Bone morphogenetic protein (BMP)and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

Journal of Biological Chemistry

Volumn 284, Issue 23, 2009, Pages 15794-15804

  Upton, Paul D ^a   Davies, Rachel J ^a   Trembath, Richard C ^b   Morrell, Nicholas W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEINS; DIFFERENTIAL SIGNALING; ENDOGLIN; GROWTH INHIBITION; INTERLEUKIN-8; KINASE RECEPTORS; MITOGENIC; PULMONARY ARTERIAL HYPERTENSION; PULMONARY ARTERY ENDOTHELIAL CELLS; RECEPTOR-LIKE KINASE; RELATIVE CONTRIBUTION; SELECTIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTORS; TYPE II;

BIOACTIVITY; BLOOD VESSEL PROSTHESES; BONE; GENE EXPRESSION; GLYCOPROTEINS; NUCLEIC ACIDS; PROTEINS; RNA; SELF ASSEMBLY; SIGNALING;

ENDOTHELIAL CELLS;

ACTIVIN RECEPTOR 2; ACTIVIN RECEPTOR LIKE KINASE 1; BONE MORPHOGENETIC PROTEIN 9; ENDOGLIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; INTERLEUKIN 8; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMALL INTERFERING RNA; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; GDF2 PROTEIN, HUMAN; GROWTH DIFFERENTIATION FACTOR; MESSENGER RNA; PRIMER DNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENDOTHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM; AORTA; CELL LINE; CYTOLOGY; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MICROCIRCULATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

ACTIVIN RECEPTORS, TYPE II; AORTA; BONE MORPHOGENETIC PROTEIN RECEPTORS; BONE MORPHOGENETIC PROTEINS; CELL LINE; DNA PRIMERS; ENDOTHELIUM, VASCULAR; GROWTH DIFFERENTIATION FACTORS; HUMANS; MICROCIRCULATION; PULMONARY ARTERY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSCRIPTION, GENETIC;

EID: 67650188576     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.002881     Document Type: Article

References (50)

