-
1
-
-
0029036377
-
The catalytic mechanism and structure of thymidylate synthase
-
Carreras, C.W. & Santi, D.V. (1995). The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem. 64, 721-762.
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 721-762
-
-
Carreras, C.W.1
Santi, D.V.2
-
2
-
-
0023121146
-
Atomic structure of thymidylate synthase: Target for rational drug design
-
Hardy, LW., et al., & Stroud, R.M. (1987). Atomic structure of thymidylate synthase: target for rational drug design. Science 235, 448-455.
-
(1987)
Science
, vol.235
, pp. 448-455
-
-
Hardy, L.W.1
Stroud, R.M.2
-
3
-
-
0025295135
-
Pairwise specificity and sequential binding in enzyme catalysis: Thymidylate synthase
-
Finer-Moore, J.S., Montfort, W.R. & Stroud, R.M. (1990). Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase. Biochemistry 29, 6977-6986.
-
(1990)
Biochemistry
, vol.29
, pp. 6977-6986
-
-
Finer-Moore, J.S.1
Montfort, W.R.2
Stroud, R.M.3
-
4
-
-
0027102178
-
Cofactor triggers the conformational change in thymidylate synthase: Implications for an ordered binding mechanism
-
Kamb, A., Finer-Moore, J.S. & Stroud, R.M. (1992). Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism. Biochemistry 31, 12876-12884.
-
(1992)
Biochemistry
, vol.31
, pp. 12876-12884
-
-
Kamb, A.1
Finer-Moore, J.S.2
Stroud, R.M.3
-
5
-
-
0027171350
-
Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei
-
Finer-Moore, J., et al., & Stroud, R.M. (1993). Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J. Mol. Biol. 232, 1101-1116.
-
(1993)
J. Mol. Biol.
, vol.232
, pp. 1101-1116
-
-
Finer-Moore, J.1
Stroud, R.M.2
-
6
-
-
0027151834
-
Stereochemistry of a multistep/bipartite methyl transfer reaction: Thymidylate synthase
-
Stroud, R.M. & Finer-Moore, J.S. (1993). Stereochemistry of a multistep/bipartite methyl transfer reaction: thymidylate synthase. FASEB J. 7, 671-677.
-
(1993)
FASEB J.
, vol.7
, pp. 671-677
-
-
Stroud, R.M.1
Finer-Moore, J.S.2
-
7
-
-
0025615583
-
Plastic adaptation toward mutations in proteins: Structural comparison of thymidylate synthases
-
Perry, K.M., et al., & Stroud, R.M. (1990). Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins 8, 315-333.
-
(1990)
Proteins
, vol.8
, pp. 315-333
-
-
Perry, K.M.1
Stroud, R.M.2
-
8
-
-
0000875305
-
Studies on fluorinated pyrimidines: XIII. Inhibition of thymidylate synthase
-
Hartman, K.-R. & Heidelberger, C. (1958). Studies on fluorinated pyrimidines: XIII. Inhibition of thymidylate synthase. J. Biol. Chem. 236, 3006-3013.
-
(1958)
J. Biol. Chem.
, vol.236
, pp. 3006-3013
-
-
Hartman, K.-R.1
Heidelberger, C.2
-
10
-
-
0025311258
-
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate
-
Erratum. (1990). Biochemistry 29, 10864
-
Montfort, W.R., et al., & Stroud, R.M. (1990). Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry 29, 6964-6977. Erratum. (1990). Biochemistry 29, 10864.
-
(1990)
Biochemistry
, vol.29
, pp. 6964-6977
-
-
Montfort, W.R.1
Stroud, R.M.2
-
11
-
-
0028174639
-
A C-terminal conformational equilibrium in thymidylate synthase observed by electron paramagnetic resonance spectroscopy
-
Carreras, C.W., Naber, N., Cooke, R. & Santi, D.V. (1994). A C-terminal conformational equilibrium in thymidylate synthase observed by electron paramagnetic resonance spectroscopy. Biochemistry 33, 2071-2077.
-
(1994)
Biochemistry
, vol.33
, pp. 2071-2077
-
-
Carreras, C.W.1
Naber, N.2
Cooke, R.3
Santi, D.V.4
-
12
-
-
0030466872
-
An essential role for water in an enzyme reaction mechanism: The crystal structure of the thymidylate synthase mutant E580
-
Sage, C.R., Rutenber, E.E., Stout, T.J. & Stroud, R.M. (1996). An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E580. Biochemistry 35, 16270-16281.
