RNase H but do cause aberrant integrations in vivo
-
Oh J, Chang KW, Hughes SH. 2006. Mutations in the U5 sequences adjacent to the primer binding site do not affect tRNA cleavage by Rous sarcoma virus RNase H but do cause aberrant integrations in vivo. J Virol 80:451-459.
-
(2006)
J Virol
, vol.80
, pp. 451-459
-
-
Oh, J.1
Chang, K.W.2
Hughes, S.H.3
-
130
-
-
0033380262
-
Studies on a "jumping gene machine": Higher-order nucleoprotein complexes in Mu DNA transposition
-
Chaconas G. 1999. Studies on a "jumping gene machine": Higher-order nucleoprotein complexes in Mu DNA transposition. Biochem Cell Biol 77:487-491.
-
(1999)
Biochem Cell Biol
, vol.77
, pp. 487-491
-
-
Chaconas, G.1
-
131
-
-
84870324937
-
Retroviral integrase proteins and HIV-1 DNA integration
-
Krishnan L, Engelman A. 2012. Retroviral integrase proteins and HIV-1 DNA integration. J Biol Chem 287:40858-40866.
-
(2012)
J Biol Chem
, vol.287
, pp. 40858-40866
-
-
Krishnan, L.1
Engelman, A.2
-
132
-
-
0031449687
-
A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration
-
Wei S-Q, Mizuuchi K, Craigie R. 1997. A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration. EMBO J. 16:7511-7520.
-
(1997)
EMBO J.
, vol.16
, pp. 7511-7520
-
-
Wei, S.-Q.1
Mizuuchi, K.2
Craigie, R.3
-
133
-
-
0033546149
-
Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome
-
Chen H, Wei S-Q, Engelman A. 1999. Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome. J Biol Chem 274:17358-17364.
-
(1999)
J Biol Chem
, vol.274
, pp. 17358-17364
-
-
Chen, H.1
Wei, S.-Q.2
Engelman, A.3
-
134
-
-
77954761903
-
Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy
-
Kotova S, Li M, Dimitriadis EK, Craigie R. 2010. Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy. J Mol Biol 399:491-500.
-
(2010)
J Mol Biol
, vol.399
, pp. 491-500
-
-
Kotova, S.1
Li, M.2
Dimitriadis, E.K.3
Craigie, R.4
-
135
-
-
80455178762
-
FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75
-
Kessl JJ, Li M, Ignatov M, Shkriabai N, Eidahl JO, Feng L, Musier-Forsyth K, Craigie R, Kvaratskhelia M. 2011. FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. Nucleic Acids Res 39:9009-9022.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 9009-9022
-
-
Kessl, J.J.1
Li, M.2
Ignatov, M.3
Shkriabai, N.4
Eidahl, J.O.5
Feng, L.6
Musier-Forsyth, K.7
Craigie, R.8
Kvaratskhelia, M.9
-
136
-
-
33747330377
-
Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
-
Guiot E, Carayon K, Delelis O, Simon F, Tauc P, Zubin E, Gottikh M, Mouscadet J-F, Brochon J-C, Deprez E. 2006. Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity. J Biol Chem 281:22707-22719.
-
(2006)
J Biol Chem
, vol.281
, pp. 22707-22719
-
-
Guiot, E.1
Carayon, K.2
Delelis, O.3
Simon, F.4
Tauc, P.5
Zubin, E.6
Gottikh, M.7
Mouscadet, J.-F.8
Brochon, J.-C.9
Deprez, E.10
-
137
-
-
79955769735
-
Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking
-
Bojja RS, Andrake MD, Weigand S, Merkel G, Yarychkivska O, Henderson A, Kummerling M, Skalka AM. 2011. Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking. J Biol Chem 286:17047-17059.
-
(2011)
J Biol Chem
, vol.286
, pp. 17047-17059
-
-
Bojja, R.S.1
Andrake, M.D.2
Weigand, S.3
Merkel, G.4
Yarychkivska, O.5
Henderson, A.6
Kummerling, M.7
Skalka, A.M.8
-
138
-
-
84874839394
-
Architecture and assembly of HIV integrase multimers in the absence of DNA substrates
-
Bojja RS, Andrake MD, Merkel G, Weigand S, Dunbrack RLJ, Skalka AM. 2013. Architecture and assembly of HIV integrase multimers in the absence of DNA substrates. J Biol Chem 288:7373-7386.
-
(2013)
J Biol Chem
, vol.288
, pp. 7373-7386
-
-
Bojja, R.S.1
Andrake, M.D.2
Merkel, G.3
Weigand, S.4
Dunbrack, R.L.J.5
Skalka, A.M.6
-
139
-
-
0027973067
-
Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase
-
Hickman AB, Palmer I, Engelman A, Craigie R, Wingfield P. 1994. Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase. J Biol Chem 269:29279-29287.
-
(1994)
J Biol Chem
, vol.269
, pp. 29279-29287
-
-
Hickman, A.B.1
Palmer, I.2
Engelman, A.3
Craigie, R.4
Wingfield, P.5
-
140
-
-
0028865574
-
High-resolution structure of the catalytic domain of avian sarcoma virus integrase
-
Bujacz G, Jaskolski M, Alexandratos J, Wlodawer A, Merkel G, Katz RA, Skalka AM. 1995. High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J Mol Biol 253:333-346.
