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Volumn 36, Issue , 2016, Pages 62-70

Regulating Fbw7 on the road to cancer

Author keywords

Fbw7; Oncogene; Protein degradation; SCF ubiquitin ligase; Tumor suppressor

Indexed keywords

CARCINOGENESIS; ANIMAL; CELL TRANSFORMATION; CHEMISTRY; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; PATHOLOGY; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84958159750     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2015.09.005     Document Type: Review
Times cited : (35)

References (111)
  • 1
    • 4444318673 scopus 로고    scopus 로고
    • The SCF ubiquitin ligase: insights into a molecular machine
    • Cardozo T., Pagano M. The SCF ubiquitin ligase: insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 2004, 5:739-751. 10.1038/nrm1471.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 739-751
    • Cardozo, T.1    Pagano, M.2
  • 2
    • 84889084791 scopus 로고    scopus 로고
    • Building and remodelling Cullin-RING E3 ubiquitin ligases
    • Lydeard J.R., Schulman B.A., Harper J.W. Building and remodelling Cullin-RING E3 ubiquitin ligases. EMBO Rep. 2013, 14:1050-1061. 10.1038/embor.2013.173.
    • (2013) EMBO Rep. , vol.14 , pp. 1050-1061
    • Lydeard, J.R.1    Schulman, B.A.2    Harper, J.W.3
  • 3
    • 84878260314 scopus 로고    scopus 로고
    • Mechanisms and function of substrate recruitment by F-box proteins
    • Skaar J.R., Pagan J.K., Pagano M. Mechanisms and function of substrate recruitment by F-box proteins. Nat. Rev. Mol. Cell Biol. 2013, 14:369-381. 10.1038/nrm3582.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 369-381
    • Skaar, J.R.1    Pagan, J.K.2    Pagano, M.3
  • 4
    • 79952853588 scopus 로고    scopus 로고
    • Small RING finger proteins RBX1 and RBX2 of SCF E3 ubiquitin ligases: the role in cancer and as cancer targets
    • Wei D., Sun Y. Small RING finger proteins RBX1 and RBX2 of SCF E3 ubiquitin ligases: the role in cancer and as cancer targets. Genes Cancer 2010, 1:700-707. 10.1177/1947601910382776.
    • (2010) Genes Cancer , vol.1 , pp. 700-707
    • Wei, D.1    Sun, Y.2
  • 5
    • 6944227551 scopus 로고    scopus 로고
    • A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
    • Welcker M., Orian A., Grim J.E., Grim J.A., Eisenman R.N., Clurman B.E. A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr. Biol. 2004, 14:1852-1857. 10.1016/j.cub.2004.09.083.
    • (2004) Curr. Biol. , vol.14 , pp. 1852-1857
    • Welcker, M.1    Orian, A.2    Grim, J.E.3    Grim, J.A.4    Eisenman, R.N.5    Clurman, B.E.6
  • 6
    • 33846266628 scopus 로고    scopus 로고
    • Fbw7 isoform interaction contributes to cyclin E proteolysis
    • Zhang W., Koepp D.M. Fbw7 isoform interaction contributes to cyclin E proteolysis. Mol. Cancer Res. 2006, 4:935-943. 10.1158/1541-7786.MCR-06-0253.
    • (2006) Mol. Cancer Res. , vol.4 , pp. 935-943
    • Zhang, W.1    Koepp, D.M.2
  • 7
    • 34047255191 scopus 로고    scopus 로고
    • Fbw7/hCDC4 dimerization regulates its substrate interactions
    • Welcker M., Clurman B.E. Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div. 2007, 2:7. 10.1186/1747-1028-2-7.
    • (2007) Cell Div. , vol.2 , pp. 7
    • Welcker, M.1    Clurman, B.E.2
  • 8
    • 34047249627 scopus 로고    scopus 로고
    • Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases
    • Hao B., Oehlmann S., Sowa M.E., Harper J.W., Pavletich N.P. Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol. Cell 2007, 26:131-143. 10.1016/j.molcel.2007.02.022.
    • (2007) Mol. Cell , vol.26 , pp. 131-143
    • Hao, B.1    Oehlmann, S.2    Sowa, M.E.3    Harper, J.W.4    Pavletich, N.P.5
  • 9
    • 34250017680 scopus 로고    scopus 로고
    • Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination
    • Tang X., Orlicky S., Lin Z., Willems A., Neculai D., Ceccarelli D., et al. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell 2007, 129:1165-1176. 10.1016/j.cell.2007.04.042.
    • (2007) Cell , vol.129 , pp. 1165-1176
    • Tang, X.1    Orlicky, S.2    Lin, Z.3    Willems, A.4    Neculai, D.5    Ceccarelli, D.6
  • 11
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    • Welcker M., Clurman B.E. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 2008, 8:83-93. 10.1038/nrc2290.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 83-93
    • Welcker, M.1    Clurman, B.E.2
  • 12
    • 84888869831 scopus 로고    scopus 로고
    • Fbw7 dimerization determines the specificity and robustness of substrate degradation
    • Welcker M., Larimore E.A., Swanger J., Bengoechea-Alonso M.T., Grim J.E., Ericsson J., et al. Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev. 2013, 27:2531-2536. 10.1101/gad.229195.113.
    • (2013) Genes Dev. , vol.27 , pp. 2531-2536
    • Welcker, M.1    Larimore, E.A.2    Swanger, J.3    Bengoechea-Alonso, M.T.4    Grim, J.E.5    Ericsson, J.6
  • 14
    • 2942650133 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
    • Welcker M., Orian A., Jin J., Grim J.E., Grim J.A., Harper J.W., et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:9085-9090. 10.1073/pnas.0402770101.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 9085-9090
    • Welcker, M.1    Orian, A.2    Jin, J.3    Grim, J.E.4    Grim, J.A.5    Harper, J.W.6
  • 15
    • 2942614705 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
    • Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., et al. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 2004, 23:2116-2125. 10.1038/sj.emboj.7600217.
    • (2004) EMBO J. , vol.23 , pp. 2116-2125
    • Yada, M.1    Hatakeyama, S.2    Kamura, T.3    Nishiyama, M.4    Tsunematsu, R.5    Imaki, H.6
  • 16
    • 1342275412 scopus 로고    scopus 로고
    • The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling
    • Nateri A.S., Riera-Sans L., Da Costa C., Behrens A. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 2004, 303:1374-1378. 10.1126/science.1092880.
