-
1
-
-
33846541321
-
Experimental approaches to the study of HIV-1 latency
-
Han, Y., Wind-Rotolo, M., Yang, H. C., Siliciano, J. D. and Siliciano, R. F. (2007). Experimental approaches to the study of HIV-1 latency. Nat. Rev. Microbiol. 5, 95-106.
-
(2007)
Nat. Rev. Microbiol
, vol.5
, pp. 95-106
-
-
Han, Y.1
Wind-Rotolo, M.2
Yang, H.C.3
Siliciano, J.D.4
Siliciano, R.F.5
-
2
-
-
27544447472
-
Molecular mechanisms of HIV-1 proviral latency. Expert Rev. Anti. Infect
-
Bisgrove, D., Lewinski, M., Bushman, F. and Verdin, E. (2005). Molecular mechanisms of HIV-1 proviral latency. Expert Rev. Anti. Infect. Ther. 3, 805-814.
-
(2005)
Ther
, vol.3
, pp. 805-814
-
-
Bisgrove, D.1
Lewinski, M.2
Bushman, F.3
Verdin, E.4
-
3
-
-
3242769788
-
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
-
Hazuda, D. J., Young, S. D., Guare, J. P., Anthony, N. J., Gomez, R. P., Wai, J. S., Vacca, J. P., Handt, L., Motzel, S. L., Klein, H. J., Dornadula, G., Danovich, R. M., Witmer, M. V., Wilson, K. A., Tussey, L., Schleif, W. A., Gabryelski, L. S., Jin, L., Miller, M. D., Casimiro, D. R., Emini, E. A. and Shiver, J. W. (2004). Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science 305, 528-532.
-
(2004)
Science
, vol.305
, pp. 528-532
-
-
Hazuda, D.J.1
Young, S.D.2
Guare, J.P.3
Anthony, N.J.4
Gomez, R.P.5
Wai, J.S.6
Vacca, J.P.7
Handt, L.8
Motzel, S.L.9
Klein, H.J.10
Dornadula, G.11
Danovich, R.M.12
Witmer, M.V.13
Wilson, K.A.14
Tussey, L.15
Schleif, W.A.16
Gabryelski, L.S.17
Jin, L.18
Miller, M.D.19
Casimiro, D.R.20
Emini, E.A.21
Shiver, J.W.22
more..
-
4
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
Grinsztejn, B., Nguyen, B. Y., Katlama, C., Gatell, J. M., Lazzarin, A., Vittecoq, D., Gonzalez, C. J., Chen, J., Harvey, C. M. and Isaacs, R. D. (2007). Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 369, 1261-1269.
-
(2007)
Lancet
, vol.369
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
Gatell, J.M.4
Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
-
5
-
-
0023647997
-
Correct integration of retroviral DNA in vitro
-
Brown, P. O., Bowerman, B., Varmus, H. E. and Bishop, J. M. (1987). Correct integration of retroviral DNA in vitro. Cell 49, 347-356.
-
(1987)
Cell
, vol.49
, pp. 347-356
-
-
Brown, P.O.1
Bowerman, B.2
Varmus, H.E.3
Bishop, J.M.4
-
6
-
-
0025031786
-
The IN protein of Moloney murine leukemia virus processes the viral DNAends and accomplishes their integration in vitro
-
Craigie, R., Fujiwara, T. and Bushman, F. (1990). The IN protein of Moloney murine leukemia virus processes the viral DNAends and accomplishes their integration in vitro. Cell 62, 829-837.
-
(1990)
Cell
, vol.62
, pp. 829-837
-
-
Craigie, R.1
Fujiwara, T.2
Bushman, F.3
-
7
-
-
0026330796
-
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
-
Engelman, A., Mizuuchi, K. and Craigie, R. (1991). HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell 67, 1211-1221.
-
(1991)
Cell
, vol.67
, pp. 1211-1221
-
-
Engelman, A.1
Mizuuchi, K.2
Craigie, R.3
-
8
-
-
0001363865
-
Integration
-
Coffin, J. M, Hughes, S. H. and Varmus, H. E, eds, pp, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
Brown, P. O. (1999) Integration. In: Retroviruses Coffin, J. M., Hughes, S. H. and Varmus, H. E., (eds.), pp. 161-203, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
-
(1999)
Retroviruses
, pp. 161-203
-
-
Brown, P.O.1
-
9
-
-
0035968306
-
HIV integrase, a brief overview from chemistry to therapeutics
-
Craigie, R. (2001). HIV integrase, a brief overview from chemistry to therapeutics. J. Biol. Chem. 276, 23213-23216.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 23213-23216
-
-
Craigie, R.1
-
10
-
-
22744450170
-
Retroviral DNA integration and the DNA damage response
-
Skalka, A. M. and Katz, R. A. (2005). Retroviral DNA integration and the DNA damage response. Cell Death Differ. 12 Suppl. 1, 971-978.
-
(2005)
Cell Death Differ
, vol.12
, Issue.SUPPL. 1
, pp. 971-978
-
-
Skalka, A.M.1
Katz, R.A.2
-
11
-
-
0025133394
-
Retroviral DNA integration directed by HIV integration protein in vitro
-
Bushman, F. D., Fujiwara, T. and Craigie, R. (1990). Retroviral DNA integration directed by HIV integration protein in vitro. Science 249, 1555-1558.
-
(1990)
Science
, vol.249
, pp. 1555-1558
-
-
Bushman, F.D.1
Fujiwara, T.2
Craigie, R.3
-
12
-
-
0025011051
-
The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro
-
Katz, R. A., Merkel, G., Kulkosky, J., Leis, J. and Skalka, A. M. (1990). The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell 63, 87-95.
-
(1990)
Cell
, vol.63
, pp. 87-95
-
-
Katz, R.A.1
Merkel, G.2
Kulkosky, J.3
Leis, J.4
Skalka, A.M.5
-
13
-
-
0025184912
-
Removal of 3′-OH-terminal nucleotides from blunt-ended long terminal repeat termini by the avian retrovirus integration protein
-
Vora, A. C., Fitzgerald, M. L. and Grandgenett, D. P. (1990). Removal of 3′-OH-terminal nucleotides from blunt-ended long terminal repeat termini by the avian retrovirus integration protein. J. Virol. 64, 5656-5659.
-
(1990)
J. Virol
, vol.64
, pp. 5656-5659
-
-
Vora, A.C.1
Fitzgerald, M.L.2
Grandgenett, D.P.3
-
14
-
-
0026034790
-
Activities of human immunodeficiency virus (HIV) integration protein in vitro: Specific cleavage and integration of HIV DNA
-
Bushman, F. D. and Craigie, R. (1991). Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA. Proc. Natl. Acad. Sci. USA 88, 1339-1343.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 1339-1343
-
-
Bushman, F.D.1
Craigie, R.2
-
15
-
-
0024654338
-
A nucleoprotein complex mediates the integration of retroviral DNA
-
Bowerman, B., Brown, P. O., Bishop, J. M. and Varmus, H. E. (1989). A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev. 3, 469-478.
-
(1989)
Genes Dev
, vol.3
, pp. 469-478
-
-
Bowerman, B.1
Brown, P.O.2
Bishop, J.M.3
Varmus, H.E.4
-
16
-
-
0025337327
-
Human immunodeficiency virus integration in a cell-free system
-
Ellison, V., Abrams, H., Roe, T., Lifson, J. and Brown, P. (1990). Human immunodeficiency virus integration in a cell-free system. J. Virol. 64, 2711-2715.
-
(1990)
J. Virol
, vol.64
, pp. 2711-2715
-
-
Ellison, V.1
Abrams, H.2
Roe, T.3
Lifson, J.4
Brown, P.5
-
17
-
-
0025313138
-
Integration of human immunodeficiency virus type 1 DNA in vitro
-
Farnet, C. M. and Haseltine, W. A. (1990). Integration of human immunodeficiency virus type 1 DNA in vitro. Proc. Natl. Acad. Sci. USA 87, 4164-4168.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 4164-4168
-
-
Farnet, C.M.1
Haseltine, W.A.2
-
18
-
-
0027199982
-
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection
-
Bukrinsky, M. I., Sharova, N., McDonald, T. L., Pushkarskaya, T., Tarpley, W. G. and Stevenson, M. (1993). Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection. Proc. Nat. Acad. Sci. USA 90, 6125-6129.
-
(1993)
Proc. Nat. Acad. Sci. USA
, vol.90
, pp. 6125-6129
-
-
Bukrinsky, M.I.1
Sharova, N.2
McDonald, T.L.3
Pushkarskaya, T.4
Tarpley, W.G.5
Stevenson, M.6
-
19
-
-
0030972160
-
Human immunodeficiency virus type 1 preintegration complexes: Studies of organization and composition
-
Miller, M. D., Farnet, C. M. and Bushman, F. D. (1997). Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. J. Virol. 71, 5382-5390.
-
(1997)
J. Virol
, vol.71
, pp. 5382-5390
-
-
Miller, M.D.1
Farnet, C.M.2
Bushman, F.D.3
-
20
-
-
3042760021
-
Global nature of dynamic protein-chromatin interactions in vivo: Three-dimensional genome scanning and dynamic interaction networks of chromatin proteins
-
Phair, R. D., Scaffidi, P., Elbi, C., Vecerova, J., Dey, A., Ozato, K., Brown, D. T., Hager, G., Bustin, M. and Misteli, T. (2004). Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol. Cell. Biol. 24, 6393-6402.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 6393-6402
-
-
Phair, R.D.1
Scaffidi, P.2
Elbi, C.3
Vecerova, J.4
Dey, A.5
Ozato, K.6
Brown, D.T.7
Hager, G.8
Bustin, M.9
Misteli, T.10
-
21
-
-
33745020770
-
Determinants of histone H1 mobility and chromatin binding in living cells
-
Catez, F., Ueda, T. and Bustin, M. (2006). Determinants of histone H1 mobility and chromatin binding in living cells. Nat. Struct. Mol. Biol. 13, 305-310.
-
(2006)
Nat. Struct. Mol. Biol
, vol.13
, pp. 305-310
-
-
Catez, F.1
Ueda, T.2
Bustin, M.3
-
22
-
-
0035078745
-
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1
-
Fassati, A. and Goff, S. P. (2001). Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1. J. Virol. 75, 3626-3635.
-
(2001)
J. Virol
, vol.75
, pp. 3626-3635
-
-
Fassati, A.1
Goff, S.P.2
-
23
-
-
33847139800
-
The road to chromatin - nuclear entry of retroviruses
-
Suzuki, Y. and Craigie, R. (2007). The road to chromatin - nuclear entry of retroviruses. Nat. Rev. Microbiol. 5, 187-196.
-
(2007)
Nat. Rev. Microbiol
, vol.5
, pp. 187-196
-
-
Suzuki, Y.1
Craigie, R.2
-
24
-
-
0037043699
-
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
-
Sheehy, A. M., Gaddis, N. C., Choi, J. D. and Malim, M. H. (2002). Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418, 646-650.
-
(2002)
Nature
, vol.418
, pp. 646-650
-
-
Sheehy, A.M.1
Gaddis, N.C.2
Choi, J.D.3
Malim, M.H.4
-
25
-
-
0141796317
-
Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors
-
Towers, G. J., Hatziioannou, T., Cowan, S., Goff, S. P., Luban, J. and Bieniasz, P. D. (2003). Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat. Med. 9, 1138-1143.
