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Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 10, 2002, Pages 6661-6666

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

(14) Grobler, Jay A a Stillmock, Kara a Hu, Binghua a Witmer, Marc a Felock, Peter a Espeseth, Amy S a Wolfe, Abigail a Egbertson, Melissa a Bourgeois, Michele a Melamed, Jeffrey a Wai, John S a Young, Steve a Vacca, Joseph a Hazuda, Daria J a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [1 (4 FLUOROBENZYL) 2 PYRROLYL] 2,4 DIOXOBUTYRIC ACID; 4 [1 (4 FLUOROBENZYL)PYRROL 2 YL 2,4 DIKETOBUTANOIC ACID]; BUTYRIC ACID DERIVATIVE; DIKETONE; HETEROCYCLIC COMPOUND; INTEGRASE; MAGNESIUM ION; METAL; OXOACID; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME REARRANGEMENT; COMPETITIVE INHIBITION; DNA INTEGRATION; DNA STRAND; DNA STRAND BREAKAGE; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; METAL BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; BINDING, COMPETITIVE; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; LIGANDS; MAGNESIUM; MANGANESE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOSPHOTRANSFERASES; STREPTAVIDIN; STYRENES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037076324 PISSN: 00278424 EISSN: None Source Type: Journal
DOI: 10.1073/pnas.092056199 Document Type: Article

Times cited : (398)

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