    • (2004) Science , vol.303 , pp. 1374-1378
    • Nateri, A.S.1    Riera-Sans, L.2    Da Costa, C.3    Behrens, A.4
  • 17
    • 79952261405 scopus 로고    scopus 로고
    • SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
    • Inuzuka H., Shaik S., Onoyama I., Gao D., Tseng A., Maser R.S., et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011, 471:104-109. 10.1038/nature09732.
    • (2011) Nature , vol.471 , pp. 104-109
    • Inuzuka, H.1    Shaik, S.2    Onoyama, I.3    Gao, D.4    Tseng, A.5    Maser, R.S.6
  • 18
    • 79952271269 scopus 로고    scopus 로고
    • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    • Wertz I.E., Kusam S., Lam C., Okamoto T., Sandoval W., Anderson D.J., et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 2011, 471:110-114. 10.1038/nature09779.
    • (2011) Nature , vol.471 , pp. 110-114
    • Wertz, I.E.1    Kusam, S.2    Lam, C.3    Okamoto, T.4    Sandoval, W.5    Anderson, D.J.6
  • 19
    • 34547820257 scopus 로고    scopus 로고
    • The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    • Thompson B.J., Buonamici S., Sulis M.L., Palomero T., Vilimas T., Basso G., et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J. Exp. Med. 2007, 204:1825-1835. 10.1084/jem.20070872.
    • (2007) J. Exp. Med. , vol.204 , pp. 1825-1835
    • Thompson, B.J.1    Buonamici, S.2    Sulis, M.L.3    Palomero, T.4    Vilimas, T.5    Basso, G.6
  • 20
    • 42149132696 scopus 로고    scopus 로고
    • Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
    • Matsuoka S., Oike Y., Onoyama I., Iwama A., Arai F., Takubo K., et al. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev. 2008, 22:986-991. 10.1101/gad.1621808.
    • (2008) Genes Dev. , vol.22 , pp. 986-991
    • Matsuoka, S.1    Oike, Y.2    Onoyama, I.3    Iwama, A.4    Arai, F.5    Takubo, K.6
  • 21
    • 84876157836 scopus 로고    scopus 로고
    • Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch
    • Ishikawa Y., Hosogane M., Okuyama R., Aoyama S., Onoyama I., Nakayama K.I., et al. Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch. Oncogene 2013, 32:1921-1932. 10.1038/onc.2012.213.
    • (2013) Oncogene , vol.32 , pp. 1921-1932
    • Ishikawa, Y.1    Hosogane, M.2    Okuyama, R.3    Aoyama, S.4    Onoyama, I.5    Nakayama, K.I.6
  • 22
    • 78049231370 scopus 로고    scopus 로고
    • Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
    • Hoeck J.D., Jandke A., Blake S.M., Nye E., Spencer-Dene B., Brandner S., et al. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat. Neurosci. 2010, 13:1365-1372. 10.1038/nn.2644.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1365-1372
    • Hoeck, J.D.1    Jandke, A.2    Blake, S.M.3    Nye, E.4    Spencer-Dene, B.5    Brandner, S.6
  • 23
    • 79953899846 scopus 로고    scopus 로고
    • Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells
    • Matsumoto A., Onoyama I., Sunabori T., Kageyama R., Okano H., Nakayama K.I. Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J. Biol. Chem. 2011, 286:13754-13764. 10.1074/jbc.M110.194936.
    • (2011) J. Biol. Chem. , vol.286 , pp. 13754-13764
    • Matsumoto, A.1    Onoyama, I.2    Sunabori, T.3    Kageyama, R.4    Okano, H.5    Nakayama, K.I.6
  • 24
    • 78650928027 scopus 로고    scopus 로고
    • Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
    • Onoyama I., Suzuki A., Matsumoto A., Tomita K., Katagiri H., Oike Y., et al. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J. Clin. Investig. 2011, 121:342-354. 10.1172/JCI40725.
    • (2011) J. Clin. Investig. , vol.121 , pp. 342-354
    • Onoyama, I.1    Suzuki, A.2    Matsumoto, A.3    Tomita, K.4    Katagiri, H.5    Oike, Y.6
  • 25
    • 84905815332 scopus 로고    scopus 로고
    • Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells
    • Sancho R., Gruber R., Gu G., Behrens A. Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells. Cell Stem Cell 2014, 15:139-153. 10.1016/j.stem.2014.06.019.
    • (2014) Cell Stem Cell , vol.15 , pp. 139-153
    • Sancho, R.1    Gruber, R.2    Gu, G.3    Behrens, A.4
  • 26
    • 84923796552 scopus 로고    scopus 로고
    • FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification
    • Kourtis N., Moubarak R.S., Aranda-Orgilles B., Lui K., Aydin I.T., Trimarchi T., et al. FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification. Nat. Cell Biol. 2015, 17:322-332. 10.1038/ncb3121.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 322-332
    • Kourtis, N.1    Moubarak, R.S.2    Aranda-Orgilles, B.3    Lui, K.4    Aydin, I.T.5    Trimarchi, T.6
  • 27
    • 79952766066 scopus 로고    scopus 로고
    • Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress
    • Matsumoto A., Tateishi Y., Onoyama I., Okita Y., Nakayama K., Nakayama K.I. Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci. 2011, 102:749-755. 10.1111/j.1349-7006.2011.01851.x.
    • (2011) Cancer Sci. , vol.102 , pp. 749-755
    • Matsumoto, A.1    Tateishi, Y.2    Onoyama, I.3    Okita, Y.4    Nakayama, K.5    Nakayama, K.I.6
  • 28
    • 84877724618 scopus 로고    scopus 로고
    • FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4
    • Balamurugan K., Sharan S., Klarmann K.D., Zhang Y., Coppola V., Summers G.H., et al. FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4. Nat. Commun. 2013, 4:1662. 10.1038/ncomms2677.
    • (2013) Nat. Commun. , vol.4 , pp. 1662
    • Balamurugan, K.1    Sharan, S.2    Klarmann, K.D.3    Zhang, Y.4    Coppola, V.5    Summers, G.H.6
  • 29
    • 84856604061 scopus 로고    scopus 로고
    • GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α
    • Flügel D., Görlach A., Kietzmann T. GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α. Blood 2012, 119:1292-1301. 10.1182/blood-2011-08-375014.