-
(1995)
J Mol Biol
, vol.253
, pp. 333-346
-
-
Bujacz, G.1
Jaskolski, M.2
Alexandratos, J.3
Wlodawer, A.4
Merkel, G.5
Katz, R.A.6
Skalka, A.M.7
-
141
-
-
0033762592
-
Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase
-
Eijkelenboom AP, van den Ent FM, Wechselberger R, Plasterk RH, Kaptein R, Boelens R. 2000. Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase. J Biomol NMR 18:119-128.
-
(2000)
J Biomol NMR
, vol.18
, pp. 119-128
-
-
Eijkelenboom, A.P.1
van den Ent, F.M.2
Wechselberger, R.3
Plasterk, R.H.4
Kaptein, R.5
Boelens, R.6
-
142
-
-
0029116747
-
Solution structure of the DNA binding domain of HIV-1 integrase
-
Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM. 1995. Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry 34:9826-9833.
-
(1995)
Biochemistry
, vol.34
, pp. 9826-9833
-
-
Lodi, P.J.1
Ernst, J.A.2
Kuszewski, J.3
Hickman, A.B.4
Engelman, A.5
Craigie, R.6
Clore, G.M.7
Gronenborn, A.M.8
-
143
-
-
0029145047
-
The DNA-binding domain of HIV-1 integrase has an SH3-like fold
-
Eijkelenboom APAM, Puras Lutzke RA, Boelens R, Plasterk RHA, Kaptein R, Hård K. 1995. The DNA-binding domain of HIV-1 integrase has an SH3-like fold. Nat Struct Biol 2:807-810.
-
(1995)
Nat Struct Biol
, vol.2
, pp. 807-810
-
-
Eijkelenboom, A.P.A.M.1
Puras Lutzke, R.A.2
Boelens, R.3
Plasterk, R.H.A.4
Kaptein, R.5
Hård, K.6
-
144
-
-
0032791840
-
Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase
-
Eijkelenboom APAM, Sprangers R, Hård K, Puras Lutzke RA, Plasterk RHA, Boelens R, Kaptein R. 1999. Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase. Proteins 36:556-564.
-
(1999)
Proteins
, vol.36
, pp. 556-564
-
-
Eijkelenboom, A.P.A.M.1
Sprangers, R.2
Hård, K.3
Puras Lutzke, R.A.4
Plasterk, R.H.A.5
Boelens, R.6
Kaptein, R.7
-
145
-
-
42649119825
-
The SH3 domain-a family of versatile peptide- and protein-recognition module
-
Kaneko T, Li L, Li SS. 2008. The SH3 domain-a family of versatile peptide- and protein-recognition module. Front Biosci 13:4938-4952.
-
(2008)
Front Biosci
, vol.13
, pp. 4938-4952
-
-
Kaneko, T.1
Li, L.2
Li, S.S.3
-
146
-
-
0028533719
-
Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus
-
Baumann H, Knapp S, Lundbäck T, Ladenstein R, Härd T. 1994. Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus. Nat Struct Biol 1:808-819.
-
(1994)
Nat Struct Biol
, vol.1
, pp. 808-819
-
-
Baumann, H.1
Knapp, S.2
Lundbäck, T.3
Ladenstein, R.4
Härd, T.5
-
147
-
-
0034681278
-
X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293) - an initial glance of the viral DNA binding platform
-
Chen Z, Yan Y, Munshi S, Li Y, Zugay-Murphy J, Xu B, Witmer M, Felock P, Wolfe A, Sardana V. 2000. X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293) - an initial glance of the viral DNA binding platform. J Mol Biol 296:521-533.
-
(2000)
J Mol Biol
, vol.296
, pp. 521-533
-
-
Chen, Z.1
Yan, Y.2
Munshi, S.3
Li, Y.4
Zugay-Murphy, J.5
Xu, B.6
Witmer, M.7
Felock, P.8
Wolfe, A.9
Sardana, V.10
-
148
-
-
0034681303
-
Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase
-
Yang Z-N, Mueser TC, Bushman FD, Hyde CC. 2000. Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase. J Mol Biol 296:535-548.
-
(2000)
J Mol Biol
, vol.296
, pp. 535-548
-
-
Yang, Z.-N.1
Mueser, T.C.2
Bushman, F.D.3
Hyde, C.C.4
-
149
-
-
0037126629
-
Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein
-
Wang J-Y, Ling H, Yang W, Craigie R. 2001. Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J. 20:7333-7343.
-
(2001)
EMBO J.
, vol.20
, pp. 7333-7343
-
-
Wang, J.-Y.1
Ling, H.2
Yang, W.3
Craigie, R.4
-
150
-
-
42949114952
-
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
-
Engelman A, Cherepanov P. 2008. The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS Pathog. 4:e1000046.
-
(2008)
PLoS Pathog.
