-
1
-
-
0014704663
-
Quantitation of new bone formation in intramuscular implants of bone matrix in rabbits
-
Urist, M. R., Jurist, J. M. Jr, Dubuc, F. L. & Strates, B. S. Quantitation of new bone formation in intramuscular implants of bone matrix in rabbits. Clin. Orthop. Relat. Res. 68, 279-293 (1970).
-
(1970)
Clin. Orthop. Relat. Res.
, vol.68
, pp. 279-293
-
-
Urist, M.R.1
Jurist, J.M.2
Dubuc, F.L.3
Strates, B.S.4
-
2
-
-
0024779690
-
Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone
-
Rosen, V., et al. Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone. Connect. Tissue Res. 20, 313-319 (1989).
-
(1989)
Connect. Tissue Res.
, vol.20
, pp. 313-319
-
-
Rosen, V.1
-
3
-
-
42549158413
-
Bone morphogenetic protein 9 is a circulating vascular quiescence factor
-
David, L., et al. Bone morphogenetic protein 9 is a circulating vascular quiescence factor. Circ. Res. 102, 914-922 (2008).
-
(2008)
Circ. Res.
, vol.102
, pp. 914-922
-
-
David, L.1
-
5
-
-
84880943217
-
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-Dependent arterial quiescence
-
Laux, D. W., et al. Circulating Bmp10 acts through endothelial Alk1 to mediate flow-Dependent arterial quiescence. Development 140, 3403-3412 (2013).
-
(2013)
Development
, vol.140
, pp. 3403-3412
-
-
Laux, D.W.1
-
6
-
-
64049114344
-
A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4 BMP6 and BMP9 in bovine and human serum
-
Herrera, B. & Inman, G. J. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 10, 20 (2009).
-
(2009)
BMC Cell Biol.
, vol.10
, pp. 20
-
-
Herrera, B.1
Inman, G.J.2
-
7
-
-
0028332818
-
Identification of type i receptors for osteogenic protein 1 and bone morphogenetic protein 4
-
ten Dijke, P., et al. Identification of type I receptors for osteogenic protein 1 and bone morphogenetic protein 4. J. Biol. Chem. 269, 16985-16988 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16985-16988
-
-
Ten Dijke, P.1
-
8
-
-
0029153741
-
Identification of a human type II receptor for bone morphogenetic protein 4 that forms differential heteromeric complexes with bone morphogenetic protein type i receptors
-
Nohno, T., et al. Identification of a human type II receptor for bone morphogenetic protein 4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J. Biol. Chem. 270, 22522-22526 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22522-22526
-
-
Nohno, T.1
-
9
-
-
0029117276
-
Cloning and characterization of a human type II receptor for bone morphogenetic proteins
-
Rosenzweig, B. L., et al. Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc. Natl Acad. Sci. USA 92, 7632-7636 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7632-7636
-
-
Rosenzweig, B.L.1
-
10
-
-
33847369980
-
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) endothelial cells
-
David, L., Mallet, C., Mazerbourg, S., Feige, J. J. & Bailly, S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) endothelial cells. Blood 109, 1953-1961 (2006).
-
(2006)
Blood
, vol.109
, pp. 1953-1961
-
-
David, L.1
Mallet, C.2
Mazerbourg, S.3
Feige, J.J.4
Bailly, S.5
-
11
-
-
67349187409
-
Bone morphogenetic protein heterodimers assemble heteromeric type i receptor complexes to pattern the dorsoventral axis
-
Little, S. C. & Mullins, M. C. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol. 11, 637-643 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 637-643
-
-
Little, S.C.1
Mullins, M.C.2
-
12
-
-
0032006298
-
Establishment of a BMP 4 morphogen gradient by long-range inhibition
-
Jones, C. M. & Smith, J. C. Establishment of a BMP 4 morphogen gradient by long-range inhibition. Dev. Biol. 194, 12-17 (1998).
-
(1998)
Dev. Biol.
, vol.194
, pp. 12-17
-
-
Jones, C.M.1
Smith, J.C.2
-
13
-
-
77951243657
-
Identification of a key residue mediating bone morphogenetic protein (BMP) 6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity
-
Song, K., et al. Identification of a key residue mediating bone morphogenetic protein (BMP) 6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity. J. Biol. Chem. 285, 12169-12180 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12169-12180
-
-
Song, K.1
-
14
-
-
84861495270
-
Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium
-
Yao, Y., et al. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood 119, 5037-5047 (2012).
-
(2012)
Blood
, vol.119
, pp. 5037-5047
-
-
Yao, Y.1
-
15
-
-
43149095145
-
Bone morphogenetic proteins signal through the transforming growth factor-β type III receptor
-
Kirkbride, K. C., Townsend, T. A., Bruinsma, M. W., Barnett, J. V. & Blobe, G. C. Bone morphogenetic proteins signal through the transforming growth factor-β type III receptor. J. Biol. Chem. 283, 7628-7637 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7628-7637
-
-
Kirkbride, K.C.1
Townsend, T.A.2
Bruinsma, M.W.3
Barnett, J.V.4
Blobe, G.C.5
-
16
-
-
34247331476
-
BMP 9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
-
Scharpfenecker, M., et al. BMP 9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. J. Cell Sci. 120, 964-972 (2007).
-
(2007)
J. Cell Sci.
, vol.120
, pp. 964-972
-
-
Scharpfenecker, M.1
-
17
-
-
70849085415
-
The RGM/ DRAGON family of BMP co-receptors
-
Corradini, E., Babitt, J. L. & Lin, H. Y. The RGM/ DRAGON family of BMP co-receptors. Cytokine Growth Factor Rev. 20, 389-398 (2009).
-
(2009)
Cytokine Growth Factor Rev.
, vol.20
, pp. 389-398
-
-
Corradini, E.1
Babitt, J.L.2
Lin, H.Y.3
-
18
-
-
33744985816
-
Soluble endoglin contributes to the pathogenesis of preeclampsia
-
Venkatesha, S., et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat. Med. 12, 642-649 (2006).
-
(2006)
Nat. Med.
, vol.12
, pp. 642-649
-
-
Venkatesha, S.1
-
19
-
-
84877635803
-
Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2
-
Choi, E. J., et al. Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2. PLoS ONE 8, e63138 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e63138
-
-
Choi, E.J.1
-
20
-
-
84860852036
-
Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse
-
Choi, E. J., et al. Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc. Dis. 33, 540-547 (2012).
-
(2012)
Cerebrovasc. Dis.
, vol.33
, pp. 540-547
-
-
Choi, E.J.1
-
21
-
-
84871655253
-
Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-Endoglin antibodies
-
Nolan-Stevaux, O., et al. Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-Endoglin antibodies. PLoS ONE 7, e50920 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e50920
-
-
Nolan-Stevaux, O.1
-
22
-
-
67650188576
-
Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase 1 in human pulmonary artery endothelial cells
-
Upton, P. D., Davies, R. J., Trembath, R. C. & Morrell, N. W. Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase 1 in human pulmonary artery endothelial cells. J. Biol. Chem. 284, 15794-15804 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 15794-15804
-
-
Upton, P.D.1
Davies, R.J.2
Trembath, R.C.3
Morrell, N.W.4
-
23
-
-
57549104510
-
High-Density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2
-
Yao, Y., et al. High-Density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler. Thromb. Vasc. Biol. 28, 2266-2274 (2008).
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 2266-2274
-
-
Yao, Y.1
-
24
-
-
40949158527
-
BMP 2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells
-
Li, X., Yang, H. Y. & Giachelli, C. M. BMP 2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis 199,271-277 (2008).
-
(2008)
Atherosclerosis
, vol.199
, pp. 271-277
-
-
Li, X.1
Yang, H.Y.2
Giachelli, C.M.3
-
25
-
-
34547882714
-
A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-Terminal tail domain of BMP type II receptor
-
Chan, M. C., et al. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-Terminal tail domain of BMP type II receptor. Mol. Cell. Biol. 27, 5776-5789 (2007).
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 5776-5789
-
-
Chan, M.C.1
-
26
-
-
42949178711
-
Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells
-
Yu, P. B., et al. Bone morphogenetic protein (BMP) type ii receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J. Biol. Chem. 283, 3877-3888 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3877-3888
-
-
Yu, P.B.1
-
27
-
-
21644447416
-
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
-
Yu, P. B., Beppu, H., Kawai, N., Li, E. & Bloch, K. D. Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J. Biol. Chem. 280, 24443-24450 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 24443-24450
-
-
Yu, P.B.1
Beppu, H.2
Kawai, N.3
Li, E.4
Bloch, K.D.5
-
28
-
-
77952670323
-
Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-Dependent signaling pathway
-
Pachori, A. S., et al. Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-Dependent signaling pathway. J. Mol. Cell. Cardiol. 48, 1255-1265 (2010).
