메뉴 건너뛰기




Volumn 389, Issue 1-2, 2009, Pages 141-148

Identifying amino acid residues that contribute to the cellular-DNA binding site on retroviral integrase

Author keywords

Endonuclease; HIV AIDS; Integrase; Integration; Retrovirus; Rous sarcoma virus

Indexed keywords

AMINO ACID; ASPARTIC ACID; INTEGRASE; INTEGRASE INHIBITOR; VIRUS DNA;

EID: 67349135952     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.04.014     Document Type: Article
Times cited : (12)

References (37)
  • 1
    • 45249094281 scopus 로고    scopus 로고
    • Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity
    • Al-Mawsawi L.Q., Hombrouck A., Dayam R., Debyser Z., and Neamati N. Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity. Virology 377 (2008) 355-363
    • (2008) Virology , vol.377 , pp. 355-363
    • Al-Mawsawi, L.Q.1    Hombrouck, A.2    Dayam, R.3    Debyser, Z.4    Neamati, N.5
  • 3
    • 0001363865 scopus 로고    scopus 로고
    • Integration
    • Coffin J.M., Hughes S.H., and Varmus H.E. (Eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
    • Brown P.O. Integration. In: Coffin J.M., Hughes S.H., and Varmus H.E. (Eds). "Retroviruses" (1997), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York 161-203
    • (1997) "Retroviruses" , pp. 161-203
    • Brown, P.O.1
  • 5
    • 0029643858 scopus 로고    scopus 로고
    • The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations
    • Bujacz G., Jaskolski M., Alexandratos J., Wlodawer A., Merkel G., Katz R.A., and Skalka A.M. The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations. Structure 4 (1996) 89-96
    • (1996) Structure , vol.4 , pp. 89-96
    • Bujacz, G.1    Jaskolski, M.2    Alexandratos, J.3    Wlodawer, A.4    Merkel, G.5    Katz, R.A.6    Skalka, A.M.7
  • 6
    • 0030746054 scopus 로고    scopus 로고
    • Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity
    • Bujacz G., Alexandratos J., Wlodawer A., Merkel G., Andrake M., Katz R.A., and Skalka A.M. Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J. Biol. Chem. 272 (1997) 18161-18168
    • (1997) J. Biol. Chem. , vol.272 , pp. 18161-18168
    • Bujacz, G.1    Alexandratos, J.2    Wlodawer, A.3    Merkel, G.4    Andrake, M.5    Katz, R.A.6    Skalka, A.M.7
  • 7
    • 0025031786 scopus 로고
    • The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro
    • Craigie R., Fujiwara T., and Bushman F. The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro. Cell 62 (1990) 829-837
    • (1990) Cell , vol.62 , pp. 829-837
    • Craigie, R.1    Fujiwara, T.2    Bushman, F.3
  • 8
    • 55549143334 scopus 로고    scopus 로고
    • Insight into the integrase-DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase
    • Delelis O., Carayon K., Guiot E., Leh H., Tauc P., Brochon J.C., Mouscadet J.F., and Deprez E. Insight into the integrase-DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase. J. Biol. Chem. 283 (2008) 27838-27849
    • (2008) J. Biol. Chem. , vol.283 , pp. 27838-27849
    • Delelis, O.1    Carayon, K.2    Guiot, E.3    Leh, H.4    Tauc, P.5    Brochon, J.C.6    Mouscadet, J.F.7    Deprez, E.8
  • 9
    • 29744433678 scopus 로고    scopus 로고
    • Division of labor within human immunodeficiency virus integrase complexes: determinants of catalysis and target DNA capture
    • Diamond T.L., and Bushman F.D. Division of labor within human immunodeficiency virus integrase complexes: determinants of catalysis and target DNA capture. J. Virol. 79 (2005) 15376-15387
    • (2005) J. Virol. , vol.79 , pp. 15376-15387
    • Diamond, T.L.1    Bushman, F.D.2
  • 10
    • 33845626163 scopus 로고    scopus 로고
    • Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay
    • Diamond T.L., and Bushman F.D. Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay. Nucleic Acids Res. 34 (2006) 6116-6125
    • (2006) Nucleic Acids Res. , vol.34 , pp. 6116-6125
    • Diamond, T.L.1    Bushman, F.D.2
  • 11
    • 0034824775 scopus 로고    scopus 로고
    • Mapping DNA-binding sites of HIV-1 integrase by protein footprinting
    • Dirac A.M., and Kjems J. Mapping DNA-binding sites of HIV-1 integrase by protein footprinting. Eur. J. Biochem. 268 (2001) 743-751
    • (2001) Eur. J. Biochem. , vol.268 , pp. 743-751
    • Dirac, A.M.1    Kjems, J.2
  • 12
    • 58149091892 scopus 로고    scopus 로고
    • Defining the DNA substrate binding sites on HIV-1 integrase
