Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations

Biochemical Journal

Volumn 432, Issue 1, 2010, Pages 77-87

  Durgan, Joanne ^a,b   Parker, Peter J ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cancer associated mutation; F box WD40 protein 7 (Fbw7); Isoform specific regulation; Nuclear localization; Protein kinase C (PKC)

Indexed keywords

CANCER-ASSOCIATED MUTATIONS; F-BOX WD40 PROTEIN 7 (FBW7); ISOFORMS; NUCLEAR LOCALIZATION; PROTEIN KINASE C (PKC);

AMINO ACIDS; DEGRADATION; MAMMALS; ONCOGENIC VIRUSES; PHOSPHORYLATION; TUMORS;

PROTEINS;

F BOX WD40 PROTEIN 7 ALPHA; GLUTATHIONE TRANSFERASE; PROLINE; PROTEIN KINASE C; SERINE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; ENZYME DEGRADATION; FEMALE; GENE MUTATION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; F-BOX PROTEINS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN KINASE C; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN-PROTEIN LIGASES;

MAMMALIA;

EID: 78649755783     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100799     Document Type: Article

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