    • (2012) Blood , vol.119 , pp. 1292-1301
    • Flügel, D.1    Görlach, A.2    Kietzmann, T.3
  • 30
    • 84899515719 scopus 로고    scopus 로고
    • Aberrant regulation of FBW7 in cancer
    • Wang L., Ye X., Liu Y., Wei W., Wang Z. Aberrant regulation of FBW7 in cancer. Oncotarget 2014, 5:2000-2015.
    • (2014) Oncotarget , vol.5 , pp. 2000-2015
    • Wang, L.1    Ye, X.2    Liu, Y.3    Wei, W.4    Wang, Z.5
  • 31
    • 33748751591 scopus 로고    scopus 로고
    • Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-in response to DNA binding
    • Punga T., Bengoechea-Alonso M.T., Ericsson J. Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-in response to DNA binding. J. Biol. Chem. 2006, 281:25278-25286. 10.1074/jbc.M604983200.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25278-25286
    • Punga, T.1    Bengoechea-Alonso, M.T.2    Ericsson, J.3
  • 32
    • 84864000763 scopus 로고    scopus 로고
    • Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer
    • Grim J.E., Knoblaugh S.E., Guthrie K.A., Hagar A., Swanger J., Hespelt J., et al. Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol. Cell. Biol. 2012, 32:2160-2167. 10.1128/MCB.00305-12.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 2160-2167
    • Grim, J.E.1    Knoblaugh, S.E.2    Guthrie, K.A.3    Hagar, A.4    Swanger, J.5    Hespelt, J.6
  • 33
    • 34250001084 scopus 로고    scopus 로고
    • SRC-coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock
    • Wu R.-C., Feng Q., Lonard D.M., O'Malley B.W. SRC-coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell 2007, 129:1125-1140. 10.1016/j.cell.2007.04.039.
    • (2007) Cell , vol.129 , pp. 1125-1140
    • Wu, R.-C.1    Feng, Q.2    Lonard, D.M.3    O'Malley, B.W.4
  • 34
    • 84861869979 scopus 로고    scopus 로고
    • Ubiquitin and proteasomes in transcription
    • Geng F., Wenzel S., Tansey W.P. Ubiquitin and proteasomes in transcription. Annu. Rev. Biochem. 2012, 81:177-201. 10.1146/annurev-biochem-052110-120012.
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 177-201
    • Geng, F.1    Wenzel, S.2    Tansey, W.P.3
  • 35
    • 84880651314 scopus 로고    scopus 로고
    • Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis
    • Farrell A.S., Pelz C., Wang X., Daniel C.J., Wang Z., Su Y., et al. Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. Mol. Cell. Biol. 2013, 33:2930-2949. 10.1128/MCB.01455-12.
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 2930-2949
    • Farrell, A.S.1    Pelz, C.2    Wang, X.3    Daniel, C.J.4    Wang, Z.5    Su, Y.6
  • 36
    • 84873051970 scopus 로고    scopus 로고
    • The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with mediator
    • Davis M.A., Larimore E.A., Fissel B.M., Swanger J., Taatjes D.J., Clurman B.E. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with mediator. Genes Dev. 2013, 27:151-156. 10.1101/gad.207720.112.
    • (2013) Genes Dev. , vol.27 , pp. 151-156
    • Davis, M.A.1    Larimore, E.A.2    Fissel, B.M.3    Swanger, J.4    Taatjes, D.J.5    Clurman, B.E.6
  • 37
    • 84923811117 scopus 로고    scopus 로고
    • The mediator complex: a central integrator of transcription
    • Allen B.L., Taatjes D.J. The mediator complex: a central integrator of transcription. Nat. Rev. Mol. Cell Biol. 2015, 16:155-166. 10.1038/nrm3951.
    • (2015) Nat. Rev. Mol. Cell Biol. , vol.16 , pp. 155-166
    • Allen, B.L.1    Taatjes, D.J.2
  • 38
    • 77956165036 scopus 로고    scopus 로고
    • F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor
    • Sancho R., Jandke A., Davis H., Diefenbacher M.E., Tomlinson I., Behrens A. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 2010, 139:929-941. 10.1053/j.gastro.2010.05.078.
    • (2010) Gastroenterology , vol.139 , pp. 929-941
    • Sancho, R.1    Jandke, A.2    Davis, H.3    Diefenbacher, M.E.4    Tomlinson, I.5    Behrens, A.6
  • 39
    • 84879364450 scopus 로고    scopus 로고
    • The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
    • King B., Trimarchi T., Reavie L., Xu L., Mullenders J., Ntziachristos P., et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 2013, 153:1552-1566. 10.1016/j.cell.2013.05.041.
    • (2013) Cell , vol.153 , pp. 1552-1566
    • King, B.1    Trimarchi, T.2    Reavie, L.3    Xu, L.4    Mullenders, J.5    Ntziachristos, P.6
  • 40
    • 10644269326 scopus 로고    scopus 로고
    • Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
    • Mao J.-H., Perez-losada J., Wu D., DelRosario R., Tsunematsu R., Nakayama K.I., et al. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 2004, 432:775-779. 10.1038/nature03155.
    • (2004) Nature , vol.432 , pp. 775-779
    • Mao, J.-H.1    Perez-losada, J.2    Wu, D.3    DelRosario, R.4    Tsunematsu, R.5    Nakayama, K.I.6
  • 41
    • 84876434253 scopus 로고    scopus 로고
    • Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
    • Reavie L., Buckley S.M., Loizou E., Takeishi S., Aranda-Orgilles B., Ndiaye-Lobry D., et al. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell 2013, 23:362-375. 10.1016/j.ccr.2013.01.025.
    • (2013) Cancer Cell , vol.23 , pp. 362-375
    • Reavie, L.1    Buckley, S.M.2    Loizou, E.3    Takeishi, S.4    Aranda-Orgilles, B.5    Ndiaye-Lobry, D.6
  • 42
    • 84876422526 scopus 로고    scopus 로고
    • Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence
    • Takeishi S., Matsumoto A., Onoyama I., Naka K., Hirao A., Nakayama K.I. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell 2013, 23:347-361. 10.1016/j.ccr.2013.01.026.