1. Tuder, R. M., Marecki, J. C., Richter, A., Fijalkowska, I., and Flores, S. (2007) Clin. Chest Med. 28, 23-42, vii
2. Lane, K. B., Machado, R. D., Pauciulo, M. W., Thomson, J. R., Phillips, J. A., 3rd, Loyd, J. E., Nichols, W. C., and Trembath, R. C. (2000) Nat. Genet. 26, 81-84
3. Deng, Z., Morse, J. H., Slager, S. L., Cuervo, N., Moore, K. J., Venetos, G., Kalachikov, S., Cayanis, E., Fischer, S. G., Barst, R. J., Hodge, S. E., and Knowles, J. A. (2000) Am. J. Hum. Genet. 67, 737-744
4. Machado, R. D., Aldred, M. A., James, V., Harrison, R. E., Patel, B., Schwalbe, E. C., Gruenig, E., Janssen, B., Koehler, R., Seeger, W., Eickelberg, O., Olschewski, H., Elliott, C. G., Glissmeyer, E., Carlquist, J., Kim, M., Torbicki, A., Fijalkowska, A., Szewczyk, G., Parma, J., Abramowicz, M. J., Galie, N., Morisaki, H., Kyotani, S., Nakanishi, N., Morisaki, T., Humbert, M., Simonneau, G., Sitbon, O., Soubrier, F., Coulet, F., Morrell, N. W., and Trembath, R. C. (2006) Hum. Mutat. 27, 121-132
5. Sadick, H., Sadick, M., Götte, K., Naim, R., Riedel, F., Bran, G., and Hörmann, K. (2006) Wien. Klin. Wochenschr. 118, 72-80
6. Cottin, V., Plauchu, H., Bayle, J. Y., Barthelet, M., Revel, D., and Cordier, J. F. (2004) Am. J. Respir. Crit. Care Med. 169, 994-1000
7. McAllister, K. A., Grogg, K. M., Johnson, D. W., Gallione, C. J., Baldwin, M. A., Jackson, C. E., Helmbold, E. A., Markel, D. S., McKinnon, W. C., and Murrell, J. (1994) Nat. Genet. 8, 345-351
8. Johnson, D. W., Berg, J. N., Baldwin, M. A., Gallione, C. J., Marondel, I., Yoon, S. J., Stenzel, T. T., Speer, M., Pericak-Vance, M. A., Diamond, A., Guttmacher, A. E., Jackson, C. E., Attisano, L., Kucherlapati, R., Porteous, M. E., and Marchuk, D. A. (1996) Nat. Genet. 13, 189-195
9. Trembath, R. C. (2001) J. Heart Lung Transplant. 20, 175
10. Abdalla, S. A., Gallione, C. J., Barst, R. J., Horn, E. M., Knowles, J. A., Marchuk, D. A., Letarte, M., and Morse, J. H. (2004) Eur. Respir. J. 23, 373-377
11. Trembath, R. C., Thomson, J. R., Machado, R. D., Morgan, N. V., Atkinson, C., Winship, I., Simonneau, G., Galie, N., Loyd, J. E., Humbert, M., Nichols, W. C., Morrell, N. W., Berg, J., Manes, A., McGaughran, J., Pauciulo, M., and Wheeler, L. (2001) N. Engl. J. Med. 345, 325-334
12. van den Driesche, S., Mummery, C. L., and Westermann, C. J. (2003) Cardiovasc. Res. 58, 20-31
13. Ebisawa, T., Tada, K., Kitajima, I., Tojo, K., Sampath, T. K., Kawabata, M., Miyazono, K., and Imamura, T. (1999) J. Cell Sci. 112, 3519-3527
14. Liu, F., Hata, A., Baker, J. C., Doody, J., Cárcamo, J., Harland, R. M., and Massagué, J. (1996) Nature 381, 620-623
15. Hoodless, P. A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M. B., Attisano, L., and Wrana, J. L. (1996) Cell 85, 489-500
16. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
17. Verrecchia, F., Vindevoghel, L., Lechleider, R. J., Uitto, J., Roberts, A. B., and Mauviel, A. (2001) Oncogene 20, 3332-3340
18. Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G., and Whitman, M. (1997) Nature 389, 85-89
19. Hoodless, P. A., Tsukazaki, T., Nishimatsu, S., Attisano, L., Wrana, J. L., and Thomsen, G. H. (1999) Dev. Biol. 207, 364-379
20. Goumans, M. J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S., and ten Dijke, P. (2003) Mol. Cell 12, 817-828
21. Goumans, M. J., Valdimarsdottir, G., Itoh, S., Rosendahl, A., Sideras, P., and ten Dijke, P. (2002) EMBO J. 21, 1743-1753
22. David, L., Mallet, C., Mazerbourg, S., Feige, J. J., and Bailly, S. (2007) Blood 109, 1953-1961
23. Scharpfenecker, M., van Dinther, M., Liu, Z., van Bezooijen, R. L., Zhao, Q., Pukac, L., Löwik, C. W., and ten Dijke, P. (2007) J. Cell Sci. 120, 964-972