, vol.4
-
-
Engelman, A.1
Cherepanov, P.2
-
151
-
-
43049182995
-
Integrase, LEDGF/p75 and HIV replication
-
Poeschla EM. 2008. Integrase, LEDGF/p75 and HIV replication. Cell Mol Life Sci 65:1403-1424.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 1403-1424
-
-
Poeschla, E.M.1
-
152
-
-
10344221084
-
Identification of an evolutionarily-conserved domain in LEDGF/p75 that binds HIV-1 integrase
-
Cherepanov P, Devroe E, Silver PA, Engelman A. 2004. Identification of an evolutionarily-conserved domain in LEDGF/p75 that binds HIV-1 integrase. J Biol Chem 279:48883-48892.
-
(2004)
J Biol Chem
, vol.279
, pp. 48883-48892
-
-
Cherepanov, P.1
Devroe, E.2
Silver, P.A.3
Engelman, A.4
-
153
-
-
0041856142
-
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
-
Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y. 2003. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J Biol Chem 278:33528-33539.
-
(2003)
J Biol Chem
, vol.278
, pp. 33528-33539
-
-
Maertens, G.1
Cherepanov, P.2
Pluymers, W.3
Busschots, K.4
De Clercq, E.5
Debyser, Z.6
Engelborghs, Y.7
-
154
-
-
22444437424
-
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
-
Cherepanov P, Sun Z-YJ, Rahman S, Maertens G, Wagner G, Engelman A. 2005. Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat Struct Mol Biol 12:526-532.
-
(2005)
Nat Struct Mol Biol
, vol.12
, pp. 526-532
-
-
Cherepanov, P.1
Sun, Z.-Y.J.2
Rahman, S.3
Maertens, G.4
Wagner, G.5
Engelman, A.6
-
155
-
-
77952553431
-
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
-
Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, Bardiot D, Van der Veken NJ, Van Remoortel B, Strelkov SV, De Maeyer M, Chaltin P, Debyser Z. 2010. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat Chem Biol 6:442-448.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 442-448
-
-
Christ, F.1
Voet, A.2
Marchand, A.3
Nicolet, S.4
Desimmie, B.A.5
Marchand, D.6
Bardiot, D.7
Van der Veken, N.J.8
Van Remoortel, B.9
Strelkov, S.V.10
De Maeyer, M.11
Chaltin, P.12
Debyser, Z.13
-
156
-
-
84895852851
-
Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors
-
Jurado KA, Engelman A. 2013. Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors. Expert Rev Mol Med 15:e14.
-
(2013)
Expert Rev Mol Med
, vol.15
-
-
Jurado, K.A.1
Engelman, A.2
-
157
-
-
84921373211
-
Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses
-
Wang H, Shun MC, Li X, Di Nunzio F, Hare S, Cherepanov P, Engelman A. 2014. Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses. Mol Ther Methods Clin Dev 1:2.
-
(2014)
Mol Ther Methods Clin Dev
, vol.1
, pp. 2
-
-
Wang, H.1
Shun, M.C.2
Li, X.3
Di Nunzio, F.4
Hare, S.5
Cherepanov, P.6
Engelman, A.7
-
158
-
-
0029838374
-
Sequence analysis of the human DNA flanking sites of human immunodeficiency virus type 1 integration
-
Stevens SW, Griffith JD. 1996. Sequence analysis of the human DNA flanking sites of human immunodeficiency virus type 1 integration. J Virol 70:6459-6462.
-
(1996)
J Virol
, vol.70
, pp. 6459-6462
-
-
Stevens, S.W.1
Griffith, J.D.2
-
159
-
-
0031957564
-
Chromosome structure and human immunodeficiency virus type 1 cDNA integration: Centromeric alphoid repeats are a disfavored target
-
Carteau S, Hoffmann C, Bushman F. 1998. Chromosome structure and human immunodeficiency virus type 1 cDNA integration: Centromeric alphoid repeats are a disfavored target. J Virol 72:4005-4014.
-
(1998)
J Virol
, vol.72
, pp. 4005-4014
-
-
Carteau, S.1
Hoffmann, C.2
Bushman, F.3
-
160
-
-
17844381584
-
Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites
-
Holman AG, Coffin JM. 2005. Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites. Proc Natl Acad Sci USA 102:6103-6107.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 6103-6107
-
-
Holman, A.G.1
Coffin, J.M.2
-
161
-
-
16244386233
-
Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses
-
Wu X, Li Y, Crise B, Burgess SM, Munroe DJ. 2005. Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses. J Virol 79:5211-5214.
-
(2005)
J Virol
, vol.79
, pp. 5211-5214
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
Munroe, D.J.5
-
163
-
-
66449124914
-
Bending and compaction of DNA by proteins
-
In Rice PA, Correll CC (ed), RSC Publishing, London
-
Johnson RC, Stella S, Heiss JK. 2008. Bending and compaction of DNA by proteins, p. 176-220. In Rice PA, Correll CC (ed), Protein-Nucleic Acid Interactions: Structural Biology. RSC Publishing, London.
