Differential regulation of FBXW7 isoforms by various stress stimuli

Cell Cycle

Volumn 12, Issue 22, 2013, Pages 3547-3554

  Sionov, Ronit Vogt ^a   Netzer, Efrat ^a   Shaulian, Eitan ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Cell cycle; FBXW7; mRNA expression; p53; Stress response

Indexed keywords

FBXW7 PROTEIN; FBXWALPHA PROTEIN; FBXWGAMMA PROTEIN; ISOPROTEIN; NUTLIN 3; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL STRAIN HCT116; ENDOPLASMIC RETICULUM STRESS; GENE REPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

CELL CYCLE; FBXW7; MRNA EXPRESSION; P53; STRESS-RESPONSE;

CELL CYCLE; CELL CYCLE PROTEINS; DNA DAMAGE; F-BOX PROTEINS; HCT116 CELLS; HUMANS; PROTEIN ISOFORMS; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 84890406728     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.26591     Document Type: Article

References (40)

1. Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C. Inactivation of hCDC4 can cause chromosomal instability. Nature 2004; 428:77-81; PMID:14999283; http://dx.doi.org/10.1038/ nature02313 (Pubitemid 38332360)
2. Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 2008; 8:83-93; PMID:18094723; http://dx.doi.org/10.1038/nrc2290 (Pubitemid 351161321)
3. Wang Z, Inuzuka H, Zhong J, Wan L, Fukushima H, Sarkar FH, Wei W. Tumor suppressor functions of FBW7 in cancer development and progression. FEBS Lett 2012; 586:1409-18; PMID:22673505; http://dx.doi.org/10.1016/j.febslet.2012.03. 017
4. Wang Z, Inuzuka H, Fukushima H, Wan L, Gao D, Shaik S, Sarkar FH, Wei W. Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Rep 2012; 13:36-43; PMID:22157894; http://dx.doi.org/10.1038/embor.2011.231
5. Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 2011; 475:122; PMID:21368834; http://dx.doi.org/10.1038/nature09779
6. Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011; 471:104-9; PMID:21368833; http://dx.doi.org/10.1038/nature09732
7. Finkin S, Aylon Y, Anzi S, Oren M, Shaulian E. Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent druginduced polyploidy. Oncogene 2008; 27:4411-21; PMID:18391985; http://dx.doi.org/10.1038/onc.2008.77
8. Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001; 294:173-7; PMID:11533444; http://dx.doi.org/10.1126/ science.1065203 (Pubitemid 32952972)
9. Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004; 101:9085-90; PMID:15150404; http://dx.doi.org/10.1073/pnas.0402770101 (Pubitemid 38781615)
10. Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, Ishida N, Okumura F, Nakayama K, Nakayama KI. Phosphorylationdependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004; 23:2116-25; PMID:15103331; http://dx.doi.org/10.1038/sj.emboj.7600217 (Pubitemid 38737738)
11. Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 2005; 8:25-33; PMID:16023596; http://dx.doi.org/10.1016/j. ccr.2005.06.005 (Pubitemid 40991812)
12. Nateri AS, Riera-Sans L, Da Costa C, Behrens A. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 2004; 303:1374-8; PMID:14739463; http://dx.doi.org/10.1126/science.1092880 (Pubitemid 38269431)
13. Oberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 2001; 276:35847-53; PMID:11461910; http://dx.doi.org/10.1074/jbc. M103992200
14. Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A 2004; 101:3338-45; PMID:14766969; http://dx.doi.org/10.1073/pnas. 0307875101 (Pubitemid 38338196)
15. Spruck CH, Strohmaier H, Sangfelt O, Muller HM, Hubalek M, Muller-Holzner E, Marth C, Widschwendter M, Reed SI. hCDC4 gene mutations in endometrial cancer. Cancer Res 2002; 62:4535-9; PMID:12183400
16. Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE. A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol 2004; 14:1852-7; PMID:15498494; http://dx.doi.org/10.1016/j.cub.2004.09.083 (Pubitemid 39412248)
17. Welcker M, Clurman BE. Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div 2007; 2:7; PMID:17298674; http://dx.doi.org/10.1186/1747- 1028-2-7
18. van Drogen F, Sangfelt O, Malyukova A, Matskova L, Yeh E, Means AR, Reed SI. Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol Cell 2006; 23:37-48; PMID:16818231; http://dx.doi.org/10.1016/j.molcel.2006.05.020 (Pubitemid 43963444)
19. Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE. Isoform-and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J Cell Biol 2008; 181:913-20; PMID:18559665; http://dx.doi.org/10.1083/jcb.200802076 (Pubitemid 351846825)
