Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?

Chemistry and Biology

Volumn 6, Issue 3, 1999, Pages 127-131

  Oefner, C ^a   Binggeli, A ^a   Breu, V ^a   Bur, D ^a   Clozel, J P ^b   D'Arcy, A ^a   Dorn, A ^a   Fischli, W ^b   Gruninger F ^a   Guller R ^c   Hirth, G ^a   Märki, Hp ^a   Mathews, S ^a   Muller M ^a   Ridley, R G ^a   Stadler, H ^a   Vieira, E ^a   Wilhelm, M ^a   Winkler, Fk ^a   Wostl, W ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

^c Chemspeed Ltd   (Switzerland)

Author keywords

Aspartic proteinase; Drug design; Induced fit; Renin; X ray analysis

Indexed keywords

EID: 0033102135     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(99)89004-8     Document Type: Article

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