-
(2003)
Nat. Med
, vol.9
, pp. 1138-1143
-
-
Towers, G.J.1
Hatziioannou, T.2
Cowan, S.3
Goff, S.P.4
Luban, J.5
Bieniasz, P.D.6
-
26
-
-
1542288934
-
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
-
Stremlau, M., Owens, C. M., Perron, M. J., Kiessling, M., Autissier, P. and Sodroski, J. (2004). The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 427, 848-853.
-
(2004)
Nature
, vol.427
, pp. 848-853
-
-
Stremlau, M.1
Owens, C.M.2
Perron, M.J.3
Kiessling, M.4
Autissier, P.5
Sodroski, J.6
-
27
-
-
9244260598
-
Intrinsic immunity: A front-line defense against viral attack
-
Bieniasz, P. D. (2004). Intrinsic immunity: a front-line defense against viral attack. Nat. Immunol. 5, 1109-1115.
-
(2004)
Nat. Immunol
, vol.5
, pp. 1109-1115
-
-
Bieniasz, P.D.1
-
28
-
-
33746270438
-
Cyclophilin, TRIM5, and innate immunity to HIV-1
-
Sokolskaja, E. and Luban, J. (2006). Cyclophilin, TRIM5, and innate immunity to HIV-1. Curr. Opin. Microbiol. 9, 404-408.
-
(2006)
Curr. Opin. Microbiol
, vol.9
, pp. 404-408
-
-
Sokolskaja, E.1
Luban, J.2
-
29
-
-
33947379083
-
Host factors exploited by retroviruses
-
Goff, S. P. (2007). Host factors exploited by retroviruses. Nat. Rev. Microbiol. 5, 253-263.
-
(2007)
Nat. Rev. Microbiol
, vol.5
, pp. 253-263
-
-
Goff, S.P.1
-
30
-
-
0032616706
-
Host proteins in retroviral cDNA integration
-
Bushman, F. D. (1999). Host proteins in retroviral cDNA integration. Adv. Virus Res. 52, 301-317.
-
(1999)
Adv. Virus Res
, vol.52
, pp. 301-317
-
-
Bushman, F.D.1
-
31
-
-
0042164434
-
The roles of cellular factors in retroviral integration
-
Engelman, A. (2003). The roles of cellular factors in retroviral integration. Curr. Top. Microbiol. Immunol. 281, 209-238.
-
(2003)
Curr. Top. Microbiol. Immunol
, vol.281
, pp. 209-238
-
-
Engelman, A.1
-
32
-
-
33646193491
-
Dynamics of virus-host interplay in HIV-1 replication
-
Sorin, M. and Kalpana, G. V. (2006). Dynamics of virus-host interplay in HIV-1 replication. Curr. HIV Res. 4, 117-130.
-
(2006)
Curr. HIV Res
, vol.4
, pp. 117-130
-
-
Sorin, M.1
Kalpana, G.V.2
-
33
-
-
32344452179
-
Cellular cofactors of HIV-1 integration
-
Van Maele, B., Busschots, K., Vandekerckhove, L., Christ, F. and Debyser, Z. (2006). Cellular cofactors of HIV-1 integration. Trends Biochem. Sci. 31, 98-105.
-
(2006)
Trends Biochem. Sci
, vol.31
, pp. 98-105
-
-
Van Maele, B.1
Busschots, K.2
Vandekerckhove, L.3
Christ, F.4
Debyser, Z.5
-
34
-
-
0037162715
-
HIV-1 integration in the human genome favors active genes and local hotspots
-
Schroder, A. R., Shinn, P., Chen, H., Berry, C., Ecker, J. R. and Bushman, F. (2002). HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110, 521-529.
-
(2002)
Cell
, vol.110
, pp. 521-529
-
-
Schroder, A.R.1
Shinn, P.2
Chen, H.3
Berry, C.4
Ecker, J.R.5
Bushman, F.6
-
35
-
-
0037841763
-
Transcription start regions in the human genome are favored targets for MLV integration
-
Wu, X., Li, Y., Crise, B. and Burgess, S. M. (2003). Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749-1751.
-
(2003)
Science
, vol.300
, pp. 1749-1751
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
-
36
-
-
6344270072
-
Genome-wide analyses of avian sarcoma virus integration sites
-
Narezkina, A., Taganov, K. D., Litwin, S., Stoyanova, R., Hayashi, J., Seeger, C., Skalka, A. M. and Katz, R. A. (2004). Genome-wide analyses of avian sarcoma virus integration sites. J. Virol. 78, 11656-11663.
-
(2004)
J. Virol
, vol.78
, pp. 11656-11663
-
-
Narezkina, A.1
Taganov, K.D.2
Litwin, S.3
Stoyanova, R.4
Hayashi, J.5
Seeger, C.6
Skalka, A.M.7
Katz, R.A.8
-
37
-
-
19344375031
-
Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences
-
Mitchell, R. S., Beitzel, B. F., Schroder, A. R., Shinn, P., Chen, H., Berry, C. C., Ecker, J. R. and Bushman, F. D. (2004). Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences. PLoS Biol. 2, E234.
-
(2004)
PLoS Biol
, vol.2
-
-
Mitchell, R.S.1
Beitzel, B.F.2
Schroder, A.R.3
Shinn, P.4
Chen, H.5
Berry, C.C.6
Ecker, J.R.7
Bushman, F.D.8
-
38
-
-
20044396722
-
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells
-
Hematti, P., Hong, B. K., Ferguson, C., Adler, R., Hanawa, H., Sellers, S., Holt, I. E., Eckfeldt, C. E., Sharma, Y., Schmidt, M. et al. (2004). Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol. 2, e423.
-
(2004)
PLoS Biol
, vol.2
-
-
Hematti, P.1
Hong, B.K.2
Ferguson, C.3
Adler, R.4
Hanawa, H.5
Sellers, S.6
Holt, I.E.7
Eckfeldt, C.E.8
Sharma, Y.9
Schmidt, M.10
-
39
-
-
25144445833
-
Simian immunodeficiency virus integration preference is similar to that of human immunodeficiency virus type 1
-
Crise, B., Li, Y., Yuan, C., Morcock, D. R., Whitby, D., Munroe, D. J., Arthur, L. O. and Wu, X. (2005). Simian immunodeficiency virus integration preference is similar to that of human immunodeficiency virus type 1. J. Virol. 79, 12199-12204.
-
(2005)
J. Virol
, vol.79
, pp. 12199-12204
-
-
Crise, B.1
Li, Y.2
Yuan, C.3
Morcock, D.R.4
Whitby, D.5
Munroe, D.J.6
Arthur, L.O.7
Wu, X.8
-
40
-
-
13444303842
-
Relationship between retroviral DNA-integration-site selection and host cell transcription
-
Maxfield, L. F., Fraize, C. D. and Coffin, J. M. (2005). Relationship between retroviral DNA-integration-site selection and host cell transcription. Proc. Natl. Acad. Sci. USA 102, 1436-1441.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 1436-1441
-
-
Maxfield, L.F.1
Fraize, C.D.2
Coffin, J.M.3
-
41
-
-
28144462457
-
Genome-wide analysis of retroviral DNA integration
-
Bushman, F., Lewinski, M., Ciuffi, A., Barr, S., Leipzig, J., Hannenhalli, S. and Hoffmann, C. (2005). Genome-wide analysis of retroviral DNA integration. Nat. Rev. Microbiol. 3, 848-858.
-
(2005)
Nat. Rev. Microbiol
, vol.3
, pp. 848-858
-
-
Bushman, F.1
Lewinski, M.2
Ciuffi, A.3
Barr, S.4
Leipzig, J.5
Hannenhalli, S.6
Hoffmann, C.7
-
42
-
-
24644489049
-
Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome
-
Barr, S. D., Leipzig, J., Shinn, P., Ecker, J. R. and Bushman, F. D. (2005). Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome. J. Virol. 79, 12035-12044.
-
(2005)
J. Virol
, vol.79
, pp. 12035-12044
-
-
Barr, S.D.1
Leipzig, J.2
Shinn, P.3
Ecker, J.R.4
Bushman, F.D.5
-
43
-
-
33748639703
-
Integration site choice of a feline immunodeficiency virus vector
-
Kang, Y., Moressi, C. J., Scheetz, T. E., Xie, L., Tran, D. T., Casavant, T. L., Ak, P., Benham, C. J., Davidson, B. L. and McCray, P. B., Jr. (2006). Integration site choice of a feline immunodeficiency virus vector. J. Virol. 80, 8820-8823.
-
(2006)
J. Virol
, vol.80
, pp. 8820-8823
-
-
Kang, Y.1
Moressi, C.J.2
Scheetz, T.E.3
Xie, L.4
Tran, D.T.5
Casavant, T.L.6
Ak, P.7
Benham, C.J.8
Davidson, B.L.9
McCray Jr., P.B.10
-
44
-
-
30344434648
-
Integration site selection by HIV-based vectors in dividing and growth-arrested IMR-90 lung fibroblasts
-
Ciuffi, A., Mitchell, R. S., Hoffmann, C., Leipzig, J., Shinn, P., Ecker, J. R. and Bushman, F. D. (2006). Integration site selection by HIV-based vectors in dividing and growth-arrested IMR-90 lung fibroblasts. Mol. Ther. 13, 366-373.
-
(2006)
Mol. Ther
, vol.13
, pp. 366-373
-
-
Ciuffi, A.1
Mitchell, R.S.2
Hoffmann, C.3
Leipzig, J.4
Shinn, P.5
Ecker, J.R.6
Bushman, F.D.7
-
45
-
-
33746210165
-
Genomic sites of human immunodeficiency virus type 2 (HIV-2) integration: Similarities to HIV-1 in vitro and possible differences in vivo
-
MacNeil, A., Sankale, J. L., Meloni, S. T., Sarr, A. D., Mboup, S. and Kanki, P. (2006). Genomic sites of human immunodeficiency virus type 2 (HIV-2) integration: similarities to HIV-1 in vitro and possible differences in vivo. J. Virol. 80, 7316-7321.
-
(2006)
J. Virol
, vol.80
, pp. 7316-7321
-
-
MacNeil, A.1
Sankale, J.L.2
Meloni, S.T.3
Sarr, A.D.4
Mboup, S.5
Kanki, P.6
-
46
-
-
33748205021
-
The integration profile of EIAV-based vectors
-
Hacker, C. V., Vink, C. A., Wardell, T. W., Lee, S., Treasure, P., Kingsman, S. M., Mitrophanous, K. A. and Miskin, J. E. (2006). The integration profile of EIAV-based vectors. Mol. Ther. 14, 536-545.
-
(2006)
Mol. Ther
, vol.14
, pp. 536-545
-
-
Hacker, C.V.1
Vink, C.A.2
Wardell, T.W.3
Lee, S.4
Treasure, P.5
Kingsman, S.M.6
Mitrophanous, K.A.7
Miskin, J.E.8
-
47
-
-
24044455869
-
Genome sequencing in microfabricated high-density picolitre reactors
-
Margulies, M., Egholm, M., Altman, W. E., Attiya, S., Bader, J. S., Bemben, L. A., Berka, J., Braverman, M. S., Chen, Y. J., Chen, Z. et al. (2005). Genome sequencing in microfabricated high-density picolitre reactors. Nature 437, 376-380.
-
(2005)
Nature
, vol.437
, pp. 376-380
-
-
Margulies, M.1
Egholm, M.2
Altman, W.E.3
Attiya, S.4
Bader, J.S.5
Bemben, L.A.6
Berka, J.7
Braverman, M.S.8
Chen, Y.J.9
Chen, Z.10
-
48
-
-
34547635063
-
HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications
-
Published online before print, 1 June
-
Wang, G. P., Ciuffi, A., Leipzig, J., Berry, C. C. and Bushman, F. D. (2007). HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications. Genome Res. Published online before print, 1 June.