    • (2013) Cancer Cell , vol.23 , pp. 347-361
    • Takeishi, S.1    Matsumoto, A.2    Onoyama, I.3    Naka, K.4    Hirao, A.5    Nakayama, K.I.6
  • 43
    • 77952673813 scopus 로고    scopus 로고
    • Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
    • Rocher-Ros V., Marco S., Mao J.-H., Gines S., Metzger D., Chambon P., et al. Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 2010, 29:2950-2961. 10.1038/onc.2010.57.
    • (2010) Oncogene , vol.29 , pp. 2950-2961
    • Rocher-Ros, V.1    Marco, S.2    Mao, J.-H.3    Gines, S.4    Metzger, D.5    Chambon, P.6
  • 44
    • 77954894921 scopus 로고    scopus 로고
    • MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation
    • Galli F., Rossi M., D'Alessandra Y., De Simone M., Lopardo T., Haupt Y., et al. MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation. J. Cell Sci. 2010, 123:2423-2433. 10.1242/jcs.061010.
    • (2010) J. Cell Sci. , vol.123 , pp. 2423-2433
    • Galli, F.1    Rossi, M.2    D'Alessandra, Y.3    De Simone, M.4    Lopardo, T.5    Haupt, Y.6
  • 45
    • 84859430011 scopus 로고    scopus 로고
    • Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma
    • Busino L., Millman S.E., Scotto L., Kyratsous C.A., Basrur V., O'Connor O., et al. Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat. Cell Biol. 2012, 14:375-385. 10.1038/ncb2463.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 375-385
    • Busino, L.1    Millman, S.E.2    Scotto, L.3    Kyratsous, C.A.4    Basrur, V.5    O'Connor, O.6
  • 46
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
    • Cerami E., Gao J., Dogrusoz U., Gross B.E., Sumer S.O., Aksoy B.A., et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012, 2:401-404. 10.1158/2159-8290.CD-12-0095.
    • (2012) Cancer Discov. , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3    Gross, B.E.4    Sumer, S.O.5    Aksoy, B.A.6
  • 47
    • 51749095471 scopus 로고    scopus 로고
    • FBXW7 targets mTOR for Degradation and genetically cooperates with PTEN in tumor suppression
    • Mao J.-H., Kim I.-J., Wu D., Climent J., Kang H.C., DelRosario R., et al. FBXW7 targets mTOR for Degradation and genetically cooperates with PTEN in tumor suppression. Science 2008, 321:1499-1502. 10.1126/science.1162981.
    • (2008) Science , vol.321 , pp. 1499-1502
    • Mao, J.-H.1    Kim, I.-J.2    Wu, D.3    Climent, J.4    Kang, H.C.5    DelRosario, R.6
  • 48
    • 78649494384 scopus 로고    scopus 로고
    • Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
    • Akhoondi S., Lindström L., Widschwendter M., Corcoran M., Bergh J., Spruck C., et al. Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res. 2010, 12:R105. 10.1186/bcr2788.
    • (2010) Breast Cancer Res. , vol.12 , pp. R105
    • Akhoondi, S.1    Lindström, L.2    Widschwendter, M.3    Corcoran, M.4    Bergh, J.5    Spruck, C.6
  • 49
    • 84908011711 scopus 로고    scopus 로고
    • Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities
    • Davis R.J., Welcker M., Clurman B.E. Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities. Cancer Cell 2014, 26:455-464. 10.1016/j.ccell.2014.09.013.
    • (2014) Cancer Cell , vol.26 , pp. 455-464
    • Davis, R.J.1    Welcker, M.2    Clurman, B.E.3
  • 50
    • 84897959817 scopus 로고    scopus 로고
    • Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines
    • Davis H., Lewis A., Behrens A., Tomlinson I. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. Gut 2014, 63:792-799. 10.1136/gutjnl-2013-304719.
    • (2014) Gut , vol.63 , pp. 792-799
    • Davis, H.1    Lewis, A.2    Behrens, A.3    Tomlinson, I.4
  • 51
    • 79955845570 scopus 로고    scopus 로고
    • FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development
    • Davis H., Lewis A., Spencer-Dene B., Tateossian H., Stamp G., Behrens A., et al. FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J. Pathol. 2011, 224:180-189. 10.1002/path.2874.
    • (2011) J. Pathol. , vol.224 , pp. 180-189
    • Davis, H.1    Lewis, A.2    Spencer-Dene, B.3    Tateossian, H.4    Stamp, G.5    Behrens, A.6
  • 52
    • 0141591688 scopus 로고    scopus 로고
    • Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
    • Welcker M., Singer J., Loeb K.R., Grim J., Bloecher A., Gurien-West M., et al. Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol. Cell 2003, 12:381-392.
    • (2003) Mol. Cell , vol.12 , pp. 381-392
    • Welcker, M.1    Singer, J.2    Loeb, K.R.3    Grim, J.4    Bloecher, A.5    Gurien-West, M.6
  • 53
    • 38349057556 scopus 로고    scopus 로고
    • SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis
    • Olson B.L., Hock M.B., Ekholm-Reed S., Wohlschlegel J.A., Dev K.K., Kralli A., et al. SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev. 2008, 22:252-264. 10.1101/gad.1624208.
    • (2008) Genes Dev. , vol.22 , pp. 252-264
    • Olson, B.L.1    Hock, M.B.2    Ekholm-Reed, S.3    Wohlschlegel, J.A.4    Dev, K.K.5    Kralli, A.6
  • 54
    • 84857831583 scopus 로고    scopus 로고
    • DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells
    • Taira N., Mimoto R., Kurata M., Yamaguchi T., Kitagawa M., Miki Y., et al. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J. Clin. Investig. 2012, 122:859-872. 10.1172/JCI60818.
    • (2012) J. Clin. Investig. , vol.122 , pp. 859-872
    • Taira, N.1    Mimoto, R.2    Kurata, M.3    Yamaguchi, T.4    Kitagawa, M.5    Miki, Y.6
  • 55
    • 33644850537 scopus 로고    scopus 로고
    • The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability
    • Yeh E.S., Lew B.O., Means A.R. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J. Biol. Chem. 2006, 281:241-251. 10.1074/jbc.M505770200.