-
(2010)
J. Mol. Cell. Cardiol.
, vol.48
, pp. 1255-1265
-
-
Pachori, A.S.1
-
29
-
-
84894099573
-
Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart
-
Wu, X., et al. Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart. Life Sci. 97, 145-154 (2014).
-
(2014)
Life Sci.
, vol.97
, pp. 145-154
-
-
Wu, X.1
-
30
-
-
84928969296
-
Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency
-
Malhotra, R., et al. Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. PLoS ONE 10, e0117098 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0117098
-
-
Malhotra, R.1
-
31
-
-
84857650449
-
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis
-
Derwall, M., et al. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 32, 613-622 (2012).
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 613-622
-
-
Derwall, M.1
-
32
-
-
84880693575
-
Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation
-
Heinke, J., et al. Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation. J. Cell Sci. 126, 3082-3094 (2013).
-
(2013)
J. Cell Sci.
, vol.126
, pp. 3082-3094
-
-
Heinke, J.1
-
33
-
-
84888084861
-
Bone morphogenetic protein 9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression
-
Yoshimatsu, Y., et al. Bone morphogenetic protein 9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc. Natl Acad. Sci. USA 110, 18940-18945 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 18940-18945
-
-
Yoshimatsu, Y.1
-
34
-
-
0036744820
-
Interaction of FGF Ihh/Pthlh and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation
-
Minina, E., Kreschel, C., Naski, M. C., Ornitz, D. M. & Vortkamp, A. Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev. Cell 3, 439-449 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 439-449
-
-
Minina, E.1
Kreschel, C.2
Naski, M.C.3
Ornitz, D.M.4
Vortkamp, A.5
-
35
-
-
70349260659
-
Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells
-
Shao, E. S., Lin, L., Yao, Y. & Bostrom, K. I. Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells. Blood 114, 2197-2206 (2009).
-
(2009)
Blood
, vol.114
, pp. 2197-2206
-
-
Shao, E.S.1
Lin, L.2
Yao, Y.3
Bostrom, K.I.4
-
36
-
-
0037840398
-
P38 MAP kinase regulates BMP 4 stimulated VEGF synthesis via p70 S6 kinase in osteoblasts
-
Tokuda, H., et al. p38 MAP kinase regulates BMP 4 stimulated VEGF synthesis via p70 S6 kinase in osteoblasts. Am. J. Physiol. Endocrinol. Metab. 284, E1202-E1209 (2003).
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.284
, pp. E1202-E1209
-
-
Tokuda, H.1
-
37
-
-
80455178772
-
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
-
Morikawa, M., et al. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res. 39, 8712-8727 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 8712-8727
-
-
Morikawa, M.1
-
38
-
-
0347519180
-
Functional Notch signaling is required for BMP4 induced inhibition of myogenic differentiation
-
Dahlqvist, C., et al. Functional Notch signaling is required for BMP4 induced inhibition of myogenic differentiation. Development 130, 6089-6099 (2003).
-
(2003)
Development
, vol.130
, pp. 6089-6099
-
-
Dahlqvist, C.1
-
39
-
-
2942652831
-
Regulation of Notch signaling genes during BMP2 induced differentiation of osteoblast precursor cells
-
de Jong, D. S., et al. Regulation of Notch signaling genes during BMP2 induced differentiation of osteoblast precursor cells. Biochem. Biophys. Res. Commun. 320, 100-107 (2004).
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.320
, pp. 100-107
-
-
De Jong, D.S.1
-
40
-
-
10744231139
-
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
-
Itoh, F., et al. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 23, 541-551 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 541-551
-
-
Itoh, F.1
-
41
-
-
84858286273
-
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades
-
Moya, I. M., et al. Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev. Cell 22, 501-514 (2012).
-
(2012)
Dev. Cell
, vol.22
, pp. 501-514
-
-
Moya, I.M.1
-
42
-
-
84880947851
-
Bmp signaling represses Vegfa to promote outflow tract cushion development
-
Bai, Y., et al. Bmp signaling represses Vegfa to promote outflow tract cushion development. Development 140, 3395-3402 (2013).
-
(2013)
Development
, vol.140
, pp. 3395-3402
-
-
Bai, Y.1
-
43
-
-
84881184474
-
Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development
-
Garside, V. C., Chang, A. C., Karsan, A. & Hoodless, P. A. Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development. Cell. Mol. Life Sci. 70, 2899-2917 (2013).
-
(2013)
Cell. Mol. Life Sci.
, vol.70
, pp. 2899-2917
-
-
Garside, V.C.1
Chang, A.C.2
Karsan, A.3
Hoodless, P.A.4
-
44
-
-
0036036399
-
Lunatic fringe FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
-
Mustonen, T., et al. Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Dev. Biol. 248, 281-293 (2002).
-
(2002)
Dev. Biol.
, vol.248
, pp. 281-293
-
-
Mustonen, T.1
-
45
-
-
77956571716
-
BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
-
Tirosh-Finkel, L., et al. BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137, 2989-3000 (2010).
-
(2010)
Development
, vol.137
, pp. 2989-3000
-
-
Tirosh-Finkel, L.1
-
46
-
-
76649106431
-
ALK1 Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth
-
Mitchell, D., et al. ALK1 Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol. Cancer Ther. 9, 379-388 (2010).
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 379-388
-
-
Mitchell, D.1
-
47
-
-
34447137331
-
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
-
Babitt, J. L., et al. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest. 117, 1933-1939 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1933-1939
-
-
Babitt, J.L.1
-
48
-
-
37249010753
-
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
-
Yu, P. B., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 4, 33-41 (2008).
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 33-41
-
-
Yu, P.B.1
-
49
-
-
0035074094
-
Lost a fin encodes a type i BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation
-
Mintzer, K. A., et al. Lost a fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development 128, 859-869 (2001).
-
(2001)
Development
, vol.128
, pp. 859-869
-
-
Mintzer, K.A.1
-
50
-
-
47949090917
-
Structure-Activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
-
Cuny, G. D., et al. Structure-Activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg. Med. Chem. Lett. 18, 4388-4392 (2008).
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4388-4392
-
-
Cuny, G.D.1
-
51
-
-
84907939471
-
Structure-Activity relationship of 3,5 diaryl 2 aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants
-
Mohedas, A. H., et al. Structure-Activity relationship of 3,5 diaryl 2 aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J. Med. Chem. 57, 7900-7915 (2014).
-
(2014)
J. Med. Chem.
, vol.57
, pp. 7900-7915
-
-
Mohedas, A.H.1
-
52
-
-
84876994820
-
A new class of small molecule inhibitor of BMP signaling
-
Sanvitale, C. E., et al. A new class of small molecule inhibitor of BMP signaling. PLoS ONE 8, e62721 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e62721
-
-
Sanvitale, C.E.1
-
53
-
-
84862768629
-
BMP signaling in vascular diseases
-
Cai, J., Pardali, E., Sánchez-Duffhues, G. & ten Dijke, P. BMP signaling in vascular diseases. FEBS Lett. 586, 1993-2002 (2012).
-
(2012)
FEBS Lett.
, vol.586
, pp. 1993-2002
-
-
Cai, J.1
Pardali, E.2
Sánchez-Duffhues, G.3
Ten Dijke, P.4
-
54
-
-
84856186176
-
TGFβ signaling and cardiovascular diseases
-
Pardali, E. & ten Dijke, P. TGFβ signaling and cardiovascular diseases. Int. J. Biol. Sci. 8, 195-213 (2012).
-
(2012)
Int. J. Biol. Sci.
, vol.8
, pp. 195-213
-
-
Pardali, E.1
Ten Dijke, P.2
-
55
-
-
77952343641
-
BMP 9 induces proliferation of multiple types of endothelial cells in vitro and in vivo
-
Suzuki, Y., et al. BMP 9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell Sci. 123, 1684-1692 (2010).
-
(2010)
J. Cell Sci.
, vol.123
, pp. 1684-1692
-
-
Suzuki, Y.1
-
56
-
-
76149089505
-
Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
-
Cunha, S. I., et al. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. J. Exp. Med. 207, 85-100 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 85-100
-
-
Cunha, S.I.1
-
57
-
-
84885789800
-
Activin receptor-like kinase 1 as a target for anti-Angiogenesis therapy
-
Hawinkels, L. J., Garcia de Vinuesa, A. & Ten Dijke, P. Activin receptor-like kinase 1 as a target for anti-Angiogenesis therapy. Expert Opin. Investig. Drugs 22, 1371-1383 (2013).
