SCOPUS 정보 검색 플랫폼

Virtual Screening for Bioactive Molecules

Volumn 10, Issue , 2008, Pages 229-264

Structure-Based Library Design

(1) Stahl, Martin a

a F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

3 D structural information; Ligands; Potential; Receptor ligand interactions

Indexed keywords

LIBRARY DESIGNS; POTENTIAL; RECEPTOR-LIGAND INTERACTIONS; STRUCTURAL INFORMATION; STRUCTURE-BASED;

LIGANDS;

EID: 84956796236 PISSN: None EISSN: None Source Type: Book
DOI: 10.1002/9783527613083.ch11 Document Type: Chapter

Times cited : (12)

References (212)

1
- 0001520694
- M. A. Navia, M. A. Murcko, Curr. Op. Struct. Biol. 1992,2, 202-210.
- (1992) Curr. Op. Struct. Biol. , vol.2 , pp. 202-210
- Navia, M.A.¹ Murcko, M.A.²

2
- 0028297112
- J. Greer, J. W. Erickson, J. J. Baldwin, M. D. Varney, J. Med. Chem. 1994,37,1035-1054.
- (1994) J. Med. Chem. , vol.37 , pp. 1035-1054
- Greer, J.¹ Erickson, J.W.² Baldwin, J.J.³ Varney, M.D.⁴

3
- 0028773887
- C. L. M. J. Verlinde, W. G. J. Hoi, Structure 1994,2,577-587.
- (1994) Structure , vol.2 , pp. 577-587
- Verlinde, C.L.M.J.¹ Hoi, W.G.J.²

4
- 0030039619
- R. S. Bohacek, C. McMartin, W. C. Guida, Med. Res. Rev. 1996,16, 3-50.
- (1996) Med. Res. Rev. , vol.16 , pp. 3-50
- Bohacek, R.S.¹ McMartin, C.² Guida, W.C.³

5
- 0030712269
- R. E. Hubbard, Curr. Op. Biotechnology 1997,8, 696-700.
- (1997) Curr. Op. Biotechnology , vol.8 , pp. 696-700
- Hubbard, R.E.¹

6
- 0031189711
- R. E. Babine, S. L. Bender, Chem. Rev. 1997, 97,1359-1472.
- (1997) Chem. Rev. , vol.97 , pp. 1359-1472
- Babine, R.E.¹ Bender, S.L.²

7
- 0002716826
- H. Kubinyi, Curr. Op. Drug Disc. Dev. 1998,1,4-15.
- (1998) Curr. Op. Drug Disc. Dev. , vol.1 , pp. 4-15
- Kubinyi, H.¹

8
- 0033025637
- H. Kubinyi, J. Recept. Signal Transduction Res. 1999,19,15-39.
- (1999) J. Recept. Signal Transduction Res. , vol.19 , pp. 15-39
- Kubinyi, H.¹

9
- 0025135112
- D. S. Goodsell, A. J. Olson, Proteins 1990,8,195-202.
- (1990) Proteins , vol.8 , pp. 195-202
- Goodsell, D.S.¹ Olson, A.J.²

10
- 0029705324
- D. S. Goodsell, G. M. Morris, A. J. Olson, J. Mol. Recognition 1996, 9,1-5.
- (1996) J. Mol. Recognition , vol.9 , pp. 1-5
- Goodsell, D.S.¹ Morris, G.M.² Olson, A.J.³

11
- 0030203710
- G. M. Morris, D. S. Goodsell, R. Huey, A. J. Olson, J. Comput.-Aided Mol. Design 1996, 10, 293-304.
- (1996) J. Comput.-Aided Mol. Design , vol.10 , pp. 293-304
- Morris, G.M.¹ Goodsell, D.S.² Huey, R.³ Olson, A.J.⁴

12
- 11644261806
- G. M. Morris, D. S. Goodsell, R, S. Halliday, R. Huey, W. E. Hart, R. K. Belew, A. J. Olson, J. Comp. Chem. 1998,14,1639-1662.
- (1998) J. Comp. Chem. , vol.14 , pp. 1639-1662
- Morris, G.M.¹ Goodsell, D.S.² Halliday, R.S.³ Huey, R.⁴ Hart, W.E.⁵ Belew, R.K.⁶ Olson, A.J.⁷

13
- 0020491251
- I. D. Kuntz, J. M. Blaney, S. J. Oatley, R. Langridge, T. Ferrin, J. Mol. Biol. 1982,161, 269-288.
- (1982) J. Mol. Biol. , vol.161 , pp. 269-288
- Kuntz, I.D.¹ Blaney, J.M.² Oatley, S.J.³ Langridge, R.⁴ Ferrin, T.⁵

14
- 0023936327
- R. DesJarlais, R. P. Sheridan, G. L. Seibel, J. S. Dixon, I. D. Kuntz, R. Venkataraghavan, J. Med. Chem. 1988,57,722-729.
- (1988) J. Med. Chem. , vol.57 , pp. 722-729
- DesJarlais, R.¹ Sheridan, R.P.² Seibel, G.L.³ Dixon, J.S.⁴ Kuntz, I.D.⁵ Venkataraghavan, R.⁶

15
- 84986432941
- E. C. Meng, B. K. Shoichet, I. D. Kuntz, J. Comp. Chem. 1992, 75,505-524.
- (1992) J. Comp. Chem. , vol.75 , pp. 505-524
- Meng, E.C.¹ Shoichet, B.K.² Kuntz, I.D.³

16
- 0027379219
- E. C. Meng, D. A. Gschwend, J. M. Blaney, I. D. Kuntz, Proteins 1993,17,266-278.
- (1993) Proteins , vol.17 , pp. 266-278
- Meng, E.C.¹ Gschwend, D.A.² Blaney, J.M.³ Kuntz, I.D.⁴

17
- 6244283606
- T. J. A. Ewing, I. D. Kuntz, J. Comp. Chem. 1997,18,1175-1189.
- (1997) J. Comp. Chem. , vol.18 , pp. 1175-1189
- Ewing, T.J.A.¹ Kuntz, I.D.²

18
- 0000903085
- Y. Sun, T. J. A. Ewing, A. G. Skillman, I. D. Kuntz, J. Comput.-Aided Mol. Design 1998, 12, 579-604.
- (1998) J. Comput.-Aided Mol. Design , vol.12 , pp. 579-604
- Sun, Y.¹ Ewing, T.J.A.² Skillman, A.G.³ Kuntz, I.D.⁴

19
- 0030076041
- M. Rarey, S. Wefing, T. Lengauer, J. Comput.-Aided Mol. Design 1996,10,41-54.
- (1996) J. Comput.-Aided Mol. Design , vol.10 , pp. 41-54
- Rarey, M.¹ Wefing, S.² Lengauer, T.³

20
- 0030599010
- M. Rarey, B. Kramer, T. Lengauer, G. Klebe, J. Mol. Biol. 1996,261, 470-489.
- (1996) J. Mol. Biol. , vol.261 , pp. 470-489
- Rarey, M.¹ Kramer, B.² Lengauer, T.³ Klebe, G.⁴

21
- 0031181870
- M. Rarey, B. Kramer, T. Lengauer, J. Comput.-Aided Mol. Design 1997,11,369-384.
- (1997) J. Comput.-Aided Mol. Design , vol.11 , pp. 369-384
- Rarey, M.¹ Kramer, B.² Lengauer, T.³

22
- 0032961895
- M. Rarey, B. Kramer, T. Lengauer, Proteins 1999,34,17-28.
- (1999) Proteins , vol.34 , pp. 17-28
- Rarey, M.¹ Kramer, B.² Lengauer, T.³

23
- 0032950520
- M. Rarey, B. Kramer, T. Lengauer, Bioinformatics 1999,15, 243-250.
- (1999) Bioinformatics , vol.15 , pp. 243-250
- Rarey, M.¹ Kramer, B.² Lengauer, T.³

24
- 84956798341
- Germany, March 15-18
- M. Rarey, Recent Developments of FlexX: Parallel Virtual Screening and Processing of Combinatorial Libraries, Talk given at the International Workshop on Virtual Screening, Schloss Rauis-chholzhausen, Germany, March 15-18,1999
- (1999) Recent Developments of FlexX: Parallel Virtual Screening and Processing of Combinatorial Libraries, Talk given at the International Workshop on Virtual Screening, Schloss Rauis-chholzhausen
- Rarey, M.¹

25
- 0028412035
- M. D. Miller, S. K. Kearsley, D. J. Underwood, R. P. Sheridan, J. Comput.-Aided Mol. Design 1994,8,153-174.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 153-174
- Miller, M.D.¹ Kearsley, S.K.² Underwood, D.J.³ Sheridan, R.P.⁴

26
- 0028522982
- S. K. Kearsley, D. J. Underwood, R. P. Sheridan, M. D. Miller, J. Comput.-Aided Mol. Design 1994,8, 565-582.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 565-582
- Kearsley, S.K.¹ Underwood, D.J.² Sheridan, R.P.³ Miller, M.D.⁴

27
- 0028882706
- G. Jones, P. Willett, Curr. Op. Biotechnology 1995,6, 652-656.
- (1995) Curr. Op. Biotechnology , vol.6 , pp. 652-656
- Jones, G.¹ Willett, P.²

