Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): Coapplication of structure-based design and rapid multiple analogue synthesis on solid support

Journal of Medicinal Chemistry

Volumn 41, Issue 3, 1998, Pages 401-406

  Brady, S F ^a   Stauffer, K J ^a   Lumma, W C ^a   Smith, G M ^a   Ramjit, H G ^a   Lewis, S D ^a   Lucas, B J ^a   Gardell, S J ^a   Lyle, E A ^a   Appleby, S D ^a   Cook, J J ^a   Holahan, M A ^a   Stranieri, M T ^a   Lynch J J , Jr ^a   Lin, J H ^a   Chen, I W ^a   Vastag, K ^a   Naylor Olsen, A M ^a   Vacca, J P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N (9 HYDROXY 9 FLUORENECARBOXYL)PROLYL 4 AMINOCYCLOHEXYLMETHYL AMIDE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; THROMBOSIS;

EID: 19244378454     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9705014     Document Type: Article

References (11)