    • Dolan J., Chen A., Weber I.T., Harrison R.W., and Leis J. Defining the DNA substrate binding sites on HIV-1 integrase. J. Mol. Biol. 385 (2009) 568-579
    • (2009) J. Mol. Biol. , vol.385 , pp. 568-579
    • Dolan, J.1    Chen, A.2    Weber, I.T.3    Harrison, R.W.4    Leis, J.5
  • 13
    • 0028584269 scopus 로고
    • Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases
    • Dyda F., Hickman A.B., Jenkins T.M., Engelman A., Craigie R., and Davies D.R. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science 266 (1994) 1981-1986
    • (1994) Science , vol.266 , pp. 1981-1986
    • Dyda, F.1    Hickman, A.B.2    Jenkins, T.M.3    Engelman, A.4    Craigie, R.5    Davies, D.R.6
  • 14
    • 0028067324 scopus 로고
    • The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding
    • Engelman A., Hickman A.B., and Craigie R. The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. J. Virol. 68 (1994) 5911-5917
    • (1994) J. Virol. , vol.68 , pp. 5911-5917
    • Engelman, A.1    Hickman, A.B.2    Craigie, R.3
  • 16
    • 0037334017 scopus 로고    scopus 로고
    • An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA
    • Harper A.L., Sudol M., and Katzman M. An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA. J. Virol. 77 (2003) 3838-3845
    • (2003) J. Virol. , vol.77 , pp. 3838-3845
    • Harper, A.L.1    Sudol, M.2    Katzman, M.3
  • 17
    • 47949131197 scopus 로고    scopus 로고
    • HIV integrase inhibitors-out of the pipeline and into the clinic
    • Havlir D.V. HIV integrase inhibitors-out of the pipeline and into the clinic. N. Engl. J. Med. 359 (2008) 416-418
    • (2008) N. Engl. J. Med. , vol.359 , pp. 416-418
    • Havlir, D.V.1
  • 18
    • 0030875813 scopus 로고    scopus 로고
    • Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking
    • Heuer T.S., and Brown P.O. Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking. Biochemistry 36 (1997) 10655-10665
    • (1997) Biochemistry , vol.36 , pp. 10655-10665
    • Heuer, T.S.1    Brown, P.O.2
  • 20
    • 0030828521 scopus 로고    scopus 로고
    • Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking
    • Jenkins T.M., Esposito D., Engelman A., and Craigie R. Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J. 16 (1997) 6849-6859
    • (1997) EMBO J. , vol.16 , pp. 6849-6859
    • Jenkins, T.M.1    Esposito, D.2    Engelman, A.3    Craigie, R.4
  • 21
    • 0025011051 scopus 로고
    • The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro
    • Katz R.A., Merkel G., Kulkosky J., Leis J., and Skalka A.M. The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell 63 (1990) 87-95
    • (1990) Cell , vol.63 , pp. 87-95
    • Katz, R.A.1    Merkel, G.2    Kulkosky, J.3    Leis, J.4    Skalka, A.M.5
  • 22
    • 0029148615 scopus 로고
    • Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases
    • Katzman M., and Sudol M. Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases. J. Virol. 69 (1995) 5687-5696
    • (1995) J. Virol. , vol.69 , pp. 5687-5696
    • Katzman, M.1    Sudol, M.2
  • 23
    • 0029993527 scopus 로고    scopus 로고
    • Nonspecific alcoholysis, a novel endonuclease activity of human immunodeficiency virus type 1 and other retroviral integrases
    • Katzman M., and Sudol M. Nonspecific alcoholysis, a novel endonuclease activity of human immunodeficiency virus type 1 and other retroviral integrases. J. Virol. 70 (1996) 2598-2604
    • (1996) J. Virol. , vol.70 , pp. 2598-2604
    • Katzman, M.1    Sudol, M.2
  • 24
    • 0024431589 scopus 로고
    • The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration
    • Katzman M., Katz R.A., Skalka A.M., and Leis J. The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J. Virol. 63 (1989) 5319-5327
    • (1989) J. Virol. , vol.63 , pp. 5319-5327
    • Katzman, M.1    Katz, R.A.2    Skalka, A.M.3    Leis, J.4
  • 25
    • 0033959536 scopus 로고    scopus 로고
    • Mapping target site selection for the non-specific nuclease activities of retroviral integrase
    • Katzman M., Sudol M., Pufnock J.S., Zeto S., and Skinner L.M. Mapping target site selection for the non-specific nuclease activities of retroviral integrase. Virus Res. 66 (2000) 87-100
    • (2000) Virus Res. , vol.66 , pp. 87-100
    • Katzman, M.1    Sudol, M.2    Pufnock, J.S.3    Zeto, S.4    Skinner, L.M.5
  • 27
    • 16244383537 scopus 로고    scopus 로고