28
- 0028854034
- G. Jones, P. Willett, R. C. Glen, J. Mol. Biol. 1995,245, 43-53.
- (1995) J. Mol. Biol. , vol.245 , pp. 43-53
- Jones, G.¹ Willett, P.² Glen, R.C.³

29
- 0031552362
- G. Jones, P. Willett, R. C. Glen, A. R. Leach, R. Taylor, J. Mol. Biol. 1997,267,727-7'48.
- (1997) J. Mol. Biol. , vol.267 , pp. 727-748
- Jones, G.¹ Willett, P.² Glen, R.C.³ Leach, A.R.⁴ Taylor, R.⁵

30
- 0031087525
- C. W. Murray, D. E. Clark, T. R. Auton, M. A. Firth, J. Li, R. A. Sykes, B. Waskowycz, D. R. Westhead, S. C. Young, J. Comput.-Aided Mol. Design 1996,11,193-207.
- (1996) J. Comput.-Aided Mol. Design , vol.11 , pp. 193-207
- Murray, C.W.¹ Clark, D.E.² Auton, T.R.³ Firth, M.A.⁴ Li, J.⁵ Sykes, R.A.⁶ Waskowycz, B.⁷ Westhead, D.R.⁸ Young, S.C.⁹

31
- 0028036120
- R. S. Bohacek, C. McMartin, J. Am. Chem. Soc. 1994,116, 5560-5571.
- (1994) J. Am. Chem. Soc. , vol.116 , pp. 5560-5571
- Bohacek, R.S.¹ McMartin, C.²

32
- 0000934205
- R. S. DeWitte, E. I. Shakhnovich, J. Am. Chem. Soc. 1996,118,11733-11744.
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 11733-11744
- DeWitte, R.S.¹ Shakhnovich, E.I.²

33
- 0031003647
- R. S. DeWitte, A. V. Ishchenko, E. I. Shaknovich, J. Am. Chem. Soc. 1997,119,4608-4617.
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 4608-4617
- DeWitte, R.S.¹ Ishchenko, A.V.² Shaknovich, E.I.³

34
- 0027193713
- S. H. Rotstein, M. A. Murcko, J. Med. Chem. 1993,56,1700-1710.
- (1993) J. Med. Chem. , vol.56 , pp. 1700-1710
- Rotstein, S.H.¹ Murcko, M.A.²

35
- 0027586682
- V. J. Gillet, A. P. Johnson, P. Mata, S. Sike, P. Williams, J. Comput-Aided Mol. Design 1993,7,127-153.
- (1993) J. Comput-Aided Mol. Design , vol.7 , pp. 127-153
- Gillet, V.J.¹ Johnson, A.P.² Mata, P.³ Sike, S.⁴ Williams, P.⁵

36
- 0028167547
- V. J. Gillet, W. Newell, P. Mata, G. Myatt, S. Sike, Z. Zsoldos, A. P. Johnson, J. Chem. Inf. Corn-put. Sci. 1994,34, 207-217.
- (1994) J. Chem. Inf. Corn-put. Sci. , vol.34 , pp. 207-217
- Gillet, V.J.¹ Newell, W.² Mata, P.³ Myatt, G.⁴ Sike, S.⁵ Zsoldos, Z.⁶ Johnson, A.P.⁷

37
- 0002820943
- K. Miiller (Ed.) Es-com, Leiden
- V. J. Gillet, G. Myatt, Z. Zsoldos, A. P. Johnson, in De Novo Design, Vol. 3, K. Miiller (Ed.) Es-com, Leiden 1995, p. 34-50.
- (1995) De Novo Design , vol.3 , pp. 34-50
- Gillet, V.J.¹ Myatt, G.² Zsoldos, Z.³ Johnson, A.P.⁴

38
- 0026813925
- H.-J. Bohm, J. Comput.-Aided Mol. Design 1992,6, 61-78.
- (1992) J. Comput.-Aided Mol. Design , vol.6 , pp. 61-78
- Bohm, H.-J.¹

39
- 0027027467
- H.-J. Bohm, J. Comput.-Aided Mol. Design 1992, 6, 593-606.
- (1992) J. Comput.-Aided Mol. Design , vol.6 , pp. 593-606
- Bohm, H.-J.¹

40
- 0030204057
- H.-J. Bohm, J. Comput.-Aided Mol. Design 1996,10, 265-272.
- (1996) J. Comput.-Aided Mol. Design , vol.10 , pp. 265-272
- Bohm, H.-J.¹

41
- 0028081385
- B. Waszkowycz, D. E. Clark, D. Frenkel, J. Li, C. W. Murray, B. Robson, D. R. Westhead, J. Med. Chem. 1994,37, 3994-4002.
- (1994) J. Med. Chem. , vol.37 , pp. 3994-4002
- Waszkowycz, B.¹ Clark, D.E.² Frenkel, D.³ Li, J.⁴ Murray, C.W.⁵ Robson, B.⁶ Westhead, D.R.⁷

42
- 0029242576
- D. E. Clark, D. Frenkel, S. A. Levy, J. Li, C. W. Murray, B. Robson, B. Waszkowycz, D. R. West-head, J. Comput-Aided Mol. Design 1995, 9,13-32.
- (1995) J. Comput-Aided Mol. Design , vol.9 , pp. 13-32
- Clark, D.E.¹ Frenkel, D.² Levy, S.A.³ Li, J.⁴ Murray, C.W.⁵ Robson, B.⁶ Waszkowycz, B.⁷ West-head, D.R.⁸

43
- 0025988461
- A. Itai, Y. Nishibata, Tetrahedron 1991, 47, 8985-8990.
- (1991) Tetrahedron , vol.47 , pp. 8985-8990
- Itai, A.¹ Nishibata, Y.²

44
- 0348242299
- D. A. Pearlman, M. A. Murcko, J. Comp. Chem. 1993,14,1184-1193.
- (1993) J. Comp. Chem. , vol.14 , pp. 1184-1193
- Pearlman, D.A.¹ Murcko, M.A.²

45
- 84956723620
- D. K. Gehlhaar, K. E. Moerder, D. Zichi, C. J. Sherman, R. C. Ogden, S. T. Freer, J. Med. Chem. 1995,38,4-472.
- (1995) J. Med. Chem. , vol.38 , pp. 4-472
- Gehlhaar, D.K.¹ Moerder, K.E.² Zichi, D.³ Sherman, C.J.⁴ Ogden, R.C.⁵ Freer, S.T.⁶

46
- 0025916872
- A. Miranker, M. Karplus, Proteins 1991,11,29-34.
- (1991) Proteins , vol.11 , pp. 29-34
- Miranker, A.¹ Karplus, M.²

47
- 0028282687
- M. B. Eisen, D. C. Wiley, M. Karplus, R. E. Hubbard, Proteins 1994,19,199-221.
- (1994) Proteins , vol.19 , pp. 199-221
- Eisen, M.B.¹ Wiley, D.C.² Karplus, M.³ Hubbard, R.E.⁴

48
- 0028380643
- G. Lauri, P. A. Bartlett, J. Comput.-Aided Mol. Design 1994,8, 51-66.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 51-66
- Lauri, G.¹ Bartlett, P.A.²

49
- 0026694615
- R. A. Lewis, D. C. Roe, C. Huang, T. E. Ferrin, R. Langridge, I. D. Kuntz, J. Mol. Graphics 1992, 10,66-78.
- (1992) J. Mol. Graphics , vol.10 , pp. 66-78
- Lewis, R.A.¹ Roe, D.C.² Huang, C.³ Ferrin, T.E.⁴ Langridge, R.⁵ Kuntz, I.D.⁶

50
- 0029320812
- D. C. Roe, I. D. Kuntz, J. Comput-Aided Mol. Design 1995,9,269-282.
- (1995) J. Comput-Aided Mol. Design , vol.9 , pp. 269-282
- Roe, D.C.¹ Kuntz, I.D.²

51
- 0001391169
- C. M. W. Ho, G. R. Marshall, J. Comput.-Aided Mol. Design 1993, 7,623-647.
- (1993) J. Comput.-Aided Mol. Design , vol.7 , pp. 623-647
- Ho, C.M.W.¹ Marshall, G.R.²

52
- 0031058541
- M. K. Gilson, J. A. Given, B. L. Bush, J. A. McCammon, Biophys. J. 1997, 72,1047-1069.
- (1997) Biophys. J. , vol.72 , pp. 1047-1069
- Gilson, M.K.¹ Given, J.A.² Bush, B.L.³ McCammon, J.A.⁴

53
- 0002647913
- K. B. Lipkowitz, D. B. Boyd (Eds.) VCH Publishers, New York
- T. P. Straatsma, in Reviews in Computational Chemistry, Vol. 9, K. B. Lipkowitz, D. B. Boyd (Eds.) VCH Publishers, New York 1991, pp. 81-98.
- (1991) Reviews in Computational Chemistry , vol.9 , pp. 81-98
- Straatsma, T.P.¹

54
- 0000539622
- P. A. Kollman, Ace. Chem. Res. 1996,29, 461-469.
- (1996) Ace. Chem. Res. , vol.29 , pp. 461-469
- Kollman, P.A.¹

55
- 0028155689
- J. Aquist, C. Medina, J.-E. Samuelsson, Prot. Eng. 1994, 7, 385-391.
- (1994) Prot. Eng. , vol.7 , pp. 385-391
- Aquist, J.¹ Medina, C.² Samuelsson, J.-E.³