-
(2008)
Protein-Nucleic Acid Interactions: Structural Biology
, pp. 176-220
-
-
Johnson, R.C.1
Stella, S.2
Heiss, J.K.3
-
164
-
-
0034724393
-
Insertion site preferences of the P transposable element in Drosophila melanogaster
-
Liao G-c, Rehm EJ, Rubin GM. 2000. Insertion site preferences of the P transposable element in Drosophila melanogaster. Proc Natl Acad Sci USA 97:3347-3351.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3347-3351
-
-
Liao, G.-C.1
Rehm, E.J.2
Rubin, G.M.3
-
165
-
-
0037169531
-
DNA transposition of bacteriophage Mu: A quantitative analysis of target site selection in vitro
-
Haapa-Paananen S, Rita H, Savilahti H. 2002. DNA transposition of bacteriophage Mu: A quantitative analysis of target site selection in vitro. J Biol Chem 277:2843-2851.
-
(2002)
J Biol Chem
, vol.277
, pp. 2843-2851
-
-
Haapa-Paananen, S.1
Rita, H.2
Savilahti, H.3
-
166
-
-
84899865250
-
Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding
-
Serrao E, Krishnan L, Shun M-C, Li X, Cherepanov P, Engelman A, Maertens GN. 2014. Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding. Nucleic Acids Res 42:5146-5176.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 5146-5176
-
-
Serrao, E.1
Krishnan, L.2
Shun, M.-C.3
Li, X.4
Cherepanov, P.5
Engelman, A.6
Maertens, G.N.7
-
167
-
-
67349135952
-
Identifying amino acid residues that contribute to the cellular-DNA binding site on retroviral integrase
-
Nowak MG, Sudol M, Lee NE, Konsavage WMJ, Katzman M. 2009. Identifying amino acid residues that contribute to the cellular-DNA binding site on retroviral integrase. Virology 389:141-148.
-
(2009)
Virology
, vol.389
, pp. 141-148
-
-
Nowak, M.G.1
Sudol, M.2
Lee, N.E.3
Konsavage, W.M.J.4
Katzman, M.5
-
168
-
-
0026799383
-
Polynucleotidyl transfer reactions in transpositional DNA recombination
-
Mizuuchi K. 1992. Polynucleotidyl transfer reactions in transpositional DNA recombination. J Biol Chem 267:21273-21276.
-
(1992)
J Biol Chem
, vol.267
, pp. 21273-21276
-
-
Mizuuchi, K.1
-
169
-
-
33645962475
-
Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity
-
Yang W, Lee JY, Nowotny M. 2006. Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity. Mol Cell 22:5-13.
-
(2006)
Mol Cell
, vol.22
, pp. 5-13
-
-
Yang, W.1
Lee, J.Y.2
Nowotny, M.3
-
170
-
-
79958776843
-
Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations
-
Rosta E, Nowotny M, Yang W, Hummer G. 2011. Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations. J Am Chem Soc 133:8934-8941.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 8934-8941
-
-
Rosta, E.1
Nowotny, M.2
Yang, W.3
Hummer, G.4
-
171
-
-
33646004109
-
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
-
Nowotny M, Yang W. 2006. Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release. EMBO J. 25:1924-1933.
-
(2006)
EMBO J.
, vol.25
, pp. 1924-1933
-
-
Nowotny, M.1
Yang, W.2
-
172
-
-
21244451435
-
Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis
-
Nowotny M, Gaidamakov SA, Crouch RJ, Yang W. 2005. Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell 121:1005-1016.
-
(2005)
Cell
, vol.121
, pp. 1005-1016
-
-
Nowotny, M.1
Gaidamakov, S.A.2
Crouch, R.J.3
Yang, W.4
-
173
-
-
0026696624
-
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection
-
Pryciak PM, Varmus HE. 1992. Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell 69:769-780.
-
(1992)
Cell
, vol.69
, pp. 769-780
-
-
Pryciak, P.M.1
Varmus, H.E.2
-
174
-
-
0026567862
-
Retroviral integration into minichromosomes in vitro
-
Pryciak PM, Sil A, Varmus HE. 1992. Retroviral integration into minichromosomes in vitro. EMBO J. 11:291-303.
-
(1992)
EMBO J.
, vol.11
, pp. 291-303
-
-
Pryciak, P.M.1
Sil, A.2
Varmus, H.E.3
-
175
-
-
0028264042
-
Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core
-
Pruss D, Bushman F, Wolffe A. 1994. Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core. Proc Natl Acad Sci USA 91:5913-5917.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 5913-5917
-
-
Pruss, D.1
Bushman, F.2
Wolffe, A.3
-
176
-
-
0028125005
-
The influence of DNA and nucleosome structure on integration events directed by HIV integrase
-
Pruss D, Reeves R, Bushman FD, Wolffe AP. 1994. The influence of DNA and nucleosome structure on integration events directed by HIV integrase. J Biol Chem 269:25031-25041.
-
(1994)
J Biol Chem
, vol.269
, pp. 25031-25041
-
-
Pruss, D.1
Reeves, R.2
Bushman, F.D.3
Wolffe, A.P.4
-
177
-
-
0026713302
-
Simian virus 40 minichromosomes as targets for retroviral integration in vivo
-
Pryciak PM, Müller HP, Varmus HE. 1992. Simian virus 40 minichromosomes as targets for retroviral integration in vivo. Proc Natl Acad Sci USA 89:9237-9241.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9237-9241
-
-
Pryciak, P.M.1
Müller, H.P.2
Varmus, H.E.3
-
178
-
-
34547635063
-
HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications
-
Wang GP, CiuffiA, Leipzig J, Berry CC, Bushman FD. 2007. HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications. Genome Res 17:1186-1194.
