-
1
-
-
23144464363
-
Transcriptional regulation and transformation by Myc proteins
-
Adhikary S., and Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6 (2005) 635-645
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 635-645
-
-
Adhikary, S.1
Eilers, M.2
-
2
-
-
42149102636
-
Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer
-
Astanehe A., Arenillas D., Wasserman W.W., Leung P.C., Dunn S.E., Davies B.R., Mills G.B., and Auersperg N. Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer. J. Cell Sci. 121 (2008) 664-674
-
(2008)
J. Cell Sci.
, vol.121
, pp. 664-674
-
-
Astanehe, A.1
Arenillas, D.2
Wasserman, W.W.3
Leung, P.C.4
Dunn, S.E.5
Davies, B.R.6
Mills, G.B.7
Auersperg, N.8
-
3
-
-
33750044299
-
When translation meets transformation: the mTOR story
-
Averous J., and Proud C.G. When translation meets transformation: the mTOR story. Oncogene 25 (2006) 6423-6435
-
(2006)
Oncogene
, vol.25
, pp. 6423-6435
-
-
Averous, J.1
Proud, C.G.2
-
4
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov V.J., Issaeva N., Shilov A., Hultcrantz M., Pugacheva E., Chumakov P., Bergman J., Wiman K.G., and Selivanova G. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat. Med. 8 (2002) 282-288
-
(2002)
Nat. Med.
, vol.8
, pp. 282-288
-
-
Bykov, V.J.1
Issaeva, N.2
Shilov, A.3
Hultcrantz, M.4
Pugacheva, E.5
Chumakov, P.6
Bergman, J.7
Wiman, K.G.8
Selivanova, G.9
-
5
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
Chin L., Tam A., Pomerantz J., Wong M., Holash J., Bardeesy N., Shen Q., O'Hagan R., Pantginis J., Zhou H., et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400 (1999) 468-472
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
Tam, A.2
Pomerantz, J.3
Wong, M.4
Holash, J.5
Bardeesy, N.6
Shen, Q.7
O'Hagan, R.8
Pantginis, J.9
Zhou, H.10
-
6
-
-
0037383322
-
GSK-3: tricks of the trade for a multi-tasking kinase
-
Doble B.W., and Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116 (2003) 1175-1186
-
(2003)
J. Cell Sci.
, vol.116
, pp. 1175-1186
-
-
Doble, B.W.1
Woodgett, J.R.2
-
7
-
-
60649103811
-
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between poptosis and growth arrest induced by pharmacologically activated p53
-
Enge M., Bao W., Hedström E., Jackson S.P., Moumen A., and Selivanova G. MDM2-dependent downregulation of p21 and hnRNP K provides a switch between poptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 15 (2009) 171-183
-
(2009)
Cancer Cell
, vol.15
, pp. 171-183
-
-
Enge, M.1
Bao, W.2
Hedström, E.3
Jackson, S.P.4
Moumen, A.5
Selivanova, G.6
-
8
-
-
0033180211
-
Reversible tumorigenesis by MYC in hematopoietic lineages
-
Felsher D.W., and Bishop J.M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell 4 (1999) 199-207
-
(1999)
Mol. Cell
, vol.4
, pp. 199-207
-
-
Felsher, D.W.1
Bishop, J.M.2
-
9
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y., Maya R., Kazaz A., and Oren M. Mdm2 promotes the rapid degradation of p53. Nature 387 (1997) 296-299
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
10
-
-
23844476499
-
p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest
-
Ho J.S., Ma W., Mao D.Y., and Benchimol S. p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol. Cell. Biol. 25 (2005) 7423-7431
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 7423-7431
-
-
Ho, J.S.1
Ma, W.2
Mao, D.Y.3
Benchimol, S.4
-
11
-
-
0036479115
-
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
-
Hoffman W.H., Biade S., Zilfou J.T., Chen J., and Murphy M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J. Biol. Chem. 277 (2002) 3247-3257
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3247-3257
-
-
Hoffman, W.H.1
Biade, S.2
Zilfou, J.T.3
Chen, J.4
Murphy, M.5
-
13
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva N., Bozko P., Enge M., Protopopova M., Verhoef L.G., Masucci M., Pramanik A., and Selivanova G. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat. Med. 10 (2004) 1321-1328
-
(2004)
Nat. Med.
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
Protopopova, M.4
Verhoef, L.G.5
Masucci, M.6
Pramanik, A.7
Selivanova, G.8
-
14
-
-
39549110602
-
Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
-
Johnson T.M., Meade K., Pathak N., Marques M.R., and Attardi L.D. Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. Proc. Natl. Acad. Sci. USA 105 (2008) 1215-1220
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1215-1220
-
-
Johnson, T.M.1
Meade, K.2
Pathak, N.3
Marques, M.R.4
Attardi, L.D.5
-
15
-
-
0037039319
-
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
-
Kaeser M.D., and Iggo R.D. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl. Acad. Sci. USA 99 (2002) 95-100
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 95-100
-
-
Kaeser, M.D.1
Iggo, R.D.2
-
16
-
-
0038420033
-
hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53
-
Kimura T., Gotoh M., Nakamura Y., and Arakawa H. hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci. 94 (2003) 431-436
-
(2003)
Cancer Sci.