56
- 0031637651
- T. Hansson, J. Marelius, J. Aquist, J. Comput.-Aided Mol. Design 1998,12, 27-35.
- (1998) J. Comput.-Aided Mol. Design , vol.12 , pp. 27-35
- Hansson, T.¹ Marelius, J.² Aquist, J.³

57
- 0031080551
- M. K. Gilson, J. A. Given, M. S. Head, Chem. Biol. 1997, 4, 87-92.
- (1997) Chem. Biol. , vol.4 , pp. 87-92
- Gilson, M.K.¹ Given, J.A.² Head, M.S.³

58
- 0028334097
- A. E. Mark, W. F. van Gunsteren, J. Mol. Biol. 1997, 240,167-176.
- (1997) J. Mol. Biol. , vol.240 , pp. 167-176
- Mark, A.E.¹ van Gunsteren, W.F.²

59
- 0021745755
- P. R. Andrews, D. J. Craik, J. L. Martin, J. Med. Chem. 1984,27, 1648-1657.
- (1984) J. Med. Chem. , vol.27 , pp. 1648-1657
- Andrews, P.R.¹ Craik, D.J.² Martin, J.L.³

60
- 0032527698
- T. J. Stout, C. R. Sage, R. M. Stroud, Structure 1998,6, 839-848.
- (1998) Structure , vol.6 , pp. 839-848
- Stout, T.J.¹ Sage, C.R.² Stroud, R.M.³

61
- 0029623184
- Ajay, M. A. Murcko, J. Med. Chem. 1995,38, 4953-4967.
- (1995) J. Med. Chem. , vol.38 , pp. 4953-4967
- Murcko, A.M.A.¹

62
- 0001872472
- J. D. Hirst, Curr. Op. Drug Disc. Dev. 1998,1, 28-33.
- (1998) Curr. Op. Drug Disc. Dev. , vol.1 , pp. 28-33
- Hirst, J.D.¹

63
- 0003146950
- Vol. 9/10/11, H. Kubinyi, G. Folkers, Y. C. McMartin (Eds.) Kluwer/Escom, Dordrecht
- R. M. A. Knegtel, P. D. J. Grootenhuis, in 3D QSAR in drug design: ligand protein interactions and molecular similarity, Vol. 9/10/11, H. Kubinyi, G. Folkers, Y. C. McMartin (Eds.) Kluwer/Escom, Dordrecht 1998, pp. 99-114.
- (1998) 3D QSAR in drug design: ligand protein interactions and molecular similarity , pp. 99-114
- Knegtel, R.M.A.¹ Grootenhuis, P.D.J.²

64
- 0002225424
- Vol. 9/10/11, H. Kubinyi, G. Folkers, Y. C. McMartin (Eds.) Kluwer/Escom, Dordrecht
- T. I. Oprea, G. R. Marshall, in 3D QSAR in drug design: ligand protein interactions and molecular similarity, Vol. 9/10/11, H. Kubinyi, G. Folkers, Y. C. McMartin (Eds.) Kluwer/Escom, Dordrecht 1998, pp. 3-17.
- (1998) 3D QSAR in drug design: ligand protein interactions and molecular similarity , pp. 3-17
- Oprea, T.I.¹ Marshall, G.R.²

65
- 0032993815
- J. R. H. Tame, J. Comput.-Aided Mol. Design 1999,13, 99-108.
- (1999) J. Comput.-Aided Mol. Design , vol.13 , pp. 99-108
- Tame, J.R.H.¹

66
- 0033367874
- H.-J. Bohm, M. Stahl, Med. Chem. Res. 1999, 9,445-462.
- (1999) Med. Chem. Res. , vol.9 , pp. 445-462
- Bohm, H.-J.¹ Stahl, M.²

67
- 0029063951
- M. K. Holloway, J. M. Wai, T. A. Halgren, P. M. D. Fitzgerald, J. P. Vacca, B. D. Dorsey, R. B. Levin, W. J. Thompson, L. J. Chen, S. J. deSolms, N. Gaffin, T. A. Lyle, W. A. Sanders, T. J. Tucker, M. Wiggins, C. M. Wiscount, O. W. Woltersdorf, S. D. Young, P. L. Darke, J. A. Zugay, J. Med. Chem. 1995,38, 305-317.
- (1995) J. Med. Chem. , vol.38 , pp. 305-317
- Holloway, M.K.¹ Wai, J.M.² Halgren, T.A.³ Fitzgerald, P.M.D.⁴ Vacca, J.P.⁵ Dorsey, B.D.⁶ Levin, R.B.⁷ Thompson, W.J.⁸ Chen, L.J.⁹ deSolms, S.J.¹⁰ Gaffin, N.¹¹ Lyle, T.A.¹² Sanders, W.A.¹³ Tucker, T.J.¹⁴ Wiggins, M.¹⁵ Wiscount, C.M.¹⁶ Woltersdorf, O.W.¹⁷ Young, S.D.¹⁸ Darke, P.L.¹⁹ Zugay, J.A.²⁰ more..

68
- 0001452822
- P. D. J. Grootenhuis, P. J. M. van Galen, Acta Cryst. 1995, D51, 560-566.
- (1995) Acta Cryst. , vol.D51 , pp. 560-566
- Grootenhuis, P.D.J.¹ van Galen, P.J.M.²

69
- 0021757436
- S. J. Weiner, P. A. Kollman, D. A. Case, U. C. Singh, C. Ghio, G. Alagona, S. Profeta, P. Weiner, J. Am. Chem. Soc. 1984,106,765-784.
- (1984) J. Am. Chem. Soc. , vol.106 , pp. 765-784
- Weiner, S.J.¹ Kollman, P.A.² Case, D.A.³ Singh, U.C.⁴ Ghio, C.⁵ Alagona, G.⁶ Profeta, S.⁷ Weiner, P.⁸

70
- 84988053694
- S. J. Weiner, P. A. Kollman, D. T. Nguyen, D. A. Case, J. Comp. Chem. 1986, 7, 230-252.
- (1986) J. Comp. Chem. , vol.7 , pp. 230-252
- Weiner, S.J.¹ Kollman, P.A.² Nguyen, D.T.³ Case, D.A.⁴

71
- 84986512474
- B. R. Brooks, R. E. Bruccoleri, B. D. Olafson, D. J. States, S. Swaminathan, M. Karplus, J. Comp. Chem. 1983,4,187-217.
- (1983) J. Comp. Chem. , vol.4 , pp. 187-217
- Brooks, B.R.¹ Bruccoleri, R.E.² Olafson, B.D.³ States, D.J.⁴ Swaminathan, S.⁵ Karplus, M.⁶

72
- 0000231302
- M. Vieth, J. D. Hirst, A. Kolinski, C. L. Brooks, J. Comp. Chem. 1998,19,1612-1622.
- (1998) J. Comp. Chem. , vol.19 , pp. 1612-1622
- Vieth, M.¹ Hirst, J.D.² Kolinski, A.³ Brooks, C.L.⁴

73
- 0029016182
- A. Nicholls, B. Honig, Science 1995,268,1144-1149.
- (1995) Science , vol.268 , pp. 1144-1149
- Nicholls, A.¹ Honig, B.²

74
- 0033214412
- N. Majeux, M. Scarsi, J. Apostolakis, C. Ehrhardt, A. Caflisch, Proteins 1999,37, 88-105.
- (1999) Proteins , vol.37 , pp. 88-105
- Majeux, N.¹ Scarsi, M.² Apostolakis, J.³ Ehrhardt, C.⁴ Caflisch, A.⁵

75
- 0032939345
- B. K. Shoichet, A. R. Leach, I. D. Kuntz, Proteins 1999,34,4-16.
- (1999) Proteins , vol.34 , pp. 4-16
- Shoichet, B.K.¹ Leach, A.R.² Kuntz, I.D.³

76
- 0030021877
- T. Zhang, D. E. Koshland, jr., Protein Sci. 1996,5, 348-356.
- (1996) Protein Sci. , vol.5 , pp. 348-356
- Zhang, T.¹ Koshland, D.E.²

77
- 0033137131
- M. Schapira, M. Trotov, R. Abagyan, J. Mol Recognition 1999,12,177-190.
- (1999) J. Mol Recognition , vol.12 , pp. 177-190
- Schapira, M.¹ Trotov, M.² Abagyan, R.³

78
- 0038833031
- P. H. Hunenberger, V. Helms, N. Narayana, S. S. Taylor, J. A. McCammon, Biochemistry 1999,38, 2358-2366.
- (1999) Biochemistry , vol.38 , pp. 2358-2366
- Hunenberger, P.H.¹ Helms, V.² Narayana, N.³ Taylor, S.S.⁴ McCammon, J.A.⁵

79
- 0032112610
- J. Bostrom, P.-O. Norrby, T. Liljefors, J. Comput.-Aided Mol. Design 1998,12, 383-396.
- (1998) J. Comput.-Aided Mol. Design , vol.12 , pp. 383-396
- Bostrom, J.¹ Norrby, P.-O.² Liljefors, T.³

80
- 0032197018
- M. Vieth, J. D. Hirst, C. L. Brooks, III, J. Comput.-Aided Mol. Design 1998,12,563-572.
- (1998) J. Comput.-Aided Mol. Design , vol.12 , pp. 563-572
- Vieth, M.¹ Hirst, J.D.² Brooks, C.L.³