    • (2006) J. Biol. Chem. , vol.281 , pp. 241-251
    • Yeh, E.S.1    Lew, B.O.2    Means, A.R.3
  • 56
    • 2342526543 scopus 로고    scopus 로고
    • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
    • Yeh E., Cunningham M., Arnold H., Chasse D., Monteith T., Ivaldi G., et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat. Cell Biol. 2004, 6:308-318. 10.1038/ncb1110.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 308-318
    • Yeh, E.1    Cunningham, M.2    Arnold, H.3    Chasse, D.4    Monteith, T.5    Ivaldi, G.6
  • 57
    • 33749186359 scopus 로고    scopus 로고
    • Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner
    • Matsumoto A., Onoyama I., Nakayama K.I. Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner. Biochem. Biophys. Res. Commun. 2006, 350:114-119. 10.1016/j.bbrc.2006.09.003.
    • (2006) Biochem. Biophys. Res. Commun. , vol.350 , pp. 114-119
    • Matsumoto, A.1    Onoyama, I.2    Nakayama, K.I.3
  • 58
    • 84890406728 scopus 로고    scopus 로고
    • Differential regulation of FBXW7 isoforms by various stress stimuli
    • Sionov R.V., Netzer E., Shaulian E. Differential regulation of FBXW7 isoforms by various stress stimuli. Cell Cycle 2013, 12:3547-3554. 10.4161/cc.26591.
    • (2013) Cell Cycle , vol.12 , pp. 3547-3554
    • Sionov, R.V.1    Netzer, E.2    Shaulian, E.3
  • 59
    • 84961288227 scopus 로고    scopus 로고
    • F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner
    • Yumimoto K., Akiyoshi S., Ueo H., Sagara Y., Onoyama I., Ueo H., et al. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J. Clin. Investig. 2015, 125:621-635. 10.1172/JCI78782.
    • (2015) J. Clin. Investig. , vol.125 , pp. 621-635
    • Yumimoto, K.1    Akiyoshi, S.2    Ueo, H.3    Sagara, Y.4    Onoyama, I.5    Ueo, H.6
  • 60
    • 0038420033 scopus 로고    scopus 로고
    • HCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53
    • Kimura T., Gotoh M., Nakamura Y., Arakawa H. hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci. 2003, 94:431-436.
    • (2003) Cancer Sci. , vol.94 , pp. 431-436
    • Kimura, T.1    Gotoh, M.2    Nakamura, Y.3    Arakawa, H.4
  • 61
    • 65449154815 scopus 로고    scopus 로고
    • Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis
    • Grinkevich V.V., Nikulenkov F., Shi Y., Enge M., Bao W., Maljukova A., et al. Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis. Cancer Cell 2009, 15:441-453. 10.1016/j.ccr.2009.03.021.
    • (2009) Cancer Cell , vol.15 , pp. 441-453
    • Grinkevich, V.V.1    Nikulenkov, F.2    Shi, Y.3    Enge, M.4    Bao, W.5    Maljukova, A.6
  • 62
    • 84879384549 scopus 로고    scopus 로고
    • Fbw7 repression by Hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions
    • Sancho R., Blake S.M., Tendeng C., Clurman B.E., Lewis J., Behrens A. Fbw7 repression by Hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. PLOS Biol. 2013, 11:e1001586. 10.1371/journal.pbio.1001586.
    • (2013) PLOS Biol. , vol.11 , pp. e1001586
    • Sancho, R.1    Blake, S.M.2    Tendeng, C.3    Clurman, B.E.4    Lewis, J.5    Behrens, A.6
  • 63
    • 84884263191 scopus 로고    scopus 로고
    • The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia
    • Mansour M.R., Sanda T., Lawton L.N., Li X., Kreslavsky T., Novina C.D., et al. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J. Exp. Med. 2013, 210:1545-1557. 10.1084/jem.20122516.
    • (2013) J. Exp. Med. , vol.210 , pp. 1545-1557
    • Mansour, M.R.1    Sanda, T.2    Lawton, L.N.3    Li, X.4    Kreslavsky, T.5    Novina, C.D.6
  • 64
    • 84925282873 scopus 로고    scopus 로고
    • Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia
    • Kumar V., Palermo R., Talora C., Campese A.F., Checquolo S., Bellavia D., et al. Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia. Leukemia 2014, 28:2324-2335.
    • (2014) Leukemia , vol.28 , pp. 2324-2335
    • Kumar, V.1    Palermo, R.2    Talora, C.3    Campese, A.F.4    Checquolo, S.5    Bellavia, D.6
  • 65
    • 80052518795 scopus 로고    scopus 로고
    • Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen
    • Wang Q., Li D.-C., Li Z.-F., Liu C.-X., Xiao Y.-M., Zhang B., et al. Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen. Oncogene 2011, 30:3875-3886. 10.1038/onc.2011.103.
    • (2011) Oncogene , vol.30 , pp. 3875-3886
    • Wang, Q.1    Li, D.-C.2    Li, Z.-F.3    Liu, C.-X.4    Xiao, Y.-M.5    Zhang, B.6
  • 66
    • 79959923295 scopus 로고    scopus 로고
    • MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression
    • Lerner M., Lundgren J., Akhoondi S., Jahn A., Ng H.-F., Akbari Moqadam F., et al. MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle 2011, 10:2172-2183.
    • (2011) Cell Cycle , vol.10 , pp. 2172-2183
    • Lerner, M.1    Lundgren, J.2    Akhoondi, S.3    Jahn, A.4    Ng, H.-F.5    Akbari Moqadam, F.6
  • 67
    • 84885942420 scopus 로고    scopus 로고
    • A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis
    • Olive V., Sabio E., Bennett M.J., De Jong C.S., Biton A., McGann J.C., et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife 2013, 2:e00822. 10.7554/eLife.00822.
    • (2013) Elife , vol.2 , pp. e00822
    • Olive, V.1    Sabio, E.2    Bennett, M.J.3    De Jong, C.S.4    Biton, A.5    McGann, J.C.6
  • 68
    • 84922902863 scopus 로고    scopus 로고
    • MiR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7
    • Zhou C., Shen L., Mao L., Wang B., Li Y., Yu H. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7. Biochem. Biophys. Res. Commun. 2015, 458:63-69. 10.1016/j.bbrc.2015.01.066.
