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Volumn 107, Issue 36, 2010, Pages 15910-15915

Structure-based modeling of the functional HIV-1 intasome and its inhibition

Author keywords

Drug resistance; HIV AIDS; Integrase; Integration; Raltegravir

Indexed keywords

DNA; INTEGRASE;

EID: 77957670046     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002346107     Document Type: Article
Times cited : (181)

References (54)
  • 1
    • 77958010223 scopus 로고    scopus 로고
    • Reverse transcription and integration
    • eds Kurth R, Bannert N (Caister Academic Press, Norfolk, United Kingdom)
    • Engelman A (2010) Reverse transcription and integration. Retroviruses: Molecular Biology, Genomics and Pathogenesis, eds Kurth R, Bannert N (Caister Academic Press, Norfolk, United Kingdom), pp 129-159.
    • (2010) Retroviruses: Molecular Biology, Genomics and Pathogenesis , pp. 129-159
    • Engelman, A.1
  • 2
    • 0028584269 scopus 로고
    • Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
    • Dyda F, et al. (1994) Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases. Science 266:1981-1986.
    • (1994) Science , vol.266 , pp. 1981-1986
    • Dyda, F.1
  • 3
    • 0034616993 scopus 로고    scopus 로고
    • Three-dimensional structure of the Tn5 synaptic complex transposition intermediate
    • Davies DR, Goryshin IY, Reznikoff WS, Rayment I (2000) Three-dimensional structure of the Tn5 synaptic complex transposition intermediate. Science 289:77-85.
    • (2000) Science , vol.289 , pp. 77-85
    • Davies, D.R.1    Goryshin, I.Y.2    Reznikoff, W.S.3    Rayment, I.4
  • 4
    • 70149109999 scopus 로고    scopus 로고
    • Molecular architecture of the Mos1 paired-end complex: The structural basis of DNA transposition in a eukaryote
    • Richardson JM, Colloms SD, Finnegan DJ, Walkinshaw MD (2009) Molecular architecture of the Mos1 paired-end complex: The structural basis of DNA transposition in a eukaryote. Cell 138:1096-1108.
    • (2009) Cell , vol.138 , pp. 1096-1108
    • Richardson, J.M.1    Colloms, S.D.2    Finnegan, D.J.3    Walkinshaw, M.D.4
  • 5
    • 0031004162 scopus 로고    scopus 로고
    • HIV-1 cDNA integration: Requirement of HMG I(Y) protein for function of preintegration complexes in vitro
    • Farnet CM, Bushman FD (1997) HIV-1 cDNA integration: Requirement of HMG I(Y) protein for function of preintegration complexes in vitro. Cell 88:483-492.
    • (1997) Cell , vol.88 , pp. 483-492
    • Farnet, C.M.1    Bushman, F.D.2
  • 6
    • 0031449687 scopus 로고    scopus 로고
    • A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration
    • Wei S-Q, Mizuuchi K, Craigie R (1997) A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration. EMBO J 16:7511-7520.
    • (1997) EMBO J , vol.16 , pp. 7511-7520
    • Wei, S.-Q.1    Mizuuchi, K.2    Craigie, R.3
  • 7
    • 0033546149 scopus 로고    scopus 로고
    • Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome
    • DOI 10.1074/jbc.274.24.17358
    • Chen H, Wei S-Q, Engelman A (1999) Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome. J Biol Chem 274:17358-17364. (Pubitemid 29275203)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.24 , pp. 17358-17364
    • Chen, H.1    Wei, S.-Q.2    Engelman, A.3
  • 8
    • 33645285267 scopus 로고    scopus 로고
    • Retroviral DNA integration: Reaction pathway and critical intermediates
    • Li M, Mizuuchi M, Burke TRJ, Jr, Craigie R (2006) Retroviral DNA integration: Reaction pathway and critical intermediates. EMBO J 25:1295-1304.
    • (2006) EMBO J , vol.25 , pp. 1295-1304
    • Li, M.1    Mizuuchi, M.2    Burke Jr., T.R.J.3    Craigie, R.4
  • 9
    • 0030972160 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 preintegration complexes: Studies of organization and composition
    • Miller MD, Farnet CM, Bushman FD (1997) Human immunodeficiency virus type 1 preintegration complexes: Studies of organization and composition. J Virol 71: 5382-5390.
    • (1997) J Virol , vol.71 , pp. 5382-5390
    • Miller, M.D.1    Farnet, C.M.2    Bushman, F.D.3
  • 10
    • 0034812967 scopus 로고    scopus 로고
    • Asymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: Implications for functional end coupling during the chemical steps of DNA transposition
    • Chen H, Engelman A (2001) Asymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: Implications for functional end coupling during the chemical steps of DNA transposition. Mol Cell Biol 21:6758-6767.
    • (2001) Mol Cell Biol , vol.21 , pp. 6758-6767
    • Chen, H.1    Engelman, A.2
  • 11
    • 36049049062 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate
    • Pandey KK, et al. (2007) Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate. J Virol 81:12189-12199.