20. Kimura T, Gotoh M, Nakamura Y, Arakawa H. hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci 2003; 94:431-6; PMID:12824889; http://dx.doi.org/10.1111/j.1349-7006.2003.tb01460.x (Pubitemid 36790475)
21. Matsumoto A, Onoyama I, Nakayama KI. Expression of mouse Fbxw7 isoforms is regulated in a cell cycleor p53-dependent manner. Biochem Biophys Res Commun 2006; 350:114-9; PMID:16989775; http://dx.doi.org/10.1016/j.bbrc.2006.09.003 (Pubitemid 44472621)
22. Wu CC, Yang TY, Yu CT, Phan L, Ivan C, Sood AK, Hsu SL, Lee MH. p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation. Cell Cycle 2012; 11:3433-42; PMID:22894933; http://dx.doi.org/10. 4161/cc.21732
23. Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, Balmain A, Saura CA. Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 2010; 29:2950-61; PMID:20208556; http://dx.doi.org/10.1038/onc.2010.57
24. Balamurugan K, Wang JM, Tsai HH, Sharan S, Anver M, Leighty R, Sterneck E. The tumour suppressor C/EBP? inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO J 2010; 29:4106-17; PMID:21076392; http://dx.doi.org/10. 1038/emboj.2010.280
25. Sancho R, Blake SM, Tendeng C, Clurman BE, Lewis J, Behrens A. Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol 2013; 11:e1001586; PMID:23776410; http://dx.doi.org/10.1371/journal.pbio.1001586
26. Xu Y, Sengupta T, Kukreja L, Minella AC. MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. J Biol Chem 2010; 285:34439-46; PMID:20826802; http://dx.doi.org/10.1074/jbc. M110.152306
27. Lerner M, Lundgren J, Akhoondi S, Jahn A, Ng HF, Akbari Moqadam F, Oude Vrielink JA, Agami R, Den Boer ML, Grander D, et al. MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle 2011; 10:2172-83; PMID:21597324; http://dx.doi.org/10.4161/cc.10.13.16248
28. Akhoondi S, Sun D, von der Lehr N, Apostolidou S, Klotz K, Maljukova A, Cepeda D, Fiegl H, Dafou D, Marth C, et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 2007; 67:9006-12; PMID:17909001; http://dx.doi.org/10.1158/0008-5472.CAN-07-1320 (Pubitemid 47535882)
29. Merrill GF. Cell synchronization. Methods Cell Biol 1998; 57:229-49; PMID:9648108; http://dx.doi.org/10.1016/S0091-679X(08)61582-4 (Pubitemid 128787443)
30. Pedrali-Noy G, Spadari S, Miller-Faures A, Miller AO, Kruppa J, Koch G. Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin. Nucleic Acids Res 1980; 8:377-87; PMID:6775308; http://dx.doi.org/10.1093/nar/8.2.377
31. Marusyk A, Wheeler LJ, Mathews CK, DeGregori J. p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol 2007; 27:5336-51; PMID:17515610; http://dx.doi.org/10.1128/MCB.01316-06 (Pubitemid 47124389)
32. Sakaue-Sawano A, Kurokawa H, Morimura T, Hanyu A, Hama H, Osawa H, Kashiwagi S, Fukami K, Miyata T, Miyoshi H, et al. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 2008; 132:487-98; PMID:18267078; http://dx.doi.org/10.1016/j.cell.2007.12.033 (Pubitemid 351191996)
33. Lew DJ, Dulić V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 1991; 66:1197-206; PMID:1833066; http://dx.doi.org/10.1016/0092-8674(91)90042-W (Pubitemid 121001409)
34. Anzi S, Finkin S, Shaulian E. Transcriptional repression of c-Jun's E3 ubiquitin ligases contributes to c-Jun induction by UV. Cell Signal 2008; 20:862-71; PMID:18295447; http://dx.doi.org/10.1016/j. cellsig.2007.12.020
35. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282:1497-501; PMID:9822382; http://dx.doi.org/10. 1126/science.282.5393.1497 (Pubitemid 28538613)
36. Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 2004; 432:775-9; PMID:15592418; http://dx.doi.org/10.1038/nature03155 (Pubitemid 39656299)
37. Akhoondi S, Lindstrom L, Widschwendter M, Corcoran M, Bergh J, Spruck C, Grander D, Sangfelt O. Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res 2010; 12:R105; PMID:21122106; http://dx.doi.org/10. 1186/bcr2788
38. Matsumoto A, Tateishi Y, Onoyama I, Okita Y, Nakayama K, Nakayama KI. Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci 2011; 102:749-55; PMID:21205095; http://dx.doi.org/10.1111/j.1349-7006.2011.01851.x
39. Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M, Numico G, Comino A, et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 2003; 3:387-402; PMID:12726864; http://dx.doi.org/10.1016/S1535-6108(03)00079-5 (Pubitemid 38340307)
40. Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin WG Jr. Chemosensitivity linked to p73 function. Cancer Cell 2003; 3:403-10; PMID:12726865; http://dx.doi.org/10.1016/S1535-6108(03)00078-3 (Pubitemid 38340308)