Patchy deletion of Bmpr1a potentiates proximal pulmonary artery remodeling in mice exposed to chronic hypoxia

Biomechanics and Modeling in Mechanobiology

Volumn 12, Issue 1, 2013, Pages 33-42

  Vanderpool, Rebecca R ^a   El Bizri, Nesrine ^b   Rabinovitch, Marlene ^b   Chesler, Naomi C ^a  

^a University of Wisconsin Madison   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arterial stiffness; Characteristic impedance; Knockout mouse; Pulmonary hemodynamics; Pulmonary hypertension; Pulsatile pressure flow relationships

Indexed keywords

BLOOD PRESSURE; COLLAGEN; HEMODYNAMICS; MAMMALS; PULSATILE FLOW;

ARTERIAL STIFFNESS; CHARACTERISTIC IMPEDANCE; HAEMODYNAMICS; KNOCKOUT MICE; PRESSURE FLOW RELATIONSHIP; PULMONARY ARTERY; PULMONARY HEMODYNAMIC; PULMONARY HYPERTENSION; PULSATILE PRESSURE-FLOW RELATIONSHIP; PULSATILE PRESSURES;

STIFFNESS;

MUS;

BMPR1A PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN RECEPTOR 1;

ANIMAL; ANOXIA; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; FEMALE; GENETICS; MALE; MECHANOTRANSDUCTION; METABOLISM; MOUSE; MOUSE MUTANT; PATHOPHYSIOLOGY; PULMONARY ARTERY; VASCULAR RESISTANCE; YOUNG MODULUS;

ANIMALS; ANOXIA; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; COMPUTER SIMULATION; ELASTIC MODULUS; FEMALE; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, KNOCKOUT; MODELS, CARDIOVASCULAR; PULMONARY ARTERY; VASCULAR RESISTANCE;

MLCS; MLOWN;

EID: 84872610226     PISSN: 16177959     EISSN: 16177940     Source Type: Journal    
DOI: 10.1007/s10237-012-0379-6     Document Type: Article

References (36)

1. Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW (2002) Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 105(14): 1672-1678
2. Bellusci S, Henderson R, Winnier G, Oikawa T, Hogan BL (1996) Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122(6): 1693-1702
3. Benumof J (1985) One-lung ventilation and hypoxic pulmonary vasoconstriction: implications for anesthetic management. Anesth Analg 64(8): 821-833
4. Cardoso WV (2001) Molecular regulation of lung development. Annu Rev Physiol 63: 471-494. doi: 10.1146/annurev.physiol.63.1.47163/1/471[pii]
5. Du L, Sullivan CC, Chu D, Cho AJ, Kido M, Wolf PL, Yuan JX, Deutsch R, Jamieson SW, Thistlethwaite PA (2003) Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med 348(6): 500-509. doi: 348/6/500[pii]10. 1056/NEJMoa021650
6. El-Bizri N, Wang L, Merklinger S, Guignabert C, Desai T, Urashima T, Sheikh A, Knutsen R, Mecham R, Mishina Y, Rabinovitch M (2008) Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. Circ Res 102(3): 380-388. doi: CIRCRESAHA.107.161059[pii]10.1161/CIRCRESAHA.107.161059
7. Gan CT, Lankhaar JW, Westerhof N, Marcus JT, Becker A, Twisk JW, Boonstra A, Postmus PE, Vonk-Noordegraaf A (2007) Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension. Chest 132(6): 1906-1912
8. Gilboa L, Nohe A, Geissendorfer T, Sebald W, Henis YI, Knaus P (2000) Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. Mol Biol Cell 11(3): 1023-1035
9. Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P (2005) Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 97(2): 185-191
10. Jain AK (2010) Data clustering: 50 years beyond K-means. Pattern Recognit Lett 31: 651-666
11. Jain AK, Murty MN, Flynn PJ (1999) Data clustering: a review. ACM Comput Surv 31(3): 264-323
12. King JA, Marker PC, Seung KJ, Kingsley DM (1994) BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev Biol 166(1): 112-122. doi: S0012-1606(84)71300-5[pii]10.1006/dbio.1994.1300
13. Li F, Xia W, Yuan S, Sun R (2009) Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease. Pediatr Cardiol 30(3): 363-366
14. Mahapatra S, Nishimura R, Sorajja P, Cha S, McGoon M (2006) Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension. J Am Coll Cardiol 47(4): 799-803
15. Mathers J, Benumof J, Wahrenbrock E (1977) General anesthetics and regional hypoxic pulmonary vasoconstriction. Anesthesiology 46(2): 111-114
16. McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J (2009) ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol 53(17): 1573-1619. doi: S0735-1097(09)00142-9[pii]10.1016/j.jacc.2009.01.004
17. Milnor WR (1989) Hemodynamics, 2nd edn. Williams & Wilkins, Baltimore
18. Milnor WR, Conti CR, Lewis KB, O'Rourke MF (1969) Pulmonary arterial pulse wave velocity and impedance in man. Circ Res 25(6): 637-649
19. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M (2005) Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit care Med 171(5): 494-499
20. Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M (2004) Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287(4): L665-672
21. Newman JH, Phillips JA 3rd, Loyd JE (2008) Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies. Ann Intern Med 148(4): 278-283. doi: 148/4/278[pii]
22. Nichols WW, O'Rourke MF, Hartley C, McDonald DA (2005) McDonald's blood flow in arteries: theoretical, experimental, and clinical principles, 5th edn. Arnold, London
23. Ooi CY, Wang Z, Tabima DM, Eickhoff JC, Chesler NC (2010) The role of collagen in extralobar pulmonary artery stiffening in response to hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 299(6): H1823-1831. doi: ajpheart.00493.2009[pii]10.1152/ajpheart.00493.2009
24. Schwenke DO, Pearson JT, Mori H, Shirai M (2006) Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice. J Pharmacol Toxicol Methods 53(3): 277-283. doi: S1056-8719(05)00142-5[pii]10.1016/j.vascn.2005.11. 003
25. Sheedy W, Thompson JS, Morice AH (1996) A comparison of pathophysiological changes during hypobaric and normobaric hypoxia in rats. Respiration 63(4): 217-222
26. Stenmark KR, Fagan KA, Frid MG (2006) Hypoxia-induced pulmonary vascular remodeling - cellular and molecular mechanisms. Circ Res 99(7): 675-691. doi: 10.1161/01.RES.0000243584.45145.3f
27. Tabima D, Chesler N (2010) The effects of vasoactivity and hypoxic pulmonary hypertension on extralobar pulmonary artery biomechanics. J Biomech 43(10): 1864-1869. doi: S0021-9290(10)00178-8[pii]10.1016/j.jbiomech.2010.03.033
28. Tabima DM, Chesler NC (2010) The effects of vasoactivity and hypoxic pulmonary hypertension on extralobar pulmonary artery biomechanics. J Biomech 43(10): 1864-1869. doi: S0021-9290(10)00178-8[pii]10.1016/j.jbiomech.2010.03.033
29. Tabima DM, Hacker TA, Chesler NC (2010) Measuring right ventricular function in the normal and hypertensive mouse hearts using admittance-derived pressure-volume loops. Am J Physiol Heart Circ Physiol. doi: ajpheart.00805.2010[pii]10.1152/ajpheart.00805.2010
30. Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, Fukuchi Y (2006) Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 290(3): L450-458. doi: 00206.2005[pii]10.1152/ajplung.00206.2005
31. Thomson J, Machado R, Pauciulo M, Morgan N, Yacoub M, Corris P, McNeil K, Loyd J, Nichols W, Trembath R (2001) Familial and sporadic primary pulmonary hypertension is caused by BMPR2 gene mutations resulting in haploinsufficiency of the bone morphogenetic protein tùype II receptor. J Heart Lung Transplant 20(2): 149. doi: S1053-2498(01)00259-5[pii]
32. Tuchscherer HA, Vanderpool RR, Chesler NC (2007) Pulmonary vascular remodeling in isolated mouse lungs: effects on pulsatile pressure-flow relationships. J Biomech 40(5): 993-1001
33. Tuchscherer HA, Webster EB, Chesler NC (2006) Pulmonary vascular resistance and impedance in isolated mouse lungs: effects of pulmonary emboli. Ann Biomed Eng 34(4): 660-668
34. Urist MR (1965) Bone: formation by autoinduction. Science 150(698): 893-899
35. Vanderpool RR, Kim AR, Molthen R, Chesler NC (2011) Effects of acute Rho kinase inhibition on chronic hypoxia-induced changes in proximal and distal pulmonary arterial structure and function. J Appl Physiol 110(1): 188-198. doi: japplphysiol.00533.2010[pii]10.1152/japplphysiol.00533.2010
36. Vanderpool RR, Naeije R, Chesler NC (2010) Impedance in isolated mouse lungs for the determination of site of action of vasoactive agents and disease. Ann Biomed Eng 38(5): 1854-1861. doi: 10.1007/s10439-010-9960-2