-
(1996)
Biochemistry
, vol.35
, pp. 16270-16281
-
-
Sage, C.R.1
Rutenber, E.E.2
Stout, T.J.3
Stroud, R.M.4
-
13
-
-
0029118446
-
Carrier-and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: Correlates of molecular-structure and biological activity
-
Westerhof, G.R., et al., & Pinedo, H. M. (1995). Carrier-and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. Mol. Pharmacol. 48, 459-471.
-
(1995)
Mol. Pharmacol.
, vol.48
, pp. 459-471
-
-
Westerhof, G.R.1
Pinedo, H.M.2
-
14
-
-
0026068379
-
Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: Role of carrier- and receptor-mediated transport systems
-
Westerhof, G.R., et al., & Schornagel, J.H. (1991). Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems. Cancer Res. 51, 5507-5513.
-
(1991)
Cancer Res.
, vol.51
, pp. 5507-5513
-
-
Westerhof, G.R.1
Schornagel, J.H.2
-
16
-
-
0025608931
-
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors
-
Jansen, G., et al., & Jackman, A.L. (1990). Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors. Cancer Res. 50, 7544-7548.
-
(1990)
Cancer Res.
, vol.50
, pp. 7544-7548
-
-
Jansen, G.1
Jackman, A.L.2
-
17
-
-
0021015054
-
Biochemical effects of a quinazoline inhibitor of thymidylate synthase, CB371 7, on human lymphoblastoid cells
-
Jackson, R.C., Jackman, A.L. & Calvert, A.H. (1983). Biochemical effects of a quinazoline inhibitor of thymidylate synthase, CB371 7, on human lymphoblastoid cells. Biochem. Pharmacol. 32, 3783-3790.
-
(1983)
Biochem. Pharmacol.
, vol.32
, pp. 3783-3790
-
-
Jackson, R.C.1
Jackman, A.L.2
Calvert, A.H.3
-
19
-
-
0027477992
-
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase
-
Duch, D.S., et al., & Wilson, H.R. (1993). Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res. 53, 810-818.
-
(1993)
Cancer Res.
, vol.53
, pp. 810-818
-
-
Duch, D.S.1
Wilson, H.R.2
-
20
-
-
0029947689
-
In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase
-
Hanlon, M.H. & Ferone, R. (1996). In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase. Cancer Res. 56, 3301-3306.
-
(1996)
Cancer Res.
, vol.56
, pp. 3301-3306
-
-
Hanlon, M.H.1
Ferone, R.2
-
21
-
-
0027502819
-
The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells
-
Gibson, W., et al., & Jackman, A.L. (1993). The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells. Biochem. Pharmacol. 45, 863-869.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 863-869
-
-
Gibson, W.1
Jackman, A.L.2
-
22
-
-
0025744809
-
The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats
-
Jodrell, D.I., Newell, D.R., Gibson, W., Hughes, L.R. & Calvert, A.H. (1991). The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats. Cancer Chemother. Pharmacol. 28, 331-338.
-
(1991)
Cancer Chemother. Pharmacol.
, vol.28
, pp. 331-338
-
-
Jodrell, D.I.1
Newell, D.R.2
Gibson, W.3
Hughes, L.R.4
Calvert, A.H.5
-
23
-
-
0026519367
-
Kinetic characteristics of ICI D1694: A quinazoline antifolate which inhibits thymidylate synthase
-
Ward, W.H., Kimbell, R. & Jackman, A.L. (1992). Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase. Biochem. Pharmacol. 43, 2029-2031.
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 2029-2031
-
-
Ward, W.H.1
Kimbell, R.2
Jackman, A.L.3
-
25
-
-
0022518273
-
Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase
-
Pogolotti, A.L., Jr., Danenberg, P.V. & Santi, D.V. (1986). Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. J. Med. Chem. 29, 478-482.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 478-482
-
-
Pogolotti Jr., A.L.1
Danenberg, P.V.2
Santi, D.V.3
-
26
-
-
0000299873
-
-
Blakely, R.L. & Bencovic, S.J., eds, Wiley, New York
-
Santi, D.V. & Danenberg, P.V. (1 984). In Folates and Pterins, Vol. I. (Blakely, R.L. & Bencovic, S.J., eds), pp. 345-399, Wiley, New York.