    • (2015) Biochem. Biophys. Res. Commun. , vol.458 , pp. 63-69
    • Zhou, C.1    Shen, L.2    Mao, L.3    Wang, B.4    Li, Y.5    Yu, H.6
  • 69
    • 84879852051 scopus 로고    scopus 로고
    • An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis
    • Jeon T.-I., Esquejo R.M., Roqueta-Rivera M., Phelan P.E., Moon Y.-A., Govindarajan S.S., et al. An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis. Cell Metab. 2013, 18:51-61. 10.1016/j.cmet.2013.06.010.
    • (2013) Cell Metab. , vol.18 , pp. 51-61
    • Jeon, T.-I.1    Esquejo, R.M.2    Roqueta-Rivera, M.3    Phelan, P.E.4    Moon, Y.-A.5    Govindarajan, S.S.6
  • 70
    • 84944274865 scopus 로고    scopus 로고
    • MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7
    • Gong J., Cui Z., Li L., Ma Q., Wang Q., Gao Y., et al. MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7. Tumour Biol. 2015, 10.1007/s13277-015-3510-3.
    • (2015) Tumour Biol.
    • Gong, J.1    Cui, Z.2    Li, L.3    Ma, Q.4    Wang, Q.5    Gao, Y.6
  • 71
    • 84910628229 scopus 로고    scopus 로고
    • Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma
    • Li L., Sarver A.L., Khatri R., Hajeri P.B., Kamenev I., French A.J., et al. Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma. J. Pathol. 2014, 234:488-501. 10.1002/path.4407.
    • (2014) J. Pathol. , vol.234 , pp. 488-501
    • Li, L.1    Sarver, A.L.2    Khatri, R.3    Hajeri, P.B.4    Kamenev, I.5    French, A.J.6
  • 72
    • 78649755783 scopus 로고    scopus 로고
    • Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations
    • Durgan J., Parker P.J. Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations. Biochem. J. 2010, 432:77-87. 10.1042/BJ20100799.
    • (2010) Biochem. J. , vol.432 , pp. 77-87
    • Durgan, J.1    Parker, P.J.2
  • 73
    • 45349091765 scopus 로고    scopus 로고
    • Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase
    • Grim J.E., Gustafson M.P., Hirata R.K., Hagar A.C., Swanger J., Welcker M., et al. Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J. Cell Biol. 2008, 181:913-920. 10.1083/jcb.200802076.
    • (2008) J. Cell Biol. , vol.181 , pp. 913-920
    • Grim, J.E.1    Gustafson, M.P.2    Hirata, R.K.3    Hagar, A.C.4    Swanger, J.5    Welcker, M.6
  • 74
    • 33745508920 scopus 로고    scopus 로고
    • Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms
    • Van Drogen F., Sangfelt O., Malyukova A., Matskova L., Yeh E., Means A.R., et al. Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol. Cell 2006, 23:37-48. 10.1016/j.molcel.2006.05.020.
    • (2006) Mol. Cell , vol.23 , pp. 37-48
    • Van Drogen, F.1    Sangfelt, O.2    Malyukova, A.3    Matskova, L.4    Yeh, E.5    Means, A.R.6
  • 75
    • 84919772749 scopus 로고    scopus 로고
    • Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α
    • Trausch-Azar J.S., Abed M., Orian A., Schwartz A.L. Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α. J. Cell. Physiol. 2015, 230:842-852. 10.1002/jcp.24812.
    • (2015) J. Cell. Physiol. , vol.230 , pp. 842-852
    • Trausch-Azar, J.S.1    Abed, M.2    Orian, A.3    Schwartz, A.L.4
  • 76
    • 84883521293 scopus 로고    scopus 로고
    • Parkin-dependent degradation of the F-Box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
    • Ekholm-Reed S., Goldberg M.S., Schlossmacher M.G., Reed S.I. Parkin-dependent degradation of the F-Box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 2013, 33:3627-3643. 10.1128/MCB.00535-13.
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 3627-3643
    • Ekholm-Reed, S.1    Goldberg, M.S.2    Schlossmacher, M.G.3    Reed, S.I.4
  • 77
    • 47549085556 scopus 로고    scopus 로고
    • Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma
    • Bonetti P., Davoli T., Sironi C., Amati B., Pelicci P.G., Colombo E. Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J. Cell Biol. 2008, 182:19-26. 10.1083/jcb.200711040.
    • (2008) J. Cell Biol. , vol.182 , pp. 19-26
    • Bonetti, P.1    Davoli, T.2    Sironi, C.3    Amati, B.4    Pelicci, P.G.5    Colombo, E.6
  • 78
    • 79952260898 scopus 로고    scopus 로고
    • Nucleolar targeting of the Fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3
    • Welcker M., Larimore E.A., Frappier L., Clurman B.E. Nucleolar targeting of the Fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. Mol. Cell. Biol. 2011, 31:1214-1224. 10.1128/MCB.01347-10.
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 1214-1224
    • Welcker, M.1    Larimore, E.A.2    Frappier, L.3    Clurman, B.E.4
  • 79
    • 14844312051 scopus 로고    scopus 로고
    • The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4
    • Welcker M., Clurman B.E. The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4. J. Biol. Chem. 2005, 280:7654-7658. 10.1074/jbc.M413377200.
    • (2005) J. Biol. Chem. , vol.280 , pp. 7654-7658
    • Welcker, M.1    Clurman, B.E.2
  • 80
    • 84863000735 scopus 로고    scopus 로고
    • Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase
    • Min S.-H., Lau A.W., Lee T.H., Inuzuka H., Wei S., Huang P., et al. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol. Cell 2012, 46:771-783. 10.1016/j.molcel.2012.04.012.
    • (2012) Mol. Cell , vol.46 , pp. 771-783
    • Min, S.-H.1    Lau, A.W.2    Lee, T.H.3    Inuzuka, H.4    Wei, S.5    Huang, P.6
  • 81
    • 0033529757 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism
    • Galan J.M., Peter M. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:9124-9129.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 9124-9129
    • Galan, J.M.1    Peter, M.2
  • 82
    • 79960354038 scopus 로고    scopus 로고
    • PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity
    • Schülein C., Eilers M., Popov N. PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity. FEBS Lett. 2011, 585:2151-2157. 10.1016/j.febslet.2011.05.036.