, vol.94
, pp. 431-436
-
-
Kimura, T.1
Gotoh, M.2
Nakamura, Y.3
Arakawa, H.4
-
17
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
Komarov P.G., Komarova E.A., Kondratov R.V., Christov-Tselkov K., Coon J.S., Chernov M.V., and Gudkov A.V. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285 (1999) 1733-1737
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
Komarova, E.A.2
Kondratov, R.V.3
Christov-Tselkov, K.4
Coon, J.S.5
Chernov, M.V.6
Gudkov, A.V.7
-
18
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat M.H., Jones S.N., and Vousden K.H. Regulation of p53 stability by Mdm2. Nature 387 (1997) 299-303
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
19
-
-
42949114938
-
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
-
Lain S., Hollick J.J., Campbell J., Staples O.D., Higgins M., Aoubala M., McCarthy A., Appleyard V., Murray K.E., Baker L., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 (2008) 454-463
-
(2008)
Cancer Cell
, vol.13
, pp. 454-463
-
-
Lain, S.1
Hollick, J.J.2
Campbell, J.3
Staples, O.D.4
Higgins, M.5
Aoubala, M.6
McCarthy, A.7
Appleyard, V.8
Murray, K.E.9
Baker, L.10
-
20
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko O., and Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13 (2006) 951-961
-
(2006)
Cell Death Differ.
, vol.13
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
21
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe S.W., Cepero E., and Evan G. Intrinsic tumour suppression. Nature 432 (2004) 307-315
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
22
-
-
33845611951
-
Modeling the therapeutic efficacy of p53 restoration in tumors
-
Martins C.P., Brown-Swigart L., and Evan G.I. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127 (2006) 1323-1334
-
(2006)
Cell
, vol.127
, pp. 1323-1334
-
-
Martins, C.P.1
Brown-Swigart, L.2
Evan, G.I.3
-
23
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
Maurer U., Charvet C., Wagman A.S., Dejardin E., and Green D.R. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 (2006) 749-760
-
(2006)
Mol. Cell
, vol.21
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
24
-
-
8844232663
-
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
-
Minsky N., and Oren M. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol. Cell 16 (2004) 631-639
-
(2004)
Mol. Cell
, vol.16
, pp. 631-639
-
-
Minsky, N.1
Oren, M.2
-
25
-
-
0028292480
-
Identification of a p53-dependent negative response element in the bcl-2 gene
-
Miyashita T., Harigai M., Hanada M., and Reed J.C. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res. 54 (1994) 3131-3135
-
(1994)
Cancer Res.
, vol.54
, pp. 3131-3135
-
-
Miyashita, T.1
Harigai, M.2
Hanada, M.3
Reed, J.C.4
-
26
-
-
0029803281
-
Wild-type p53 negatively regulates the expression of a microtubule-associated protein
-
Murphy M., Hinman A., and Levine A.J. Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev. 10 (1996) 2971-2980
-
(1996)
Genes Dev.
, vol.10
, pp. 2971-2980
-
-
Murphy, M.1
Hinman, A.2
Levine, A.J.3
-
27
-
-
0038075338
-
Decision making by p53: life, death and cancer
-
Oren M. Decision making by p53: life, death and cancer. Cell Death Differ. 10 (2003) 431-442
-
(2003)
Cell Death Differ.
, vol.10
, pp. 431-442
-
-
Oren, M.1
-
28
-
-
0037013147
-
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
-
Pelengaris S., Khan M., and Evan G.I. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109 (2002) 321-334
-
(2002)
Cell
, vol.109
, pp. 321-334
-
-
Pelengaris, S.1
Khan, M.2
Evan, G.I.3
-
29
-
-
44649094568
-
p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter
-
Pietrzak M., and Puzianowska-Kuznicka M. p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter. Biol. Chem. 389 (2008) 383-393
-
(2008)
Biol. Chem.
, vol.389
, pp. 383-393
-
-
Pietrzak, M.1
Puzianowska-Kuznicka, M.2
-
32
-
-
57149118022
-
Chromatin immunoprecipitation-on-chip reveals stress-dependent p53 occupancy in primary normal cells but not in established cell lines
-
Shaked H., Shiff I., Kott-Gutkowski M., Siegfried Z., Haupt Y., and Simon I. Chromatin immunoprecipitation-on-chip reveals stress-dependent p53 occupancy in primary normal cells but not in established cell lines. Cancer Res. 68 (2008) 9671-9677
-
(2008)
Cancer Res.
