Studies on a 'jumping gene machine': Higher-order nucleoprotein complexes in Mu DNA transposition

Biochemistry and Cell Biology

Volumn 77, Issue 6, 1999, Pages 487-491

  Chaconas, George ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

DNA breakage and reunion; DNA transposition; Higher order nucleoprotein complexes; Site specific recombination; Transposons

Indexed keywords

CURVED DNA; VIRUS DNA; VIRUS NUCLEOPROTEIN;

BACTERIOPHAGE MU; DNA CLEAVAGE; DNA RECOMBINATION; DNA REPLICATION; DNA TRANSFER; DNA TRANSPOSITION; IN VITRO STUDY; NONHUMAN; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; REVIEW; TRANSPOSON;

BACTERIA (MICROORGANISMS); BACTERIAL VIRUS; DNA VIRUSES; ENTEROBACTERIA PHAGE MU;

EID: 0033380262     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o99-060     Document Type: Review

References (37)

1. Adzuma, K., and Mizuuchi, K. 1988. Target immunity of Mu transposition reflects a differential distribution of Mu B protein. Cell, 53: 257-266.
2. Adzuma, K., and Mizuuchi, K. 1989. Interaction of proteins located at a distance along DNA: mechanism of target immunity in the Mu DNA strand-transfer reaction. Cell, 57: 41-47.
3. Allison, R.G., and Chaconas, G. 1992. Role of the A protein-binding sites in the in vitro transposition of Mu DNA. A complex circuit of interactions involving the Mu ends and the transpositional enhancer. J. Biol. Chem. 267: 19 963-19 970.
4. Bainton, R.J., Kubo, K.M., Feng, J.N., and Craig, N.L. 1993. Tn7 transposition: target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system. Cell, 72: 931-943.
5. Chaconas, G., Lavoie, B.D., and Watson, M.A. 1996. DNA transposition - jumping gene machine, some assembly required. Curr. Biol. 6: 817-820.
6. Craigie, R., and Mizuuchi, K. 1985. Mechanism of transposition of bacteriophage Mu: structure of a transposition intermediate. Cell, 41: 867-876.
7. Craigie, R., and Mizuuchi, K. 1987. Transposition of Mu DNA: joining of Mu to target DNA can be uncoupled from cleavage at the ends of Mu. Cell, 51: 493-501.
8. Craigie, R., Mizuuchi, M., and Mizuuchi, K. 1984. Site-specific recognition of the bacteriophage Mu ends by the Mu A protein. Cell, 39: 387-394.
9. Craigie, R., Arndt-Jovin, D.J., and Mizuuchi, K. 1985. A defined system for the DNA strand-transfer reaction at the initiation of bacteriophage Mu transposition: protein and DNA substrate requirements. Proc. Natl. Acad. Sci. U.S.A. 82: 7570-7574.
10. Echols, H. 1990. Nucleoprotein structures initiating DNA replication, transcription, and site-specific recombination. J. Biol. Chem. 265: 14 697-14 700.
11. Hallet, B., and Sherratt, D.J. 1997. Transposition and site-specific recombination: adapting DNA cut-and-paste mechanisms to a variety of genetic rearrangements. FEMS Microbiol. Rev. 21: 157-178.
12. Jones, J.M., and Nakai, H. 1997. The X174-type primosome promotes replisome assembly at the site of recombination in bacteriophage Mu transposition. EMBO J. 16: 6886-6895.
13. Kobryn, K., Lavoie, B.D., and Chaconas, G. 1999. Supercoiling-dependent site-specific binding of HU to naked Mu DNA. J. Mol. Biol. 289: 777-784.
14. Kruklitis, R., Welty, D.J., and Nakai, H. 1996. C1pX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis. EMBO J. 15: 935-944.
15. Lavoie, B.D. and Chaconas, G. 1993. Site-specific HU binding in the Mu transpososome: conversion of a sequence-independent DNA-binding protein into a chemical nuclease. Genes Dev. 7: 2510-2519.