-
(2007)
Genome Res
-
-
Wang, G.P.1
Ciuffi, A.2
Leipzig, J.3
Berry, C.C.4
Bushman, F.D.5
-
49
-
-
0026567862
-
Retroviral integration into minichromosomes in vitro
-
Pryciak, P. M., Sil, A. and Varmus, H. E. (1992). Retroviral integration into minichromosomes in vitro. EMBO J. 11, 291-303.
-
(1992)
EMBO J
, vol.11
, pp. 291-303
-
-
Pryciak, P.M.1
Sil, A.2
Varmus, H.E.3
-
50
-
-
0026696624
-
Nucleosomes, DNA binding proteins, and DNA sequence modulate retroviral integration target site selection
-
Pryciak, P. M. and Varmus, H. E. (1992). Nucleosomes, DNA binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell 69, 769-780.
-
(1992)
Cell
, vol.69
, pp. 769-780
-
-
Pryciak, P.M.1
Varmus, H.E.2
-
51
-
-
0028264042
-
Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core
-
Pruss, D., Bushman, F. D. and Wolffe, A. P. (1994). Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core. Proc. Nat. Acad. Sci. USA 91, 5913-5917.
-
(1994)
Proc. Nat. Acad. Sci. USA
, vol.91
, pp. 5913-5917
-
-
Pruss, D.1
Bushman, F.D.2
Wolffe, A.P.3
-
52
-
-
0028125005
-
The influence of DNA and nucleosome structure on integration events directed by HIV integrase
-
Pruss, D., Reeves, R., Bushman, F. D. and Wolffe, A. P. (1994). The influence of DNA and nucleosome structure on integration events directed by HIV integrase. J. Biol. Chem. 269, 25031-25041.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 25031-25041
-
-
Pruss, D.1
Reeves, R.2
Bushman, F.D.3
Wolffe, A.P.4
-
53
-
-
0028067639
-
DNA bending creates favored sites for retroviral integration: An explanation for preferred insertion sites in nucleosomes
-
Muller, H. P. and Varmus, H. E. (1994). DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. EMBO J. 13, 4704-4714.
-
(1994)
EMBO J
, vol.13
, pp. 4704-4714
-
-
Muller, H.P.1
Varmus, H.E.2
-
54
-
-
0028340554
-
Distribution of targets for avian retrovirus DNA integration in vivo
-
Withers-Ward, E. S., Kitamura, Y., Barnes, J. P. and Coffin, J. M. (1994). Distribution of targets for avian retrovirus DNA integration in vivo. Genes Dev. 8, 1473-1487.
-
(1994)
Genes Dev
, vol.8
, pp. 1473-1487
-
-
Withers-Ward, E.S.1
Kitamura, Y.2
Barnes, J.P.3
Coffin, J.M.4
-
55
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W. et al. (2001). Initial sequencing and analysis of the human genome. Nature 409, 860-921.
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
Linton, L.M.2
Birren, B.3
Nusbaum, C.4
Zody, M.C.5
Baldwin, J.6
Devon, K.7
Dewar, K.8
Doyle, M.9
FitzHugh, W.10
-
56
-
-
0035895505
-
The sequence of the human genome
-
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A. et al. (2001). The sequence of the human genome. Science 291, 1304-1351.
-
(2001)
Science
, vol.291
, pp. 1304-1351
-
-
Venter, J.C.1
Adams, M.D.2
Myers, E.W.3
Li, P.W.4
Mural, R.J.5
Sutton, G.G.6
Smith, H.O.7
Yandell, M.8
Evans, C.A.9
Holt, R.A.10
-
57
-
-
38349112349
-
Mouse mammary tumor virus integration site selection in human and mouse genomes
-
Faschinger, A., Rouault, F., Sollner, J., Lukas, A., Salmons, B., Gunzburg, W. H. and Indik, S. (2008). Mouse mammary tumor virus integration site selection in human and mouse genomes. J. Virol. 82, 1360-1367.
-
(2008)
J. Virol
, vol.82
, pp. 1360-1367
-
-
Faschinger, A.1
Rouault, F.2
Sollner, J.3
Lukas, A.4
Salmons, B.5
Gunzburg, W.H.6
Indik, S.7
-
58
-
-
33646161948
-
Genome-wide mapping of foamy virus vector integrations into a human cell line
-
Nowrouzi, A., Dittrich, M., Klanke, C., Heinkelein, M., Rammling, M., Dandekar, T., von Kalle, C. and Rethwilm, A. (2006). Genome-wide mapping of foamy virus vector integrations into a human cell line. J. Gen. Virol. 87, 1339-1347.
-
(2006)
J. Gen. Virol
, vol.87
, pp. 1339-1347
-
-
Nowrouzi, A.1
Dittrich, M.2
Klanke, C.3
Heinkelein, M.4
Rammling, M.5
Dandekar, T.6
von Kalle, C.7
Rethwilm, A.8
-
59
-
-
31944444349
-
Foamy virus vector integration sites in normal human cells
-
Trobridge, G. D., Miller, D. G., Jacobs, M. A., Allen, J. M., Kiem, H. P., Kaul, R. and Russell, D. W. (2006). Foamy virus vector integration sites in normal human cells. Proc. Natl. Acad. Sci. USA 103, 1498-1503.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1498-1503
-
-
Trobridge, G.D.1
Miller, D.G.2
Jacobs, M.A.3
Allen, J.M.4
Kiem, H.P.5
Kaul, R.6
Russell, D.W.7
-
60
-
-
0036209708
-
Integration site selection by lentiviruses: Biology and possible control
-
Bushman, F. D. (2002). Integration site selection by lentiviruses: biology and possible control. Curr. Top. Microbiol. Immunol. 261, 165-177.
-
(2002)
Curr. Top. Microbiol. Immunol
, vol.261
, pp. 165-177
-
-
Bushman, F.D.1
-
61
-
-
0031957564
-
Chromosome structure and human immunodeficiency virus type 1 cDNA integration: Centromeric alphoid repeats are a disfavored target
-
Carteau, S., Hoffmann, C. and Bushman, F. (1998). Chromosome structure and human immunodeficiency virus type 1 cDNA integration: centromeric alphoid repeats are a disfavored target. J. Virol. 72, 4005-4014.
-
(1998)
J. Virol
, vol.72
, pp. 4005-4014
-
-
Carteau, S.1
Hoffmann, C.2
Bushman, F.3
-
62
-
-
0037446948
-
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
-
Jordan, A., Bisgrove, D. and Verdin, E. (2003). HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 22, 1868-1877.
-
(2003)
EMBO J
, vol.22
, pp. 1868-1877
-
-
Jordan, A.1
Bisgrove, D.2
Verdin, E.3
-
63
-
-
21044451712
-
Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription
-
Lewinski, M. K., Bisgrove, D., Shinn, P., Chen, H., Hoffmann, C., Hannenhalli, S., Verdin, E., Berry, C. C., Ecker, J. R. and Bushman, F. D. (2005). Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J. Virol. 79, 6610-6619.
-
(2005)
J. Virol
, vol.79
, pp. 6610-6619
-
-
Lewinski, M.K.1
Bisgrove, D.2
Shinn, P.3
Chen, H.4
Hoffmann, C.5
Hannenhalli, S.6
Verdin, E.7
Berry, C.C.8
Ecker, J.R.9
Bushman, F.D.10
-
64
-
-
0032538795
-
Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation
-
Ge, H., Si, Y. and Roeder, R. G. (1998). Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J. 17, 6723-6729.
-
(1998)
EMBO J
, vol.17
, pp. 6723-6729
-
-
Ge, H.1
Si, Y.2
Roeder, R.G.3
-
65
-
-
0032239750
-
A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2
-
Ge, H., Si, Y. and Wolffe, A. P. (1998). A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol. Cell 2, 751-759.
-
(1998)
Mol. Cell
, vol.2
, pp. 751-759
-
-
Ge, H.1
Si, Y.2
Wolffe, A.P.3
-
66
-
-
0032976273
-
Lens epithelium-derived growth factor: Increased resistance to thermal and oxidative stresses
-
Singh, D. P., Ohguro, N., Chylack, L. T., Jr. and Shinohara, T. (1999). Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses. Invest. Ophthalmol. Vis. Sci. 40, 1444-1451.
-
(1999)
Invest. Ophthalmol. Vis. Sci
, vol.40
, pp. 1444-1451
-
-
Singh, D.P.1
Ohguro, N.2
Chylack Jr., L.T.3
Shinohara, T.4
-
67
-
-
0034609950
-
Activation of LEDGF gene by thermal-and oxidative-stresses
-
Sharma, P., Singh, D. P., Fatma, N., Chylack, L. T., Jr. and Shinohara, T. (2000). Activation of LEDGF gene by thermal-and oxidative-stresses. Biochem. Biophys. Res. Commun. 276, 1320-1324.
-
(2000)
Biochem. Biophys. Res. Commun
, vol.276
, pp. 1320-1324
-
-
Sharma, P.1
Singh, D.P.2
Fatma, N.3
Chylack Jr., L.T.4
Shinohara, T.5
-
68
-
-
0034811440
-
LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes
-
Singh, D. P., Fatma, N., Kimura, A., Chylack, L. T., Jr. and Shinohara, T. (2001). LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes. Biochem. Biophys. Res. Commun. 283, 943-955.
-
(2001)
Biochem. Biophys. Res. Commun
, vol.283
, pp. 943-955
-
-
Singh, D.P.1
Fatma, N.2
Kimura, A.3
Chylack Jr., L.T.4
Shinohara, T.5
-
69
-
-
0034917865
-
Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus
-
Nishizawa, Y., Usukura, J., Singh, D. P., Chylack, L. T., Jr. and Shinohara, T. (2001). Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus. Cell Tissue Res. 305, 107-114.
-
(2001)
Cell Tissue Res
, vol.305
, pp. 107-114
-
-
Nishizawa, Y.1
Usukura, J.2
Singh, D.P.3
Chylack Jr., L.T.4
Shinohara, T.5
-
70
-
-
0035966103
-
Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress
-
Fatma, N., Singh, D. P., Shinohara, T. and Chylack, L. T., Jr. (2001). Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. J. Biol. Chem. 276, 48899-48907.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 48899-48907
-
-
Fatma, N.1
Singh, D.P.2
Shinohara, T.3
Chylack Jr., L.T.4
-
71
-
-
0036715347
-
Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: Implications for autoimmunity in atopic disorders
-
Wu, X., Daniels, T., Molinaro, C., Lilly, M. B. and Casiano, C. A. (2002). Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders. Cell Death Differ. 9, 915-925.
-
(2002)
Cell Death Differ
, vol.9
, pp. 915-925
-
-
Wu, X.1
Daniels, T.2
Molinaro, C.3
Lilly, M.B.4
Casiano, C.A.5
-
72
-
-
0042763088
-
LEDGF/p75: A novel nuclear autoantigen at the crossroads of cell survival and apoptosis
-
Ganapathy, V., Daniels, T. and Casiano, C. A. (2003). LEDGF/p75: a novel nuclear autoantigen at the crossroads of cell survival and apoptosis. Autoimmun. Rev. 2, 290-297.