-
(2013)
Expert Opin. Investig. Drugs
, vol.22
, pp. 1371-1383
-
-
Hawinkels, L.J.1
Garcia De Vinuesa, A.2
Ten Dijke, P.3
-
58
-
-
41049094560
-
Endoglin in angiogenesis and vascular diseases
-
ten Dijke, P., Goumans, M. J. & Pardali, E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 11, 79-89 (2008).
-
(2008)
Angiogenesis
, vol.11
, pp. 79-89
-
-
Ten Dijke, P.1
Goumans, M.J.2
Pardali, E.3
-
59
-
-
0037159280
-
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells
-
Valdimarsdottir, G., et al. Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells. Circulation 106, 2263-2270 (2002).
-
(2002)
Circulation
, vol.106
, pp. 2263-2270
-
-
Valdimarsdottir, G.1
-
60
-
-
0035924693
-
The Id proteins and angiogenesis
-
Benezra, R., Rafii, S. & Lyden, D. The Id proteins and angiogenesis. Oncogene 20, 8334-8341 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 8334-8341
-
-
Benezra, R.1
Rafii, S.2
Lyden, D.3
-
61
-
-
84887034168
-
Bone morphogenetic proteins protect pulmonary microvascular endothelial cells from apoptosis by upregulating α B crystallin
-
Ciumas, M., et al. Bone morphogenetic proteins protect pulmonary microvascular endothelial cells from apoptosis by upregulating α B crystallin. Arterioscler. Thromb. Vasc. Biol. 33, 2577-2584 (2013).
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, pp. 2577-2584
-
-
Ciumas, M.1
-
62
-
-
84881636538
-
Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells
-
Yang, J., et al. Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 305, L312-L321 (2013).
-
(2013)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.305
, pp. L312-L321
-
-
Yang, J.1
-
63
-
-
78649885341
-
ID family protein expression and regulation in hypoxic pulmonary hypertension
-
Lowery, J. W., et al. ID family protein expression and regulation in hypoxic pulmonary hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299, R1463-R1477 (2010).
-
(2010)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.299
, pp. R1463-R1477
-
-
Lowery, J.W.1
-
64
-
-
33744925666
-
Non-redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cells
-
Asirvatham, A. J., Schmidt, M. A. & Chaudhary, J. Non-redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cells. Prostate 66, 921-935 (2006).
-
(2006)
Prostate
, vol.66
, pp. 921-935
-
-
Asirvatham, A.J.1
Schmidt, M.A.2
Chaudhary, J.3
-
65
-
-
84856718814
-
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA 21 (miR 21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins
-
Kang, H., et al. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA 21 (miR 21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J. Biol. Chem. 287, 3976-3986 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 3976-3986
-
-
Kang, H.1
-
66
-
-
84895544024
-
Down-regulation of miR 96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation
-
Kim, S., Hata, A. & Kang, H. Down-regulation of miR 96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation. J. Cell. Biochem. 115, 889-895 (2014).
-
(2014)
J. Cell. Biochem.
, vol.115
, pp. 889-895
-
-
Kim, S.1
Hata, A.2
Kang, H.3
-
67
-
-
37549065952
-
Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors
-
Lagna, G., et al. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J. Biol. Chem. 282, 37244-37255 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 37244-37255
-
-
Lagna, G.1
-
68
-
-
84876182757
-
BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow
-
Zhou, J., et al. BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow. J. Thromb. Haemost. 11, 741-755 (2013).
-
(2013)
J. Thromb. Haemost.
, vol.11
, pp. 741-755
-
-
Zhou, J.1
-
69
-
-
84946416387
-
Flow-induced protein kinase A CREB pathway acts via BMP signaling to promote HSC emergence
-
Kim, P. G., et al. Flow-induced protein kinase A CREB pathway acts via BMP signaling to promote HSC emergence. J. Exp. Med. 212, 633-648 (2015).
-
(2015)
J. Exp. Med.
, vol.212
, pp. 633-648
-
-
Kim, P.G.1
-
70
-
-
79955448391
-
Interaction between alk1 and blood flow in the development of arteriovenous malformations
-
Corti, P., et al. Interaction between alk1 and blood flow in the development of arteriovenous malformations. Development 138, 1573-1582 (2011).
-
(2011)
Development
, vol.138
, pp. 1573-1582
-
-
Corti, P.1
-
71
-
-
84866742560
-
TGFβ signalling in context
-
Massague, J. TGFβ signalling in context. Nat. Rev. Mol. Cell Biol. 13, 616-630 (2012).
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 616-630
-
-
Massague, J.1
-
73
-
-
0030926093
-
The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: The role of ingression and tissue movement during gastrulation
-
Tam, P. P., Parameswaran, M., Kinder, S. J. & Weinberger, R. P. The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation. Development 124, 1631-1642 (1997).
-
(1997)
Development
, vol.124
, pp. 1631-1642
-
-
Tam, P.P.1
Parameswaran, M.2
Kinder, S.J.3
Weinberger, R.P.4
-
74
-
-
0033658229
-
Cardiac morphogenesis and dysmorphogenesis i Normal development
-
Wessels, A. & Markwald, R. Cardiac morphogenesis and dysmorphogenesis I. Normal development. Methods Mol. Biol. 136, 239-259 (2000).
-
(2000)
Methods Mol. Biol.
, vol.136
, pp. 239-259
-
-
Wessels, A.1
Markwald, R.2
-
75
-
-
0034648772
-
A genetic blueprint for cardiac development
-
Srivastava, D. & Olson, E. N. A genetic blueprint for cardiac development. Nature 407, 221-226 (2000).
-
(2000)
Nature
, vol.407
, pp. 221-226
-
-
Srivastava, D.1
Olson, E.N.2
-
76
-
-
84863114955
-
TGFβ and BMP signaling in cardiac cushion formation: Lessons from mice and chicken
-
Kruithof, B. P., Duim, S. N., Moerkamp, A. T. & Goumans, M. J. TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken. Differentiation 84, 89-102 (2012).
-
(2012)
Differentiation
, vol.84
, pp. 89-102
-
-
Kruithof, B.P.1
Duim, S.N.2
Moerkamp, A.T.3
Goumans, M.J.4
-
77
-
-
34047098378
-
Role of bone morphogenetic proteins in cardiac differentiation
-
van Wijk, B., Moorman, A. F. & van den Hoff, M. J. Role of bone morphogenetic proteins in cardiac differentiation. Cardiovasc. Res. 74, 244-255 (2007).
-
(2007)
Cardiovasc. Res.
, vol.74
, pp. 244-255
-
-
Van Wijk, B.1
Moorman, A.F.2
Van Den Hoff, M.J.3
-
78
-
-
51449091152
-
Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells
-
Hao, J., et al. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 3, e2904 (2008).
-
(2008)
PLoS ONE
, vol.3
, pp. e2904
-
-
Hao, J.1
-
79
-
-
22844439586
-
Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells
-
Yuasa, S., et al. Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nat. Biotechnol. 23, 607-611 (2005).
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 607-611
-
-
Yuasa, S.1
-
80
-
-
79961149681
-
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages
-
Bernardo, A. S., et al. BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell 9, 144-155 (2011).
-
(2011)
Cell Stem Cell
, vol.9
, pp. 144-155
-
-
Bernardo, A.S.1
-
81
-
-
84931042699
-
Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells
-
Faial, T., et al. Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells. Development 142, 2121-2135 (2015).
-
(2015)
Development
, vol.142
, pp. 2121-2135
-
-
Faial, T.1
-
82
-
-
79251616707
-
Cardiopoietic factors: Extracellular signals for cardiac lineage commitment
-
Noseda, M., Peterkin, T., Simoes, F. C., Patient, R. & Schneider, M. D. Cardiopoietic factors: extracellular signals for cardiac lineage commitment. Circ. Res. 108, 129-152 (2011).
-
(2011)
Circ. Res.
, vol.108
, pp. 129-152
-
-
Noseda, M.1
Peterkin, T.2
Simoes, F.C.3
Patient, R.4
Schneider, M.D.5
-
83
-
-
84887039950
-
Coordinate Nodal and BMP inhibition directs Baf60c dependent cardiomyocyte commitment
-
Cai, W., et al. Coordinate Nodal and BMP inhibition directs Baf60c dependent cardiomyocyte commitment. Genes Dev. 27, 2332-2344 (2013).
-
(2013)
Genes Dev.
, vol.27
, pp. 2332-2344
-
-
Cai, W.1
-
84
-
-
79551597211
-
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
-
Kattman, S. J., et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8, 228-240 (2011).