-
(2007)
Genome Res
, vol.17
, pp. 1186-1194
-
-
Wang, G.P.1
Ciuffi, A.2
Leipzig, J.3
Berry, C.C.4
Bushman, F.D.5
-
179
-
-
79960404187
-
Gammaretroviral integration into nucleosomal target DNA in vivo
-
Roth SL, Malani N, Bushman FD. 2011. Gammaretroviral integration into nucleosomal target DNA in vivo. J Virol 85:7393-7401.
-
(2011)
J Virol
, vol.85
, pp. 7393-7401
-
-
Roth, S.L.1
Malani, N.2
Bushman, F.D.3
-
181
-
-
8644231282
-
Human cell proteins and human immunodeficiency virus DNA integration
-
Turlure F, Devroe E, Silver PA, Engelman A. 2004. Human cell proteins and human immunodeficiency virus DNA integration. Front Biosci 9:3187-3208.
-
(2004)
Front Biosci
, vol.9
, pp. 3187-3208
-
-
Turlure, F.1
Devroe, E.2
Silver, P.A.3
Engelman, A.4
-
182
-
-
32344452179
-
Cellular co-factors of HIV-1 integration
-
Van Maele B, Busschots K, Vandekerckhove L, Christ F, Debyser Z. 2006. Cellular co-factors of HIV-1 integration. Trends Biochem Sci 31:98-105.
-
(2006)
Trends Biochem Sci
, vol.31
, pp. 98-105
-
-
Van Maele, B.1
Busschots, K.2
Vandekerckhove, L.3
Christ, F.4
Debyser, Z.5
-
183
-
-
57449101502
-
Host cell factors and HIV-1 integration
-
Engelman A. 2007. Host cell factors and HIV-1 integration. Future HIV Ther 1:415-426.
-
(2007)
Future HIV Ther
, vol.1
, pp. 415-426
-
-
Engelman, A.1
-
184
-
-
70649108820
-
Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 is critical for HIV-1 infection
-
Nishitsuji H, Hayashi T, Takahashi T, Miyano M, Kannagi M, Masuda T. 2009. Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 is critical for HIV-1 infection. PLoS One 4:e7825.
-
(2009)
PLoS One
, vol.4
-
-
Nishitsuji, H.1
Hayashi, T.2
Takahashi, T.3
Miyano, M.4
Kannagi, M.5
Masuda, T.6
-
185
-
-
0030987672
-
HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway
-
Gallay P, Hope T, Chin D, Trono D. 1997. HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci USA 94:9825-9830.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9825-9830
-
-
Gallay, P.1
Hope, T.2
Chin, D.3
Trono, D.4
-
186
-
-
0041312658
-
Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7
-
Fassati A, Gorlich D, Harrison I, Zaytseva L, Mingot JM. 2003. Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7. EMBO J. 22:3675-3685.
-
(2003)
EMBO J.
, vol.22
, pp. 3675-3685
-
-
Fassati, A.1
Gorlich, D.2
Harrison, I.3
Zaytseva, L.4
Mingot, J.M.5
-
187
-
-
77956621342
-
Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication
-
Ao Z, Danappa Jayappa K, Wang B, Zheng Y, Kung S, Rassart E, Depping R, Kohler M, Cohen EA, Yao X. 2010. Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication. J Virol 84:8650-8663.
-
(2010)
J Virol
, vol.84
, pp. 8650-8663
-
-
Ao, Z.1
Danappa Jayappa, K.2
Wang, B.3
Zheng, Y.4
Kung, S.5
Rassart, E.6
Depping, R.7
Kohler, M.8
Cohen, E.A.9
Yao, X.10
-
188
-
-
34250369626
-
Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication
-
Ao Z, Huang G, Yao H, Xu Z, Labine M, Cochrane AW, Yao X. 2007. Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication. J Biol Chem 282:13456-13467.
-
(2007)
J Biol Chem
, vol.282
, pp. 13456-13467
-
-
Ao, Z.1
Huang, G.2
Yao, H.3
Xu, Z.4
Labine, M.5
Cochrane, A.W.6
Yao, X.7
-
189
-
-
49649105669
-
Transportin-SR2 imports HIV into the nucleus
-
Christ F, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A, Debyser Z. 2008. Transportin-SR2 imports HIV into the nucleus. Curr Biol 18:1192-1202.
-
(2008)
Curr Biol
, vol.18
, pp. 1192-1202
-
-
Christ, F.1
Thys, W.2
De Rijck, J.3
Gijsbers, R.4
Albanese, A.5
Arosio, D.6
Emiliani, S.7
Rain, J.C.8
Benarous, R.9
Cereseto, A.10
Debyser, Z.11
-
190
-
-
72849130164
-
The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase
-
Krishnan L, Matreyek KA, Oztop I, Lee K, Tipper CH, Li X, Dar MJ, Kewalramani VN, Engelman A. 2010. The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. J Virol 84:397-406.