-
(2003)
Autoimmun. Rev
, vol.2
, pp. 290-297
-
-
Ganapathy, V.1
Daniels, T.2
Casiano, C.A.3
-
73
-
-
0346036088
-
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
-
Cherepanov, P., Maertens, G., Proost, P., Devreese, B., Van Beeumen, J., Engelborghs, Y., De Clercq, E. and Debyser, Z. (2003). HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J. Biol. Chem. 278, 372-381.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 372-381
-
-
Cherepanov, P.1
Maertens, G.2
Proost, P.3
Devreese, B.4
Van Beeumen, J.5
Engelborghs, Y.6
De Clercq, E.7
Debyser, Z.8
-
74
-
-
0041856142
-
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
-
Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., De Clercq, E., Debyser, Z. and Engelborghs, Y. (2003). LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J. Biol. Chem. 278, 33528-33539.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 33528-33539
-
-
Maertens, G.1
Cherepanov, P.2
Pluymers, W.3
Busschots, K.4
De Clercq, E.5
Debyser, Z.6
Engelborghs, Y.7
-
75
-
-
4143092604
-
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral pre-integration complexes
-
Llano, M., Vanegas, M., Fregoso, O., Saenz, D. T., Chung, S., Peretz, M. and Poeschla, E. M. (2004). LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral pre-integration complexes. J. Virol. 78, 9524-9537.
-
(2004)
J. Virol
, vol.78
, pp. 9524-9537
-
-
Llano, M.1
Vanegas, M.2
Fregoso, O.3
Saenz, D.T.4
Chung, S.5
Peretz, M.6
Poeschla, E.M.7
-
76
-
-
8644231282
-
Human cell proteins and human immunodeficiency virus DNA integration
-
Turlure, F., Devroe, E., Silver, P. A. and Engelman, A. (2004). Human cell proteins and human immunodeficiency virus DNA integration. Front. Biosci. 9, 3187-3208.
-
(2004)
Front. Biosci
, vol.9
, pp. 3187-3208
-
-
Turlure, F.1
Devroe, E.2
Silver, P.A.3
Engelman, A.4
-
77
-
-
4043112782
-
Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase (IN) interactor LEDGF/p75
-
Maertens, G., Cherepanov, P., Debyser, Z., Engelborghs, Y. and Engelman, A. (2004). Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase (IN) interactor LEDGF/p75. J. Biol. Chem. 279, 33421-33429.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 33421-33429
-
-
Maertens, G.1
Cherepanov, P.2
Debyser, Z.3
Engelborghs, Y.4
Engelman, A.5
-
78
-
-
11244255412
-
LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase
-
Llano, M., Delgado, S., Vanegas, M. and Poeschla, E. M. (2004). LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase. J. Biol. Chem. 279, 55570-55577.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 55570-55577
-
-
Llano, M.1
Delgado, S.2
Vanegas, M.3
Poeschla, E.M.4
-
79
-
-
10344221084
-
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional coactivator p75 (LEDGF/p75) that binds HIV-1 integrase
-
Cherepanov, P., Devroe, E., Silver, P. A. and Engelman, A. (2004). Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional coactivator p75 (LEDGF/p75) that binds HIV-1 integrase. J. Biol. Chem. 279, 48883-48892.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 48883-48892
-
-
Cherepanov, P.1
Devroe, E.2
Silver, P.A.3
Engelman, A.4
-
80
-
-
18844429520
-
Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering
-
Vanegas, M., Llano, M., Delgado, S., Thompson, D., Peretz, M. and Poeschla, E. (2005). Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J. Cell Sci. 118, 1733-1743.
-
(2005)
J. Cell Sci
, vol.118
, pp. 1733-1743
-
-
Vanegas, M.1
Llano, M.2
Delgado, S.3
Thompson, D.4
Peretz, M.5
Poeschla, E.6
-
81
-
-
22444437424
-
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
-
Cherepanov, P., Sun, Z. Y., Rahman, S., Maertens, G., Wagner, G. and Engelman, A. (2005). Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat. Struct. Mol. Biol. 12, 526-532.
-
(2005)
Nat. Struct. Mol. Biol
, vol.12
, pp. 526-532
-
-
Cherepanov, P.1
Sun, Z.Y.2
Rahman, S.3
Maertens, G.4
Wagner, G.5
Engelman, A.6
-
82
-
-
28444445583
-
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
-
Cherepanov, P., Ambrosio, A. L., Rahman, S., Ellenberger, T. and Engelman, A. (2005). Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proc. Natl. Acad. Sci. USA 102, 17308-17313.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17308-17313
-
-
Cherepanov, P.1
Ambrosio, A.L.2
Rahman, S.3
Ellenberger, T.4
Engelman, A.5
-
83
-
-
29144440079
-
Seeing is believing: Structure of the catalytic domain of HIV-1 integrase in complex with human LEDGF/p75
-
Bradley, C. M. and Craigie, R. (2005). Seeing is believing: structure of the catalytic domain of HIV-1 integrase in complex with human LEDGF/p75. Proc. Natl. Acad. Sci. USA 102, 17543-17544.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17543-17544
-
-
Bradley, C.M.1
Craigie, R.2
-
84
-
-
10144237224
-
Antinuclear autoantibodies in prostate cancer: Immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis
-
Daniels, T., Zhang, J., Gutierrez, I., Elliot, M. L., Yamada, B., Heeb, M. J., Sheets, S. M., Wu, X. and Casiano, C. A. (2005). Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis. Prostate 62, 14-26.
-
(2005)
Prostate
, vol.62
, pp. 14-26
-
-
Daniels, T.1
Zhang, J.2
Gutierrez, I.3
Elliot, M.L.4
Yamada, B.5
Heeb, M.J.6
Sheets, S.M.7
Wu, X.8
Casiano, C.A.9
-
85
-
-
28644443483
-
A role for LEDGF/p75 in targeting HIV DNA integration
-
Ciuffi, A., Llano, M., Poeschla, E., Hoffmann, C., Leipzig, J., Shinn, P., Ecker, J. R. and Bushman, F. (2005). A role for LEDGF/p75 in targeting HIV DNA integration. Nat. Med. 11, 1287-1289.
-
(2005)
Nat. Med
, vol.11
, pp. 1287-1289
-
-
Ciuffi, A.1
Llano, M.2
Poeschla, E.3
Hoffmann, C.4
Leipzig, J.5
Shinn, P.6
Ecker, J.R.7
Bushman, F.8
-
86
-
-
21844431868
-
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication
-
Emiliani, S., Mousnier, A., Busschots, K., Maroun, M., Van Maele, B., Tempe, D., Vandekerckhove, L., Moisant, F., Ben-Slama, L., Witvrouw, M. et al. (2005). Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication. J. Biol. Chem. 280, 25517-25523.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 25517-25523
-
-
Emiliani, S.1
Mousnier, A.2
Busschots, K.3
Maroun, M.4
Van Maele, B.5
Tempe, D.6
Vandekerckhove, L.7
Moisant, F.8
Ben-Slama, L.9
Witvrouw, M.10
-
87
-
-
24044489892
-
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding
-
Busschots, K., Vercammen, J., Emiliani, S., Benarous, R., Engelborghs, Y., Christ, F. and Debyser, Z. (2005). The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding. J. Biol. Chem. 280, 17841-17847.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 17841-17847
-
-
Busschots, K.1
Vercammen, J.2
Emiliani, S.3
Benarous, R.4
Engelborghs, Y.5
Christ, F.6
Debyser, Z.7
-
88
-
-
20444433204
-
Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75
-
Maertens, G., Vercammen, J., Debyser, Z. and Engelborghs, Y. (2005). Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75. FASEB J. 19, 1039-1041.
-
(2005)
FASEB J
, vol.19
, pp. 1039-1041
-
-
Maertens, G.1
Vercammen, J.2
Debyser, Z.3
Engelborghs, Y.4
-
89
-
-
33645528413
-
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
-
Turlure, F., Maertens, G., Rahman, S., Cherepanov, P. and Engelman, A. (2006). A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo. Nucleic Acids Res. 34, 1663-1675.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1663-1675
-
-
Turlure, F.1
Maertens, G.2
Rahman, S.3
Cherepanov, P.4
Engelman, A.5
-
90
-
-
33644831457
-
Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication
-
Vandegraaff, N., Devroe, E., Turlure, F., Silver, P. A. and Engelman, A. (2006). Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Virology 346, 415-426.
-
(2006)
Virology
, vol.346
, pp. 415-426
-
-
Vandegraaff, N.1
Devroe, E.2
Turlure, F.3
Silver, P.A.4
Engelman, A.5
-
91
-
-
33745776919
-
Modest but reproducible inhibition of human immunodeficiency virus type 1 infection in macrophages following LEDGFp75 silencing
-
Zielske, S. and Stevenson, M. (2006). Modest but reproducible inhibition of human immunodeficiency virus type 1 infection in macrophages following LEDGFp75 silencing. J. Virol. 80, 7275-7280.
-
(2006)
J. Virol
, vol.80
, pp. 7275-7280
-
-
Zielske, S.1
Stevenson, M.2
-
92
-
-
33745745419
-
Retroviral DNA integration: HIV and the role of LEDGF/p75
-
Ciuffi, A. and Bushman, F. D. (2006). Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet. 22, 388-395.
-
(2006)
Trends Genet
, vol.22
, pp. 388-395
-
-
Ciuffi, A.1
Bushman, F.D.2
-
93
-
-
33745617039
-
Identification and characterization of the chromatin binding domains of the HIV-1 integrase interactor LEDGF/p75
-
Llano, M., Vanegas, M., Hutchins, N., Thompson, D., Delgado, S. and Poeschla, E. M. (2006). Identification and characterization of the chromatin binding domains of the HIV-1 integrase interactor LEDGF/p75. J. Mol. Biol. 360, 760-773.
-
(2006)
J. Mol. Biol
, vol.360
, pp. 760-773
-
-
Llano, M.1
Vanegas, M.2
Hutchins, N.3
Thompson, D.4
Delgado, S.5
Poeschla, E.M.6
-
94
-
-
33749175924
-
Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations
-
Sutherland, H. G., Newton, K., Brownstein, D. G., Holmes, M. C., Kress, C., Semple, C. A. and Bickmore, W. A. (2006). Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol. Cell. Biol. 26, 7201-7210.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 7201-7210
-
-
Sutherland, H.G.1
Newton, K.2
Brownstein, D.G.3
Holmes, M.C.4
Kress, C.5
Semple, C.A.6
Bickmore, W.A.7
-
95
-
-
32444439020
-
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus
-
Vandekerckhove, L., Christ, F., Van Maele, B., De Rijck, J., Gijsbers, R., Van den Haute, C., Witvrouw, M. and Debyser, Z. (2006). Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. J. Virol. 80, 1886-1896.
-
(2006)
J. Virol
, vol.80
, pp. 1886-1896
-
-
Vandekerckhove, L.1
Christ, F.2
Van Maele, B.3
De Rijck, J.4
Gijsbers, R.5
Van den Haute, C.6
Witvrouw, M.7
Debyser, Z.8
-
96
-
-
33750358735
-
An Essential Role for LEDGF/p75 in HIV Integration
-
Llano, M., Saenz, D. T., Meehan, A., Wongthida, P., Peretz, M., Walker, W. H., Teo, W. and Poeschla, E. M. (2006). An Essential Role for LEDGF/p75 in HIV Integration. Science 314, 461-464.
-
(2006)
Science
, vol.314
, pp. 461-464
-
-
Llano, M.1
Saenz, D.T.2
Meehan, A.3
Wongthida, P.4
Peretz, M.5
Walker, W.H.6
Teo, W.7
Poeschla, E.M.8
-
97
-
-
33751242046
-
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication
-
De Rijck, J., Vandekerckhove, L., Gijsbers, R., Hombrouck, A., Hendrix, J., Vercammen, J., Engelborghs, Y., Christ, F. and Debyser, Z. (2006). Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication. J. Virol. 80, 11498-11509.
