An allosteric inhibitor of substrate recognition by the SCF Cdc4 ubiquitin ligase

Nature Biotechnology

Volumn 28, Issue 7, 2010, Pages 733-737

  Orlicky, Stephen ^a   Tang, Xiaojing ^a   Neduva, Victor ^b   Elowe, Nadine ^c   Brown, Eric D ^c   Sicheri, Frank ^a,d   Tyers, Mike ^a,b,d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c MCMASTER UNIVERSITY   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CRYSTAL STRUCTURE; MAMMALS; PHOSPHORYLATION; PROTEINS;

ALLOSTERIC INHIBITION; ALLOSTERIC INHIBITOR; COCRYSTAL STRUCTURE; DICARBOXYLIC ACID; FLUORESCENCE POLARIZATION; INHIBITORY EFFECT; KEY DETERMINANTS; PHOSPHORYLATED SUBSTRATES; PROTEIN DEGRADATION; SUBSTRATE BINDING; SUBSTRATE RECOGNITION; SUBSTRATE-BINDING SITES; UBIQUITIN LIGASES; UBIQUITINATION;

SUBSTRATES;

PROTEIN CDC42; UBIQUITIN PROTEIN LIGASE;

ARTICLE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; UBIQUITINATION; ALLOSTERISM; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; METABOLISM; PROTEIN CONFORMATION;

ALLOSTERIC REGULATION; MODELS, MOLECULAR; PROTEIN CONFORMATION; UBIQUITIN-PROTEIN LIGASES;

EID: 77954513389     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1646     Document Type: Article

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