24. David, L., Mallet, C., Keramidas, M., Lamandé, N., Gasc, J. M., Dupuis-Girod, S., Plauchu, H., Feige, J. J., and Bailly, S. (2008) Circ. Res. 102, 914-922
25. Lux, A., Salway, F., Dressman, H. K., Kröner-Lux, G., Hafner, M., Day, P. J., Marchuk, D. A., and Garland, J. (2006) BMC Cardiovasc. Disord. 6, 13
26. Park, S. O., Lee, Y. J., Seki, T., Hong, K. H., Fliess, N., Jiang, Z., Park, A., Wu, X., Kaartinen, V., Roman, B. L., and Oh, S. P. (2008) Blood 111, 633-642
27. Morrell, N. W., Yang, X., Upton, P. D., Jourdan, K. B., Morgan, N., Sheares, K. K., and Trembath, R. C. (2001) Circulation 104, 790-795
28. Livak, K. J., and Schmittgen, T. D. (2001) Methods 25, 402-408
29. Cowburn, A. S., Deighton, J., Walmsley, S. R., and Chilvers, E. R. (2004) Eur. J. Immunol. 34, 1733-1743
30. Morrell, N. W., Upton, P. D., Kotecha, S., Huntley, A., Yacoub, M. H., Polak, J. M., and Wharton, J. (1999) Am. J. Physiol. 277, L440-448
31. Seki, T., Hong, K. H., and Oh, S. P. (2006) Lab. Investig. 86, 116-129
32. Uhl, M., Aulwurm, S., Wischhusen, J., Weiler, M., Ma, J. Y., Almirez, R., Mangadu, R., Liu, Y. W., Platten, M., Herrlinger, U., Murphy, A., Wong, D. H., Wick, W., Higgins, L. S., and Weller, M. (2004) Cancer Res. 64, 7954-7961
33. Upton, P. D., Long, L., Trembath, R. C., and Morrell, N. W. (2008) Mol. Pharmacol. 73, 539-552
34. Harrison, R. E., Flanagan, J. A., Sankelo, M., Abdalla, S. A., Rowell, J., Machado, R. D., Elliott, C. G., Robbins, I. M., Olschewski, H., McLaughlin, V., Gruenig, E., Kermeen, F., Halme, M., Räisänen-Sokolowski, A., Laitinen, T., Morrell, N. W., and Trembath, R. C. (2003) J. Med. Genet. 40, 865-871
35. Lamouille, S., Mallet, C., Feige, J. J., and Bailly, S. (2002) Blood 100, 4495-4501
36. Pepper, M. S. (1997) Cytokine Growth Factor Rev. 8, 21-43
37. Valdimarsdottir, G., Goumans, M. J., Rosendahl, A., Brugman, M., Itoh, S., Lebrin, F., Sideras, P., and ten Dijke, P. (2002) Circulation 106, 2263-2270
38. Szekanecz, Z., and Koch, A. E. (2000) Arthritis Res. 2, 368-373
39. Nguyen, M., Strubel, N. A., and Bischoff, J. (1993) Nature 365, 267-269
40. Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., Doerschuk, C. M., Ley, K., and Beaudet, A. L. (1996) J. Exp. Med. 183, 2329-2336
41. Yu, Y., Moulton, K. S., Khan, M. K., Vineberg, S., Boye, E., Davis, V. M., O'Donnell, P. E., Bischoff, J., and Milstone, D. S. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 8005-8010
42. Yue, T. L., Wang, X., Sung, C. P., Olson, B., McKenna, P. J., Gu, J. L., and Feuerstein, G. Z. (1994) Circ. Res. 75 b, 1-7
43. McClintock, J. Y., and Wagner, E. M. (2005) J. Appl. Physiol. 99, 861-866
44. Chen, Y. G., and Massagué, J. (1999) J. Biol. Chem. 274, 3672-3677
45. Gallione, C. J., Richards, J. A., Letteboer, T. G., Rushlow, D., Prigoda, N. L., Leedom, T. P., Ganguly, A., Castells, A., Ploos van Amstel, J. K., Westermann, C. J., Pyeritz, R. E., and Marchuk, D. A. (2006) J. Med. Genet. 43, 793-797
46. Gallione, C. J., Repetto, G. M., Legius, E., Rustgi, A. K., Schelley, S. L., Tejpar, S., Mitchell, G., Drouin, E., Westermann, C. J., and Marchuk, D. A. (2004) Lancet 363, 852-859
47. Fernandez-L. A., Sanz-Rodriguez, F., Zarrabeitia, R., Pérez-Molino, A., Hebbel, R. P., Nguyen, J., Bernabéu, C., and Botella, L. M. (2005) Cardiovasc. Res. 68, 235-248
48. Pece-Barbara, N., Vera, S., Kathirkamathamby, K., Liebner, S., Di Guglielmo, G. M., Dejana, E., Wrana, J. L., and Letarte, M. (2005) J. Biol. Chem. 280, 27800-27808
49. Lee, N. Y., Ray, B., How, T., and Blobe, G. C. (2008) J. Biol. Chem. 283, 32527-32533
50. Sobolewski, A., Rudarakanchana, N., Upton, P. D., Yang, J., Crilley, T. K., Trembath, R. C., and Morrell, N. W. (2008) Hum. Mol. Genet. 17, 3180-3190