-
(2006)
J. Virol
, vol.80
, pp. 11498-11509
-
-
De Rijck, J.1
Vandekerckhove, L.2
Gijsbers, R.3
Hombrouck, A.4
Hendrix, J.5
Vercammen, J.6
Engelborghs, Y.7
Christ, F.8
Debyser, Z.9
-
98
-
-
33746070075
-
Transcriptional coactivator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin
-
Maertens, G. N., Cherepanov, P. and Engelman, A. (2006). Transcriptional coactivator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin. J. Cell Sci. 119, 2563-2571.
-
(2006)
J. Cell Sci
, vol.119
, pp. 2563-2571
-
-
Maertens, G.N.1
Cherepanov, P.2
Engelman, A.3
-
99
-
-
34547952059
-
Differential Interaction of HIV-1 Integrase and JPO2 with the C Terminus of LEDGF/p75
-
Bartholomeeusen, K., De Rijck, J., Busschots, K., Desender, L., Gijsbers, R., Emiliani, S., Benarous, R., Debyser, Z. and Christ, F. (2007). Differential Interaction of HIV-1 Integrase and JPO2 with the C Terminus of LEDGF/p75. J. Mol. Biol. 372, 407-421.
-
(2007)
J. Mol. Biol
, vol.372
, pp. 407-421
-
-
Bartholomeeusen, K.1
De Rijck, J.2
Busschots, K.3
Desender, L.4
Gijsbers, R.5
Emiliani, S.6
Benarous, R.7
Debyser, Z.8
Christ, F.9
-
100
-
-
33846652601
-
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
-
Cherepanov, P. (2007). LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro. Nucleic Acids Res. 35, 113-124.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 113-124
-
-
Cherepanov, P.1
-
101
-
-
34447513231
-
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
-
Shun, M. C., Raghavendra, N. K., Vandegraaff, N., Daigle, J. E., Hughes, S., Kellam, P., Cherepanov, P. and Engelman, A. (2007). LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev. 21, 1767-1778.
-
(2007)
Genes Dev
, vol.21
, pp. 1767-1778
-
-
Shun, M.C.1
Raghavendra, N.K.2
Vandegraaff, N.3
Daigle, J.E.4
Hughes, S.5
Kellam, P.6
Cherepanov, P.7
Engelman, A.8
-
102
-
-
33846049539
-
Identification of the LEDGF/p75 binding site in HIV-1 integrase
-
Busschots, K., Voet, A., De Maeyer, M., Rain, J. C., Emiliani, S., Benarous, R., Desender, L., Debyser, Z. and Christ, F. (2007). Identification of the LEDGF/p75 binding site in HIV-1 integrase. J. Mol. Biol. 365, 1480-1492.
-
(2007)
J. Mol. Biol
, vol.365
, pp. 1480-1492
-
-
Busschots, K.1
Voet, A.2
De Maeyer, M.3
Rain, J.C.4
Emiliani, S.5
Benarous, R.6
Desender, L.7
Debyser, Z.8
Christ, F.9
-
103
-
-
34247128760
-
Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration
-
Pandey, K. K., Sinha, S. and Grandgenett, D. P. (2007). Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration. J. Virol. 81, 3969-3979.
-
(2007)
J. Virol
, vol.81
, pp. 3969-3979
-
-
Pandey, K.K.1
Sinha, S.2
Grandgenett, D.P.3
-
104
-
-
33847279490
-
LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: Implications for the mechanism of viral cDNA integration
-
Raghavendra, N. K. and Engelman, A. (2007). LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration. Virology 360, 1-5.
-
(2007)
Virology
, vol.360
, pp. 1-5
-
-
Raghavendra, N.K.1
Engelman, A.2
-
105
-
-
33751417052
-
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness
-
Rahman, S., Lu, R., Vandegraaff, N., Cherepanov, P. and Engelman, A. (2007). Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. Virology 357, 79-90.
-
(2007)
Virology
, vol.357
, pp. 79-90
-
-
Rahman, S.1
Lu, R.2
Vandegraaff, N.3
Cherepanov, P.4
Engelman, A.5
-
106
-
-
34347226332
-
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium
-
Hayouka, Z., Rosenbluh, J., Levin, A., Loya, S., Lebendiker, M., Veprintsev, D., Kotler, M., Hizi, A., Loyter, A. and Friedler, A. (2007). Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium. Proc. Natl. Acad. Sci. USA 104, 8316-8321.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 8316-8321
-
-
Hayouka, Z.1
Rosenbluh, J.2
Levin, A.3
Loya, S.4
Lebendiker, M.5
Veprintsev, D.6
Kotler, M.7
Hizi, A.8
Loyter, A.9
Friedler, A.10
-
107
-
-
34249803226
-
LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro
-
Huang, T. S., Myklebust, L. M., Kjarland, E., Gjertsen, B. T., Pendino, F., Bruserud, O., Doskeland, S. O. and Lillehaug, J. R. (2007). LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Mol. Cancer 6, 31.
-
(2007)
Mol. Cancer
, vol.6
, pp. 31
-
-
Huang, T.S.1
Myklebust, L.M.2
Kjarland, E.3
Gjertsen, B.T.4
Pendino, F.5
Bruserud, O.6
Doskeland, S.O.7
Lillehaug, J.R.8
-
108
-
-
33947240704
-
HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75
-
Yu, F., Jones, G. S., Hung, M., Wagner, A. H., MacArthur, H. L., Liu, X., Leavitt, S., McDermott, M. J. and Tsiang, M. (2007). HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75. Biochemistry 46, 2899-2908.
-
(2007)
Biochemistry
, vol.46
, pp. 2899-2908
-
-
Yu, F.1
Jones, G.S.2
Hung, M.3
Wagner, A.H.4
MacArthur, H.L.5
Liu, X.6
Leavitt, S.7
McDermott, M.J.8
Tsiang, M.9
-
109
-
-
34047200871
-
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV
-
Hombrouck, A., De Rijck, J., Hendrix, J., Vandekerckhove, L., Voet, A., Maeyer, M. D., Witvrouw, M., Engelborghs, Y., Christ, F., Gijsbers, R. et al. (2007). Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV. PLoS Pathog. 3, e47.
-
(2007)
PLoS Pathog
, vol.3
-
-
Hombrouck, A.1
De Rijck, J.2
Hendrix, J.3
Vandekerckhove, L.4
Voet, A.5
Maeyer, M.D.6
Witvrouw, M.7
Engelborghs, Y.8
Christ, F.9
Gijsbers, R.10
-
110
-
-
44349171666
-
-
PLoS
-
Marshall, H. M., Ronen, K., Berry, C., Llano, M., Sutherland, H., Saenz, D., Bickmore, W., Poeschla, E. and Bushman, F. D. (2007). Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. PLoS ONE 2, e1340.
-
(2007)
Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting
, vol.ONE 2
-
-
Marshall, H.M.1
Ronen, K.2
Berry, C.3
Llano, M.4
Sutherland, H.5
Saenz, D.6
Bickmore, W.7
Poeschla, E.8
Bushman, F.D.9
-
111
-
-
0028309772
-
Molecular mechanism of retroviral DNA integration
-
Kulkosky, J. and Skalka, A. M. (1994). Molecular mechanism of retroviral DNA integration. Pharmacol. Ther. 61, 185-203.
-
(1994)
Pharmacol. Ther
, vol.61
, pp. 185-203
-
-
Kulkosky, J.1
Skalka, A.M.2
-
112
-
-
0029814410
-
Retroviral integrase, putting the pieces together
-
Andrake, M. D. and Skalka, A. M. (1996). Retroviral integrase, putting the pieces together. J. Biol. Chem. 271, 19633-19636.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 19633-19636
-
-
Andrake, M.D.1
Skalka, A.M.2
-
113
-
-
0032601402
-
HIV integrase structure and function
-
Esposito, D. and Craigie, R. (1999). HIV integrase structure and function. Adv. Virus Res. 52, 319-333.
-
(1999)
Adv. Virus Res
, vol.52
, pp. 319-333
-
-
Esposito, D.1
Craigie, R.2
-
114
-
-
0032601403
-
HIV-1 integrase: Structural organization, conformational changes, and catalysis
-
Asante-Appiah, E. and Skalka, A. M. (1999). HIV-1 integrase: structural organization, conformational changes, and catalysis. Adv. Virus Res. 52, 351-369.
-
(1999)
Adv. Virus Res
, vol.52
, pp. 351-369
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
115
-
-
2942553781
-
Structure and function of HIV-1 integrase
-
Chiu, T. K. and Davies, D. R. (2004). Structure and function of HIV-1 integrase. Curr. Top. Med. Chem. 4, 965-977.
-
(2004)
Curr. Top. Med. Chem
, vol.4
, pp. 965-977
-
-
Chiu, T.K.1
Davies, D.R.2
-
116
-
-
17844363212
-
Symmetrical recognition of cellular DNA target sequences during retroviral integration
-
Grandgenett, D. P. (2005). Symmetrical recognition of cellular DNA target sequences during retroviral integration. Proc. Natl. Acad. Sci. USA 102, 5903-5904.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 5903-5904
-
-
Grandgenett, D.P.1
-
117
-
-
33645864066
-
Retroviral DNA integration - mechanism and consequences
-
Lewinski, M. K. and Bushman, F. D. (2005). Retroviral DNA integration - mechanism and consequences. Adv. Genet. 55, 147-181.
-
(2005)
Adv. Genet
, vol.55
, pp. 147-181
-
-
Lewinski, M.K.1
Bushman, F.D.2
-
118
-
-
0030987672
-
HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway
-
Gallay, P., Hope, T., Chin, D. and Trono, D. (1997). HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc. Natl. Acad. Sci. USA 94, 9825-9830.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9825-9830
-
-
Gallay, P.1
Hope, T.2
Chin, D.3
Trono, D.4
-
119
-
-
0033526522
-
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein
-
Pluymers, W., Cherepanov, P., Schols, D., De Clercq, E. and Debyser, Z. (1999). Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein. Virology 258, 327-332.
-
(1999)
Virology
, vol.258
, pp. 327-332
-
-
Pluymers, W.1
Cherepanov, P.2
Schols, D.3
De Clercq, E.4
Debyser, Z.5
-
120
-
-
0033032198
-
Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase
-
Petit, C., Schwartz, O. and Mammano, F. (1999). Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase. J. Virol. 73, 5079-5088.
-
(1999)
J. Virol
, vol.73
, pp. 5079-5088
-
-
Petit, C.1
Schwartz, O.2
Mammano, F.3
-
121
-
-
0033912323
-
The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA
-
Petit, C., Schwartz, O. and Mammano, F. (2000). The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA. J. Virol. 74, 7119-7126.
-
(2000)
J. Virol
, vol.74
, pp. 7119-7126
-
-
Petit, C.1
Schwartz, O.2
Mammano, F.3
-
122
-
-
0033936027
-
High-level expression of active HIV-1 integrase from a synthetic gene in human cells
-
Cherepanov, P., Pluymers, W., Claeys, A., Proost, P., De Clercq, E. and Debyser, Z. (2000). High-level expression of active HIV-1 integrase from a synthetic gene in human cells. FASEB J. 14, 1389-1399.
