The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 12, 2015, Pages 3734-3739

  Sun, Xiao Xin ^a,b   He, Xia ^a,c   Yin, Li ^c   Komada, Masayuki ^d   Sears, Rosalie C ^a,b   Dai, Mu Shui ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c JIANGSU CANCER HOSPITAL   (China)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

C Myc; Deubiquitination; Nucleolus; Ubiquitination; USP36

Indexed keywords

DEUBIQUITINASE; F BOX AND WD REPEAT DOMAIN CONTAINING 7 PROTEIN ALPHA; F BOX AND WD REPEAT DOMAIN CONTAINING 7 PROTEIN GAMMA; F BOX PROTEIN; MYC PROTEIN; UBIQUITIN SPECIFIC PROTEASE 36; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; FBXW7 PROTEIN, HUMAN; GREEN FLUORESCENT PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN THIOLESTERASE; USP36 PROTEIN, HUMAN;

ANCHORAGE INDEPENDENT GROWTH; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DEUBIQUITINATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; NUCLEOLUS; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; UBIQUITINATION; BREAST TUMOR; CATALYSIS; CELL NUCLEUS; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; HELA CELL LINE; LUNG TUMOR; METABOLISM; NEOPLASM; TUMOR CELL LINE;

BREAST NEOPLASMS; CATALYSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL NUCLEOLUS; CELL NUCLEUS; CELL PROLIFERATION; F-BOX PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUNG NEOPLASMS; MICROSCOPY, FLUORESCENCE; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC; UBIQUITIN THIOLESTERASE; UBIQUITIN-PROTEIN LIGASES;

EID: 84925424005     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411713112     Document Type: Article

References (32)

1. Adhikary S, Eilers M (2005) Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 6(8):635-645.
2. Meyer N, Penn LZ (2008) Reflecting on 25 years with MYC. Nat Rev Cancer 8(12):976-990.
3. van Riggelen J, Yetil A, Felsher DW (2010) MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer 10(4):301-309.
4. Nesbit CE, Tersak JM, Prochownik EV (1999) MYC oncogenes and human neoplastic disease. Oncogene 18(19):3004-3016.
5. Farrell AS, Sears RC (2014) MYC degradation. Cold Spring Harb Perspect Med 4(3): a014365.
6. Hann SR (2006) Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function. Semin Cancer Biol 16(4):288-302.
7. Lutterbach B, Hann SR (1994) Hierarchical phosphorylation at N-terminal trans-formation- sensitive sites in c-Myc protein is regulated by mitogens and in mitosis. Mol Cell Biol 14(8):5510-5522.
8. Sears R, et al. (2000) Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14(19):2501-2514.
9. Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK (2004) The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol 14(11):965-974.
10. Yada M, et al. (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23(10):2116-2125.
11. Welcker M, et al. (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci USA 101(24):9085-9090.
12. Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE (2004) A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol 14(20):1852-1857.
13. Bahram F, von der Lehr N, Cetinkaya C, Larsson LG (2000) c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover. Blood 95(6):2104-2110.
14. Gregory MA, Hann SR (2000) c-Myc proteolysis by the ubiquitin-proteasome pathway: Stabilization of c-Myc in Burkitt's lymphoma cells. Mol Cell Biol 20(7):2423-2435.
15. Salghetti SE, Kim SY, Tansey WP (1999) Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc. EMBO J 18(3):717-726.
16. Oster SK, Ho CS, Soucie EL, Penn LZ (2002) The myc oncogene: MarvelouslY Complex. Adv Cancer Res 84:81-154.
17. Welcker M, Clurman BE (2008) FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8(2):83-93.
18. Cepeda D, et al. (2013) CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer. EMBO Mol Med 5(7):999-1018.
19. Kim SY, Herbst A, Tworkowski KA, Salghetti SE, Tansey WP (2003) Skp2 regulates Myc protein stability and activity. Mol Cell 11(5):1177-1188.
20. Popov N, Schülein C, Jaenicke LA, Eilers M (2010) Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover. Nat Cell Biol 12(10):973-981.
21. von der Lehr N, et al. (2003) The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell 11(5): 1189-1200.
22. Popov N, et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 9(7):765-774.
23. Arabi A, et al. (2005) c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol 7(3):303-310.
24. Grandori C, et al. (2005) c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol 7(3):311-318.
25. Dai MS, Lu H (2008) Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J Cell Biochem 105(3):670-677.
26. Quesada V, et al. (2004) Cloning and enzymatic analysis of 22 novel human ubiquitinspecific proteases. Biochem Biophys Res Commun 314(1):54-62.
27. Sun XX, Challagundla KB, Dai MS (2012) Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J 31(3):576-592.
28. Endo A, Kitamura N, Komada M (2009) Nucleophosmin/B23 regulates ubiquitin dynamics in nucleoli by recruiting deubiquitylating enzyme USP36. J Biol Chem 284(41): 27918-27923.
29. Endo A, et al. (2009) Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36. J Cell Sci 122(Pt 5):678-686.
30. Richardson LA, et al. (2012) A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Cell Reports 2(2):372-385.
31. Bhaskaran N, et al. (2013) Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation. Mol Cell Biol 33(1):85-97.
32. van Drogen F, et al. (2006) Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol Cell 23(1):37-48.