    • (2011) FEBS Lett. , vol.585 , pp. 2151-2157
    • Schülein, C.1    Eilers, M.2    Popov, N.3
  • 83
    • 78651104178 scopus 로고    scopus 로고
    • Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase
    • Mo J.-S., Ann E.-J., Yoon J.-H., Jung J., Choi Y.-H., Kim H.-Y., et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J. Cell Sci. 2011, 124:100-112. 10.1242/jcs.073924.
    • (2011) J. Cell Sci. , vol.124 , pp. 100-112
    • Mo, J.-S.1    Ann, E.-J.2    Yoon, J.-H.3    Jung, J.4    Choi, Y.-H.5    Kim, H.-Y.6
  • 84
    • 84861209633 scopus 로고    scopus 로고
    • Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)
    • Cizmecioglu O., Krause A., Bahtz R., Ehret L., Malek N., Hoffmann I. Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4). J. Cell Sci. 2012, 125:981-992. 10.1242/jcs.095075.
    • (2012) J. Cell Sci. , vol.125 , pp. 981-992
    • Cizmecioglu, O.1    Krause, A.2    Bahtz, R.3    Ehret, L.4    Malek, N.5    Hoffmann, I.6
  • 85
    • 84928926064 scopus 로고    scopus 로고
    • ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer
    • Ji S., Qin Y., Shi S., Liu X., Hu H., Zhou H., et al. ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Cell Res. 2015, 10.1038/cr.2015.30.
    • (2015) Cell Res.
    • Ji, S.1    Qin, Y.2    Shi, S.3    Liu, X.4    Hu, H.5    Zhou, H.6
  • 86
    • 57849107571 scopus 로고    scopus 로고
    • Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
    • Otto T., Horn S., Brockmann M., Eilers U., Schüttrumpf L., Popov N., et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell 2009, 15:67-78. 10.1016/j.ccr.2008.12.005.
    • (2009) Cancer Cell , vol.15 , pp. 67-78
    • Otto, T.1    Horn, S.2    Brockmann, M.3    Eilers, U.4    Schüttrumpf, L.5    Popov, N.6
  • 87
    • 77957564565 scopus 로고    scopus 로고
    • Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover
    • Popov N., Schülein C., Jaenicke L.A., Eilers M. Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover. Nat. Cell Biol. 2010, 12:973-981. 10.1038/ncb2104.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 973-981
    • Popov, N.1    Schülein, C.2    Jaenicke, L.A.3    Eilers, M.4
  • 88
    • 84860397404 scopus 로고    scopus 로고
    • Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation
    • Zhang J., Zhu F., Li X., Dong Z., Xu Y., Peng C., et al. Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation. Oncogene 2012, 31:1835-1844. 10.1038/onc.2011.369.
    • (2012) Oncogene , vol.31 , pp. 1835-1844
    • Zhang, J.1    Zhu, F.2    Li, X.3    Dong, Z.4    Xu, Y.5    Peng, C.6
  • 89
    • 84862797119 scopus 로고    scopus 로고
    • Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells
    • Guo Z., Zhou Y., Evers B.M., Wang Q. Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells. Biochem. Biophys. Res. Commun. 2012, 418:426-432. 10.1016/j.bbrc.2012.01.054.
    • (2012) Biochem. Biophys. Res. Commun. , vol.418 , pp. 426-432
    • Guo, Z.1    Zhou, Y.2    Evers, B.M.3    Wang, Q.4
  • 90
    • 84930858062 scopus 로고    scopus 로고
    • MTOR complex 2 stabilizes Mcl-protein by suppressing its glycogen synthase kinase 3-dependent and SCF-FBXW7-mediated degradation
    • Koo J., Yue P., Deng X., Khuri F.R., Sun S.-Y. mTOR complex 2 stabilizes Mcl-protein by suppressing its glycogen synthase kinase 3-dependent and SCF-FBXW7-mediated degradation. Mol. Cell. Biol. 2015, 35:2344-2355. 10.1128/MCB.01525-14.
    • (2015) Mol. Cell. Biol. , vol.35 , pp. 2344-2355
    • Koo, J.1    Yue, P.2    Deng, X.3    Khuri, F.R.4    Sun, S.-Y.5
  • 91
    • 84891910929 scopus 로고    scopus 로고
    • FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7
    • Wang Z., Liu Y., Zhang P., Zhang W., Wang W., Curr K., et al. FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7. Oncotarget 2013, 4:2476-2486.
    • (2013) Oncotarget , vol.4 , pp. 2476-2486
    • Wang, Z.1    Liu, Y.2    Zhang, P.3    Zhang, W.4    Wang, W.5    Curr, K.6
  • 92
    • 84862895814 scopus 로고    scopus 로고
    • Numb regulates glioma stem cell fate and growth by altering Epidermal growth factor receptor and Skp1-Cullin-F-Box ubiquitin ligase activity
    • Jiang X., Xing H., Kim T.-M., Jung Y., Huang W., Yang H.W., et al. Numb regulates glioma stem cell fate and growth by altering Epidermal growth factor receptor and Skp1-Cullin-F-Box ubiquitin ligase activity. Stem Cells 2012, 30:1313-1326. 10.1002/stem.1120.
    • (2012) Stem Cells , vol.30 , pp. 1313-1326
    • Jiang, X.1    Xing, H.2    Kim, T.-M.3    Jung, Y.4    Huang, W.5    Yang, H.W.6
  • 93
    • 84859729349 scopus 로고    scopus 로고
    • The glomuvenous malformation protein glomulin binds Rbx1 and regulates Cullin RING ligase-mediated turnover of Fbw7
    • Tron A.E., Arai T., Duda D.M., Kuwabara H., Olszewski J.L., Fujiwara Y., et al. The glomuvenous malformation protein glomulin binds Rbx1 and regulates Cullin RING ligase-mediated turnover of Fbw7. Mol. Cell 2012, 46:67-78. 10.1016/j.molcel.2012.02.005.
    • (2012) Mol. Cell , vol.46 , pp. 67-78
    • Tron, A.E.1    Arai, T.2    Duda, D.M.3    Kuwabara, H.4    Olszewski, J.L.5    Fujiwara, Y.6
  • 94
    • 84864915878 scopus 로고    scopus 로고
    • Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface
    • Duda D.M., Olszewski J.L., Tron A.E., Hammel M., Lambert L.J., Waddell M.B., et al. Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. Mol. Cell 2012, 47:371-382. 10.1016/j.molcel.2012.05.044.