-
(2000)
FASEB J
, vol.14
, pp. 1389-1399
-
-
Cherepanov, P.1
Pluymers, W.2
Claeys, A.3
Proost, P.4
De Clercq, E.5
Debyser, Z.6
-
123
-
-
0242550989
-
Intracellular transport of human immunodeficiency virus type 1 integrase
-
Devroe, E., Engelman, A. and Silver, P. A. (2003). Intracellular transport of human immunodeficiency virus type 1 integrase. J. Cell Sci. 116, 4401-4408.
-
(2003)
J. Cell Sci
, vol.116
, pp. 4401-4408
-
-
Devroe, E.1
Engelman, A.2
Silver, P.A.3
-
124
-
-
33751007834
-
HIV infection of non-dividing cells: A divisive problem
-
Fassati, A. (2006). HIV infection of non-dividing cells: a divisive problem. Retrovirology 3, 74.
-
(2006)
Retrovirology
, vol.3
, pp. 74
-
-
Fassati, A.1
-
125
-
-
0031060369
-
Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases
-
Kukolj, G., Jones, K. S. and Skalka, A. M. (1997). Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases. J. Virol. 71, 843-847.
-
(1997)
J. Virol
, vol.71
, pp. 843-847
-
-
Kukolj, G.1
Jones, K.S.2
Skalka, A.M.3
-
126
-
-
0027158091
-
Integration of murine leukemia virus DNA depends on mitosis
-
Roe, T., Reynolds, T. C., Yu, G. and Brown, P. O. (1993). Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12, 2099-2108.
-
(1993)
EMBO J
, vol.12
, pp. 2099-2108
-
-
Roe, T.1
Reynolds, T.C.2
Yu, G.3
Brown, P.O.4
-
127
-
-
0028055281
-
Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
-
Lewis, P. F. and Emerman, M. (1994). Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J. Virol. 68, 510-516.
-
(1994)
J. Virol
, vol.68
, pp. 510-516
-
-
Lewis, P.F.1
Emerman, M.2
-
128
-
-
0036889124
-
Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import
-
Dvorin, J. D., Bell, P., Maul, G. G., Yamashita, M., Emerman, M. and Malim, M. H. (2002). Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import. J. Virol. 76, 12087-12096.
-
(2002)
J. Virol
, vol.76
, pp. 12087-12096
-
-
Dvorin, J.D.1
Bell, P.2
Maul, G.G.3
Yamashita, M.4
Emerman, M.5
Malim, M.H.6
-
129
-
-
0036838711
-
Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import
-
Limon, A., Devroe, E., Lu, R., Ghory, H. Z., Silver, P. A. and Engelman, A. (2002). Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. J. Virol. 76, 10598-10607.
-
(2002)
J. Virol
, vol.76
, pp. 10598-10607
-
-
Limon, A.1
Devroe, E.2
Lu, R.3
Ghory, H.Z.4
Silver, P.A.5
Engelman, A.6
-
130
-
-
2442645205
-
Capsid is a dominant determinant of retrovirus infectivity in nondividing cells
-
Yamashita, M. and Emerman, M. (2004). Capsid is a dominant determinant of retrovirus infectivity in nondividing cells. J. Virol. 78, 5670-5678.
-
(2004)
J. Virol
, vol.78
, pp. 5670-5678
-
-
Yamashita, M.1
Emerman, M.2
-
131
-
-
34248594865
-
The cell cycle independence of HIV infections is not determined by known karyophilic viral elements
-
Yamashita, M. and Emerman, M. (2005). The cell cycle independence of HIV infections is not determined by known karyophilic viral elements. PLoS Pathog. 1, e18.
-
(2005)
PLoS Pathog
, vol.1
-
-
Yamashita, M.1
Emerman, M.2
-
132
-
-
33645793789
-
Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex
-
Dismuke, D. J. and Aiken, C. (2006). Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex. J. Virol. 80, 3712-3720.
-
(2006)
J. Virol
, vol.80
, pp. 3712-3720
-
-
Dismuke, D.J.1
Aiken, C.2
-
133
-
-
36049004869
-
Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells
-
Yamashita, M., Perez, O., Hope, T. J. and Emerman, M. (2007). Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells. PLoS Pathog. 3, 1502-1510.
-
(2007)
PLoS Pathog
, vol.3
, pp. 1502-1510
-
-
Yamashita, M.1
Perez, O.2
Hope, T.J.3
Emerman, M.4
-
134
-
-
0034603990
-
The PWWP domain: A potential protein-protein interaction domain in nuclear proteins influencing differentiation?
-
Stec, I., Nagl, S. B., van Ommen, G. J. and den Dunnen, J. T. (2000). The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? FEBS Lett. 473, 1-5.
-
(2000)
FEBS Lett
, vol.473
, pp. 1-5
-
-
Stec, I.1
Nagl, S.B.2
van Ommen, G.J.3
den Dunnen, J.T.4
-
135
-
-
0036176982
-
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds
-
Qiu, C., Sawada, K., Zhang, X. and Cheng, X. (2002). The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat. Struct. Biol. 9, 217-224.
-
(2002)
Nat. Struct. Biol
, vol.9
, pp. 217-224
-
-
Qiu, C.1
Sawada, K.2
Zhang, X.3
Cheng, X.4
-
136
-
-
33751418954
-
Selection of target sites for mobile DNA integration in the human genome
-
Berry, C., Hannenhalli, S., Leipzig, J. and Bushman, F. D. (2006). Selection of target sites for mobile DNA integration in the human genome. PLoS Comput. Biol. 2, e157.
-
(2006)
PLoS Comput. Biol
, vol.2
-
-
Berry, C.1
Hannenhalli, S.2
Leipzig, J.3
Bushman, F.D.4
-
137
-
-
0031559829
-
Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus
-
Izumoto, Y., Kuroda, T., Harada, H., Kishimoto, T. and Nakamura, H. (1997). Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem. Biophys. Res. Commun. 238, 26-32.
-
(1997)
Biochem. Biophys. Res. Commun
, vol.238
, pp. 26-32
-
-
Izumoto, Y.1
Kuroda, T.2
Harada, H.3
Kishimoto, T.4
Nakamura, H.5
-
138
-
-
0033539888
-
A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus
-
Ikegame, K., Yamamoto, M., Kishima, Y., Enomoto, H., Yoshida, K., Suemura, M., Kishimoto, T. and Nakamura, H. (1999). A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. Biochem. Biophys. Res. Commun. 266, 81-87.
-
(1999)
Biochem. Biophys. Res. Commun
, vol.266
, pp. 81-87
-
-
Ikegame, K.1
Yamamoto, M.2
Kishima, Y.3
Enomoto, H.4
Yoshida, K.5
Suemura, M.6
Kishimoto, T.7
Nakamura, H.8
-
139
-
-
0027222102
-
Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes
-
van de Wetering, M., Oosterwegel, M., van Norren, K. and Clevers, H. (1993). Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J. 12, 3847-3854.
-
(1993)
EMBO J
, vol.12
, pp. 3847-3854
-
-
van de Wetering, M.1
Oosterwegel, M.2
van Norren, K.3
Clevers, H.4
-
140
-
-
0027200940
-
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB
-
Smith, C. A., Bates, P., Rivera-Gonzalez, R., Gu, B. and DeLuca, N. A. (1993). ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. J. Virol. 67, 4676-4687.
-
(1993)
J. Virol
, vol.67
, pp. 4676-4687
-
-
Smith, C.A.1
Bates, P.2
Rivera-Gonzalez, R.3
Gu, B.4
DeLuca, N.A.5
-
141
-
-
0026036385
-
The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters
-
Wu, C. L. and Wilcox, K. W. (1991). The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters. J. Virol. 65, 1149-1159.
-
(1991)
J. Virol
, vol.65
, pp. 1149-1159
-
-
Wu, C.L.1
Wilcox, K.W.2
-
142
-
-
0027283972
-
A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain
-
Perera, L. P., Mosca, J. D., Ruyechan, W. T., Hayward, G. S., Straus, S. E. and Hay, J. (1993). A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain. J. Virol. 67, 4474-4483.
-
(1993)
J. Virol
, vol.67
, pp. 4474-4483
-
-
Perera, L.P.1
Mosca, J.D.2
Ruyechan, W.T.3
Hayward, G.S.4
Straus, S.E.5
Hay, J.6
-
143
-
-
0026773097
-
Nopp140 shuttles on tracks between nucleolus and cytoplasm
-
Meier, U. T. and Blobel, G. (1992). Nopp140 shuttles on tracks between nucleolus and cytoplasm. Cell 70, 127-138.
-
(1992)
Cell
, vol.70
, pp. 127-138
-
-
Meier, U.T.1
Blobel, G.2
-
144
-
-
0028018945
-
Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes
-
Ge, H. and Roeder, R. G. (1994). Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78, 513-523.
-
(1994)
Cell
, vol.78
, pp. 513-523
-
-
Ge, H.1
Roeder, R.G.2
-
145
-
-
0034703066
-
Degradation of HIV-1 integrase by the N-end rule pathway
-
Mulder, L. C. and Muesing, M. A. (2000). Degradation of HIV-1 integrase by the N-end rule pathway. J. Biol. Chem. 275, 29749-29753.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 29749-29753
-
-
Mulder, L.C.1
Muesing, M.A.2
-
146
-
-
2642670312
-
Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1
-
Schwartz, O., Marechal, V., Friguet, B., Arenzana-Seisdedos, F. and Heard, J. M. (1998). Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1. J. Virol. 72, 3845-3850.
-
(1998)
J. Virol
, vol.72
, pp. 3845-3850
-
-
Schwartz, O.1
Marechal, V.2
Friguet, B.3
Arenzana-Seisdedos, F.4
Heard, J.M.5
-
147
-
-
0036195928
-
Human immunodeficiency virus cDNA metabolism: Notable stability of two- long terminal repeat circles
-
Butler, S. L., Johnson, E. P. and Bushman, F. D. (2002). Human immunodeficiency virus cDNA metabolism: notable stability of two- long terminal repeat circles. J. Virol. 76, 3739-3747.
-
(2002)
J. Virol
, vol.76
, pp. 3739-3747
-
-
Butler, S.L.1
Johnson, E.P.2
Bushman, F.D.3
-
148
-
-
34748827049
-
von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step
-
Mousnier, A., Kubat, N., Massias-Simon, A., Segeral, E., Rain, J. C., Benarous, R., Emiliani, S. and Dargemont, C. (2007). von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step. Proc. Natl. Acad. Sci. USA 104, 13615-13620.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 13615-13620
-
-
Mousnier, A.1
Kubat, N.2
Massias-Simon, A.3
Segeral, E.4
Rain, J.C.5
Benarous, R.6
Emiliani, S.7
Dargemont, C.8
-
149
-
-
33745684269
-
Retroviral DNA integration: Viral and cellular determinants of target-site selection
-
Lewinski, M. K., Yamashita, M., Emerman, M., Ciuffi, A., Marshall, H., Crawford, G., Collins, F., Shinn, P., Leipzig, J., Hannenhalli, S. et al. (2006). Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog. 2, e60.
-
(2006)
PLoS Pathog
, vol.2
-
-
Lewinski, M.K.1
Yamashita, M.2
Emerman, M.3
Ciuffi, A.4
Marshall, H.5
Crawford, G.6
Collins, F.7
Shinn, P.8
Leipzig, J.9
Hannenhalli, S.10
-
150
-
-
33750626259
-
Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor
-
Ciuffi, A., Diamond, T. L., Hwang, Y., Marshall, H. M. and Bushman, F. D. (2006). Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor. Hum. Gene Ther. 17, 960-967.
