SM22α-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development and influences organogenesis

Development

Volumn 135, Issue 17, 2008, Pages 2981-2991

  El Bizri, Nesrine ^a   Guignabert, Christophe ^a   Wang, Lingli ^a   Cheng, Alexander ^a   Stankunas, Kryn ^a   Chang, Ching Pin ^a   Mishina, Yuji ^b   Rabinovitch, Marlene ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Bmpr1a (Alk3); Craniofacial development; Heart development; Matrix metalloproteinase (metallopeptidase); MMP2; MMP9; Mouse; Pericyte apoptosis; SM22 (transgelin, Tagln); Smooth muscle cell proliferation; Vasculogenesis

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; CRE RECOMBINASE; GELATINASE A; GELATINASE B; TRANSGELIN; ACTIN BINDING PROTEIN; BMPR1A PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; INTEGRASE; MUSCLE PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL; BRAIN DEVELOPMENT; CARDIOVASCULAR SYSTEM; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; EXON; GENE DELETION; GENOTYPE; HEART DEVELOPMENT; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MICROVASCULATURE; MOUSE; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; TELENCEPHALON; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; BRAIN; CELL MOTION; CONGENITAL MALFORMATION; CYTOLOGY; EMBRYO (ANATOMY); EMBRYO DEATH; ENZYMOLOGY; HEART; METABOLISM; PATHOLOGY; PERICYTE; PRENATAL DEVELOPMENT; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; TRANSGENIC MOUSE; VASCULARIZATION;

MUS;

ANIMALS; APOPTOSIS; BLOOD VESSELS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BRAIN; CELL MOVEMENT; CELL PROLIFERATION; EMBRYO LOSS; EMBRYO, MAMMALIAN; GENE DELETION; HEART; HUMANS; HYPERTENSION, PULMONARY; INTEGRASES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; ORGANOGENESIS; PERICYTES;

EID: 53349108638     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.017863     Document Type: Article

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