-
(2011)
Cell Stem Cell
, vol.8
, pp. 228-240
-
-
Kattman, S.J.1
-
85
-
-
84922598217
-
Generation of the epicardial lineage from human pluripotent stem cells
-
Witty, A. D., et al. Generation of the epicardial lineage from human pluripotent stem cells. Nat. Biotechnol. 32, 1026-1035 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1026-1035
-
-
Witty, A.D.1
-
86
-
-
84926356306
-
Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells
-
Iyer, D., et al. Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development 142, 1528-1541 (2015).
-
(2015)
Development
, vol.142
, pp. 1528-1541
-
-
Iyer, D.1
-
87
-
-
84863096257
-
The arterial and cardiac epicardium in development, disease and repair
-
Gittenberger-De Groot, A. C., et al. The arterial and cardiac epicardium in development, disease and repair. Differentiation 84, 41-53 (2012).
-
(2012)
Differentiation
, vol.84
, pp. 41-53
-
-
Gittenberger-De Groot, A.C.1
-
88
-
-
84866274786
-
Bmp indicator mice reveal dynamic regulation of transcriptional response
-
Javier, A. L., et al. Bmp indicator mice reveal dynamic regulation of transcriptional response. PLoS ONE 7, e42566 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e42566
-
-
Javier, A.L.1
-
89
-
-
3543053797
-
Spatio-Temporal activation of Smad1 and Smad5 in vivo: Monitoring transcriptional activity of Smad proteins
-
Monteiro, R. M., de Sousa Lopes, S. M., Korchynskyi, O., ten Dijke, P. & Mummery, C. L. Spatio-Temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins. J. Cell Sci. 117, 4653-4663 (2004).
-
(2004)
J. Cell Sci.
, vol.117
, pp. 4653-4663
-
-
Monteiro, R.M.1
De Sousa Lopes, S.M.2
Korchynskyi, O.3
Ten Dijke, P.4
Mummery, C.L.5
-
90
-
-
50849113091
-
Real time monitoring of BMP Smads transcriptional activity during mouse development
-
Monteiro, R. M., et al. Real time monitoring of BMP Smads transcriptional activity during mouse development. Genesis 46, 335-346 (2008).
-
(2008)
Genesis
, vol.46
, pp. 335-346
-
-
Monteiro, R.M.1
-
91
-
-
36749013666
-
Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis
-
Klaus, A., Saga, Y., Taketo, M. M., Tzahor, E. & Birchmeier, W. Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis. Proc. Natl Acad. Sci. USA 104, 18531-18536 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 18531-18536
-
-
Klaus, A.1
Saga, Y.2
Taketo, M.M.3
Tzahor, E.4
Birchmeier, W.5
-
92
-
-
0037022660
-
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3
-
Gaussin, V., et al. Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc. Natl Acad. Sci. USA 99, 2878-2883 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 2878-2883
-
-
Gaussin, V.1
-
93
-
-
31144440253
-
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
-
Ma, L., Lu, M. F., Schwartz, R. J. & Martin, J. F. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132, 5601-5611 (2005).
-
(2005)
Development
, vol.132
, pp. 5601-5611
-
-
Ma, L.1
Lu, M.F.2
Schwartz, R.J.3
Martin, J.F.4
-
94
-
-
84875639767
-
Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development
-
Wang, Y., et al. Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS ONE 8, e60244 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e60244
-
-
Wang, Y.1
-
95
-
-
25844500726
-
Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart
-
Wang, J., et al. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev. Biol. 286, 299-310 (2005).
-
(2005)
Dev. Biol.
, vol.286
, pp. 299-310
-
-
Wang, J.1
-
96
-
-
2042462926
-
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
-
Chen, H., et al. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development 131, 2219-2231 (2004).
-
(2004)
Development
, vol.131
, pp. 2219-2231
-
-
Chen, H.1
-
97
-
-
84867145472
-
Myocardin regulates BMP10 expression and is required for heart development
-
Huang, J., et al. Myocardin regulates BMP10 expression and is required for heart development. J. Clin. Invest. 122, 3678-3691 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 3678-3691
-
-
Huang, J.1
-
98
-
-
79956328903
-
Molecular mechanisms and clinical applications of angiogenesis
-
Carmeliet, P. & Jain, R. K. Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298-307 (2011).
-
(2011)
Nature
, vol.473
, pp. 298-307
-
-
Carmeliet, P.1
Jain, R.K.2
-
99
-
-
80054000495
-
Coordinating cell behaviour during blood vessel formation
-
Geudens, I. & Gerhardt, H. Coordinating cell behaviour during blood vessel formation. Development 138, 4569-4583 (2011).
-
(2011)
Development
, vol.138
, pp. 4569-4583
-
-
Geudens, I.1
Gerhardt, H.2
-
100
-
-
34250351918
-
Functional implication of BMP4 expression on angiogenesis in malignant melanoma
-
Rothhammer, T., Bataille, F., Spruss, T., Eissner, G. & Bosserhoff, A. K. Functional implication of BMP4 expression on angiogenesis in malignant melanoma. Oncogene 26, 4158-4170 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 4158-4170
-
-
Rothhammer, T.1
Bataille, F.2
Spruss, T.3
Eissner, G.4
Bosserhoff, A.K.5
-
101
-
-
0031470417
-
Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein 2
-
Nakaoka, T., et al. Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein 2. J. Clin. Invest. 100, 2824-2832 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 2824-2832
-
-
Nakaoka, T.1
-
102
-
-
0032924166
-
BMP 2 gene expression and effects on human vascular smooth muscle cells
-
Willette, R. N., et al. BMP 2 gene expression and effects on human vascular smooth muscle cells. J. Vasc. Res. 36, 120-125 (1999).
-
(1999)
J. Vasc. Res.
, vol.36
, pp. 120-125
-
-
Willette, R.N.1
-
103
-
-
0034074899
-
Bone morphogenetic protein 7 (osteogenic protein 1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro
-
Dorai, H., Vukicevic, S. & Sampath, T. K. Bone morphogenetic protein 7 (osteogenic protein 1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J. Cell. Physiol. 184, 37-45 (2000).
-
(2000)
J. Cell. Physiol.
, vol.184
, pp. 37-45
-
-
Dorai, H.1
Vukicevic, S.2
Sampath, T.K.3
-
104
-
-
17644446340
-
Bone morphogenetic protein 7 modulates genes that maintain the vascular smooth muscle cell phenotype in culture
-
Dorai, H. & Sampath, T. K. Bone morphogenetic protein 7 modulates genes that maintain the vascular smooth muscle cell phenotype in culture. J. Bone Joint Surg. Am. 83 (Suppl. 1), S70-S78 (2001).
-
(2001)
J. Bone Joint Surg. Am.
, vol.83
, Issue.SUPPL1
, pp. S70-S78
-
-
Dorai, H.1
Sampath, T.K.2
-
105
-
-
84872936093
-
Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1 deficient brain
-
Chen, W., et al. Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1 deficient brain. Arterioscler. Thromb. Vasc. Biol. 33, 305-310 (2013).
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, pp. 305-310
-
-
Chen, W.1
-
106
-
-
84890011341
-
Transforming growth factor-β1 represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3
-
Upton, P. D., Davies, R. J., Tajsic, T. & Morrell, N. W. Transforming growth factor-β1 represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3. Am. J. Respir. Cell. Mol. Biol. 49, 1135-1145 (2013).
-
(2013)
Am. J. Respir. Cell. Mol. Biol.
, vol.49
, pp. 1135-1145
-
-
Upton, P.D.1
Davies, R.J.2
Tajsic, T.3
Morrell, N.W.4
-
107
-
-
84881323919
-
Bone lessons from Marfan syndrome and related disorders: Fibrillin TGF B and BMP at the balance of too long and too short
-
Loeys, B. L., Mortier, G. & Dietz, H. C. Bone lessons from Marfan syndrome and related disorders: fibrillin, TGF B and BMP at the balance of too long and too short. Pediatr. Endocrinol. Rev. 10 (Suppl. 2), S417-S423 (2013).
-
(2013)
Pediatr. Endocrinol. Rev.
, vol.10
, Issue.SUPPL2
, pp. S417-S423
-
-
Loeys, B.L.1
Mortier, G.2
Dietz, H.C.3
-
108
-
-
84870325682
-
Exogenous activation of BMP 2 signaling overcomes TGFβ-mediated inhibition of osteogenesis in Marfan embryonic stem cells and Marfan patient-specific induced pluripotent stem cells
-
Quarto, N., Li, S., Renda, A. & Longaker, M. T. Exogenous activation of BMP 2 signaling overcomes TGFβ-mediated inhibition of osteogenesis in Marfan embryonic stem cells and Marfan patient-specific induced pluripotent stem cells. Stem Cells 30, 2709-2719 (2012).
