A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3β/FBW7 loss of function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 42, 2005, Pages 15195-15200

  Rottmann, Sabine ^a   Wang, Yan ^a   Nasoff, Marc ^a   Deveraux, Quinn L ^a   Quon, Kim C ^a,b  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b AMGEN INC   (United States)

Author keywords

FBW7; MYC; TNF related apoptosis inducing ligand

Indexed keywords

CASPASE 8; DEATH RECEPTOR 5; GLYCOGEN SYNTHASE KINASE 3BETA; LUCIFERASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER THERAPY; CARCINOGENESIS; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DRUG TARGETING; ENZYME PHOSPHORYLATION; FBW7 GENE; GENE MUTATION; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE MYC; PRIORITY JOURNAL; PROTO ONCOGENE; TUMOR SUPPRESSOR GENE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 8; CASPASES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; F-BOX PROTEINS; GENE LIBRARY; GENE SILENCING; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MEMBRANE GLYCOPROTEINS; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, SMALL INTERFERING; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; MUS MUSCULUS;

EID: 27244444199     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0505114102     Document Type: Article

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