-
(2010)
J Virol
, vol.84
, pp. 397-406
-
-
Krishnan, L.1
Matreyek, K.A.2
Oztop, I.3
Lee, K.4
Tipper, C.H.5
Li, X.6
Dar, M.J.7
Kewalramani, V.N.8
Engelman, A.9
-
191
-
-
84894305729
-
Structural basis for nuclear import of splicing factors by human Transportin 3
-
Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Öztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A, Cherepanov P. 2014. Structural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci USA 111:2728-2733.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 2728-2733
-
-
Maertens, G.N.1
Cook, N.J.2
Wang, W.3
Hare, S.4
Gupta, S.S.5
Öztop, I.6
Lee, K.7
Pye, V.E.8
Cosnefroy, O.9
Snijders, A.P.10
KewalRamani, V.N.11
Fassati, A.12
Engelman, A.13
Cherepanov, P.14
-
192
-
-
84863393356
-
Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir
-
Quashie PK, Mesplède T, Han Y-S, Oliveira M, Singhroy DN, Fujiwara T, Underwood MR, Wainberg MA. 2012. Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol 86:2696-2705.
-
(2012)
J Virol
, vol.86
, pp. 2696-2705
-
-
Quashie, P.K.1
Mesplède, T.2
Han, Y.-S.3
Oliveira, M.4
Singhroy, D.N.5
Fujiwara, T.6
Underwood, M.R.7
Wainberg, M.A.8
-
193
-
-
84878252974
-
A homology model of HIV-1 integrase and analysis of mutations designed to test the model
-
Johnson BC, Métifiot M, Ferris A, Pommier Y, Hughes SH. 2013. A homology model of HIV-1 integrase and analysis of mutations designed to test the model. J Mol Biol 425:2133-2146.
-
(2013)
J Mol Biol
, vol.425
, pp. 2133-2146
-
-
Johnson, B.C.1
Métifiot, M.2
Ferris, A.3
Pommier, Y.4
Hughes, S.H.5
-
194
-
-
0026459411
-
Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human Tlymphoid cells
-
LaFemina R, Schneider C, Robbins H, Callahan P, LeGrow K, Roth E, Schleif W, Emini E. 1992. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human Tlymphoid cells. J Virol. 66:7414-7419.
-
(1992)
J Virol.
, vol.66
, pp. 7414-7419
-
-
LaFemina, R.1
Schneider, C.2
Robbins, H.3
Callahan, P.4
LeGrow, K.5
Roth, E.6
Schleif, W.7
Emini, E.8
-
195
-
-
0027526591
-
Integration is essential for efficient gene expression ofhuman immunodeficiency virus type 1
-
Sakai H, Kawamura M, Sakuragi J, Sakuragi S, Shibata R, Ishimoto A, Ono N, Ueda S, Adachi A. 1993. Integration is essential for efficient gene expression ofhuman immunodeficiency virus type 1. J Virol 67:1169-1174.
-
(1993)
J Virol
, vol.67
, pp. 1169-1174
-
-
Sakai, H.1
Kawamura, M.2
Sakuragi, J.3
Sakuragi, S.4
Shibata, R.5
Ishimoto, A.6
Ono, N.7
Ueda, S.8
Adachi, A.9
-
196
-
-
0030051081
-
The role of manganese in promoting multimerization and assembly of human immunodeficiency virus type 1 integrase as a catalytically active complex on immobilized long terminal repeat substrates
-
Wolfe AL, Felock PJ, Hastings JC, Blau CU, Hazuda DJ. 1996. The role of manganese in promoting multimerization and assembly of human immunodeficiency virus type 1 integrase as a catalytically active complex on immobilized long terminal repeat substrates. J Virol 70:1424-1432.
-
(1996)
J Virol
, vol.70
, pp. 1424-1432
-
-
Wolfe, A.L.1
Felock, P.J.2
Hastings, J.C.3
Blau, C.U.4
Hazuda, D.J.5
-
197
-
-
0030805774
-
Discovery and analysis of inhibitors of the human immunodeficiency integrase
-
Hazuda D, Felock PJ, Hastings JC, Pramanik B, Wolfe AL. 1997. Discovery and analysis of inhibitors of the human immunodeficiency integrase. Drug Des Discov 15:17-24.
-
(1997)
Drug Des Discov
, vol.15
, pp. 17-24
-
-
Hazuda, D.1
Felock, P.J.2
Hastings, J.C.3
Pramanik, B.4
Wolfe, A.L.5
-
198
-
-
0036340605
-
Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
-
Pierson TC, Zhou Y, Kieffer TL, RuffCT, Buck C, Siliciano RF. 2002. Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection. J Virol 76:8518-8531.