-
(2006)
Hum. Gene Ther
, vol.17
, pp. 960-967
-
-
Ciuffi, A.1
Diamond, T.L.2
Hwang, Y.3
Marshall, H.M.4
Bushman, F.D.5
-
151
-
-
0032617446
-
In vivo analysis of retroviral integrase structure and function
-
Engelman, A. (1999). In vivo analysis of retroviral integrase structure and function. Adv. Virus Res. 52, 411-426.
-
(1999)
Adv. Virus Res
, vol.52
, pp. 411-426
-
-
Engelman, A.1
-
153
-
-
70049116108
-
Rapid, controlled and intensive lentiviral vector-based RNAi
-
2nd edn Kalpana, G. and Prasad, V, eds, Humana Press, Totowa, NJ, in press
-
Llano, M., Gaznick, N. and Poeschla, E. M. (2007) Rapid, controlled and intensive lentiviral vector-based RNAi. In: HIV Protocols, 2nd edn Kalpana, G. and Prasad, V. (eds.), Humana Press, Totowa, NJ, in press.
-
(2007)
HIV Protocols
-
-
Llano, M.1
Gaznick, N.2
Poeschla, E.M.3
-
154
-
-
33645285267
-
Retroviral DNA integration: Reaction pathway and critical intermediates
-
Li, M., Mizuuchi, M., Burke, T. R., Jr. and Craigie, R. (2006). Retroviral DNA integration: reaction pathway and critical intermediates. EMBO J. 25, 1295-1304.
-
(2006)
EMBO J
, vol.25
, pp. 1295-1304
-
-
Li, M.1
Mizuuchi, M.2
Burke Jr., T.R.3
Craigie, R.4
-
155
-
-
20744447462
-
Recombinant human immunodeficiency virus type 1 integrase exhibits a capacity for full-site integration in vitro that is comparable to that of purified preintegration complexes from virus-infected cells
-
Sinha, S. and Grandgenett, D. P. (2005). Recombinant human immunodeficiency virus type 1 integrase exhibits a capacity for full-site integration in vitro that is comparable to that of purified preintegration complexes from virus-infected cells. J. Virol. 79, 8208-8216.
-
(2005)
J. Virol
, vol.79
, pp. 8208-8216
-
-
Sinha, S.1
Grandgenett, D.P.2
-
156
-
-
23844491860
-
Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration
-
Li, M. and Craigie, R. (2005). Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration. J. Biol. Chem. 280, 29334-29339.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 29334-29339
-
-
Li, M.1
Craigie, R.2
-
157
-
-
14244264128
-
HIV-1 integrase crosslinked oligomers are active in vitro
-
Faure, A., Calmels, C., Desjobert, C., Castroviejo, M., Caumont-Sarcos, A., Tarrago-Litvak, L., Litvak, S. and Parissi, V. (2005). HIV-1 integrase crosslinked oligomers are active in vitro. Nucleic Acids Res. 33, 977-986.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 977-986
-
-
Faure, A.1
Calmels, C.2
Desjobert, C.3
Castroviejo, M.4
Caumont-Sarcos, A.5
Tarrago-Litvak, L.6
Litvak, S.7
Parissi, V.8
-
158
-
-
33747330377
-
Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
-
Guiot, E., Carayon, K., Delelis, O., Simon, F., Tauc, P., Zubin, E., Gottikh, M., Mouscadet, J. F., Brochon, J. C. and Deprez, E. (2006). Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity. J. Biol. Chem. 281, 22707-22719.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 22707-22719
-
-
Guiot, E.1
Carayon, K.2
Delelis, O.3
Simon, F.4
Tauc, P.5
Zubin, E.6
Gottikh, M.7
Mouscadet, J.F.8
Brochon, J.C.9
Deprez, E.10
-
159
-
-
33646526019
-
Chromosome territories - a functional nuclear landscape
-
Cremer, T., Cremer, M., Dietzel, S., Muller, S., Solovei, I. and Fakan, S. (2006). Chromosome territories - a functional nuclear landscape. Curr. Opin. Cell Biol. 18, 307-316.
-
(2006)
Curr. Opin. Cell Biol
, vol.18
, pp. 307-316
-
-
Cremer, T.1
Cremer, M.2
Dietzel, S.3
Muller, S.4
Solovei, I.5
Fakan, S.6
-
160
-
-
33745248642
-
The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity
-
Jacque, J. M. and Stevenson, M. (2006). The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity. Nature 441, 641-645.
-
(2006)
Nature
, vol.441
, pp. 641-645
-
-
Jacque, J.M.1
Stevenson, M.2
-
161
-
-
33845788704
-
Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein
-
Shun, M. C., Daigle, J. E., Vandegraaff, N. and Engelman, A. (2007). Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein. J. Virol. 81, 166-172.
-
(2007)
J. Virol
, vol.81
, pp. 166-172
-
-
Shun, M.C.1
Daigle, J.E.2
Vandegraaff, N.3
Engelman, A.4
-
162
-
-
17844381584
-
Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites
-
Holman, A. G. and Coffin, J. M. (2005). Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites. Proc. Natl. Acad. Sci. USA 102, 6103-6107.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 6103-6107
-
-
Holman, A.G.1
Coffin, J.M.2
-
163
-
-
16244386233
-
Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses
-
Wu, X., Li, Y., Crise, B., Burgess, S. M. and Munroe, D. J. (2005). Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses. J. Virol. 79, 5211-5214.
-
(2005)
J. Virol
, vol.79
, pp. 5211-5214
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
Munroe, D.J.5
-
164
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
Arkin, M. R. and Wells, J. A. (2004). Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. 3, 301-317.
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
165
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
Wells, J. A. and McClendon, C. L. (2007). Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450, 1001-1009.
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
166
-
-
10744221485
-
In vivo activation of the p53 pathway by smallmolecule antagonists of MDM2
-
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C. et al. (2004). In vivo activation of the p53 pathway by smallmolecule antagonists of MDM2. Science 303, 844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
-
167
-
-
27744586067
-
Small-molecule inhibition of TNF-alpha
-
He, M. M., Smith, A. S., Oslob, J. D., Flanagan, W. M., Braisted, A. C., Whitty, A., Cancilla, M. T., Wang, J., Lugovskoy, A. A., Yoburn, J. C. et al. (2005). Small-molecule inhibition of TNF-alpha. Science 310, 1022-1025.
-
(2005)
Science
, vol.310
, pp. 1022-1025
-
-
He, M.M.1
Smith, A.S.2
Oslob, J.D.3
Flanagan, W.M.4
Braisted, A.C.5
Whitty, A.6
Cancilla, M.T.7
Wang, J.8
Lugovskoy, A.A.9
Yoburn, J.C.10
-
168
-
-
0035068122
-
Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain
-
Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F. D., Siegel, J. S. and Choe, S. (2001). Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain. Acta Crystallogr. D Biol. Crystallogr. 57, 536-544.
-
(2001)
Acta Crystallogr. D Biol. Crystallogr
, vol.57
, pp. 536-544
-
-
Molteni, V.1
Greenwald, J.2
Rhodes, D.3
Hwang, Y.4
Kwiatkowski, W.5
Bushman, F.D.6
Siegel, J.S.7
Choe, S.8
-
169
-
-
33745623119
-
Discovery of a small-molecule HIV-1 integrase inhibitor-binding site
-
Al-Mawsawi, L. Q., Fikkert, V., Dayam, R., Witvrouw, M., Burke, T. R., Jr., Borchers, C. H. and Neamati, N. (2006). Discovery of a small-molecule HIV-1 integrase inhibitor-binding site. Proc. Natl. Acad. Sci. USA 103, 10080-10085.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 10080-10085
-
-
Al-Mawsawi, L.Q.1
Fikkert, V.2
Dayam, R.3
Witvrouw, M.4
Burke Jr., T.R.5
Borchers, C.H.6
Neamati, N.7
-
170
-
-
0029996147
-
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
-
Naldini, L., Bloemer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M. and Trono, D. (1996). In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267.
-
(1996)
Science
, vol.272
, pp. 263-267
-
-
Naldini, L.1
Bloemer, U.2
Gallay, P.3
Ory, D.4
Mulligan, R.5
Gage, F.H.6
Verma, I.M.7
Trono, D.8
-
171
-
-
0031953134
-
Efficient transduction of nondividing cells by feline immunodeficiency virus lentiviral vectors
-
Poeschla, E., Wong-Staal, F. and Looney, D. (1998). Efficient transduction of nondividing cells by feline immunodeficiency virus lentiviral vectors. Nat. Med. 4, 354-357.
-
(1998)
Nat. Med
, vol.4
, pp. 354-357
-
-
Poeschla, E.1
Wong-Staal, F.2
Looney, D.3
-
172
-
-
0031738707
-
Gene transfer vectors derived from equine infectious anemia virus
-
Olsen, J. C. (1998). Gene transfer vectors derived from equine infectious anemia virus. Gene Ther. 5, 1481-1487.
-
(1998)
Gene Ther
, vol.5
, pp. 1481-1487
-
-
Olsen, J.C.1
-
174
-
-
0026641562
-
Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer
-
Donahue, R. E., Kessler, S. W., Bodine, D., McDonagh, K., Dunbar, C., Goodman, S., Agricola, B., Byrne, E., Raffeld, M., Moen, R. et al. (1992). Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer. J. Exp. Med. 176, 1125-1135.
-
(1992)
J. Exp. Med
, vol.176
, pp. 1125-1135
-
-
Donahue, R.E.1
Kessler, S.W.2
Bodine, D.3
McDonagh, K.4
Dunbar, C.5
Goodman, S.6
Agricola, B.7
Byrne, E.8
Raffeld, M.9
Moen, R.10
-
175
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E. et al. (2003). LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302, 415-419.
-
(2003)
Science
, vol.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
McCormack, M.P.4
Wulffraat, N.5
Leboulch, P.6
Lim, A.7
Osborne, C.S.8
Pawliuk, R.9
Morillon, E.10
-
176
-
-
35549013276
-
New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy
-
Pike-Overzet, K., van der Burg, M., Wagemaker, G., van Dongen, J. J. and Staal, F. J. (2007). New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy. Mol. Ther. 15, 1910-1916.
-
(2007)
Mol. Ther
, vol.15
, pp. 1910-1916
-
-
Pike-Overzet, K.1
van der Burg, M.2
Wagemaker, G.3
van Dongen, J.J.4
Staal, F.J.5
-
177
-
-
0036222329
-
Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1
-
Holmes-Son, M. L. and Chow, S. A. (2002). Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1. Mol. Ther. 5, 360-370.
-
(2002)
Mol. Ther
, vol.5
, pp. 360-370
-
-
Holmes-Son, M.L.1
Chow, S.A.2
-
178
-
-
32444434997
-
Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells
-
Tan, W., Dong, Z., Wilkinson, T. A., Barbas, C. F., 3rd and Chow, S. A. (2006). Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells. J. Virol. 80, 1939-1948.
-
(2006)
J. Virol
, vol.80
, pp. 1939-1948
-
-
Tan, W.1
Dong, Z.2
Wilkinson, T.A.3
Barbas 3rd, C.F.4
Chow, S.A.5
-
179
-
-
0026637378
-
Hotspots and warm spots: Integration specificity of retroelements
-
Craigie, R. (1992). Hotspots and warm spots: integration specificity of retroelements. Trends Genet. 8, 187-190.
-
(1992)
Trends Genet
, vol.8
, pp. 187-190
-
-
Craigie, R.1
-
180
-
-
0029985540
-
The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci
-
Zou, S., Ke, N., Kim, J. M. and Voytas, D. F. (1996). The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci. Genes Dev. 10, 634-645.
