Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

Development (Cambridge)

Volumn 142, Issue 12, 2015, Pages 2121-2135

  Faial, Tiago ^a,b   Bernardo, Andreia S ^a,b,c   Mendjan, Sasha ^a,c   Diamanti, Evangelia ^d   Ortmann, Daniel ^a,c   Gentsch, George E ^a,b   Mascetti, Victoria L ^a,c   Trotter, Matthew W B ^a,e   Smith, James C ^a,b   Pedersen, Roger A ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e Celgene Institute for Translational Research Europe CITRE   (Spain)

Author keywords

Embryonic stem cells; Gastrulation; Gene regulatory networks; Human; SMAD; T BOX

Indexed keywords

ACTIVIN A; BONE MORPHOGENETIC PROTEIN 4; CYTOCHROME P450 26A1; HEPATOCYTE NUCLEAR FACTOR 3BETA; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRACHYURY; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG; BMP4 PROTEIN, HUMAN; BRACHYURY PROTEIN; EOMES PROTEIN, HUMAN; FETOPROTEIN; SMAD1 PROTEIN, HUMAN; SMAD2 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN;

ARTICLE; CELL POPULATION; EMBRYONIC STEM CELL; ENDODERM; EPITHELIAL MESENCHYMAL TRANSITION; GASTRULATION; GENE EXPRESSION; GENE ONTOLOGY; GENE REGULATORY NETWORK; GERM LAYER; HOX GENE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MESODERM; PRIMITIVE STREAK; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; TRANSGENIC MOUSE;

VERTEBRATA;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CELL LINE; EMBRYONIC STEM CELLS; ENDODERM; FETAL PROTEINS; GASTRULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESODERM; MICE; MICE, TRANSGENIC; NEUROGENESIS; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; T-BOX DOMAIN PROTEINS;

EID: 84931042699     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.117838     Document Type: Article

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