Specificity in structure-based drug design: Identification of a novel, selective inhibitor of Pneumocystis carinii dihydrofolate reductase

Proteins: Structure, Function and Genetics

Volumn 29, Issue 1, 1997, Pages 59-67

  Gschwend, Daniel A ^a,c   Sirawaraporn, Worachart ^b   Santi, Daniel V ^a   Kuntz, Irwin D ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Helios Pharmaceuticals   (United States)

^d UCSF Medical Center and Associate Clinical UCSF School of Pharmacy   (United States)

Author keywords

Antifungal; DOCK; Lead discovery; Molecular docking; Species specificity

Indexed keywords

DIHYDROFOLATE REDUCTASE INHIBITOR;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; DRUG DESIGN; FOLIC ACID ANTAGONISTS; LIGANDS; PNEUMOCYSTIS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE;

PNEUMOCYSTIS CARINII;

EID: 0030964552     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(199709)29:1<59::AID-PROT4>3.0.CO;2-A     Document Type: Article

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