Alternate polypurine tracts affect Rous sarcoma virus integration in vivo

Journal of Virology

Volumn 80, Issue 20, 2006, Pages 10281-10284

  Oh, Jangsuk ^a   Chang, Kevin W ^a   Alvord, W Gregory ^a   Hughes, Stephen H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; PURINE DERIVATIVE; VIRUS DNA; VIRUS VECTOR;

ARTICLE; GENE DELETION; GENE DUPLICATION; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; ROUS SARCOMA ONCOVIRUS; VIRUS CELL INTERACTION; VIRUS DNA CELL DNA INTERACTION; VIRUS GENOME;

AVIAN SARCOMA VIRUSES; GENETIC VECTORS; INTEGRASES; RECOMBINATION, GENETIC; TERMINAL REPEAT SEQUENCES; VIRUS INTEGRATION;

RICE STRIPE VIRUS; ROUS SARCOMA VIRUS;

EID: 33749474353     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00361-06     Document Type: Article

References (12)

1. Chang, K. W., J. G. Julias, W. G. Alvord, J. Oh, and S. H. Hughes. 2005. Alternate polypurine tracts (PPTs) affect the Rous sarcoma virus RNase H cleavage specificity and reveal a preferential cleavage following a GA dinucleotide sequence at the PPT-U3 junction. J. Virol. 79:13694-13704.
2. Dash, C. J., W. Rausch, and S. F. Le Grice. 2004. Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3′ polypurine tract. Nucleic Acids Res. 32:1539-1547.
3. Julias, J. G., M. J. McWilliams, S. G. Sarafianos, W. G. Alvord, E. Arnold, and S. H. Hughes. 2004. Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage. J. Virol. 78:13315-13324.
4. Katzman, M., R. A. Katz, A. M. Skalka, and J. Leis. 1989. The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J. Virol. 63:5319-5327.
5. McWilliams, M. J., J. G. Julias, S. G. Sarafianos, W. G. Alvord, E. Arnold, and S. H. Hughes. 2003. Mutations in the 5′ end of the human immunodeficiency virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer. J. Virol. 77:11150-11157.
6. Oh, J., J. G. Julias, A. L. Ferris, and S. H. Hughes. 2002. Construction and characterization of a replication-competent retroviral shuttle vector plasmid. J. Virol. 76:1762-1768.
7. Oh, J., K. W. Chang, and S. H. Hughes. 2006. Mutations in the U5 sequences adjacent to the primer binding site do not affect tRNA cleavage by Rous sarcoma virus RNase H but do cause aberrant integration in vivo. J. Virol. 80:451-459.
8. Powell, M. D., and J. G. Levin. 1996. Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract. J. Virol. 70:5288-5296.
9. Rattray, A. J., and J. J. Champoux. 1989. Plus-strand priming by Moloney murine leukemia virus. The sequence features important for cleavage by RNase H. J. Mol. Biol. 208:445-456.
10. Robson, N. D., and A. Telesnitsky. 1999. Effects of 3′ untranslated region mutations on plus-strand priming during Moloney murine leukemia virus replication. J. Virol. 73:948-957.
11. Robson, N. D., and A. Telesnitsky. 2000. Selection of optimal polypurine tract region sequences during Moloney murine leukemia virus replication. J. Virol. 74:10293-10303.
12. Telesnitsky, A., and S. P. Goff. 1997. Reverse transcriptase and the generation of retroviral DNA, p. 121-160. In J. M. Coffin, S. H. Hughes, and H. E. Varmus (ed.), Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.