    • (2012) Mol. Cell , vol.47 , pp. 371-382
    • Duda, D.M.1    Olszewski, J.L.2    Tron, A.E.3    Hammel, M.4    Lambert, L.J.5    Waddell, M.B.6
  • 96
    • 84923285082 scopus 로고    scopus 로고
    • CSN6 drives carcinogenesis by positively regulating Myc stability
    • Chen J., Shin J.-H., Zhao R., Phan L., Wang H., Xue Y., et al. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat. Commun. 2014, 5:5384. 10.1038/ncomms6384.
    • (2014) Nat. Commun. , vol.5 , pp. 5384
    • Chen, J.1    Shin, J.-H.2    Zhao, R.3    Phan, L.4    Wang, H.5    Xue, Y.6
  • 97
    • 73849083434 scopus 로고    scopus 로고
    • Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
    • Schwickart M., Huang X., Lill J.R., Liu J., Ferrando R., French D.M., et al. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010, 463:103-107. 10.1038/nature08646.
    • (2010) Nature , vol.463 , pp. 103-107
    • Schwickart, M.1    Huang, X.2    Lill, J.R.3    Liu, J.4    Ferrando, R.5    French, D.M.6
  • 98
    • 84937966446 scopus 로고    scopus 로고
    • USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer
    • Pan J., Deng Q., Jiang C., Wang X., Niu T., Li H., et al. USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer. Oncogene 2015, 34:3957-3967. 10.1038/onc.2014.327.
    • (2015) Oncogene , vol.34 , pp. 3957-3967
    • Pan, J.1    Deng, Q.2    Jiang, C.3    Wang, X.4    Niu, T.5    Li, H.6
  • 100
    • 84925424005 scopus 로고    scopus 로고
    • The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc
    • Sun X.-X., He X., Yin L., Komada M., Sears R.C., Dai M.-S. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc. Natl. Acad. Sci. U. S. A. 2015, 112:3734-3739. 10.1073/pnas.1411713112.
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 3734-3739
    • Sun, X.-X.1    He, X.2    Yin, L.3    Komada, M.4    Sears, R.C.5    Dai, M.-S.6
  • 103
    • 84919710063 scopus 로고    scopus 로고
    • Dual regulation of Fbw7 function and oncogenic transformation by Usp28
    • Schülein-Völk C., Wolf E., Zhu J., Xu W., Taranets L., Hellmann A., et al. Dual regulation of Fbw7 function and oncogenic transformation by Usp28. Cell Rep. 2014, 9:1099-1109. 10.1016/j.celrep.2014.09.057.
    • (2014) Cell Rep. , vol.9 , pp. 1099-1109
    • Schülein-Völk, C.1    Wolf, E.2    Zhu, J.3    Xu, W.4    Taranets, L.5    Hellmann, A.6
  • 104
    • 84887903330 scopus 로고    scopus 로고
    • The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth
    • Li L., Anderson S., Secombe J., Eisenman R.N. The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Development 2013, 140:4776-4787. 10.1242/dev.096941.
    • (2013) Development , vol.140 , pp. 4776-4787
    • Li, L.1    Anderson, S.2    Secombe, J.3    Eisenman, R.N.4
  • 105
    • 77954513389 scopus 로고    scopus 로고
    • An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase
    • Orlicky S., Tang X., Neduva V., Elowe N., Brown E.D., Sicheri F., et al. An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat. Biotechnol. 2010, 28:733-737. 10.1038/nbt.1646.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 733-737
    • Orlicky, S.1    Tang, X.2    Neduva, V.3    Elowe, N.4    Brown, E.D.5    Sicheri, F.6
  • 106
    • 34047209861 scopus 로고    scopus 로고
    • Reactivation of mutant p53: molecular mechanisms and therapeutic potential
    • Selivanova G., Wiman K.G. Reactivation of mutant p53: molecular mechanisms and therapeutic potential. Oncogene 2007, 26:2243-2254. 10.1038/sj.onc.1210295.
    • (2007) Oncogene , vol.26 , pp. 2243-2254
    • Selivanova, G.1    Wiman, K.G.2
  • 107
    • 27244444199 scopus 로고    scopus 로고
    • A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function
    • Rottmann S., Wang Y., Nasoff M., Deveraux Q.L., Quon K.C. A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:15195-15200. 10.1073/pnas.0505114102.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 15195-15200
    • Rottmann, S.1    Wang, Y.2    Nasoff, M.3    Deveraux, Q.L.4    Quon, K.C.5
  • 108
    • 84859167179 scopus 로고    scopus 로고
    • Deregulated MYC expression induces dependence upon AMPK-related kinase 5
    • Liu L., Ulbrich J., Müller J., Wüstefeld T., Aeberhard L., Kress T.R., et al. Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 2012, 483:608-612. 10.1038/nature10927.
    • (2012) Nature , vol.483 , pp. 608-612
    • Liu, L.1    Ulbrich, J.2    Müller, J.3    Wüstefeld, T.4    Aeberhard, L.5    Kress, T.R.6
  • 109
    • 34447137342 scopus 로고    scopus 로고
    • Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
    • Goga A., Yang D., Tward A.D., Morgan D.O., Bishop J.M. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat. Med. 2007, 13:820-827. 10.1038/nm1606.
    • (2007) Nat. Med. , vol.13 , pp. 820-827
    • Goga, A.1    Yang, D.2    Tward, A.D.3    Morgan, D.O.4    Bishop, J.M.5
  • 111
    • 84866021069 scopus 로고    scopus 로고
    • A small molecule inhibitor of ubiquitin-specific protease-induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
    • Chauhan D., Tian Z., Nicholson B., Kumar K.G.S., Zhou B., Carrasco R., et al. A small molecule inhibitor of ubiquitin-specific protease-induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell 2012, 22:345-358. 10.1016/j.ccr.2012.08.007.
    • (2012) Cancer Cell , vol.22 , pp. 345-358
    • Chauhan, D.1    Tian, Z.2    Nicholson, B.3    Kumar, K.G.S.4    Zhou, B.5    Carrasco, R.6


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