-
(2012)
Stem Cells
, vol.30
, pp. 2709-2719
-
-
Quarto, N.1
Li, S.2
Renda, A.3
Longaker, M.T.4
-
109
-
-
84910136233
-
Bone morphogenetic protein 4: A novel therapeutic target for pathological cardiac hypertrophy/heart failure
-
Guo, W. T. & Dong, D. L. Bone morphogenetic protein 4: a novel therapeutic target for pathological cardiac hypertrophy/heart failure. Heart Fail. Rev. 19, 781-788 (2014).
-
(2014)
Heart Fail. Rev.
, vol.19
, pp. 781-788
-
-
Guo, W.T.1
Dong, D.L.2
-
110
-
-
84903452153
-
Bone morphogenetic protein 2 antagonizes bone morphogenetic protein 4 induced cardiomyocyte hypertrophy and apoptosis
-
Lu, J., et al. Bone morphogenetic protein 2 antagonizes bone morphogenetic protein 4 induced cardiomyocyte hypertrophy and apoptosis. J. Cell. Physiol. 229, 1503-1510 (2014).
-
(2014)
J. Cell. Physiol.
, vol.229
, pp. 1503-1510
-
-
Lu, J.1
-
111
-
-
84941050296
-
Bone morphogenetic protein 10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction
-
Sun, L., et al. Bone morphogenetic protein 10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction. J. Cell. Biochem. 115, 1868-1876 (2014).
-
(2014)
J. Cell. Biochem.
, vol.115
, pp. 1868-1876
-
-
Sun, L.1
-
112
-
-
84875369230
-
Treatment with bone morphogenetic protein 2 limits infarct size after myocardial infarction in mice
-
Ebelt, H., et al. Treatment with bone morphogenetic protein 2 limits infarct size after myocardial infarction in mice. Shock 39, 353-360 (2013).
-
(2013)
Shock
, vol.39
, pp. 353-360
-
-
Ebelt, H.1
-
113
-
-
82755166891
-
Serum BMP 4 levels in relation to arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes
-
Son, J. W., et al. Serum BMP 4 levels in relation to arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes. Biomark. Med. 5, 827-835 (2011).
-
(2011)
Biomark. Med.
, vol.5
, pp. 827-835
-
-
Son, J.W.1
-
114
-
-
84883007268
-
Elevated serum bone morphogenetic protein 4 in patients with chronic kidney disease and coronary artery disease
-
Stahls, P. F. 3rd, Lightell, D. J. Jr, Moss, S. C., Goldman, C. K. & Woods, T. C. Elevated serum bone morphogenetic protein 4 in patients with chronic kidney disease and coronary artery disease. J. Cardiovasc. Transl. Res. 6, 232-238 (2013).
-
(2013)
J. Cardiovasc. Transl. Res.
, vol.6
, pp. 232-238
-
-
Stahls, P.F.1
Lightell, D.J.2
Moss, S.C.3
Goldman, C.K.4
Woods, T.C.5
-
115
-
-
84890776626
-
Definitions and diagnosis of pulmonary hypertension
-
Suppl.
-
Hoeper, M. M., et al. Definitions and diagnosis of pulmonary hypertension. J. Am. Coll. Cardiol. 62 (Suppl.), D42-D50 (2013).
-
(2013)
J. Am. Coll. Cardiol.
, vol.62
, pp. D42-D50
-
-
Hoeper, M.M.1
-
116
-
-
84890753066
-
Relevant issues in the pathology and pathobiology of pulmonary hypertension
-
Suppl.
-
Tuder, R. M., et al. Relevant issues in the pathology and pathobiology of pulmonary hypertension. J. Am. Coll. Cardiol. 62 (Suppl.), D4-D12 (2013).
-
(2013)
J. Am. Coll. Cardiol.
, vol.62
, pp. D4-D12
-
-
Tuder, R.M.1
-
117
-
-
33748998458
-
Pulmonary arterial hypertension
-
McLaughlin, V. V. & McGoon, M. D. Pulmonary arterial hypertension. Circulation 114, 1417-1431 (2006).
-
(2006)
Circulation
, vol.114
, pp. 1417-1431
-
-
McLaughlin, V.V.1
McGoon, M.D.2
-
118
-
-
84890738424
-
Updated clinical classification of pulmonary hypertension
-
Suppl.
-
Simonneau, G., et al. Updated clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 62 (Suppl.), D34-D41 (2013).
-
(2013)
J. Am. Coll. Cardiol.
, vol.62
, pp. D34-D41
-
-
Simonneau, G.1
-
119
-
-
0021288730
-
Familial primary pulmonary hypertension: Clinical patterns
-
Loyd, J. E., Primm, R. K. & Newman, J. H. Familial primary pulmonary hypertension: clinical patterns. Am. Rev. Respir. Dis. 129, 194-197 (1984).
-
(1984)
Am. Rev. Respir. Dis.
, vol.129
, pp. 194-197
-
-
Loyd, J.E.1
Primm, R.K.2
Newman, J.H.3
-
120
-
-
0033817459
-
Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension
-
The International PPH Consortium., et al.
-
The International PPH Consortium., et al. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension. Nat. Genet. 26, 81-84 (2000).
-
(2000)
Nat. Genet.
, vol.26
, pp. 81-84
-
-
-
121
-
-
0033838125
-
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
-
Deng, Z., et al. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am. J. Hum. Genet. 67, 737-744 (2000).
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 737-744
-
-
Deng, Z.1
-
122
-
-
32544458797
-
Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension
-
Machado, R. D., et al. Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension. Hum. Mutat. 27, 121-132 (2006).
-
(2006)
Hum. Mutat.
, vol.27
, pp. 121-132
-
-
Machado, R.D.1
-
123
-
-
0033623296
-
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family
-
Thomson, J. R., et al. Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family. J. Med. Genet. 37, 741-745 (2000).
-
(2000)
J. Med. Genet.
, vol.37
, pp. 741-745
-
-
Thomson, J.R.1
-
124
-
-
2442570729
-
Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-Dimensional gel electrophoresis and mass spectrometry
-
Hassel, S., et al. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-Dimensional gel electrophoresis and mass spectrometry. Proteomics 4, 1346-1358 (2004).
-
(2004)
Proteomics
, vol.4
, pp. 1346-1358
-
-
Hassel, S.1
-
125
-
-
67349167022
-
Novel crosstalk to BMP signalling: CGMP-Dependent kinase i modulates BMP receptor and Smad activity
-
Schwappacher, R., et al. Novel crosstalk to BMP signalling: cGMP-Dependent kinase I modulates BMP receptor and Smad activity. EMBO J. 28, 1537-1550 (2009).
-
(2009)
EMBO J.
, vol.28
, pp. 1537-1550
-
-
Schwappacher, R.1
-
126
-
-
33645751955
-
Serotonin increases susceptibility to pulmonary hypertension in BMPR2 deficient mice
-
Long, L., et al. Serotonin increases susceptibility to pulmonary hypertension in BMPR2 deficient mice. Circ. Res. 98, 818-827 (2006).
-
(2006)
Circ. Res.
, vol.98
, pp. 818-827
-
-
Long, L.1
-
127
-
-
84936891355
-
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
-
Long, L., et al. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat. Med. 21, 777-785 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 777-785
-
-
Long, L.1
-
128
-
-
84902980316
-
The genetics of pulmonary arterial hypertension
-
Austin, E. D. & Loyd, J. E. The genetics of pulmonary arterial hypertension. Circ. Res. 115, 189-202 (2014).
-
(2014)
Circ. Res.
, vol.115
, pp. 189-202
-
-
Austin, E.D.1
Loyd, J.E.2
-
129
-
-
23044504042
-
Increased susceptibility to pulmonary hypertension in heterozygous BMPR2 mutant mice
-
Song, Y., et al. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2 mutant mice. Circulation 112, 553-562 (2005).
-
(2005)
Circulation
, vol.112
, pp. 553-562
-
-
Song, Y.1
-
130
-
-
2342486700
-
Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
-
West, J., et al. Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ. Res. 94, 1109-1114 (2004).
-
(2004)
Circ. Res.
, vol.94
, pp. 1109-1114
-
-
West, J.1
-
131
-
-
20344362689
-
Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
-
Yang, X., et al. Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ. Res. 10, 1053-1063 (2005).
-
(2005)
Circ. Res.
, vol.10
, pp. 1053-1063
-
-
Yang, X.1
-
132
-
-
0035859940
-
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-β1 and bone morphogenetic proteins
-
Morrell, N. W., et al. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-β1 and bone morphogenetic proteins. Circulation 104, 790-795 (2001).
-
(2001)
Circulation
, vol.104
, pp. 790-795
-
-
Morrell, N.W.1
-
133
-
-
45149132191
-
Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: Implications for familial pulmonary arterial hypertension
-
Yang, J., et al. Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension. Circ. Res. 102, 1212-1221 (2008).