-
(1984)
Folates and Pterins, Vol. I
, vol.1
, pp. 345-399
-
-
Santi, D.V.1
Danenberg, P.V.2
-
27
-
-
85030337439
-
Mode of binding of the folate analogs PDDF and BW1843U89 to human thymidylate synthase
-
Dev, I.K., Yates, B.B., Hanlon, M., Ferone, R. & Dallas, W.S. (1992). Mode of binding of the folate analogs PDDF and BW1843U89 to human thymidylate synthase. Abstract from the Meeting of the American Association for Cancer Research, 2429.
-
(1992)
Abstract from the Meeting of the American Association for Cancer Research
, pp. 2429
-
-
Dev, I.K.1
Yates, B.B.2
Hanlon, M.3
Ferone, R.4
Dallas, W.S.5
-
28
-
-
0019379907
-
Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase
-
Lockshin, A. & Danenberg, P.V. (1981). Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase. Biochem. Pharmacol. 30, 247-257.
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 247-257
-
-
Lockshin, A.1
Danenberg, P.V.2
-
29
-
-
0012395179
-
Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: Its mechanism of action and inhibition by fluorinated nucleotides
-
Reyes, P. & Heidelberger, C. (1965). Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides. Mol. Pharmacol. 1, 14-30.
-
(1965)
Mol. Pharmacol.
, vol.1
, pp. 14-30
-
-
Reyes, P.1
Heidelberger, C.2
-
30
-
-
0026680632
-
Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase
-
Liu, L. & Santi, D.V. (1992). Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase. Biochemistry 31, 5100-5104.
-
(1992)
Biochemistry
, vol.31
, pp. 5100-5104
-
-
Liu, L.1
Santi, D.V.2
-
31
-
-
0031440846
-
A Novel dCMP methylase by engineering thymidylate synthase
-
Agarwalla, S., et al., & Santi, D.V. (1997). A Novel dCMP methylase by engineering thymidylate synthase. Biochemistry 36, 15909-1 5917.
-
(1997)
Biochemistry
, vol.36
, pp. 15909-15917
-
-
Agarwalla, S.1
Santi, D.V.2
-
32
-
-
0002452464
-
Oscillation data reduction program
-
(Sawyer, L., Isaacs, N. & Bailey, S., eds), SERC Daresbury Laboratory, UK
-
Otwinowski, Z. (1993). Oscillation data reduction program. In Proceedings of the CCP4 Study Weekend: 'Data Collection and Processing'. (Sawyer, L., Isaacs, N. & Bailey, S., eds), SERC Daresbury Laboratory, UK.
-
(1993)
Proceedings of the CCP4 Study Weekend: 'Data Collection and Processing'
-
-
Otwinowski, Z.1
-
34
-
-
0000082544
-
CHAIN - A crystallographic modelling program
-
Sack, J.S. (1988). CHAIN - a crystallographic modelling program. J. Mol. Graph. 6, 244-245.
-
(1988)
J. Mol. Graph.
, vol.6
, pp. 244-245
-
-
Sack, J.S.1
-
35
-
-
0029644940
-
Where freedom is given, liberties are taken
-
Kleywegt, G.J. & Jones, T.A. (1995). Where freedom is given, liberties are taken. Structure 3, 535-540.
-
(1995)
Structure
, vol.3
, pp. 535-540
-
-
Kleywegt, G.J.1
Jones, T.A.2
-
36
-
-
0030589514
-
Phi/Psi-chology: Ramachandran revisited
-
Kleywegt, G.J. & Jones, T.A. (1996). Phi/Psi-chology: Ramachandran revisited. Structure 4, 1395-1400.
-
(1996)
Structure
, vol.4
, pp. 1395-1400
-
-
Kleywegt, G.J.1
Jones, T.A.2
-
37
-
-
0000243829
-
PROCHECK: A program to check the stereochemical quality of protein structures
-
Laskowski, R.A., MacArthur, M.W., Moss, D.S. & Thornton, J.M. (1993). PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl. Cryst. 26, 283-291.
-
(1993)
J. Appl. Cryst.
, vol.26
, pp. 283-291
-
-
Laskowski, R.A.1
MacArthur, M.W.2
Moss, D.S.3
Thornton, J.M.4
|