    • (2007) J Virol , vol.81 , pp. 12189-12199
    • Pandey, K.K.1
  • 12
    • 52449097240 scopus 로고    scopus 로고
    • Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
    • Summa V, et al. (2008) Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem 51: 5843-5855.
    • (2008) J Med Chem , vol.51 , pp. 5843-5855
    • Summa, V.1
  • 13
    • 73549123203 scopus 로고    scopus 로고
    • Strand transfer inhibitors of HIV-1 integrase: Bringing in a new era of antiretroviral therapy
    • McColl DJ, Chen X (2010) Strand transfer inhibitors of HIV-1 integrase: Bringing IN a new era of antiretroviral therapy. Antiviral Res 85:101-118.
    • (2010) Antiviral Res , vol.85 , pp. 101-118
    • McColl, D.J.1    Chen, X.2
  • 14
    • 0037126629 scopus 로고    scopus 로고
    • Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein
    • Wang J-Y, Ling H, Yang W, Craigie R (2001) Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein. EMBO J 20:7333-7343.
    • (2001) EMBO J , vol.20 , pp. 7333-7343
    • Wang, J.-Y.1    Ling, H.2    Yang, W.3    Craigie, R.4
  • 15
    • 0034682511 scopus 로고    scopus 로고
    • Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
    • Chen JC-H, et al. (2000) Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding. Proc Natl Acad Sci USA 97:8233-8238.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8233-8238
    • Chen, J.C.-H.1
  • 16
    • 12944270496 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
    • Espeseth AS, et al. (2000) HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc Natl Acad Sci USA 97:11244-11249.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11244-11249
    • Espeseth, A.S.1
  • 17
    • 0034681278 scopus 로고    scopus 로고
    • X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293) - An initial glance of the viral DNA binding platform
    • Chen Z, et al. (2000) X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293) - an initial glance of the viral DNA binding platform. J Mol Biol 296:521-533.
    • (2000) J Mol Biol , vol.296 , pp. 521-533
    • Chen, Z.1
  • 18
    • 0034681303 scopus 로고    scopus 로고
    • Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase
    • Yang Z-N, Mueser TC, Bushman FD, Hyde CC (2000) Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase. J Mol Biol 296:535-548.
    • (2000) J Mol Biol , vol.296 , pp. 535-548
    • Yang, Z.-N.1    Mueser, T.C.2    Bushman, F.D.3    Hyde, C.C.4
  • 19
    • 70049117341 scopus 로고    scopus 로고
    • Structural basis for functional tetramerization of lentiviral integrase
    • Hare S, et al. (2009) Structural basis for functional tetramerization of lentiviral integrase. PLoS Pathog 5:e1000515.
    • (2009) PLoS Pathog , vol.5
    • Hare, S.1
  • 20
    • 0035796559 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 integrase: Arrangement of protein domains in active cDNA complexes
    • Gao K, Butler SL, Bushman F (2001) Human immunodeficiency virus type 1 integrase: Arrangement of protein domains in active cDNA complexes. EMBO J 20:3565-3576.
    • (2001) EMBO J , vol.20 , pp. 3565-3576
    • Gao, K.1    Butler, S.L.2    Bushman, F.3
  • 21
    • 26644456674 scopus 로고    scopus 로고
    • A three-dimensional model of the human immunodeficiency virus type 1 integration complex
    • Wielens J, Crosby IT, Chalmers DK (2005) A three-dimensional model of the human immunodeficiency virus type 1 integration complex. J Comput Aided Mol Des 19:301-317.
    • (2005) J Comput Aided Mol des , vol.19 , pp. 301-317
    • Wielens, J.1    Crosby, I.T.2    Chalmers, D.K.3
  • 22
    • 33645216987 scopus 로고    scopus 로고
    • Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends
    • Chen A, Weber IT, Harrison RW, Leis J (2006) Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends. J Biol Chem 281:4173-4182.
    • (2006) J Biol Chem , vol.281 , pp. 4173-4182
    • Chen, A.1    Weber, I.T.2    Harrison, R.W.3    Leis, J.4
  • 23
    • 44949212848 scopus 로고    scopus 로고
    • Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors
    • Chen X, et al. (2008) Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors. J Mol Biol 380:504-519.
    • (2008) J Mol Biol , vol.380 , pp. 504-519
    • Chen, X.1
  • 24
    • 41949095115 scopus 로고    scopus 로고
    • Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding
    • Zhao Z, et al. (2008) Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding. J Biol Chem 283:5632-5641.
    • (2008) J Biol Chem , vol.283 , pp. 5632-5641
    • Zhao, Z.1
  • 25
    • 65449189123 scopus 로고    scopus 로고
    • Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor
    • Michel F, et al. (2009) Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor. EMBO J 28:980-991.
    • (2009) EMBO J , vol.28 , pp. 980-991
    • Michel, F.1
  • 26
    • 77949365510 scopus 로고    scopus 로고
    • Retroviral intasome assembly and inhibition of DNA strand transfer
    • Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P (2010) Retroviral intasome assembly and inhibition of DNA strand transfer. Nature 464:232-236.
    • (2010) Nature , vol.464 , pp. 232-236
    • Hare, S.1    Gupta, S.S.2    Valkov, E.3    Engelman, A.4    Cherepanov, P.5
  • 27
    • 66249088004 scopus 로고    scopus 로고
    • Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs
    • Alian A, et al. (2009) Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc Natl Acad Sci USA 106:8192-8197.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8192-8197
    • Alian, A.1
  • 28
    • 34147128555 scopus 로고    scopus 로고
    • In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate
    • Savarino A (2007) In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate. Retrovirology 4:21.
    • (2007) Retrovirology , vol.4 , pp. 21
    • Savarino, A.1
  • 29
    • 0030828521 scopus 로고    scopus 로고
    • Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking
    • Jenkins TM, Esposito D, Engelman A, Craigie R (1997) Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J 16:6849-6859.
    • (1997) EMBO J , vol.16 , pp. 6849-6859
    • Jenkins, T.M.1    Esposito, D.2    Engelman, A.3    Craigie, R.4
  • 30
    • 0032189652 scopus 로고    scopus 로고
    • Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction
    • Esposito D, Craigie R (1998) Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction. EMBO J 17:5832-5843.
    • (1998) EMBO J , vol.17 , pp. 5832-5843
    • Esposito, D.1    Craigie, R.2
  • 31
    • 33644861936 scopus 로고    scopus 로고
    • Integration requires a specific interaction of the donor DNA terminal 5′-cytosine with glutamine 148 of the HIV-1 integrase flexible loop
    • Johnson AA, et al. (2006) Integration requires a specific interaction of the donor DNA terminal 5′-cytosine with glutamine 148 of the HIV-1 integrase flexible loop. J Biol Chem 281:461-467.
    • (2006) J Biol Chem , vol.281 , pp. 461-467
    • Johnson, A.A.1
  • 32
    • 0030875813 scopus 로고    scopus 로고
    • Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking
    • Heuer TS, Brown PO (1997) Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking. Biochemistry 36:10655-10665.
    • (1997) Biochemistry , vol.36 , pp. 10655-10665
    • Heuer, T.S.1    Brown, P.O.2
  • 33
    • 77957219646 scopus 로고
    • Retroviral integrase domains: DNA binding and the recognition of LTR sequences
    • Khan E, Mack JP, Katz RA, Kulkosky J, Skalka AM (1991) Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res 19:851-860.
    • (1991) Nucleic Acids Res , vol.19 , pp. 851-860
    • Khan, E.1    Mack, J.P.2    Katz, R.A.3    Kulkosky, J.4    Skalka, A.M.5
  • 34
    • 0034034265 scopus 로고    scopus 로고
    • Evolution of the Gypsy endogenous retrovirus in the Drosophila melanogaster subgroup
    • Terzian C, Ferraz C, Demaille J, Bucheton A (2000) Evolution of the Gypsy endogenous retrovirus in the Drosophila melanogaster subgroup. Mol Biol Evol 17:908-914.
    • (2000) Mol Biol Evol , vol.17 , pp. 908-914
    • Terzian, C.1    Ferraz, C.2    Demaille, J.3    Bucheton, A.4
  • 35
    • 75649146606 scopus 로고    scopus 로고
    • Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase alpha4 helix
    • Hobaika Z, et al. (2009) Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase alpha4 helix. Nucleic Acids Res 37:7691-7700.
    • (2009) Nucleic Acids Res , vol.37 , pp. 7691-7700
    • Hobaika, Z.1
  • 36
    • 0001166515 scopus 로고    scopus 로고
    • Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: Critical residues for protein oligomerization and DNA binding
    • Lutzke RA, Plasterk RH (1998) Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: Critical residues for protein oligomerization and DNA binding. J Virol 72:4841-4848.
    • (1998) J Virol , vol.72 , pp. 4841-4848
    • Lutzke, R.A.1    Plasterk, R.H.2
  • 37
    • 21244451435 scopus 로고    scopus 로고
    • Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis
    • Nowotny M, Gaidamakov SA, Crouch RJ, Yang W (2005) Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell 121:1005-1016.
    • (2005) Cell , vol.121 , pp. 1005-1016
    • Nowotny, M.1    Gaidamakov, S.A.2    Crouch, R.J.3    Yang, W.4
  • 38
    • 0037076324 scopus 로고    scopus 로고
    • Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
    • Grobler JA, et al. (2002) Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes. Proc Natl Acad Sci USA 99:6661-6666.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6661-6666