-
(2002)
J Virol
, vol.76
, pp. 8518-8531
-
-
Pierson, T.C.1
Zhou, Y.2
Kieffer, T.L.3
Ruff, C.T.4
Buck, C.5
Siliciano, R.F.6
-
199
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, Espeseth A, Gabryelski L, Schleif W, Blau C, Miller MD. 2000. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 287:646-650.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
Espeseth, A.7
Gabryelski, L.8
Schleif, W.9
Blau, C.10
Miller, M.D.11
-
200
-
-
12944270496
-
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
-
Espeseth AS, Felock P, Wolfe A, Witmer M, Grobler J, Anthony N, Egbertson M, Melamed JY, Young S, Hamill T, Cole JL, Hazuda DJ. 2000. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc Natl Acad Sci USA 97:11244-11249.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11244-11249
-
-
Espeseth, A.S.1
Felock, P.2
Wolfe, A.3
Witmer, M.4
Grobler, J.5
Anthony, N.6
Egbertson, M.7
Melamed, J.Y.8
Young, S.9
Hamill, T.10
Cole, J.L.11
Hazuda, D.J.12
-
201
-
-
0037076324
-
Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
-
Grobler JA, Stillmock K, Hu B, Witmer M, Felock P, Espeseth AS, Wolfe A, Egbertson M, Bourgeois M, Melamed J, Wai JS, Young S, Vacca J, Hazuda DJ. 2002. Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes. Proc Natl Acad Sci USA 99:6661-6666.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6661-6666
-
-
Grobler, J.A.1
Stillmock, K.2
Hu, B.3
Witmer, M.4
Felock, P.5
Espeseth, A.S.6
Wolfe, A.7
Egbertson, M.8
Bourgeois, M.9
Melamed, J.10
Wai, J.S.11
Young, S.12
Vacca, J.13
Hazuda, D.J.14
-
202
-
-
52449097240
-
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
-
Summa V, Petrocchi A, Bonelli F, Crescenzi B, Donghi M, Ferrara M, Fiore F, Gardelli C, Gonzalez Paz O, Hazuda DJ, Jones P, Kinzel O, Laufer R, Monteagudo E, Muraglia E, Nizi E, Orvieto F, Pace P, Pescatore G, Scarpelli R, Stillmock K, Witmer MV, Rowley M. 2008. Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem 51:5843-5855.
-
(2008)
J Med Chem
, vol.51
, pp. 5843-5855
-
-
Summa, V.1
Petrocchi, A.2
Bonelli, F.3
Crescenzi, B.4
Donghi, M.5
Ferrara, M.6
Fiore, F.7
Gardelli, C.8
Gonzalez Paz, O.9
Hazuda, D.J.10
Jones, P.11
Kinzel, O.12
Laufer, R.13
Monteagudo, E.14
Muraglia, E.15
Nizi, E.16
Orvieto, F.17
Pace, P.18
Pescatore, G.19
Scarpelli, R.20
Stillmock, K.21
Witmer, M.V.22
Rowley, M.23
more..
-
203
-
-
33644863638
-
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
-
Sato M, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, Kawakami H, Matsuzaki Y, Watanabe W, Yamataka K, Ikeda S, Kodama E, Matsuoka M, Shinkai H. 2006. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J Med Chem 49:1506-1508.
-
(2006)
J Med Chem
, vol.49
, pp. 1506-1508
-
-
Sato, M.1
Motomura, T.2
Aramaki, H.3
Matsuda, T.4
Yamashita, M.5
Ito, Y.6
Kawakami, H.7
Matsuzaki, Y.8
Watanabe, W.9
Yamataka, K.10
Ikeda, S.11
Kodama, E.12
Matsuoka, M.13
Shinkai, H.14
-
204
-
-
84880861322
-
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744)
-
Johns BA, Kawasuji T, Weatherhead JG, Taishi T, TemelkoffDP, Yoshida H, Akiyama T, Taoda Y, Murai H, Kiyama R, Fuji M, Tanimoto N, Jeffrey J, Foster SA, Yoshinaga T, Seki T, Kobayashi M, Sato A, Johnson MN, Garvey EP, Fujiwara T. 2013. Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744). J Med Chem 56:5901-5916.
-
(2013)
J Med Chem
, vol.56
, pp. 5901-5916
-
-
Johns, B.A.1
Kawasuji, T.2
Weatherhead, J.G.3
Taishi, T.4
Temelkoff, D.P.5
Yoshida, H.6
Akiyama, T.7
Taoda, Y.8
Murai, H.9
Kiyama, R.10
Fuji, M.11
Tanimoto, N.12
Jeffrey, J.13
Foster, S.A.14
Yoshinaga, T.15
Seki, T.16
Kobayashi, M.17
Sato, A.18
Johnson, M.N.19
Garvey, E.P.20
Fujiwara, T.21
more..
-
205
-
-
37849002059
-
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
-
Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Watanabe Y, Ohata Y, Doi S, Sato M, Kano M, Ikeda S, Matsuoka M. 2008. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 82:764-774.
-
(2008)
J Virol
, vol.82
, pp. 764-774
-
-
Shimura, K.1
Kodama, E.2
Sakagami, Y.3
Matsuzaki, Y.4
Watanabe, W.5
Yamataka, K.6
Watanabe, Y.7
Ohata, Y.8
Doi, S.9
Sato, M.10
Kano, M.11
Ikeda, S.12
Matsuoka, M.13
-
206
-
-
79952580956
-
Differential sensitivities of retroviruses to integrase strand transfer inhibitors
-
Koh Y, Matreyek KA, Engelman A. 2011. Differential sensitivities of retroviruses to integrase strand transfer inhibitors. J Virol 85:3677-3682.