81
- 0028522365
- G. Klebe, T. Mietzner, J. Comput.-Aided Mol Design 1994,8,583-606.
- (1994) J. Comput.-Aided Mol Design , vol.8 , pp. 583-606
- Klebe, G.¹ Mietzner, T.²

82
- 0001704085
- R. Wang, L. Liu, L. Lai, Y. Tang, J. Mol Model. 1998,4,379-394.
- (1998) J. Mol Model. , vol.4 , pp. 379-394
- Wang, R.¹ Liu, L.² Lai, L.³ Tang, Y.⁴

83
- 0028454828
- H.-J. Bohm, J. Comput.-Aided Mol. Design 1994,8,243-256.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 243-256
- Bohm, H.-J.¹

84
- 0032112137
- H.-J. Bohm, J. Comput.-Aided Mol. Design 1998,12, 309-323.
- (1998) J. Comput.-Aided Mol. Design , vol.12 , pp. 309-323
- Bohm, H.-J.¹

85
- 0031226772
- M. D. Elridge, C. W. Murray, T. R. Auton, G. V. Paolini, R. P. Mee, J. Comput.-Aided Mol Design 1997,11,425-445.
- (1997) J. Comput.-Aided Mol Design , vol.11 , pp. 425-445
- Elridge, M.D.¹ Murray, C.W.² Auton, T.R.³ Paolini, G.V.⁴ Mee, R.P.⁵

86
- 0030255303
- A. N. Jain, J. Comput.-Aided Mol. Design 1996,10, 427-440.
- (1996) J. Comput.-Aided Mol. Design , vol.10 , pp. 427-440
- Jain, A.N.¹

87
- 0029294584
- D. K. Gehlhaar, G. M. Verkhivker, P. A. Rejto, C. J. Sherman, D. B. Fogel, L. J. Fogel, S. T. Freer, Chem. Biol. 1995,2, 317-324.
- (1995) Chem. Biol. , vol.2 , pp. 317-324
- Gehlhaar, D.K.¹ Verkhivker, G.M.² Rejto, P.A.³ Sherman, C.J.⁴ Fogel, D.B.⁵ Fogel, L.J.⁶ Freer, S.T.⁷

88
- 13144279527
- P. J. Goodford, J. Mol. Graphics 1985,3,107-108.
- (1985) J. Mol. Graphics , vol.3 , pp. 107-108
- Goodford, P.J.¹

89
- 0024566942
- D. N. A. Boobbyer, P. J. Goodford, P. M. McWhinnie, R. C. Wade, J. Med. Chem. 1989, 32, 1083-1094.
- (1989) J. Med. Chem. , vol.32 , pp. 1083-1094
- Boobbyer, D.N.A.¹ Goodford, P.J.² McWhinnie, P.M.³ Wade, R.C.⁴

90
- 0027439587
- R. C. Wade, K. J. Clark, P. J. Goodford, J. Med. Chem. 1993,36,140-147.
- (1993) J. Med. Chem. , vol.36 , pp. 140-147
- Wade, R.C.¹ Clark, K.J.² Goodford, P.J.³

91
- 0027510004
- R. C. Wade, P. J. Goodford, J. Med. Chem. 1993,36,148-156.
- (1993) J. Med. Chem. , vol.36 , pp. 148-156
- Wade, R.C.¹ Goodford, P.J.²

92
- 0032153192
- C. W. Murray, T. R. Auton, M. D. Elridge, J. Comput.-Aided Mol Design 1999,12,503-519.
- (1999) J. Comput.-Aided Mol Design , vol.12 , pp. 503-519
- Murray, C.W.¹ Auton, T.R.² Elridge, M.D.³

93
- 0033559918
- A. M. Davis, S. J. Teague, Angew. Chem. Int. Ed. 1999,38,736-749.
- (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 736-749
- Davis, A.M.¹ Teague, S.J.²

94
- 0028102849
- S. Vajda, Z. Weng, R. Rosenfeld, C. DeLisi, Biochemistry 1994,33,13977-13988.
- (1994) Biochemistry , vol.33 , pp. 13977-13988
- Vajda, S.¹ Weng, Z.² Rosenfeld, R.³ DeLisi, C.⁴

95
- 0028455325
- E. C. Meng, I. D. Kuntz, D. J. Abraham, G. E. Kellogg, J. Comput.-Aided Mol. Design 1994, 8, 299-306.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 299-306
- Meng, E.C.¹ Kuntz, I.D.² Abraham, D.J.³ Kellogg, G.E.⁴

96
- 0029995624
- R. D. Head, M. L. Smythe, T. I. Oprea, C. L. Waller, S. M. Green, G. R. Marshall, J. Am. Chem. Soc. 1996,118, 3959-3969.
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 3959-3969
- Head, R.D.¹ Smythe, M.L.² Oprea, T.I.³ Waller, C.L.⁴ Green, S.M.⁵ Marshall, G.R.⁶

97
- 0031552370
- C. Zhang, G. Vasmatzis, J. L. Comette, C. DeLisi, J. Mol Biol. 1997,267, 707-726.
- (1997) J. Mol Biol. , vol.267 , pp. 707-726
- Zhang, C.¹ Vasmatzis, G.² Comette, J.L.³ DeLisi, C.⁴

98
- 0342489872
- UCSF Computer-Assisted Molecular Design Course, Jan. 16-18,1997, San Francisco
- P. Rose, Scoring Methods in Ligand Design, UCSF Computer-Assisted Molecular Design Course, Jan. 16-18,1997, San Francisco.
- Scoring Methods in Ligand Design
- Rose, P.¹

99
- 33751157207
- P. Gilli, V. Ferretti, G. Gilli, P. A. Brea, J. Phys. Chem. 1994, 98,1515-1518.
- (1994) J. Phys. Chem. , vol.98 , pp. 1515-1518
- Gilli, P.¹ Ferretti, V.² Gilli, G.³ Brea, P.A.⁴

100
- 0027650879
- M. J. Sippl, J. Comput.-Aided Mol. Design 1993, 7, 473-501.
- (1993) J. Comput.-Aided Mol. Design , vol.7 , pp. 473-501
- Sippl, M.J.¹

101
- 0028881193
- G. Verkhivker, K. Appelt, S. T. Freer, J. E. Villafranca, Prot. Eng. 1995, 8, 677-691.
- (1995) Prot. Eng. , vol.8 , pp. 677-691
- Verkhivker, G.¹ Appelt, K.² Freer, S.T.³ Villafranca, J.E.⁴

102
- 0001572810
- A. Wallquist, R. L. Jernigan, D. G. Covell, Protein Sci. 1995, 4, 1181-1903.
- (1995) Protein Sci. , vol.4 , pp. 1181-1903
- Wallquist, A.¹ Jernigan, R.L.² Covell, D.G.³

103
- 0029798563
- A. Wallquist, D. G. Covell, Proteins 1996,25, 403-419.
- (1996) Proteins , vol.25 , pp. 403-419
- Wallquist, A.¹ Covell, D.G.²

104
- 0033545622
- I. Muegge, Y. C. Martin, J. Med. Chem. 1999,42,791-804.
- (1999) J. Med. Chem. , vol.42 , pp. 791-804
- Muegge, I.¹ Martin, Y.C.²

105
- 0000882405
- J. B. O. Mitchell, R. A. Laskowski, A. Alex, M. J. Forster,'J. M. Thornton, J. Comp. Chem. 1999, 20,1177-1185.
- (1999) J. Comp. Chem. , vol.20 , pp. 1177-1185
- Mitchell, J.B.O.¹ Laskowski, R.A.² Alex, A.³ Forster, M.J.⁴ Thornton, J.M.⁵

106
- 0000823044
- J. B. O. Mitchell, R. A. Laskowski, A. Alex, J. M. Thornton, J. Comp. Chem. 1999,20,1165-1177.
- (1999) J. Comp. Chem. , vol.20 , pp. 1165-1177
- Mitchell, J.B.O.¹ Laskowski, R.A.² Alex, A.³ Thornton, J.M.⁴

107
- 0034645763
- H. Gohlke, M. Hendlich, G. Klebe, J. Mol. Biol. 1999,295,337-356.
- (1999) J. Mol. Biol. , vol.295 , pp. 337-356
- Gohlke, H.¹ Hendlich, M.² Klebe, G.³

108
- 84956798071
- Schloss Rauischholzhausen, Germany, March 15-18
- H. Gohlke, M. Hendlich, G. Klebe, Using Empirical Potentials to Predict Protein-Ligand Interactions, Talk given at the International Workshop on Virtual Screening, Schloss Rauischholzhausen, Germany, March 15-18,1999
- (1999) Using Empirical Potentials to Predict Protein-Ligand Interactions, Talk given at the International Workshop on Virtual Screening
- Gohlke, H.¹ Hendlich, M.² Klebe, G.³

109
- 84986518987
- B. K. Shoichet, D. L. Bodian, I. D. Kuntz, J. Comp. Chem. 1992,13, 380-387.
- (1992) J. Comp. Chem. , vol.13 , pp. 380-387
- Shoichet, B.K.¹ Bodian, D.L.² Kuntz, I.D.³

110
- 0001139413
- S. Makino, I. D. Kuntz, J. Comp. Chem. 1997,18,1812-1825.
- (1997) J. Comp. Chem. , vol.18 , pp. 1812-1825
- Makino, S.¹ Kuntz, I.D.²