    • Grobler, J.A.1
  • 39
    • 69849093567 scopus 로고    scopus 로고
    • Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors
    • Barreca ML, Iraci N, De Luca L, Chimirri A (2009) Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors. ChemMedChem 4:1446-1456.
    • (2009) ChemMedChem , vol.4 , pp. 1446-1456
    • Barreca, M.L.1    Iraci, N.2    De Luca, L.3    Chimirri, A.4
  • 40
    • 77649183663 scopus 로고    scopus 로고
    • A dynamic model of HIV integrase inhibition and drug resistance
    • Perryman AL, et al. (2010) A dynamic model of HIV integrase inhibition and drug resistance. J Mol Biol 397:600-615.
    • (2010) J Mol Biol , vol.397 , pp. 600-615
    • Perryman, A.L.1
  • 41
    • 58549092798 scopus 로고    scopus 로고
    • Functional and structural characterization of the integrase from the prototype foamy virus
    • Valkov E, et al. (2009) Functional and structural characterization of the integrase from the prototype foamy virus. Nucleic Acids Res 37:243-255.
    • (2009) Nucleic Acids Res , vol.37 , pp. 243-255
    • Valkov, E.1
  • 42
    • 58149154667 scopus 로고    scopus 로고
    • The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors
    • Langley DR, et al. (2008) The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors. Biochemistry 47:13481-13488.
    • (2008) Biochemistry , vol.47 , pp. 13481-13488
    • Langley, D.R.1
  • 43
    • 70349932423 scopus 로고    scopus 로고
    • AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
    • Morris GM, et al. (2009) AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem 30:2785-2791.
    • (2009) J Comput Chem , vol.30 , pp. 2785-2791
    • Morris, G.M.1
  • 45
    • 53249087908 scopus 로고    scopus 로고
    • Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants
    • Kobayashi M, et al. (2008) Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antiviral Res 80: 213-222.
    • (2008) Antiviral Res , vol.80 , pp. 213-222
    • Kobayashi, M.1
  • 46
    • 70350666377 scopus 로고    scopus 로고
    • Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways
    • Fransen S, et al. (2009) Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways. J Virol 83: 11440-11446.
    • (2009) J Virol , vol.83 , pp. 11440-11446
    • Fransen, S.1
  • 47
    • 73849095055 scopus 로고    scopus 로고
    • Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo
    • Delelis O, et al. (2010) Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo. Antimicrob Agents Chemother 54:491-501.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 491-501
    • Delelis, O.1
  • 48
    • 37849002059 scopus 로고    scopus 로고
    • Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
    • Shimura K, et al. (2008) Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 82:764-774.
    • (2008) J Virol , vol.82 , pp. 764-774
    • Shimura, K.1
  • 49
    • 62149093020 scopus 로고    scopus 로고
    • The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
    • Delelis O, et al. (2009) The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation. Nucleic Acids Res 37:1193-1201.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1193-1201
    • Delelis, O.1
  • 50
    • 0027246609 scopus 로고
    • Complementation between HIV integrase proteins mutated in different domains
    • van Gent DC, Vink C, Groeneger AA, Plasterk RH (1993) Complementation between HIV integrase proteins mutated in different domains. EMBO J 12:3261-3267.
    • (1993) EMBO J , vol.12 , pp. 3261-3267
    • Van Gent, D.C.1    Vink, C.2    Groeneger, A.A.3    Plasterk, R.H.4
  • 51
    • 0027179694 scopus 로고
    • Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex
    • Engelman A, Bushman FD, Craigie R (1993) Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J 12:3269-3275.
    • (1993) EMBO J , vol.12 , pp. 3269-3275
    • Engelman, A.1    Bushman, F.D.2    Craigie, R.3
  • 53
    • 33747330377 scopus 로고    scopus 로고
    • Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
    • Guiot E, et al. (2006) Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity. J Biol Chem 281:22707-22719.
    • (2006) J Biol Chem , vol.281 , pp. 22707-22719
    • Guiot, E.1
  • 54
    • 35048855942 scopus 로고    scopus 로고
    • Loop202-208 in avian sarcoma virus integrase mediates tetramer assembly and processing activity
    • Bosserman MA, O'Quinn DF, Wong I (2007) Loop202-208 in avian sarcoma virus integrase mediates tetramer assembly and processing activity. Biochemistry 46: 11231-11239.
    • (2007) Biochemistry , vol.46 , pp. 11231-11239
    • Bosserman, M.A.1    O'Quinn, D.F.2    Wong, I.3


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