PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity

FEBS Letters

Volumn 585, Issue 14, 2011, Pages 2151-2157

  Schülein, Christina ^a   Eilers, Martin ^a   Popov, Nikita ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cyclin E; Fbw7; Myc; Phosphorylation; Ubiquitination

Indexed keywords

CYCLIN E; FBW7 PROTEIN; MYC PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL STRAIN HCT116; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME SUBSTRATE; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN STABILITY; UBIQUITINATION;

EID: 79960354038     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.05.036     Document Type: Article

References (25)

1. T. Cardozo, and M. Pagano The SCF ubiquitin ligase: insights into a molecular machine Nat. Rev. Mol. Cell Biol. 5 2004 739 751 (Pubitemid 39208183)
2. M. Welcker, and B.E. Clurman FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation Nat. Rev. Cancer 8 2008 83 93 (Pubitemid 351161321)
3. X. Tang, S. Orlicky, Z. Lin, A. Willems, D. Neculai, D. Ceccarelli, F. Mercurio, B.H. Shilton, F. Sicheri, and M. Tyers Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination Cell 129 2007 1165 1176 (Pubitemid 46891040)
4. N. Popov, M. Wanzel, M. Madiredjo, D. Zhang, R. Beijersbergen, R. Bernards, R. Moll, S.J. Elledge, and M. Eilers The ubiquitin-specific protease USP28 is required for MYC stability Nat. Cell Biol. 9 2007 765 774 (Pubitemid 47019463)
5. J.E. Grim, M.P. Gustafson, R.K. Hirata, A.C. Hagar, J. Swanger, M. Welcker, H.C. Hwang, J. Ericsson, D.W. Russell, and B.E. Clurman Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase J. Cell Biol. 18 2008 913 920 (Pubitemid 351846825)
6. F. van Drogen, O. Sangfelt, A. Malyukova, L. Matskova, E. Yeh, A.R. Means, and S.I. Reed Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms Mol. Cell 23 2006 37 48 (Pubitemid 43963444)
7. K.M. Crusio, B. King, L.B. Reavie, and I. Aifantis The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation Oncogene 29 2010 4865 4873
8. N. Popov, S. Herold, M. Llamazares, C. Schülein, and M. Eilers Fbw7 and Usp28 regulate myc protein stability in response to DNA damage Cell Cycle 6 2007 2327 2331 (Pubitemid 350058681)
9. J. Durgan, and P.J. Parker Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations Biochem. J. 432 2010 77 87
10. J.S. Mo, E.J. Ann, J.H. Yoon, J. Jung, Y.H. Choi, H.Y. Kim, J.S. Ahn, S.M. Kim, M.Y. Kim, J.A. Hong, M.S. Seo, F. Lang, E.J. Choi, and H.S. Park Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase J. Cell Sci. 124 2011 100 112
11. H. Rajagopalan, P.V. Jallepalli, C. Rago, V.E. Velculescu, K.W. Kinzler, B. Vogelstein, and C. Lengauer Inactivation of hCDC4 can cause chromosomal instability Nature 428 2004 77 81 (Pubitemid 38332360)
12. A. Sundqvist, M.T. Bengoechea-Alonso, X. Ye, V. Lukiyanchuk, J. Jin, J.W. Harper, and J. Ericsson Control of lipid metabolism by phosphorylation- dependent degradation of the SREBP family of transcription factors by SCF(Fbw7) Cell Metab. 1 2005 379 391 (Pubitemid 43960622)
13. J.H. Mao, I.J. Kim, D. Wu, J. Climent, H.C. Kang, R. DelRosario, and A. Balmain FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression Science 321 2008 1499 1502
14. I.E. Wertz, S. Kusam, C. Lam, T. Okamoto, W. Sandoval, D.J. Anderson, E. Helgason, J.A. Ernst, M. Eby, J. Liu, L.D. Belmont, J.S. Kaminker, K.M. O'Rourke, K. Pujara, P.B. Kohli, A.R. Johnson, M.L. Chiu, J.R. Lill, P.K. Jackson, W.J. Fairbrother, S. Seshagiri, M.J. Ludlam, K.G. Leong, E.C. Dueber, H. Maecker, D.C. Huang, and V.M. Dixit Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 Nature 471 2011 110 114
15. H. Inuzuka, S. Shaik, I. Onoyama, D. Gao, A. Tseng, R.S. Maser, B. Zhai, L. Wan, A. Gutierrez, A.W. Lau, Y. Xiao, A.L. Christie, J. Aster, J. Settleman, S.P. Gygi, A.L. Kung, T. Look, K.I. Nakayama, R.A. DePinho, and W. Wei SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction Nature 471 2011 104 109
16. P. Bonetti, T. Davoli, C. Sironi, B. Amati, P.G. Pelicci, and E. Colombo Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma J. Cell Biol. 182 2008 19 26 (Pubitemid 352008617)
17. M. Welcker, E.A. Larimore, L. Frappier, and B.E. Clurman Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3 Mol. Cell Biol. 31 2011 1214 1224
18. A.S. Nateri, L. Riera-Sans, C. Da Costa, and A. Behrens The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling Science 303 2004 1374 1378 (Pubitemid 38269431)
19. Y. Ishikawa, I. Onoyama, K.I. Nakayama, and K. Nakayama Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7 Oncogene 27 2008 6164 6174
20. S. Matsuoka, B.A. Ballif, A. Smogorzewska, E.R. McDonald 3rd, K.E. Hurov, J. Luo, C.E. Bakalarski, Z. Zhao, N. Solimini, Y. Lerenthal, Y. Shiloh, S.P. Gygi, and S.J. Elledge ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage Science 316 2007 1160 1166 (Pubitemid 46877472)
21. J. Park, M.L. Leong, P. Buse, A.C. Maiyar, G.L. Firestone, and B.A. Hemmings Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway EMBO J. 18 1999 3024 3033 (Pubitemid 29255611)
22. J.M. Galan, and M. Peter Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism Proc. Natl. Acad. Sci. USA 96 1999 9124 9129 (Pubitemid 29374718)
23. J.R. Mills, Y. Hippo, F. Robert, S.M. Chen, A. Malina, C.J. Lin, U. Trojahn, H.G. Wendel, A. Charest, R.T. Bronson, S.C. Kogan, R. Nadon, D.E. Housman, S.W. Lowe, and J. Pelletier mTORC1 promotes survival through translational control of Mcl-1 Proc. Natl. Acad. Sci. USA 105 2008 10853 10858
24. D.J. Murphy, M.R. Junttila, L. Pouyet, A. Karnezis, K. Shchors, D.A. Bui, L. Brown-Swigart, L. Johnson, and G.I. Evan Distinct thresholds govern Myc's biological output in vivo Cancer Cell 14 2008 447 457
25. M.T. Hemann, A. Bric, J. Teruya-Feldstein, A. Herbst, J.A. Nilsson, C. Cordon-Cardo, J.L. Cleveland, W.P. Tansey, and S.W. Lowe Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants Nature 436 2005 807 811 (Pubitemid 41160633)