-
(2008)
Circ. Res.
, vol.102
, pp. 1212-1221
-
-
Yang, J.1
-
134
-
-
77955172689
-
Smad-Dependent and Smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo
-
Yang, J., et al. Smad-Dependent and Smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Circ. Res. 107, 252-262 (2010).
-
(2010)
Circ. Res.
, vol.107
, pp. 252-262
-
-
Yang, J.1
-
135
-
-
84871788547
-
Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension
-
Yang, J., et al. Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. 33, 34-42 (2013).
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, pp. 34-42
-
-
Yang, J.1
-
136
-
-
33847369980
-
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
-
David, L., Mallet, C., Mazerbourg, S., Feige, J. J. & Bailly, S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 109, 1953-1961 (2007).
-
(2007)
Blood
, vol.109
, pp. 1953-1961
-
-
David, L.1
Mallet, C.2
Mazerbourg, S.3
Feige, J.J.4
Bailly, S.5
-
137
-
-
0035797556
-
Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
-
Trembath, R. C., et al. Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. N. Engl. J. Med. 345, 325-334 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 325-334
-
-
Trembath, R.C.1
-
138
-
-
50349096148
-
Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
-
Hong, K. H., et al. Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation 118, 722-730 (2008).
-
(2008)
Circulation
, vol.118
, pp. 722-730
-
-
Hong, K.H.1
-
139
-
-
81055125053
-
Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress
-
Jerkic, M., et al. Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress. Cardiovasc. Res. 92, 375-384 (2011).
-
(2011)
Cardiovasc. Res.
, vol.92
, pp. 375-384
-
-
Jerkic, M.1
-
140
-
-
33644865928
-
Bone morphogenetic protein receptor 2 signaling promotes pulmonary arterial endothelial cell survival: Implications for loss of-function mutations in the pathogenesis of pulmonary hypertension
-
Teichert-Kuliszewska, K., et al. Bone morphogenetic protein receptor 2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss of-function mutations in the pathogenesis of pulmonary hypertension. Circ. Res. 98, 209-217 (2006).
-
(2006)
Circ. Res.
, vol.98
, pp. 209-217
-
-
Teichert-Kuliszewska, K.1
-
141
-
-
84936891355
-
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
-
Long, L., et al. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat. Med. 21, 777-785 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 777-785
-
-
Long, L.1
-
142
-
-
84883480295
-
Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension
-
Drake, K. M., Dunmore, B. J., McNelly, L. N., Morrell, N. W. & Aldred, M. A. Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension. Am. J. Respir. Cell. Mol. Biol. 49, 403-409 (2013).
-
(2013)
Am. J. Respir. Cell. Mol. Biol.
, vol.49
, pp. 403-409
-
-
Drake, K.M.1
Dunmore, B.J.2
McNelly, L.N.3
Morrell, N.W.4
Aldred, M.A.5
-
143
-
-
53349173222
-
Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: Potential for rescue
-
Sobolewski, A., et al. Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue. Hum. Mol. Genet. 17, 3180-3190 (2008).
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 3180-3190
-
-
Sobolewski, A.1
-
144
-
-
84856721781
-
Targeted gene delivery of BMPR2 attenuates pulmonary hypertension
-
Reynolds, A. M., Holmes, M. D., Danilov, S. M. & Reynolds, P. N. Targeted gene delivery of BMPR2 attenuates pulmonary hypertension. Eur. Respir. J. 39, 329-343 (2012).
-
(2012)
Eur. Respir. J.
, vol.39
, pp. 329-343
-
-
Reynolds, A.M.1
Holmes, M.D.2
Danilov, S.M.3
Reynolds, P.N.4
-
145
-
-
78549286371
-
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II
-
Durrington, H. J., et al. Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II. J. Biol. Chem. 285, 37641-37649 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37641-37649
-
-
Durrington, H.J.1
-
146
-
-
84883010729
-
The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations
-
Dunmore, B. J., et al. The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations. Hum. Mol. Genet. 22, 3667-3679 (2013).
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 3667-3679
-
-
Dunmore, B.J.1
-
147
-
-
84876367698
-
Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation
-
Long, L., et al. Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. Circ. Res. 112, 1159-1170 (2013).
-
(2013)
Circ. Res.
, vol.112
, pp. 1159-1170
-
-
Long, L.1
-
148
-
-
84885708429
-
Chloroquine in pulmonary arterial hypertension: A new role for an old drug?
-
Ryan, J. J. Chloroquine in pulmonary arterial hypertension: a new role for an old drug? Circ. Cardiovasc. Genet. 6, 310-311 (2013).
-
(2013)
Circ Cardiovasc. Genet.
, vol.6
, pp. 310-311
-
-
Ryan, J.J.1
-
149
-
-
84881240287
-
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
-
Spiekerkoetter, E., et al. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J. Clin. Invest. 123, 3600-3613 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3600-3613
-
-
Spiekerkoetter, E.1
-
150
-
-
84938053379
-
Low-Dose FK506 (tacrolimus) in end-stage pulmonary arterial hypertension
-
Spiekerkoetter, E., et al. Low-Dose FK506 (tacrolimus) in end-stage pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 192, 254-257 (2015).
-
(2015)
Am. J. Respir. Crit. Care Med.
, vol.192
, pp. 254-257
-
-
Spiekerkoetter, E.1
-
151
-
-
0032799731
-
Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: Issues in clinical management and review of pathogenic mechanisms
-
Shovlin, C. L. & Letarte, M. Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms. Thorax 54, 714-729 (1999).
-
(1999)
Thorax
, vol.54
, pp. 714-729
-
-
Shovlin, C.L.1
Letarte, M.2
-
152
-
-
79960845756
-
Hereditary hemorrhagic telangiectasia: An overview of diagnosis, management, and pathogenesis
-
McDonald, J., Bayrak-Toydemir, P. & Pyeritz, R. E. Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis. Genet. Med. 13, 607-616 (2011).
-
(2011)
Genet. Med.
, vol.13
, pp. 607-616
-
-
McDonald, J.1
Bayrak-Toydemir, P.2
Pyeritz, R.E.3
-
153
-
-
0043164827
-
Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFβ coreceptor
-
Sorensen, L. K., Brooke, B. S., Li, D. Y. & Urness, L. D. Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFβ coreceptor. Dev. Biol. 261, 235-250 (2003).
-
(2003)
Dev. Biol.
, vol.261
, pp. 235-250
-
-
Sorensen, L.K.1
Brooke, B.S.2
Li, D.Y.3
Urness, L.D.4
-
154
-
-
0033621804
-
Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
-
Arthur, H. M., et al. Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev. Biol. 217, 42-53 (2000).
-
(2000)
Dev. Biol.
, vol.217
, pp. 42-53
-
-
Arthur, H.M.1
-
155
-
-
0033757655
-
Arteriovenous malformations in mice lacking activin receptor-like kinase 1
-
Urness, L. D., Sorensen, L. K. & Li, D. Y. Arteriovenous malformations in mice lacking activin receptor-like kinase 1. Nat. Genet. 26, 328-331 (2000).
-
(2000)
Nat. Genet.
, vol.26
, pp. 328-331
-
-
Urness, L.D.1
Sorensen, L.K.2
Li, D.Y.3
-
156
-
-
12944273545
-
Activin receptor-like kinase 1 modulates transforming growth factor-β 1 signaling in the regulation of angiogenesis
-
Oh, S. P., et al. Activin receptor-like kinase 1 modulates transforming growth factor-β 1 signaling in the regulation of angiogenesis. Proc. Natl Acad. Sci. USA 97, 2626-2631 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2626-2631
-
-
Oh, S.P.1
-
157
-
-
0029125615
-
A second locus for hereditary hemorrhagic telangiectasia maps to chromosome 12
-
Johnson, D. W., et al. A second locus for hereditary hemorrhagic telangiectasia maps to chromosome 12. Genome Res. 5, 21-28 (1995).
-
(1995)
Genome Res.
, vol.5
, pp. 21-28
-
-
Johnson, D.W.1
-
158
-
-
1542504799
-
Primary pulmonary hypertension in families with hereditary haemorrhagic telangiectasia
-
Abdalla, S. A., et al. Primary pulmonary hypertension in families with hereditary haemorrhagic telangiectasia. Eur. Respir. J. 23, 373-377 (2004).
-
(2004)
Eur. Respir. J.
, vol.23
, pp. 373-377
-
-
Abdalla, S.A.1
-
159
-
-
75449083190
-
Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP HHT syndrome
-
Gallione, C., et al. Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP HHT syndrome. Am. J. Med. Genet. 152A, 333-339 (2010).
-
(2010)
Am. J. Med. Genet.
