Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch

Oncogene

Volumn 32, Issue 15, 2013, Pages 1921-1932

  Ishikawa, Y ^a,b   Hosogane, M ^a,b   Okuyama, R ^c   Aoyama, S ^a,b   Onoyama, I ^b,d   Nakayama, K I ^b,d   Nakayama, K ^a,b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

c Myc; Fbxw7; keratinocyte; Notch; ubiquitin ligase

Indexed keywords

DNA; FBXW7 PROTEIN; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; MYC PROTEIN; NOTCH RECEPTOR; RAS PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER SUSCEPTIBILITY; CARCINOGENICITY; CELL DIFFERENTIATION; CELL GROWTH; CELL POPULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE DELETION; GENOTYPE; HOMEOSTASIS; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; SQUAMOUS CELL CARCINOMA; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; F-BOX PROTEINS; GENES, TUMOR SUPPRESSOR; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; KERATINOCYTES; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, NOTCH; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SKIN NEOPLASMS; UBIQUITIN-PROTEIN LIGASES;

EID: 84876157836     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.213     Document Type: Article

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