-
(1996)
Genes Dev
, vol.10
, pp. 634-645
-
-
Zou, S.1
Ke, N.2
Kim, J.M.3
Voytas, D.F.4
-
181
-
-
0034816496
-
Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p
-
Xie, W., Gai, X., Zhu, Y., Zappulla, D. C., Sternglanz, R. and Voytas, D. F. (2001). Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p. Mol. Cell. Biol. 21, 6606-6614.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 6606-6614
-
-
Xie, W.1
Gai, X.2
Zhu, Y.3
Zappulla, D.C.4
Sternglanz, R.5
Voytas, D.F.6
-
182
-
-
34447328702
-
Phosphorylation regulates integration of the yeast Ty5 retrotransposon into heterochromatin
-
Dai, J., Xie, W., Brady, T. L., Gao, J. and Voytas, D. F. (2007). Phosphorylation regulates integration of the yeast Ty5 retrotransposon into heterochromatin. Mol. Cell 27, 289-299.
-
(2007)
Mol. Cell
, vol.27
, pp. 289-299
-
-
Dai, J.1
Xie, W.2
Brady, T.L.3
Gao, J.4
Voytas, D.F.5
-
183
-
-
0038612981
-
Controlling integration specificity of a yeast retrotransposon
-
Zhu, Y., Dai, J., Fuerst, P. G. and Voytas, D. F. (2003). Controlling integration specificity of a yeast retrotransposon. Proc. Natl. Acad. Sci. USA 100, 5891-5895.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 5891-5895
-
-
Zhu, Y.1
Dai, J.2
Fuerst, P.G.3
Voytas, D.F.4
-
185
-
-
0021715393
-
The significance of responses of the genome to challenge
-
McClintock, B. (1984). The significance of responses of the genome to challenge. Science 226, 792-801.
-
(1984)
Science
, vol.226
, pp. 792-801
-
-
McClintock, B.1
-
186
-
-
0036796354
-
Mammalian retroelements
-
Deininger, P. L. and Batzer, M. A. (2002). Mammalian retroelements. Genome Res. 12, 1455-1465.
-
(2002)
Genome Res
, vol.12
, pp. 1455-1465
-
-
Deininger, P.L.1
Batzer, M.A.2
-
187
-
-
34247333809
-
Mobile DNA in Old World monkeys: A glimpse through the rhesus macaque genome
-
Han, K., Konkel, M. K., Xing, J., Wang, H., Lee, J., Meyer, T. J., Huang, C. T., Sandifer, E., Hebert, K., Barnes, E. W. et al. (2007). Mobile DNA in Old World monkeys: a glimpse through the rhesus macaque genome. Science 316, 238-240.
-
(2007)
Science
, vol.316
, pp. 238-240
-
-
Han, K.1
Konkel, M.K.2
Xing, J.3
Wang, H.4
Lee, J.5
Meyer, T.J.6
Huang, C.T.7
Sandifer, E.8
Hebert, K.9
Barnes, E.W.10
-
188
-
-
0032510707
-
Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex
-
Heuer, T. S. and Brown, P. O. (1998). Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex. Biochemistry 37, 6667-6678.
-
(1998)
Biochemistry
, vol.37
, pp. 6667-6678
-
-
Heuer, T.S.1
Brown, P.O.2
-
189
-
-
0033052713
-
HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro
-
Hindmarsh, P., Ridky, T., Reeves, R., Andrake, M., Skalka, A. M. and Leis, J. (1999). HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. J. Virol. 73, 2994-3003.
-
(1999)
J. Virol
, vol.73
, pp. 2994-3003
-
-
Hindmarsh, P.1
Ridky, T.2
Reeves, R.3
Andrake, M.4
Skalka, A.M.5
Leis, J.6
-
190
-
-
0036118227
-
Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors
-
Sinha, S., Pursley, M. H. and Grandgenett, D. P. (2002). Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors. J. Virol. 76, 3105-3113.
-
(2002)
J. Virol
, vol.76
, pp. 3105-3113
-
-
Sinha, S.1
Pursley, M.H.2
Grandgenett, D.P.3
-
191
-
-
0030792182
-
Complementation of integrase function in HIV-1 virions
-
Fletcher, T. M., 3rd, Soares, M. A., McPhearson, S., Hui, H., Wiskerchen, M., Muesing, M. A., Shaw, G. M., Leavitt, A. D., Boeke, J. D. and Hahn, B. H. (1997). Complementation of integrase function in HIV-1 virions. EMBO J. 16, 5123-5138.
-
(1997)
EMBO J
, vol.16
, pp. 5123-5138
-
-
Fletcher 3rd, T.M.1
Soares, M.A.2
McPhearson, S.3
Hui, H.4
Wiskerchen, M.5
Muesing, M.A.6
Shaw, G.M.7
Leavitt, A.D.8
Boeke, J.D.9
Hahn, B.H.10
-
192
-
-
0030851908
-
Functional RTand IN incorporated into HIV-1 particles independently of the Gag/Pol precursor protein
-
Wu, X., Liu, H., Xiao, H., Conway, J. A., Hunter, E. and Kappes, J. C. (1997). Functional RTand IN incorporated into HIV-1 particles independently of the Gag/Pol precursor protein. EMBO J. 16, 5113-5122.
-
(1997)
EMBO J
, vol.16
, pp. 5113-5122
-
-
Wu, X.1
Liu, H.2
Xiao, H.3
Conway, J.A.4
Hunter, E.5
Kappes, J.C.6
-
193
-
-
0028088986
-
Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends
-
Patel, P. H. and Preston, B. D. (1994). Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends. Proc. Natl. Acad. Sci. USA 91, 549-553.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 549-553
-
-
Patel, P.H.1
Preston, B.D.2
-
194
-
-
0028239062
-
A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro
-
Ellison, V. and Brown, P. O. (1994). A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro. Proc. Natl. Acad. Sci. USA 91, 7316-7320.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7316-7320
-
-
Ellison, V.1
Brown, P.O.2
-
195
-
-
0028784884
-
Assembly and catalytic properties of retrovirus integrase-DNA complexes capable of efficiently performing concerted integration
-
Vora, A. C. and Grandgenett, D. P. (1995). Assembly and catalytic properties of retrovirus integrase-DNA complexes capable of efficiently performing concerted integration. J. Virol. 69, 7483-7488.
-
(1995)
J. Virol
, vol.69
, pp. 7483-7488
-
-
Vora, A.C.1
Grandgenett, D.P.2
-
196
-
-
0034671528
-
Modeling the late steps in HIV-1 retroviral integrase-catalyzed DNA integration
-
Brin, E., Yi, J., Skalka, A. M. and Leis, J. (2000). Modeling the late steps in HIV-1 retroviral integrase-catalyzed DNA integration. J. Biol. Chem. 275, 39287-39295.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 39287-39295
-
-
Brin, E.1
Yi, J.2
Skalka, A.M.3
Leis, J.4
-
197
-
-
0034468560
-
Repair of gaps in retroviral DNA integration intermediates
-
Yoder, K. E. and Bushman, F. D. (2000). Repair of gaps in retroviral DNA integration intermediates. J. Virol. 74, 11191-11200.
-
(2000)
J. Virol
, vol.74
, pp. 11191-11200
-
-
Yoder, K.E.1
Bushman, F.D.2
-
198
-
-
0026549933
-
Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus
-
Chow, S. A., Vincent, K. A., Ellison, V. and Brown, P. O. (1992). Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. Science 255, 723-726.
-
(1992)
Science
, vol.255
, pp. 723-726
-
-
Chow, S.A.1
Vincent, K.A.2
Ellison, V.3
Brown, P.O.4
-
199
-
-
0028584269
-
Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
-
Dyda, F., Hickman, A. B., Jenkins, T. M., Engelman, A., Craigie, R. and Davies, D. R. (1994). Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science 266, 1981-1986.
-
(1994)
Science
, vol.266
, pp. 1981-1986
-
-
Dyda, F.1
Hickman, A.B.2
Jenkins, T.M.3
Engelman, A.4
Craigie, R.5
Davies, D.R.6
-
200
-
-
0029145047
-
The DNA-binding domain of HIV-1 integrase has an SH3-like fold
-
Eijkelenboom, A. P., Lutzke, R. A., Boelens, R., Plasterk, R. H., Kaptein, R. and Hard, K. (1995). The DNA-binding domain of HIV-1 integrase has an SH3-like fold. Nat. Struct. Biol. 2, 807-810.
-
(1995)
Nat. Struct. Biol
, vol.2
, pp. 807-810
-
-
Eijkelenboom, A.P.1
Lutzke, R.A.2
Boelens, R.3
Plasterk, R.H.4
Kaptein, R.5
Hard, K.6
-
201
-
-
0030986376
-
Solution structure of the Nterminal zinc binding domain of HIV-1 integrase
-
Cai, M., Zheng, R., Caffrey, M., Craigie, R., Clore, G. M. and Gronenborn, A. M. (1997). Solution structure of the Nterminal zinc binding domain of HIV-1 integrase. Nat. Struct. Biol. 4, 567-577.
-
(1997)
Nat. Struct. Biol
, vol.4
, pp. 567-577
-
-
Cai, M.1
Zheng, R.2
Caffrey, M.3
Craigie, R.4
Clore, G.M.5
Gronenborn, A.M.6
-
202
-
-
0032483022
-
Three new structures of the core domain of HIV-1 integrase: An active site that binds magnesium
-
Goldgur, Y., Dyda, F., Hickman, A. B., Jenkins, T. M., Craigie, R. and Davies, D. R. (1998). Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc. Natl. Acad. Sci. USA 95, 9150-9154.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9150-9154
-
-
Goldgur, Y.1
Dyda, F.2
Hickman, A.B.3
Jenkins, T.M.4
Craigie, R.5
Davies, D.R.6
-
203
-
-
0034682511
-
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
-
Chen, J. C., Krucinski, J., Miercke, L. J., Finer-Moore, J. S., Tang, A. H., Leavitt, A. D. and Stroud, R. M. (2000). Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc. Natl. Acad. Sci. USA 97, 8233-8238.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8233-8238
-
-
Chen, J.C.1
Krucinski, J.2
Miercke, L.J.3
Finer-Moore, J.S.4
Tang, A.H.5
Leavitt, A.D.6
Stroud, R.M.7
-
204
-
-
0037126629
-
Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein
-
Wang, J. Y., Ling, H., Yang, W. and Craigie, R. (2001). Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J. 20, 7333-7343.
-
(2001)
EMBO J
, vol.20
, pp. 7333-7343
-
-
Wang, J.Y.1
Ling, H.2
Yang, W.3
Craigie, R.4
-
205
-
-
0029017919
-
Catalytic domain of human immunodeficiency virus type 1 integrase: Identification of a soluble mutant by systematic replacement of hydrophobic residues
-
Jenkins, T. M., Hickman, A. B., Dyda, F., Ghirlando, R., Davies, D. R. and Craigie, R. (1995). Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues. Proc. Natl. Acad. Sci. USA 92, 6057-6061.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 6057-6061
-
-
Jenkins, T.M.1
Hickman, A.B.2
Dyda, F.3
Ghirlando, R.4
Davies, D.R.5
Craigie, R.6
-
206
-
-
40249092052
-
-
Chiu, T. K. and Davies, D. R. (2007). Structure and function of HIV-1 integrase: an update. Fron. Med. Chem. 3, 1-20.
-
Chiu, T. K. and Davies, D. R. (2007). Structure and function of HIV-1 integrase: an update. Fron. Med. Chem. 3, 1-20.
-
-
-
|