111
- 84956848701
- Author, DOCK user manual, Version 4.0, Regents of the University of California, San Francisco
- Author, DOCK user manual, Version 4.0, Regents of the University of California, San Francisco 1997.
- (1997)

112
- 0033065220
- R. M. A. Knegtel, D. M. Bayada, R. A. Engh, W. von der Saal, V. J. van Geerestein, P. D. J. Grootenhuis, J. Comput.-Aided Mol. Design 1999,13,167-183.
- (1999) J. Comput.-Aided Mol. Design , vol.13 , pp. 167-183
- Knegtel, R.M.A.¹ Bayada, D.M.² Engh, R.A.³ von der Saal, W.⁴ van Geerestein, V.J.⁵ Grootenhuis, P.D.J.⁶

113
- 0032226476
- M. Stahl, H.-J. Bohm, J. Mol. Graphics Mod. 1998,16,121-132.
- (1998) J. Mol. Graphics Mod. , vol.16 , pp. 121-132
- Stahl, M.¹ Bohm, H.-J.²

114
- 0032488013
- C. Lemmen, T. Lengauer, G. Klebe, J. Med. Chem. 1998,41,4502-4520.
- (1998) J. Med. Chem. , vol.41 , pp. 4502-4520
- Lemmen, C.¹ Lengauer, T.² Klebe, G.³

115
- 0032604337
- R. B. Altman, K. Lauderdale, A. K. Dunker, L. Hunter (Eds.) World Scientific Publishing Co., Singapore
- C. Lemmen, A. Zien, R. Zimmer, T. Lengauer, in Proceedings of the Pacific Symposium on Bio-computing, R. B. Altman, K. Lauderdale, A. K. Dunker, L. Hunter (Eds.) World Scientific Publishing Co., Singapore 1999, pp. 482-493.
- (1999) Proceedings of the Pacific Symposium on Bio-computing , pp. 482-493
- Lemmen, C.¹ Zien, A.² Zimmer, R.³ Lengauer, T.⁴

116
- 84956825906
- Talk given at the International Workshop on Virtual Screening, Schloss Rauischholzhausen, Germany, March 15-18
- M. Stahl, Filters for Empirical Scoring Functions to Improve the Scoring in FlexX, Talk given at the International Workshop on Virtual Screening, Schloss Rauischholzhausen, Germany, March 15-18,1999.
- (1999) Filters for Empirical Scoring Functions to Improve the Scoring in FlexX
- Stahl, M.¹

117
- 0001027207
- E. J. Martin, R. E. Critchlow, D. C. Spellmeyer, S. Rosenberg, K. L. Spear, J. M. Blaney, Phar-macochem. Libr. 1998,29,133-146.
- (1998) Phar-macochem. Libr. , vol.29 , pp. 133-146
- Martin, E.J.¹ Critchlow, R.E.² Spellmeyer, D.C.³ Rosenberg, S.⁴ Spear, K.L.⁵ Blaney, J.M.⁶

118
- 0006964248
- G. Dale, C. Broger, A. D'Arcy, P. Hartmann, R. DeHoogt, S. Jolidon, I. Kompis, A. M. Labhardt, H. Langen, H. Locher, M. G. P. Page, D. Stuber, R. L. Then, B. Wipf, C. Oefner, J. Mol. Biol. 1997,226, 23-30.
- (1997) J. Mol. Biol. , vol.226 , pp. 23-30
- Dale, G.¹ Broger, C.² D'Arcy, A.³ Hartmann, P.⁴ DeHoogt, R.⁵ Jolidon, S.⁶ Kompis, I.⁷ Labhardt, A.M.⁸ Langen, H.⁹ Locher, H.¹⁰ Page, M.G.P.¹¹ Stuber, D.¹² Then, R.L.¹³ Wipf, B.¹⁴ Oefner, C.¹⁵

119
- 0033576680
- P. S. Charifson, J. J. Corkery, M. A. Murcko, W. P. Walters, J. Med. Chem. 1999, 42, 5100-5109.
- (1999) J. Med. Chem. , vol.42 , pp. 5100-5109
- Charifson, P.S.¹ Corkery, J.J.² Murcko, M.A.³ Walters, W.P.⁴

120
- 0032533791
- C. A. Baxter, C. W. Murray, D. E. Clark, D. R. Westhead, M. D. Eldridge, Proteins 1998, 33, 367-382.
- (1998) Proteins , vol.33 , pp. 367-382
- Baxter, C.A.¹ Murray, C.W.² Clark, D.E.³ Westhead, D.R.⁴ Eldridge, M.D.⁵

121
- 0028584446
- P. M. Colman, Curr. Op. Struct. Biol. 1994,4, 868-874.
- (1994) Curr. Op. Struct. Biol. , vol.4 , pp. 868-874
- Colman, P.M.¹

122
- 0001016942
- I. D. Kuntz, E. C. Meng, B. K. Shoichet, Ace. Chem. Res. 1994,27,117-123.
- (1994) Ace. Chem. Res. , vol.27 , pp. 117-123
- Kuntz, I.D.¹ Meng, E.C.² Shoichet, B.K.³

123
- 0029062909
- T. P. Lybrand, Curr. Op. Struct. Biol. 1995,5,224-228.
- (1995) Curr. Op. Struct. Biol. , vol.5 , pp. 224-228
- Lybrand, T.P.¹

124
- 0029100207
- R. Rosenfeld, S. Vajda, C. DeLisi, Ann. Rev. Biophys. Biomol. Struct. 1995,24,677-700.
- (1995) Ann. Rev. Biophys. Biomol. Struct. , vol.24 , pp. 677-700
- Rosenfeld, R.¹ Vajda, S.² DeLisi, C.³

125
- 0029902763
- T. Lengauer, M. Rarey, Curr. Op. Struct. Biol. 1996,6, 402-406.
- (1996) Curr. Op. Struct. Biol. , vol.6 , pp. 402-406
- Lengauer, T.¹ Rarey, M.²

126
- 84906438261
- J. S. Dixon, Proteins 1997, Suppl. 1,198-204.
- (1997) Proteins , pp. 198-204
- Dixon, J.S.¹

127
- 0032738842
- B. Kramer, M. Rarey, T. Lengauer, Proteins 1999,37, 228-241.
- (1999) Proteins , vol.37 , pp. 228-241
- Kramer, B.¹ Rarey, M.² Lengauer, T.³

128
- 0000490166
- J. Sadowski, J. Gasteiger, Chem. Rev. 1993,93, 2567-2581.
- (1993) Chem. Rev. , vol.93 , pp. 2567-2581
- Sadowski, J.¹ Gasteiger, J.²

129
- 84956756613
- Tripos Associates Inc., St. Louis.
- Concord, Tripos Associates Inc., St. Louis.
- Concord

130
- 31444452744
- J. Sadowski, C. Rudolph, J. Gasteiger, Tetrahedron Comput. Methodol. 1990,3, 537-547.
- (1990) Tetrahedron Comput. Methodol. , vol.3 , pp. 537-547
- Sadowski, J.¹ Rudolph, C.² Gasteiger, J.³

131
- 34247276151
- Molecular Networks GmbH Computerchemie, Erlangen
- Corina, 2.1, Molecular Networks GmbH Computerchemie, Erlangen 1998.
- (1998) Corina, 2.1

132
- 0027385177
- B. K. Shoichet, I. D. Kuntz, Prot. Eng. 1993,6,723-732.
- (1993) Prot. Eng. , vol.6 , pp. 723-732
- Shoichet, B.K.¹ Kuntz, I.D.²

133
- 0028452628
- R. L. DesJarlais, J. S. Dixon, J. Comput.-Aided Mol. Design 1994,8,231-242.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 231-242
- DesJarlais, R.L.¹ Dixon, J.S.²

134
- 0028491136
- N. Tomioka, A. Itai, J. Comput.-Aided Mol. Design 1994,8,347-366.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 347-366
- Tomioka, N.¹ Itai, A.²

135
- 0029025913
- D. Fischer, S. L. Lin, H. J. Wolfson, R. Nussinov, J. Mol. Biol. 1995,248,459-477.
- (1995) J. Mol. Biol. , vol.248 , pp. 459-477
- Fischer, D.¹ Lin, S.L.² Wolfson, H.J.³ Nussinov, R.⁴

136
- 0028940058
- B. Sandak, R. Nussinov, H. J. Wolfson, CABIOS1995,11, 87-99.
- (1995) CABIOS , vol.11 , pp. 87-99
- Sandak, B.¹ Nussinov, R.² Wolfson, H.J.³

137
- 0030154893
- W. Welch, J. Ruppert, A. N. Jain, Chem. Biol. 1996,3,449-462.
- (1996) Chem. Biol. , vol.3 , pp. 449-462
- Welch, W.¹ Ruppert, J.² Jain, A.N.³

138
- 0032519997
- C. M. Oshiro, I. D. Kuntz, Proteins 1998,30, 321-336.
- (1998) Proteins , vol.30 , pp. 321-336
- Oshiro, C.M.¹ Kuntz, I.D.²

139
- 0032571380
- P. Burkhard, P. Taylor, M. D. Walkinshaw, J. Mol. Biol. 1998,277,449-466.
- (1998) J. Mol. Biol. , vol.277 , pp. 449-466
- Burkhard, P.¹ Taylor, P.² Walkinshaw, M.D.³