, vol.152 A
, pp. 333-339
-
-
Gallione, C.1
-
160
-
-
84883825716
-
BMP9 mutations cause a vascular-Anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia
-
Wooderchak-Donahue, W. L., et al. BMP9 mutations cause a vascular-Anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia. Am. J. Hum. Genet. 93, 530-537 (2013).
-
(2013)
Am. J. Hum. Genet.
, vol.93
, pp. 530-537
-
-
Wooderchak-Donahue, W.L.1
-
161
-
-
77449108244
-
In vivo structure-Activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors
-
Hao, J., et al. In vivo structure-Activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem. Biol. 5, 245-253 (2010).
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 245-253
-
-
Hao, J.1
-
162
-
-
80051685812
-
Transforming growth factor Beta2 is required for valve remodeling during heart development
-
Azhar, M., et al. Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev. Dyn. 240, 2127-2141 (2011).
-
(2011)
Dev. Dyn.
, vol.240
, pp. 2127-2141
-
-
Azhar, M.1
-
163
-
-
77950538918
-
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia
-
Lebrin, F., et al. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat. Med. 16, 420-428 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 420-428
-
-
Lebrin, F.1
-
164
-
-
84907591199
-
VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2
-
Han, C., et al. VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2. Angiogenesis 17, 823-830 (2014).
-
(2014)
Angiogenesis
, vol.17
, pp. 823-830
-
-
Han, C.1
-
165
-
-
65649124507
-
Bevacizumab in hereditary hemorrhagic telangiectasia
-
Bose, P., Holter, J. L. & Selby, G. B. Bevacizumab in hereditary hemorrhagic telangiectasia. N. Engl. J. Med. 360, 2143-2144 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2143-2144
-
-
Bose, P.1
Holter, J.L.2
Selby, G.B.3
-
166
-
-
33750328315
-
Macroscopic appearance of intestinal angiodysplasias under antiangiogenic treatment with thalidomide
-
Bauditz, J., Lochs, H. & Voderholzer, W. Macroscopic appearance of intestinal angiodysplasias under antiangiogenic treatment with thalidomide. Endoscopy 38, 1036-1039 (2006).
-
(2006)
Endoscopy
, vol.38
, pp. 1036-1039
-
-
Bauditz, J.1
Lochs, H.2
Voderholzer, W.3
-
167
-
-
36949023146
-
Angiogenesis and vascular malformations: Antiangiogenic drugs for treatment of gastrointestinal bleeding
-
Bauditz, J. & Lochs, H. Angiogenesis and vascular malformations: antiangiogenic drugs for treatment of gastrointestinal bleeding. World J. Gastroenterol. 13, 5979-5984 (2007).
-
(2007)
World J. Gastroenterol.
, vol.13
, pp. 5979-5984
-
-
Bauditz, J.1
Lochs, H.2
-
168
-
-
84934436420
-
Induction of brain arteriovenous malformation in the adult mouse
-
Chen, W., Young, W. L. & Su, H. Induction of brain arteriovenous malformation in the adult mouse. Methods Mol. Biol. 1135, 309-316 (2014).
-
(2014)
Methods Mol. Biol.
, vol.1135
, pp. 309-316
-
-
Chen, W.1
Young, W.L.2
Su, H.3
-
169
-
-
84857865784
-
Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output
-
Dupuis-Girod, S., et al. Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output. JAMA 307, 948-955 (2012).
-
(2012)
JAMA
, vol.307
, pp. 948-955
-
-
Dupuis-Girod, S.1
-
170
-
-
84944344371
-
Dose-response relationship of bevacizumab in hereditary hemorrhagic telangiectasia
-
Azzopardi, N., et al. Dose-response relationship of bevacizumab in hereditary hemorrhagic telangiectasia. MAbs 7, 630-637 (2015).
-
(2015)
MAbs
, vol.7
, pp. 630-637
-
-
Azzopardi, N.1
-
171
-
-
70449392400
-
Real-Time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia
-
Park, S. O., et al. Real-Time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J. Clin. Invest. 119, 3487-3496 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3487-3496
-
-
Park, S.O.1
-
172
-
-
0027285583
-
Bone morphogenetic protein expression in human atherosclerotic lesions
-
Bostrom, K., et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J. Clin. Invest. 91, 1800-1809 (1993).
-
(1993)
J. Clin. Invest.
, vol.91
, pp. 1800-1809
-
-
Bostrom, K.1
-
173
-
-
84856225143
-
Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis
-
Saeed, O., et al. Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 32, 299-307 (2012).
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 299-307
-
-
Saeed, O.1
-
174
-
-
59449104824
-
Altered shear stress stimulates upregulation of endothelial VCAM 1 and ICAM 1 in a BMP 4 and TGF β1 dependent pathway
-
Sucosky, P., Balachandran, K., Elhammali, A., Jo, H. & Yoganathan, A. P. Altered shear stress stimulates upregulation of endothelial VCAM 1 and ICAM 1 in a BMP 4 and TGF β1 dependent pathway. Arterioscler. Thromb. Vasc. Biol. 29, 254-260 (2009).
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 254-260
-
-
Sucosky, P.1
Balachandran, K.2
Elhammali, A.3
Jo, H.4
Yoganathan, A.P.5
-
175
-
-
83555172379
-
The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease
-
Wang, L., et al. The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm. Bowel Dis. 18, 112-119 (2012).
-
(2012)
Inflamm. Bowel Dis.
, vol.18
, pp. 112-119
-
-
Wang, L.1
-
176
-
-
84880039758
-
Bone morphogenetic protein 4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy
-
Sun, B., et al. Bone morphogenetic protein 4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Biochem. Biophys. Res. Commun. 436, 591-594 (2013).
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.436
, pp. 591-594
-
-
Sun, B.1
-
177
-
-
84873056069
-
Bone morphogenetic protein 4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy
-
Sun, B., et al. Bone morphogenetic protein 4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension 61, 352-360 (2013).
-
(2013)
Hypertension
, vol.61
, pp. 352-360
-
-
Sun, B.1
-
178
-
-
84861841591
-
Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure
-
Kapur, N. K., et al. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation 125, 2728-2738 (2012).
-
(2012)
Circulation
, vol.125
, pp. 2728-2738
-
-
Kapur, N.K.1
-
179
-
-
84939462015
-
Reducing endoglin activity limits calcineurin and TRPC 6 expression and improves survival in a mouse model of right ventricular pressure overload
-
Kapur, N. K., et al. Reducing endoglin activity limits calcineurin and TRPC 6 expression and improves survival in a mouse model of right ventricular pressure overload. J. Am. Heart Assoc. 3, e000965 (2014).
-
(2014)
J. Am. Heart Assoc.
, vol.3
, pp. e000965
-
-
Kapur, N.K.1
-
180
-
-
80051920312
-
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth
-
Castonguay, R., et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J. Biol. Chem. 286, 30034-30046 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 30034-30046
-
-
Castonguay, R.1
-
181
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt, J. L., et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38, 531-539 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
-
182
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth, E., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090-2093 (2004).
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
-
183
-
-
84896714521
-
A mouse model of anemia of inflammation: Complex pathogenesis with partial dependence on hepcidin
-
Kim, A., et al. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood 123, 1129-1136 (2014).
-
(2014)
Blood
, vol.123
, pp. 1129-1136
-
-
Kim, A.1
-
184
-
-
34548594676
-
Hepcidin and its role in regulating systemic iron metabolism
-
Ganz, T. Hepcidin and its role in regulating systemic iron metabolism. Hematology Am. Soc. Hematol. Educ. Program 2006, 29-35 (2006).
-
(2006)
Hematology Am. Soc. Hematol. Educ. Program
, vol.2006
, pp. 29-35
-
-
Ganz, T.1
-
185
-
-
84929156479
-
Is anemia a new cardiovascular risk factor?
-
Kaiafa, G., et al. Is anemia a new cardiovascular risk factor? Int. J. Cardiol. 186, 117-124 (2015).
-
(2015)
Int. J. Cardiol.
, vol.186
, pp. 117-124
-
-
Kaiafa, G.1
-
186
-
-
79955980950
-
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
-
Steinbicker, A. U., et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 117, 4915-4923 (2011).
-
(2011)
Blood
, vol.117
, pp. 4915-4923
-
-
Steinbicker, A.U.1
-
187
-
-
80052647221
-
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
-
Theurl, I., et al. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood 118, 4977-4984 (2011).
-
(2011)
Blood
, vol.118
, pp. 4977-4984
-
-
Theurl, I.1
-
188
-
-
84922191755
-
Oral administration of a bone morphogenetic protein type i receptor inhibitor prevents the development of anemia of inflammation
-
Mayeur, C., et al. Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica 100, e68-E71 (2015).