16. Lavoie, B.D., and Chaconas, G. 1995. Transposition of phage Mu DNA. Curr. Top. Microbiol. Immunol. 204: 83-99.
17. Lavoie, B.D., Chan, B.S., Allison, R.G., and Chaconas, G. 1991. Structural aspects of a higher-order nucleoprotein complex: induction of an altered DNA structure at the Mu-host junction of the Mu type 1 transpososome. EMBO J. 10: 3051-3059.
18. Lavoie, B.D., Shaw, G.S., Millner, A., and Chaconas, G. 1996. Anatomy of a flexer-DNA complex inside a higher-order transposition intermediate. Cell, 85: 761-771.
19. Leung, P.C., Teplow, D.B., and Harshey, R.M. 1989. Interaction of distinct domains in Mu transposase with Mu DNA ends and an internal transpositional enhancer. Nature (London), 338: 656-658.
20. Levchenko, I., Luo, L., and Baker, T.A. 1995. Disassembly of the Mu transposase tetramer by the C1pX chaperone. Genes Dev. 9: 2399-2408.
21. Mahillon, J., and Chandler, M. 1998. Insertion sequences. Microbiol. Mol. Biol. Rev. 62: 725-774.
22. Miller, J.L., and Chaconas, G. 1986. Electron microscopic analysis of in vitro transposition intermediates of bacteriophage Mu DNA. Gene, 48: 101-108.
23. Mizuuchi, K. 1983. In vitro transposition of bacteriophage Mu: a biochemical approach to a novel replication reaction. Cell, 35: 785-794.
24. Mizuuchi, K. 1992a. Polynucleotidyl transfer reactions in transpositional DNA recombination. J. Biol. Chem. 267: 21 273-21 276.
25. Mizuuchi, K. 1992b. Transpositional recombination: mechanistic insights from studies of Mu and other elements. Annu. Rev. Biochem. 61: 1011-1051.
26. Mizuuchi, K. 1997. Polynucleotidyl transfer reactions in site-specific DNA recombination. Genes Cells, 2: 1-12.
27. Mizuuchi, M., and Mizuuchi, K. 1989. Efficient Mu transposition requires interaction of transposase with a DNA sequence at the Mu operator: implications for regulation. Cell, 58: 399-408.
28. Mizuuchi, M., Baker, T.A., and Mizuuchi, K. 1992. Assembly of the active form of the transposase-Mu DNA complex: a critical control point in Mu transposition. Cell, 70: 303-311.
29. Naigamwalla, D.Z., and Chaconas, G. 1997. A new set of Mu DNA transposition intermediates: alternate pathways of target capture preceding strand transfer. EMBO J. 16: 5227-5234.
30. Plasterk, R. 1998. VDJ recombination. Ragtime jumping [news]. Nature (London), 394: 718-719.
31. Roth, D.B., and Craig, N.L. 1998. VDJ recombination: a transposase goes to work. Cell 94: 411-414.
32. Sakai, J., and Kleckner, N. 1997. The Tn10 synaptic complex can capture a target DNA only after transposon excision. Cell, 89: 205-214.
33. Surette, M.G., and Chaconas, G. 1989. A protein factor which reduces the negative supercoiling requirement in the Mu DNA strand transfer reaction is Escherichia coli integration host factor. J. Biol. Chem. 264: 3028-3034.
34. Surette, M.G., and Chaconas, G. 1992. The Mu transpositional enhancer can function in trans: requirement of the enhancer for synapsis but not strand cleavage. Cell, 68: 1101-1108.
35. Surette, M.G., Buch, S.J., and Chaconas, G. 1987. Transpososomes: stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA. Cell, 49: 253-262.
36. Surette, M.G., Lavoie, B.D., and Chaconas, G. 1989. Action at a distance in Mu DNA transposition: an enhancer-like element is the site of action of supercoiling relief activity by integration host factor (IHF). EMBO J. 8: 3483-3489.
37. Watson, M.A., and Chaconas, G. 1996. Three-site synapsis during Mu DNA transposition: a critical intermediate preceding engagement of the active site. Cell, 85: 435-445.