140
- 0032899039
- D. K. Hendrix, T. E. Klein, I. D. Kuntz, Protein Sci. 1999,8,1010-1022.
- (1999) Protein Sci. , vol.8 , pp. 1010-1022
- Hendrix, D.K.¹ Klein, T.E.² Kuntz, I.D.³

141
- 0003878215
- J.-P. Salo, A. Yliniemela, J. Taskinen, J. Chem. Inf. Comput. Sci. 1998,38, 832-839.
- (1998) J. Chem. Inf. Comput. Sci. , vol.38 , pp. 832-839
- Salo, J.-P.¹ Yliniemela, A.² Taskinen, J.³

142
- 0031965676
- D. M. Lorber, B. K. Shoichet, Protein Sci. 1998, 7, 938-950.
- (1998) Protein Sci. , vol.7 , pp. 938-950
- Lorber, D.M.¹ Shoichet, B.K.²

143
- 0001168253
- S. Makino, I. D. Kuntz, J. Comp. Chem. 1998,19,1834-1852.
- (1998) J. Comp. Chem. , vol.19 , pp. 1834-1852
- Makino, S.¹ Kuntz, I.D.²

144
- 84986467005
- A. R. Leach, I. D. Kuntz, J. Comp. Chem. 1992,13, 730-748.
- (1992) J. Comp. Chem. , vol.13 , pp. 730-748
- Leach, A.R.¹ Kuntz, I.D.²

145
- 0032840569
- S. Makino, T. J. A. Ewing, I. D. Kuntz, J. Comput.-Aided Mol. Design 1999,13, 513-532.
- (1999) J. Comput.-Aided Mol. Design , vol.13 , pp. 513-532
- Makino, S.¹ Ewing, T.J.A.² Kuntz, I.D.³

146
- 0032855301
- M. Liu, S. Wang, J. Comput.-Aided Mol. Design 1999,13, 435-451.
- (1999) J. Comput.-Aided Mol. Design , vol.13 , pp. 435-451
- Liu, M.¹ Wang, S.²

147
- 0001386835
- D. J. Diller, C. L. M. J. Verlinde, J. Comp. Chem. 1999,16,1740-1751.
- (1999) J. Comp. Chem. , vol.16 , pp. 1740-1751
- Diller, D.J.¹ Verlinde, C.L.M.J.²

148
- 0033168443
- J. Wang, P. A. Kollman, I. D. Kuntz, Proteins 1999,1999,1-19.
- (1999) Proteins , vol.1999 , pp. 1-19
- Wang, J.¹ Kollman, P.A.² Kuntz, I.D.³

149
- 84986435824
- R. S. Judson, Y. T. Tan, E. Mori, C. Melius, E. P. Jaeger, A. M. Treasurywala, A. Mathiowetz, J. Comp. Chem. 1995,16,1405-1420.
- (1995) J. Comp. Chem. , vol.16 , pp. 1405-1420
- Judson, R.S.¹ Tan, Y.T.² Mori, E.³ Melius, C.⁴ Jaeger, E.P.⁵ Treasurywala, A.M.⁶ Mathiowetz, A.⁷

150
- 0029283717
- C. M. Oshiro, I. D. Kuntz, J. S. Dixon, J. Comput.-Aided Mol. Design 1995, 9,113-130.
- (1995) J. Comput.-Aided Mol. Design , vol.9 , pp. 113-130
- Oshiro, C.M.¹ Kuntz, I.D.² Dixon, J.S.³

151
- 84986492468
- K. P. Clark, Ajay, J. Comp. Chem. 1995,16,1210-1220.
- (1995) Ajay, J. Comp. Chem. , vol.16 , pp. 1210-1220
- Clark, K.P.¹

152
- 0032718788
- C. W. Murray, C. A. Baxter, A. D. Frenkel, J. Comput.-Aided Mol. Design 1999,13,547-562.
- (1999) J. Comput.-Aided Mol. Design , vol.13 , pp. 547-562
- Murray, C.W.¹ Baxter, C.A.² Frenkel, A.D.³

153
- 0002833057
- J. Apostolakis, A. Pluckthun, A. Caflisch, J. Comp. Chem. 1998,19,21-37.
- (1998) J. Comp. Chem. , vol.19 , pp. 21-37
- Apostolakis, J.¹ Pluckthun, A.² Caflisch, A.³

154
- 84956812570
- Blackwell Science, Oxford
- G. M. Keserii, I. Kolossvary, Molecular mechanics and conformational analysis in drug design, Blackwell Science, Oxford 1999.
- (1999) Molecular mechanics and conformational analysis in drug design
- Keserii, G.M.¹ Kolossvary, I.²

155
- 0000147236
- I. Kolossvary, W. C. Guida, J. Comp. Chem. 1999,20,1671-1684.
- (1999) J. Comp. Chem. , vol.20 , pp. 1671-1684
- Kolossvary, I.¹ Guida, W.C.²

156
- 0032190489
- V. Schnecke, C. A. Swanson, E. D. Getzoff, J. A. Tainer, L. A. Kuhn, Proteins 1998,33, 74-87.
- (1998) Proteins , vol.33 , pp. 74-87
- Schnecke, V.¹ Swanson, C.A.² Getzoff, E.D.³ Tainer, J.A.⁴ Kuhn, L.A.⁵

157
- 0028158936
- A. R. Leach, J. Mol. Biol. 1994,235, 345-356.
- (1994) J. Mol. Biol. , vol.235 , pp. 345-356
- Leach, A.R.¹

158
- 0031717170
- L. Schaffer, G. M. Verkhivker, Proteins 1998,33,295-310.
- (1998) Proteins , vol.33 , pp. 295-310
- Schaffer, L.¹ Verkhivker, G.M.²

159
- 0031581852
- R. M. A. Knegtel, I. D. Kuntz, C. M. Oshiro, J. Mol. Biol. 1997,266, 424-440.
- (1997) J. Mol. Biol. , vol.266 , pp. 424-440
- Knegtel, R.M.A.¹ Kuntz, I.D² Oshiro, C.M.³

160
- 13144295022
- J. H. Toney, P. M. D. Fitzgerald, N. Grover-Sharma, S. H. Olson, W. J. May, J. G. Sundelof, D. E. Vanderwall, K. A. Cleary, S. K. Grant, J. K. Wu, J. W. Kozarich, D. L. Pompliano, G. G. Hammond, Chem. Biol. 1998,5,185-196.
- (1998) Chem. Biol. , vol.5 , pp. 185-196
- Toney, J.H.¹ Fitzgerald, P.M.D.² Grover-Sharma, N.³ Olson, S.H.⁴ May, W.J.⁵ Sundelof, J.G.⁶ Vanderwall, D.E.⁷ Cleary, K.A.⁸ Grant, S.K.⁹ Wu, J.K.¹⁰ Kozarich, J.W.¹¹ Pompliano, D.L.¹² Hammond, G.G.¹³

161
- 0033587105
- W. E. Minke, D. J. Diller, W. G. J. Hoi, C. L. M. J. Verlinde, J. Med. Chem. 1999, 42,1778-1788.
- (1999) J. Med. Chem. , vol.42 , pp. 1778-1788
- Minke, W.E.¹ Diller, D.J.² Hoi, W.G.J.³ Verlinde, C.L.M.J.⁴

162
- 0032806924
- T. G. Davies, R. E. Hubbard, J. R. H. Tame, Protein Sci. 1999,8,1432-1444.
- (1999) Protein Sci. , vol.8 , pp. 1432-1444
- Davies, T.G.¹ Hubbard, R.E.² Tame, J.R.H.³

163
- 15944378734
- K. B. Lipkowitz, D. B. Boyd (Eds.) VCH Publishers, New York
- L. M. Balbes, S. W. Mascarella, D. B. Boyd, in Reviews in Computational Chemistry, Vol. 5, K. B. Lipkowitz, D. B. Boyd (Eds.) VCH Publishers, New York 1994, pp. 337-379.
- (1994) Reviews in Computational Chemistry , vol.5 , pp. 337-379
- Balbes, L.M.¹ Mascarella, S.W.² Boyd, D.B.³

164
- 0030534012
- K. B. Lipkowitz, D. B. Boyd (Eds.) VCH Publishers, New York
- A. C. Good, J. S. Mason, in Reviews in Computational Chemistry, Vol. 7, K. B. Lipkowitz, D. B. Boyd (Eds.) VCH Publishers, New York 1996, pp. 67-117.
- (1996) Reviews in Computational Chemistry , vol.7 , pp. 67-117
- Good, A.C.¹ Mason, J.S.²

165
- 84956770099
- K. B. Lipkowitz, D. B. Boyd (Eds.) Wiley-VCH, New York
- D. E. Clark, C. W. Murray, J. Li, in Reviews in Computational Chemistry, Vol. 72, K. B. Lipkowitz, D. B. Boyd (Eds.) Wiley-VCH, New York 1997, p. 67-126.
- (1997) Reviews in Computational Chemistry , vol.72 , pp. 67-126
- Clark, D.E.¹ Murray, C.W.² Li, J.³

166
- 0031491262
- K. B. Lipkowitz, D. B. Boyd (Eds.) Wiley-VCH, New York
- M. A. Murcko, in Reviews in Computational Chemistry, Vol. 11, K. B. Lipkowitz, D. B. Boyd (Eds.) Wiley-VCH, New York 1997, p. 1-66.
- (1997) Reviews in Computational Chemistry , vol.11 , pp. 1-66
- Murcko, M.A.¹