, vol.68
, pp. 9671-9677
-
-
Shaked, H.1
Shiff, I.2
Kott-Gutkowski, M.3
Siegfried, Z.4
Haupt, Y.5
Simon, I.6
-
33
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., et al. The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
Mandelker, D.7
Leary, R.J.8
Ptak, J.9
Silliman, N.10
-
34
-
-
0035921849
-
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
-
Strohmaier H., Spruck C.H., Kaiser P., Won K.A., Sangfelt O., and Reed S.I. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413 (2001) 316-322
-
(2001)
Nature
, vol.413
, pp. 316-322
-
-
Strohmaier, H.1
Spruck, C.H.2
Kaiser, P.3
Won, K.A.4
Sangfelt, O.5
Reed, S.I.6
-
35
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
-
Tovar C., Rosinski J., Filipovic Z., Higgins B., Kolinsky K., Hilton H., Zhao X., Vu B.T., Qing W., Packman K., et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc. Natl. Acad. Sci. USA 103 (2006) 1888-1893
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
Higgins, B.4
Kolinsky, K.5
Hilton, H.6
Zhao, X.7
Vu, B.T.8
Qing, W.9
Packman, K.10
-
36
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., Kong N., Kammlott U., Lukacs C., Klein C., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
-
37
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A., Kirsch D.G., McLaughlin M.E., Tuveson D.A., Grimm J., Lintault L., Newman J., Reczek E.E., Weissleder R., and Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature 445 (2007) 661-665
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
Newman, J.7
Reczek, E.E.8
Weissleder, R.9
Jacks, T.10
-
39
-
-
47749096347
-
BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death
-
Wade M., Rodewald L.W., Espinosa J.M., and Wahl G.M. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle 7 (2008) 1973-1982
-
(2008)
Cell Cycle
, vol.7
, pp. 1973-1982
-
-
Wade, M.1
Rodewald, L.W.2
Espinosa, J.M.3
Wahl, G.M.4
-
40
-
-
0037025173
-
Cancer. Addiction to oncogenes-the Achilles heal of cancer
-
Weinstein I.B. Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297 (2002) 63-64
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
41
-
-
0029757120
-
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene
-
Werner H., Karnieli E., Rauscher F.J., and LeRoith D. Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. USA 93 (1996) 8318-8323
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 8318-8323
-
-
Werner, H.1
Karnieli, E.2
Rauscher, F.J.3
LeRoith, D.4
-
42
-
-
33645751553
-
Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription
-
White D.E., Talbott K.E., Arva N.C., and Bargonetti J. Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription. Cancer Res. 66 (2006) 3463-3470
-
(2006)
Cancer Res.
, vol.66
, pp. 3463-3470
-
-
White, D.E.1
Talbott, K.E.2
Arva, N.C.3
Bargonetti, J.4
-
43
-
-
33947521882
-
Integrative content-driven concepts for bioinformatics "beyond the cell"
-
Wingender E., Crass T., Hogan J.D., Kel A.E., Kel-Margoulis O.V., and Potapov A.P. Integrative content-driven concepts for bioinformatics "beyond the cell". J. Biosci. 32 (2007) 169-180
-
(2007)
J. Biosci.
, vol.32
, pp. 169-180
-
-
Wingender, E.1
Crass, T.2
Hogan, J.D.3
Kel, A.E.4
Kel-Margoulis, O.V.5
Potapov, A.P.6
-
44
-
-
0035019156
-
Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells
-
Wysocka J., Reilly P.T., and Herr W. Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells. Mol. Cell. Biol. 21 (2001) 3820-3829
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3820-3829
-
-
Wysocka, J.1
Reilly, P.T.2
Herr, W.3
-
45
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W., Zender L., Miething C., Dickins R.A., Hernando E., Krizhanovsky V., Cordon-Cardo C., and Lowe S.W. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445 (2007) 656-660
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
Cordon-Cardo, C.7
Lowe, S.W.8
-
46
-
-
2942614705
-
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
-
Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., and Nakayama K.I. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 23 (2004) 2116-2125
-
(2004)
EMBO J.
, vol.23
, pp. 2116-2125
-
-
Yada, M.1
Hatakeyama, S.2
Kamura, T.3
Nishiyama, M.4
Tsunematsu, R.5
Imaki, H.6
Ishida, N.7
Okumura, F.8
Nakayama, K.9
Nakayama, K.I.10
-
47
-
-
20444369867
-
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
-
Yang Y., Ludwig R.L., Jensen J.P., Pierre S.A., Medaglia M.V., Davydov I.V., Safiran Y.J., Oberoi P., Kenten J.H., Phillips A.C., et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 7 (2005) 547-559
-
(2005)
Cancer Cell
, vol.7
, pp. 547-559
-
-
Yang, Y.1
Ludwig, R.L.2
Jensen, J.P.3
Pierre, S.A.4
Medaglia, M.V.5
Davydov, I.V.6
Safiran, Y.J.7
Oberoi, P.8
Kenten, J.H.9
Phillips, A.C.10
-
48
-
-
24044529785
-
Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53
-
Zhu N., Gu L., Findley H.W., and Zhou M. Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53. Biochem. Biophys. Res. Comm. 335 (2005) 1272-1279
-
(2005)
Biochem. Biophys. Res. Comm.
, vol.335
, pp. 1272-1279
-
-
Zhu, N.1
Gu, L.2
Findley, H.W.3
Zhou, M.4
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