-
(2015)
Haematologica
, vol.100
, pp. e68-E71
-
-
Mayeur, C.1
-
189
-
-
0034193390
-
BMP type II receptor is required for gastrulation and early development of mouse embryos
-
Beppu, H., et al. BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev. Biol. 221, 249-258 (2000).
-
(2000)
Dev. Biol.
, vol.221
, pp. 249-258
-
-
Beppu, H.1
-
190
-
-
8644256840
-
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
-
Beppu, H., et al. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L1241-L1247 (2004).
-
(2004)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.287
, pp. L1241-L1247
-
-
Beppu, H.1
-
191
-
-
0037235556
-
BMP signaling is required for septation of the outflow tract of the mammalian heart
-
Delot, E. C., Bahamonde, M. E., Zhao, M. & Lyons, K. M. BMP signaling is required for septation of the outflow tract of the mammalian heart. Development 130, 209-220 (2003).
-
(2003)
Development
, vol.130
, pp. 209-220
-
-
Delot, E.C.1
Bahamonde, M.E.2
Zhao, M.3
Lyons, K.M.4
-
192
-
-
40749102181
-
Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature
-
Frank, D. B., et al. Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L98-L109 (2008).
-
(2008)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.294
, pp. L98-L109
-
-
Frank, D.B.1
-
193
-
-
4544386270
-
BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease
-
Roberts, K. E., et al. BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease. Eur. Respir. J. 24, 371-374 (2004).
-
(2004)
Eur. Respir. J.
, vol.24
, pp. 371-374
-
-
Roberts, K.E.1
-
194
-
-
0033817459
-
Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension
-
The International PPH Consortium, et al.
-
The International PPH Consortium, et al. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension. Nat. Genet. 26, 81-84 (2000).
-
(2000)
Nat. Genet.
, vol.26
, pp. 81-84
-
-
-
195
-
-
84863279449
-
Cytoskeletal defects in Bmpr2 associated pulmonary arterial hypertension
-
Johnson, J. A., et al. Cytoskeletal defects in Bmpr2 associated pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 302, L474-L484 (2012).
-
(2012)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.302
, pp. L474-L484
-
-
Johnson, J.A.1
-
196
-
-
57049159708
-
Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions
-
West, J., et al. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L744-L755 (2008).
-
(2008)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.295
, pp. L744-L755
-
-
West, J.1
-
197
-
-
0037341510
-
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2
-
Srinivasan, S., et al. A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. Hum. Mol. Genet. 12, 473-482 (2003).
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 473-482
-
-
Srinivasan, S.1
-
198
-
-
0030813490
-
The activin receptor-like kinase 1 gene: Genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2
-
Berg, J. N., et al. The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2. Am. J. Hum. Genet. 61, 60-67 (1997).
-
(1997)
Am. J. Hum. Genet.
, vol.61
, pp. 60-67
-
-
Berg, J.N.1
-
199
-
-
9144219585
-
Molecular and functional analysis identifies ALK 1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia
-
Harrison, R. E., et al. Molecular and functional analysis identifies ALK 1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. J. Med. Genet. 40, 865-871 (2003).
-
(2003)
J. Med. Genet.
, vol.40
, pp. 865-871
-
-
Harrison, R.E.1
-
200
-
-
0033612141
-
Defective angiogenesis in mice lacking endoglin
-
Li, D. Y., et al. Defective angiogenesis in mice lacking endoglin. Science 284, 1534-1537 (1999).
-
(1999)
Science
, vol.284
, pp. 1534-1537
-
-
Li, D.Y.1
-
201
-
-
0028171579
-
Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
-
McAllister, K. A., et al. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat. Genet. 8, 345-351 (1994).
-
(1994)
Nat. Genet.
, vol.8
, pp. 345-351
-
-
McAllister, K.A.1
-
202
-
-
84886901002
-
Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation
-
Levet, S., et al. Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation. Blood 122, 598-607 (2013).
-
(2013)
Blood
, vol.122
, pp. 598-607
-
-
Levet, S.1
-
203
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard, D., et al. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41, 478-481 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 478-481
-
-
Meynard, D.1
-
204
-
-
0029850112
-
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
-
Zhang, H. & Bradley, A. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122, 2977-2986 (1996).
-
(1996)
Development
, vol.122
, pp. 2977-2986
-
-
Zhang, H.1
Bradley, A.2
-
205
-
-
0141445966
-
An essential role of Bmp4 in the atrioventricular septation of the mouse heart
-
Jiao, K., et al. An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev. 17, 2362-2367 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 2362-2367
-
-
Jiao, K.1
-
206
-
-
6244256053
-
Bmpr encodes a type i bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
-
Mishina, Y., Suzuki, A., Ueno, N. & Behringer, R. R. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 9, 3027-3037 (1995).
-
(1995)
Genes Dev.
, vol.9
, pp. 3027-3037
-
-
Mishina, Y.1
Suzuki, A.2
Ueno, N.3
Behringer, R.R.4
-
207
-
-
53349108638
-
SM22α targeted deletion of bone morphogenetic protein receptor IA in mice impairs cardiac and vascular development, and influences organogenesis
-
El-Bizri, N., et al. SM22α targeted deletion of bone morphogenetic protein receptor IA in mice impairs cardiac and vascular development, and influences organogenesis. Development 135, 2981-2991 (2008).
-
(2008)
Development
, vol.135
, pp. 2981-2991
-
-
El-Bizri, N.1
-
208
-
-
39449096751
-
Smooth muscle protein 22α mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling
-
El-Bizri, N., et al. Smooth muscle protein 22α mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. Circ. Res. 102, 380-388 (2008).
-
(2008)
Circ. Res.
, vol.102
, pp. 380-388
-
-
El-Bizri, N.1
-
209
-
-
84872610226
-
Patchy deletion of Bmpr1a potentiates proximal pulmonary artery remodeling in mice exposed to chronic hypoxia
-
Vanderpool, R. R., El-Bizri, N., Rabinovitch, M. & Chesler, N. C. Patchy deletion of Bmpr1a potentiates proximal pulmonary artery remodeling in mice exposed to chronic hypoxia. Biomech. Model Mechanobiol. 12, 33-42 (2013).
-
(2013)
Biomech. Model Mechanobiol.
, vol.12
, pp. 33-42
-
-
Vanderpool, R.R.1
El-Bizri, N.2
Rabinovitch, M.3
Chesler, N.C.4
-
210
-
-
0034972978
-
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
-
Howe, J. R., et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat. Genet. 28, 184-187 (2001).
-
(2001)
Nat. Genet.
, vol.28
, pp. 184-187
-
-
Howe, J.R.1
-
211
-
-
0034829630
-
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes
-
Zhou, X. P., et al. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am. J. Hum. Genet. 69, 704-711 (2001).
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 704-711
-
-
Zhou, X.P.1
-
212
-
-
0033960316
-
The type i BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
-
Yi, S. E., Daluiski, A., Pederson, R., Rosen, V. & Lyons, K. M. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127, 621-630 (2000).
-
(2000)
Development
, vol.127
, pp. 621-630
-
-
Yi, S.E.1
Daluiski, A.2
Pederson, R.3
Rosen, V.4
Lyons, K.M.5
-
213
-
-
84861581610
-
Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension
-
Chida, A., et al. Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension. Circ. J. 76, 1501-1508 (2012).
-
(2012)
Circ. J.
, vol.76
, pp. 1501-1508
-
-
Chida, A.1
-
214
-
-
80855128771
-
BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium
-
Helbing, T., et al. BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium. Blood 118, 5040-5049 (2011).
-
(2011)
Blood
, vol.118
, pp. 5040-5049
-
-
Helbing, T.1
-
215
-
-
77955790531
-
Intersegmental vessel formation in zebrafish: Requirement for VEGF but not BMP signalling revealed by selective and non-selective BMP antagonists
-
Cannon, J. E., Upton, P. D., Smith, J. C. & Morrell, N. W. Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non-selective BMP antagonists. Br. J. Pharmacol. 161, 140-149 (2010).
-
(2010)
Br. J. Pharmacol.
, vol.161
, pp. 140-149
-
-
Cannon, J.E.1
Upton, P.D.2
Smith, J.C.3
Morrell, N.W.4
-
216
-
-
84920285128
-
BMP type i receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease
-
Kajimoto, H., et al. BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease. Kidney Int. 87, 128-136 (2015).
-
(2015)
Kidney Int.
, vol.87
, pp. 128-136
-
-
Kajimoto, H.1
-
217
-
-
84861557944
-
Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting
-
van Meeteren, L. A., et al. Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J. Biol. Chem. 287, 18551-18561 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 18551-18561
-
-
Van Meeteren, L.A.1
|