167
- 84956744467
- 461-415
- R. A. Lewis, A. R. Leach, J. Comput.-Aided Mol. Design 1994,8,461-415.
- (1994) J. Comput.-Aided Mol. Design , vol.8
- Lewis, R.A.¹ Leach, A.R.²

168
- 0028522983
- H.-J. Bohm, J. Comput.-Aided Mol. Design 1994,8,623-632.
- (1994) J. Comput.-Aided Mol. Design , vol.8 , pp. 623-632
- Bohm, H.-J.¹

169
- 0027546998
- C. M. Ho, G. R. Marshall, J. Comput.-Aided Mol. Design 1993, 7, 3-15.
- (1993) J. Comput.-Aided Mol. Design , vol.7 , pp. 3-15
- Ho, C.M.¹ Marshall, G.R.²

170
- 0029285723
- R. C. Glen, A. W. R. Payne, J. Comput.-Aided Mol. Design 1995,9,181-191.
- (1995) J. Comput.-Aided Mol. Design , vol.9 , pp. 181-191
- Glen, R.C.¹ Payne, A.W.R.²

171
- 0026345685
- J. B. Moon, W. J. Howe, Proteins 1991, 27,314-320.
- (1991) Proteins , vol.27 , pp. 314-320
- Moon, J.B.¹ Howe, W.J.²

172
- 34249753351
- K. Miiller (Ed.) Escom, Leiden
- A. Caflisch, M. Karplus, in De Novo Design, Vol. 3, K. Miiller (Ed.) Escom, Leiden 1995, pp. 51-84.
- (1995) De Novo Design , vol.3 , pp. 51-84
- Caflisch, A.¹ Karplus, M.²

173
- 0002606755
- W. P. Walters, M. T. Stahl, M. A. Murcko, Drug Discovery Today 1998,3,160-178.
- (1998) Drug Discovery Today , vol.3 , pp. 160-178
- Walters, W.P.¹ Stahl, M.T.² Murcko, M.A.³

174
- 0028337945
- T. Hurst, J. Chem. Inf. Comput. Sci. 1994,1994,190-196.
- (1994) J. Chem. Inf. Comput. Sci. , vol.1994 , pp. 190-196
- Hurst, T.¹

175
- 0032218265
- J. W. Godden, F. Stahura, J. Bajorath, J. Mol. Graphics Mod. 1999,16,139-143.
- (1999) J. Mol. Graphics Mod. , vol.16 , pp. 139-143
- Godden, J.W.¹ Stahura, F.² Bajorath, J.³

176
- 0028708270
- L. C. Kuo, J. A. Shafer (Eds.) Academic Press, San Diego
- M. D. Miller, R. P. Sheridan, S. K. Kearsley, D. J. Underwood, in Methods in Enzymology, Vol. 241, L. C. Kuo, J. A. Shafer (Eds.) Academic Press, San Diego 1994, pp. 354-370.
- (1994) Methods in Enzymology , vol.241 , pp. 354-370
- Miller, M.D.¹ Sheridan, R.P.² Kearsley, S.K.³ Underwood, D.J.⁴

177
- 0029836953
- S. B. Shuker, P. J. Hajduk, R. P. Meadows, S. W. Fesik, Science 1996,274,1531-1534.
- (1996) Science , vol.274 , pp. 1531-1534
- Shuker, S.B.¹ Hajduk, P.J.² Meadows, R.P.³ Fesik, S.W.⁴

178
- 0033566211
- I. Muegge, Y. C. Martin, P. J. Hajduk, S. W. Fesik, J. Med. Chem. 1999,42,2498-2503.
- (1999) J. Med. Chem. , vol.42 , pp. 2498-2503
- Muegge, I.¹ Martin, Y.C.² Hajduk, P.J.³ Fesik, S.W.⁴

179
- 0025054246
- R. L. DesJarlais, G. L. Seibel, I. D. Kuntz, P. S. Furth, J. C. Alvarez, P. R. Ortiz de Montellano, D. L. DeCamp, L. M. Babe, C. S. Craik, Proc. Natl Acad. Sci. USA 1990,87, 6644-6648.
- (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 6644-6648
- DesJarlais, R.L.¹ Seibel, G.L.² Kuntz, I.D.³ Furth, P.S.⁴ Alvarez, J.C.⁵ Ortiz de Montellano, P.R.⁶ DeCamp, D.L.⁷ Babe, L.M.⁸ Craik, C.S.⁹

180
- 0027522358
- B. K. Shoichet, R. M. Stroud, D. V. Santi, I. D. Kuntz, K. M. Perry, Science 1993,259,1445-1450.
- (1993) Science , vol.259 , pp. 1445-1450
- Shoichet, B.K.¹ Stroud, R.M.² Santi, D.V.³ Kuntz, I.D.⁴ Perry, K.M.⁵

181
- 0030753409
- L. R. Hoffman, I. D. Kuntz, J. M. White, J. Virology 1997, 71, 8808-8820.
- (1997) J. Virology , vol.71 , pp. 8808-8820
- Hoffman, L.R.¹ Kuntz, I.D.² White, J.M.³

182
- 0030964552
- D. A. Gschwend, W. Sirawaraporn, D. V. Santi, I. D. Kuntz, Proteins 1997,29,59-67.
- (1997) Proteins , vol.29 , pp. 59-67
- Gschwend, D.A.¹ Sirawaraporn, W.² Santi, D.V.³ Kuntz, I.D.⁴

183
- 17044457282
- I. Massova, P. Martin, A. Bulychev, R. Kocz, M. Doyle, B. F. P. Edwards, S. Mobashery, Bioorg. Med. Chem. Lett. 1998,8,2463-2466.
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 2463-2466
- Massova, I.¹ Martin, P.² Bulychev, A.³ Kocz, R.⁴ Doyle, M.⁵ Edwards, B.F.P.⁶ Mobashery, S.⁷

184
- 0033133969
- D. Tondi, U. Slomczynska, M. P. Costi, D. M. Watterson, S. Ghelli, B. K. Shoichet, Chem. Biol. 1999,6,319-331.
- (1999) Chem. Biol. , vol.6 , pp. 319-331
- Tondi, D.¹ Slomczynska, U.² Costi, M.P.³ Watterson, D.M.⁴ Ghelli, S.⁵ Shoichet, B.K.⁶

185
- 0028057975
- P. Y. S. Lam, P. K. Jadhav, C. J. Eyerman, C. N. Hodge, Y. Ru, L. T. Bacheler, J. L. Meek, M. J. Otto, M. M. Rayner, Y. N. Wong, C.-H. Chang, P. C. Weber, D. A. Jackson, T. R. Sharpe, S. Er-ickson-Viitanen, Science 1994,263,380-384.
- (1994) Science , vol.263 , pp. 380-384
- Lam, P.Y.S.¹ Jadhav, P.K.² Eyerman, C.J.³ Hodge, C.N.⁴ Ru, Y.⁵ Bacheler, L.T.⁶ Meek, J.L.⁷ Otto, M.J.⁸ Rayner, M.M.⁹ Wong, Y.N.¹⁰ Chang, C.-H.¹¹ Weber, P.C.¹² Jackson, D.A.¹³ Sharpe, T.R.¹⁴ Er-ickson-Viitanen, S.¹⁵

186
- 0004313701
- MDL Information Systems Inc., San Leandro, CA.
- Available Chemicals Directory, MDL Information Systems Inc., San Leandro, CA.
- Available Chemicals Directory,

187
- 0031587932
- T. Toyoda, R. K. B. Brobey, G.-I. Sano, T. Horii, N. Tomioka, A. Itai, Biochem. Biophys. Res. Comm. 1997,235, 515-519.
- (1997) Biochem. Biophys. Res. Comm. , vol.235 , pp. 515-519
- Toyoda, T.¹ Brobey, R.K.B.² Sano, G.-I.³ Horii, T.⁴ Tomioka, N.⁵ Itai, A.⁶

188
- 0033574397
- P. Burkhard, U. Hommel, M. Sanner, M. D. Walkinshaw, J. Mol. Biol. 1999,287,853-858.
- (1999) J. Mol. Biol. , vol.287 , pp. 853-858
- Burkhard, P.¹ Hommel, U.² Sanner, M.³ Walkinshaw, M.D.⁴

189
- 0034628541
- E. Perola, K. Xu, T. M. Kollmeyer, S. H. Kaufmann, F. G. Prendergast. Y.-P. Pang, J. Med. Chem. 2000, 43, 401-408.
- (2000) J. Med. Chem. , vol.43 , pp. 401-408
- Perola, E.¹ Xu, K.² Kollmeyer, T.M.³ Kaufmann, S.H.⁴ Prendergast, Y.-P.⁵ Pang, F.G.⁶

190
- 84956794664
- A study of 100,000 compounds docked to the estrogen receptor
- A study of 100,000 compounds docked to the estrogen receptor: http://www.protherics.com/crunch/

191
- 0040570293
- J. W. Godden, F. L. Stahura, J. Bajorath, J. Comp. Chem. 1999,20,1634-1643.
- (1999) J. Comp. Chem. , vol.20 , pp. 1634-1643
- Godden, J.W.¹ Stahura, F.L.² Bajorath, J.³

