Structural basis for nuclear import of splicing factors by human Transportin 3

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 7, 2014, Pages 2728-2733

  Maertens, Goedele N ^a   Cook, Nicola J ^b   Wang, Weifeng ^c   Hare, Stephen ^a   Gupta, Saumya Shree ^a,f   Öztop, Ilker ^c   Lee, Kyeong Eun ^d   Pye, Valerie E ^b   Cosnefroy, Ophélie ^b,g   Snijders, Ambrosius P ^b   Ramani, Vineet N Kewal ^d   Fassati, Ariberto ^e   Engelman, Alan ^c   Cherepanov, Peter ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f HANNOVER MEDICAL SCHOOL   (Germany)

^g NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Host factor; Importin; SR protein; Transportin SR

Indexed keywords

ALTERNATIV SPLICING FACTOR; ARGININE; CARRIER PROTEIN; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 6; GUANOSINE TRIPHOSPHATASE; KARYOPHERIN BETA; NUCLEIC ACID BINDING PROTEIN; RNA; SERINE; SPLICING FACTOR 2; TRANSPORTIN 3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTAGENESIS; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS MUTATION; VIRUS REPLICATION;

HOST FACTOR; IMPORTIN; SR PROTEIN; TRANSPORTIN-SR;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA KARYOPHERINS; BLOTTING, WESTERN; CELL NUCLEUS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HIV-1; HUMANS; IMMUNOPRECIPITATION; MODELS, MOLECULAR; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; NUCLEAR PROTEINS; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; VIRUS REPLICATION; X-RAY DIFFRACTION;

EID: 84894305729     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320755111     Document Type: Article

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