Defective angiogenesis in mice lacking endoglin

Science

Volumn 284, Issue 5419, 1999, Pages 1534-1537

  Li, Dean Y ^a,b   Sorensen, Lise K ^c   Brooke, Benjamin S ^a,b   Urness, Lisa D ^c   Davis, Elaine C ^d   Taylor, Douglas G ^a,b   Boak, Beth B ^c   Wendel, Daniel P ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGLIN; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CONGENITAL BLOOD VESSEL MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENDU OSLER WEBER DISEASE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD31; BLOOD VESSELS; CELL DIFFERENTIATION; CROSSES, GENETIC; ENDOTHELIUM, VASCULAR; FEMALE; GENE TARGETING; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; MUSCLE, SMOOTH, VASCULAR; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE-1; YOLK SAC;

EID: 0033612141     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5419.1534     Document Type: Article

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31. Supported by National Institutes of Health grants K08 HL03490-03 and T35 HL07744-06, the Culpeper Scholarship in Medical Science, and a University of Utah Seed Grant. We thank M. T. Keating for guidance and support and J. Miano and K. Thomas for clones and discussion. B.S.B. is a Howard Hughes Medical Institute Medical Student Research Training Fellow.