192
- 0033117680
- B. E. Fink, D. S. Mortensen, S. R. Stauffer, D. A. Zachary, J. A. Katzenellenbogen, Chem. Biol. 1999,6,205-219.
- (1999) Chem. Biol. , vol.6 , pp. 205-219
- Fink, B.E.¹ Mortensen, D.S.² Stauffer, S.R.³ Zachary, D.A.⁴ Katzenellenbogen, J.A.⁵

193
- 0031127997
- E. K. Kick, D. C. Roe, A. G. Skillman, G. Liu, T. J. A. Ewing, Y. Sun, I. D. Kuntz, J. A. Ellman, Chem. Biol. 1997, 4,297-307.
- (1997) Chem. Biol. , vol.4 , pp. 297-307
- Kick, E.K.¹ Roe, D.C.² Skillman, A.G.³ Liu, G.⁴ Ewing, T.J.A.⁵ Sun, Y.⁶ Kuntz, I.D.⁷ Ellman, J.A.⁸

194
- 0033594354
- T. S. Haque, A. G. Skillman, C. E. Lee, H. Habashita, I. Y. Gluzman, T. A. Ewing, D. E. Goldberg, I. D. Kuntz, J. A. Ellman, J. Med. Chem. 1999,42,1428-1440.
- (1999) J. Med. Chem. , vol.42 , pp. 1428-1440
- Haque, T.S.¹ Skillman, A.G.² Lee, C.E.³ Habashita, H.⁴ Gluzman, I.Y.⁵ Ewing, T.A.⁶ Goldberg, D.E.⁷ Kuntz, I.D.⁸ Ellman, J.A.⁹

195
- 0032542040
- C. D. Carroll, T. O. Johnson, S. Tao, G. Lauri, M. Orlowski, I. Y. Gluzman, D. E. Goldberg, R. E. Dolle, Bioorg. Med. Chem. Lett. 1998,8,3203-3206.
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 3203-3206
- Carroll, C.D.¹ Johnson, T.O.² Tao, S.³ Lauri, G.⁴ Orlowski, M.⁵ Gluzman, I.Y.⁶ Goldberg, D.E.⁷ Dolle, R.E.⁸

196
- 0033400589
- F. L. Stahura, L. Xue, J. W. Godden, J. Bajorath, J. Mol. Graphics Mod. 1999,17,1-9.
- (1999) J. Mol. Graphics Mod. , vol.17 , pp. 1-9
- Stahura, F.L.¹ Xue, L.² Godden, J.W.³ Bajorath, J.⁴

197
- 0040541621
- H.-J. Bohm, D. W. Banner, L. Weber, J. Comput.-Aided Mol. Design 1999,13, 51-56.
- (1999) J. Comput.-Aided Mol. Design , vol.13 , pp. 51-56
- Bohm, H.-J.¹ Banner, D.W.² Weber, L.³

198
- 0033102135
- C. Oefner, A. Binggeli, V. Breu, D. Bur, J.-P. Clozel, A. D'Arcy, A. Dorn, W. Fischli, F. Gruninger, R. Guller, G. Hirth, H. P. Marki, S. Mathews, M. Miiller, R. G. Ridley, H. Stadler, E. Vieira, M. Wilhelm, F. K. Winkler, W. Wostl, Chem. Biol. 1998, 6,127-131.
- (1998) Chem. Biol. , vol.6 , pp. 127-131
- Oefner, C.¹ Binggeli, A.² Breu, V.³ Bur, D.⁴ Clozel, J.-P.⁵ D'Arcy, A.⁶ Dorn, A.⁷ Fischli, W.⁸ Gruninger, F.⁹ Guller, R.¹⁰ Hirth, G.¹¹ Marki, H.P.¹² Mathews, S.¹³ Miiller, M.¹⁴ Ridley, R.G.¹⁵ Stadler, H.¹⁶ Vieira, E.¹⁷ Wilhelm, M.¹⁸ Winkler, F.K.¹⁹ Wostl, W.²⁰ more..

199
- 0031569368
- F. R. Salemme, J. Spurlino, R. Bone, Structure 1997,5, 319-324.
- (1997) Structure , vol.5 , pp. 319-324
- Salemme, F.R.¹ Spurlino, J.² Bone, R.³

200
- 0030667760
- P. L. Myers, Curr. Op. Biotechnology 1997,8,701-707.
- (1997) Curr. Op. Biotechnology , vol.8 , pp. 701-707
- Myers, P.L.¹

201
- 15444357766
- W. C. Lumma, K. M. Witherup, T. J. Tucker, S. F. Brady, J. T. Sisko, A. M. Naylor-Olsen, S. D. Lewis, B. J. Lucas, J. P. Vacca, J. Med. Chem. 1998,41,1011-1013.
- (1998) J. Med. Chem. , vol.41 , pp. 1011-1013
- Lumma, W.C.¹ Witherup, K.M.² Tucker, T.J.³ Brady, S.F.⁴ Sisko, J.T.⁵ Naylor-Olsen, A.M.⁶ Lewis, S.D.⁷ Lucas, B.J.⁸ Vacca, J.P.⁹

202
- 19244378454
- S. F. Brady, K. J. Stauffer, W. C. Lumma, G. M. Smith, H. G. Ramjit, S. D. Lewis, B. J. Lucas, S. J. Gardell, E. A. Lyle, S. D. Appleby, J. J. Cook, M. A. Holahan, M. T. Stranieri, J. J. Lynch, jr., J. H. Lin, I.-W. Chen, K. Vastag, A. M. Nayor-Olsen, J. P. Vacca, J. Med. Chem. 1998, 41,401-406.
- (1998) J. Med. Chem. , vol.41 , pp. 401-406
- Brady, S.F.¹ Stauffer, K.J.² Lumma, W.C.³ Smith, G.M.⁴ Ramjit, H.G.⁵ Lewis, S.D.⁶ Lucas, B.J.⁷ Gardell, S.J.⁸ Lyle, E.A.⁹ Appleby, S.D.¹⁰ Cook, J.J.¹¹ Holahan, M.A.¹² Stranieri, M.T.¹³ Lynch, J.J.¹⁴ Lin, J.H.¹⁵ Chen, I.-W.¹⁶ Vastag, K.¹⁷ Nayor-Olsen, A.M.¹⁸ Vacca, J.P.¹⁹

203
- 0029855561
- A. Rockwell, M. Melden, R. A. Copeland, K. Hardman, C. P. Decicco, W. F. DeGrado, J. Am. Chem. Soc. 1996,118,10337-10338.
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 10337-10338
- Rockwell, A.¹ Melden, M.² Copeland, R.A.³ Hardman, K.⁴ Decicco, C.P.⁵ DeGrado, W.F.⁶

204
- 0002716825
- H. Kubinyi, Curr. Op. Drug Disc. Dev. 1998,1,16-27.
- (1998) Curr. Op. Drug Disc. Dev. , vol.1 , pp. 16-27
- Kubinyi, H.¹

205
- 0031970278
- R. A. Fecik, K. E. Frank, E. J. Gentry, S. R. Menon, L. A. Mitschler, H. Telikepalli, Med. Res. Rev. 1998,18,149-185.
- (1998) Med. Res. Rev. , vol.18 , pp. 149-185
- Fecik, R.A.¹ Frank, K.E.² Gentry, E.J.³ Menon, S.R.⁴ Mitschler, L.A.⁵ Telikepalli, H.⁶

206
- 0032253177
- R. E. Dolle, Mol. Diversity 1998,3,199-233.
- (1998) Mol. Diversity , vol.3 , pp. 199-233
- Dolle, R.E.¹

207
- 84956807102
- M. Leibl, J. Comb. Chem. 1999,1, 3-24.
- (1999) J. Comb. Chem. , vol.1 , pp. 3-24
- Leibl, M.¹

208
- 0033156688
- R. E. Dolle, K. H. Nelson Jr, J. Comb. Chem. 1999,1,235-282.
- (1999) J. Comb. Chem. , vol.1 , pp. 235-282
- Dolle, R.E.¹ Nelson, K.H.²

209
- 0032836350
- D. L. Kilpatrick, S. Watson, S. Ulhaq, Comb. Chem. High-Throughput Screening 1999,2,211-221.
- (1999) Comb. Chem. High-Throughput Screening , vol.2 , pp. 211-221
- Kilpatrick, D.L.¹ Watson, S.² Ulhaq, S.³

210
- 0033287914
- C. D. Floyd, C. Leblanc, M. Whitaker, Prog. Med. Chem. 1999,36,91-168.
- (1999) Prog. Med. Chem. , vol.36 , pp. 91-168
- Floyd, C.D.¹ Leblanc, C.² Whitaker, M.³

211
- 0032087776
- M. Whittaker, Curr. Op. Chem. Biol. 1998,2, 386-396.
- (1998) Curr. Op. Chem. Biol. , vol.2 , pp. 386-396
- Whittaker, M.¹

212
- 0031970278
- R. A. Fecik, K. E. Frank, E. J. Gentry, S. R. Menon, L. A. Mitscher, H. Telikepalli, Med. Res. Rev. 1998,18,149-185.
- (1998) Med. Res. Rev. , vol.18 , pp. 149-185
- Fecik, R.A.¹ Frank, K.E.² Gentry, E.J.³ Menon, S.R.⁴ Mitscher, L.A.⁵ Telikepalli, H.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.