-
(2011)
J Virol
, vol.85
, pp. 3677-3682
-
-
Koh, Y.1
Matreyek, K.A.2
Engelman, A.3
-
207
-
-
78650533230
-
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
-
Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov P. 2010. Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci USA 107:20057-20062.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20057-20062
-
-
Hare, S.1
Vos, A.M.2
Clayton, R.F.3
Thuring, J.W.4
Cummings, M.D.5
Cherepanov, P.6
-
208
-
-
80052847538
-
Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572)
-
Hare S, Smith SJ, Métifiot M, Jaxa-Chamiec A, Pommier Y, Hughes SH, Cherepanov P. 2011. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol 80:565-572.
-
(2011)
Mol Pharmacol
, vol.80
, pp. 565-572
-
-
Hare, S.1
Smith, S.J.2
Métifiot, M.3
Jaxa-Chamiec, A.4
Pommier, Y.5
Hughes, S.H.6
Cherepanov, P.7
-
209
-
-
47949114939
-
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
-
Cooper DA, Steigbigel RT, Gatell JM, Rockstroh JK, Katlama C, Yeni P, Lazzarin A, Clotet B, Kumar PN, Eron JE, Schechter M, Markowitz M, Loutfy MR, Lennox JL, Zhao J, Chen J, Ryan DM, Rhodes RR, Killar JA, Gilde LR, Strohmaier KM, Meibohm AR, Miller MD, Hazuda DJ, Nessly ML, DiNubile MJ, Isaacs RD, Teppler H, Nguyen B-Y, the BENCHMRK Study Teams. 2008. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 359:355-365.
-
(2008)
N Engl J Med
, vol.359
, pp. 355-365
-
-
Cooper, D.A.1
Steigbigel, R.T.2
Gatell, J.M.3
Rockstroh, J.K.4
Katlama, C.5
Yeni, P.6
Lazzarin, A.7
Clotet, B.8
Kumar, P.N.9
Eron, J.E.10
Schechter, M.11
Markowitz, M.12
Loutfy, M.R.13
Lennox, J.L.14
Zhao, J.15
Chen, J.16
Ryan, D.M.17
Rhodes, R.R.18
Killar, J.A.19
Gilde, L.R.20
Strohmaier, K.M.21
Meibohm, A.R.22
Miller, M.D.23
Hazuda, D.J.24
Nessly, M.L.25
DiNubile, M.J.26
Isaacs, R.D.27
Teppler, H.28
Nguyen, B.-Y.29
more..
-
210
-
-
72249112823
-
HIV integrase inhibitor dissociation rates correlate with efficacy in vitro
-
Grobler JA, McKenna PM, Ly S, Stillmock KA, Bahnck CM, Danovich RM, Dornadula G, Hazuda DJ, Miller MD. 2009. HIV integrase inhibitor dissociation rates correlate with efficacy in vitro. Antiviral Ther 14 Suppl 1:A27.
-
(2009)
Antiviral Ther 14 Suppl
, vol.1
, pp. A27
-
-
Grobler, J.A.1
McKenna, P.M.2
Ly, S.3
Stillmock, K.A.4
Bahnck, C.M.5
Danovich, R.M.6
Dornadula, G.7
Hazuda, D.J.8
Miller, M.D.9
-
211
-
-
80052847754
-
Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes
-
Hightower KE, Wang R, Deanda F, Johns BA, Weaver K, Shen Y, Tomberlin GH, Carter HLr, Broderick T, Sigethy S, Seki T, Kobayashi M, Underwood MR. 2011. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes. Antimicrob Agents Chemother 55:4552-4559.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 4552-4559
-
-
Hightower, K.E.1
Wang, R.2
Deanda, F.3
Johns, B.A.4
Weaver, K.5
Shen, Y.6
Tomberlin, G.H.7
Carter, H.L.8
Broderick, T.9
Sigethy, S.10
Seki, T.11
Kobayashi, M.12
Underwood, M.R.13
-
212
-
-
77953022020
-
Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with secondgeneration resistance profiles
-
Goethals O, Vos A, Van Ginderen M, Geluykens P, Smits V, Schols D, Hertogs K, Clayton R. 2010. Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with secondgeneration resistance profiles. Virology 402:338-346.
-
(2010)
Virology
, vol.402
, pp. 338-346
-
-
Goethals, O.1
Vos, A.2
Van Ginderen, M.3
Geluykens, P.4
Smits, V.5
Schols, D.6
Hertogs, K.7
Clayton, R.8
-
213
-
-
80155188567
-
Cross-resistance profile of the novel integrase inhibitor dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir
-
Canducci F, Ceresola ER, Boeri E, Spagnuolo V, Cossarini F, Castagna A, Lazzarin A, Clementi M. 2011. Cross-resistance profile of the novel integrase inhibitor dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir. J Infect Dis 204:1811-1815.
-
(2011)
J Infect Dis
, vol.204
, pp. 1811-1815
-
-
Canducci, F.1
Ceresola, E.R.2
Boeri, E.3
Spagnuolo, V.4
Cossarini, F.5
Castagna, A.6
Lazzarin, A.7
Clementi, M.8
|