    • A substitution in Rous sarcoma virus integrase that separates its two biologically relevant enzymatic activities
    • Konsavage Jr. W.M., Burkholder S., Sudol M., Harper A.L., and Katzman M. A substitution in Rous sarcoma virus integrase that separates its two biologically relevant enzymatic activities. J. Virol. 79 (2005) 4691-4699
    • (2005) J. Virol. , vol.79 , pp. 4691-4699
    • Konsavage Jr., W.M.1    Burkholder, S.2    Sudol, M.3    Harper, A.L.4    Katzman, M.5
  • 28
    • 34247146377 scopus 로고    scopus 로고
    • Retroviral integrases that are improved for processing but impaired for joining
    • Konsavage Jr. W.M., Sudol M., Lee N.E., and Katzman M. Retroviral integrases that are improved for processing but impaired for joining. Virus Res. 125 (2007) 198-210
    • (2007) Virus Res. , vol.125 , pp. 198-210
    • Konsavage Jr., W.M.1    Sudol, M.2    Lee, N.E.3    Katzman, M.4
  • 29
    • 50349096775 scopus 로고    scopus 로고
    • Effects of varying the spacing within the D,D-35-E motif in the catalytic region of retroviral integrase
    • Konsavage Jr. W.M., Sudol M., and Katzman M. Effects of varying the spacing within the D,D-35-E motif in the catalytic region of retroviral integrase. Virology 379 (2008) 223-233
    • (2008) Virology , vol.379 , pp. 223-233
    • Konsavage Jr., W.M.1    Sudol, M.2    Katzman, M.3
  • 30
    • 0033550058 scopus 로고    scopus 로고
    • Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant
    • Lubkowski J., Dauter Z., Yang F., Alexandratos J., Merkel G., Skalka A.M., and Wlodawer A. Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant. Biochemistry 38 (1999) 13512-13522
    • (1999) Biochemistry , vol.38 , pp. 13512-13522
    • Lubkowski, J.1    Dauter, Z.2    Yang, F.3    Alexandratos, J.4    Merkel, G.5    Skalka, A.M.6    Wlodawer, A.7
  • 31
    • 0032544311 scopus 로고    scopus 로고
    • Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases
    • Maignan S., Guilloteau J.-P., Zhou-Liu Q., Clément-Mella C., and Mikol V. Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J. Mol. Biol. 282 (1998) 359-368
    • (1998) J. Mol. Biol. , vol.282 , pp. 359-368
    • Maignan, S.1    Guilloteau, J.-P.2    Zhou-Liu, Q.3    Clément-Mella, C.4    Mikol, V.5
  • 32
    • 0033952347 scopus 로고    scopus 로고
    • Subterminal viral DNA nucleotides as specific recognition signals for human immunodeficiency virus type 1 and visna virus integrases under magnesium-dependent conditions
    • Morgan A.L., and Katzman M. Subterminal viral DNA nucleotides as specific recognition signals for human immunodeficiency virus type 1 and visna virus integrases under magnesium-dependent conditions. J. Gen. Virol. 81 (2000) 839-849
    • (2000) J. Gen. Virol. , vol.81 , pp. 839-849
    • Morgan, A.L.1    Katzman, M.2
  • 34
    • 0035808442 scopus 로고    scopus 로고
    • Nucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases
    • Skinner L.M., Sudol M., Harper A.L., and Katzman M. Nucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases. J. Biol. Chem. 276 (2001) 114-124
    • (2001) J. Biol. Chem. , vol.276 , pp. 114-124
    • Skinner, L.M.1    Sudol, M.2    Harper, A.L.3    Katzman, M.4
  • 35
    • 0027210608 scopus 로고
    • Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type 1 integrase protein
    • Vink C., Oude Groeneger A.A.M., and Plasterk R.H.A. Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type 1 integrase protein. Nucleic Acids Res. 21 (1993) 1419-1425
    • (1993) Nucleic Acids Res. , vol.21 , pp. 1419-1425
    • Vink, C.1    Oude Groeneger, A.A.M.2    Plasterk, R.H.A.3
  • 36
    • 0027205243 scopus 로고
    • Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis
    • Woerner A.M., and Marcus-Sekura C.J. Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis. Nucleic Acids Res. 21 (1993) 3507-3511
    • (1993) Nucleic Acids Res. , vol.21 , pp. 3507-3511
    • Woerner, A.M.1    Marcus-Sekura, C.J.2
  • 37
    • 0034681303 scopus 로고    scopus 로고
    • Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase
    • Yang Z.-N., Mueser T.C., Bushman F.D., and Hyde C.C. Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase. J. Mol. Biol. 296 (2000) 535-548
    • (2000) J. Mol. Biol. , vol.296 , pp. 535-548
    • Yang, Z.-N.1    Mueser, T.C.2    Bushman, F.D.3    Hyde, C.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.