Relevant issues in the pathology and pathobiology of pulmonary hypertension

Journal of the American College of Cardiology

Volumn 62, Issue 25 SUPPL., 2013, Pages

  Tuder, Rubin M ^a   Archer, Stephen L ^b   Dorfmüller, Peter ^c   Erzurum, Serpil C ^d   Guignabert, Christophe ^e   Michelakis, Evangelos ^f   Rabinovitch, Marlene ^g   Schermuly, Ralph ^h   Stenmark, Kurt R ⁱ   Morrell, Nicholas W ^j  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b QUEEN S UNIVERSITY   (Canada)

^c CENTRE CHIRURGICAL MARIE LANNELONGUE   (France)

^d LERNER RESEARCH INSTITUTE   (United States)

^e Universite Paris Sud   (France)

^f UNIVERSITY OF ALBERTA   (Canada)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

ⁱ Nutrition Obesity Research Center at the University of Colorado   (United States)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

inflammation; metabolism; pulmonary arteries; pulmonary veins

Indexed keywords

ACTIVIN RECEPTOR 1; BONE MORPHOGENETIC PROTEIN 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ADAPTIVE IMMUNITY; APOPTOSIS; CELL GROWTH; CELL PROLIFERATION; CONFERENCE PAPER; DISEASE COURSE; DISEASE SEVERITY; GENE MUTATION; HEART ATRIUM REMODELING; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; MICROSATELLITE INSTABILITY; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; VASCULITIS;

ACTIVIN RECEPTOR-LIKE KINASE; ALK; BMPR2; BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR; DC; DENDRITIC CELL; ENDOPLASMIC RETICULUM; ER; HIF; HYPOXIA INDUCIBLE FACTOR; IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION; INFLAMMATION; IPAH; LEFT HEART FAILURE; LHF; METABOLISM; PAH; PH; PULMONARY ARTERIAL HYPERTENSION; PULMONARY ARTERIES; PULMONARY HYPERTENSION; PULMONARY VEINS;

ANIMALS; HUMANS; HYPERTENSION, PULMONARY; MUSCLE, SMOOTH, VASCULAR; PULMONARY ARTERY; PULMONARY VEINS; SIGNAL TRANSDUCTION;

EID: 84890753066     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.10.025     Document Type: Conference Paper

References (100)

1. R.M. Tuder, S.H. Abman, and T. Braun Development and pathology of pulmonary hypertension J Am Coll Cardiol 54 2009 S3 S9
2. N.W. Morrell, S. Adnot, and S.L. Archer Cellular and molecular basis of pulmonary arterial hypertension J Am Coll Cardiol 54 2009 S20 S31
3. A. Zaiman, I. Fijalkowska, P.M. Hassoun, and R.M. Tuder One hundred years of research in the pathogenesis of pulmonary hypertension Am J Respir Cell Mol Biol 33 2005 425 431
4. S.L. Merklinger, P.L. Jones, E.C. Martinez, and M. Rabinovitch Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension Circulation 112 2005 423 431
5. M. Izikki, C. Guignabert, and E. Fadel Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents J Clin Invest 119 2009 512 523
6. F. Perros, D. Montani, and P. Dorfmuller Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 178 2008 81 88
7. R.T. Schermuly, E. Dony, and H.A. Ghofrani Reversal of experimental pulmonary hypertension by PDGF inhibition J Clin Invest 115 2005 2811 2821
8. L. Long, A. Crosby, and X. Yang Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease Circulation 119 2009 566 576
9. A.L. Zaiman, M. Podowski, and S. Medicherla Role of TGF-β/ALK5 kinase in monocrotaline-induced pulmonary hypertension Am J Respir Crit Care Med 177 2008 896 905
10. J. Kim, Y. Kang, and Y. Kojima An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension Nat Med 19 2013 74 82
11. A. Courboulin, R. Paulin, and N.J. Giguère Role for miR-204 in human pulmonary arterial hypertension J Exp Med 208 2011 535 548
12. J.R. Lavoie, and D.J. Stewart Genetically modified endothelial progenitor cells in the therapy of cardiovascular disease and pulmonary hypertension Curr Vasc Pharmacol 10 2012 289 299
13. K. Asosingh, S. Farha, and A. Lichtin Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension Blood 120 2012 1218 1227
14. S. Gunther, X. Jais, and S. Maitre Computed tomography findings of pulmonary venoocclusive disease in scleroderma patients presenting with precapillary pulmonary hypertension Arthritis Rheum 64 2012 2995 3005
15. E. Stacher, B.B. Graham, and J.M. Hunt Modern age pathology of pulmonary arterial hypertension Am J Respir Crit Care Med 186 2012 261 272
16. J.M. Hunt, B. Bethea, and X. Liu Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease Am J Physiol Lung Cell Mol Physiol 305 2013 L725 L736
17. S.L. Archer, E.K. Weir, and M.R. Wilkins Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies Circulation 121 2010 2045 2066
18. M. Oka, N. Homma, and L. Taraseviciene-Stewart Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats Circ Res 100 2007 923 929
19. Z. Deng, J.H. Morse, and S.L. Slager Familial primary pulmonary hypertension (gene PPH1) Is caused by mutations in the bone morphogenetic protein receptor-II gene Am J Hum Genet 67 2000 737 744
20. K.B. Lane, R.D. Machado, and M.W. Pauciulo Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension Nat Genet 26 2000 81 84
21. R.D. Machado, M.A. Aldred, and V. James Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension Hum Mutat 27 2006 121 132
22. R.C. Trembath, J.R. Thomson, and R.D. Machado Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia N Engl J Med 345 2001 325 334
23. A. Chaouat, F. Coulet, and C. Favre Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension Thorax 59 2004 446 448
24. M. Shintani, H. Yagi, T. Nakayama, T. Saji, and R. Matsuoka A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension J Med Genet 46 2009 331 337
25. E.D. Austin, L. Ma, and C. Leduc Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension Circ Cardiovasc Genet 5 2012 336 343
26. L. Ma, D. Roman-Campos, and E.D. Austin A novel channelopathy in pulmonary arterial hypertension N Engl J Med 369 2013 351 361
27. B. Girerd, D. Montani, and F. Coulet Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation Am J Respir Crit Care Med 181 2010 851 861
28. C.G. Elliott, E.W. Glissmeyer, and G.T. Havlena Relationship of BMPR2 mutations to vasoreactivity in pulmonary arterial hypertension Circulation 113 2006 2509 2515
29. M.E. Yeager, G.R. Halley, H.A. Golpon, N.F. Voelkel, and R.M. Tuder Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension Circ Res 88 2001 e8 e11
30. M.A. Aldred, S.A. Comhair, and M. Varella-Garcia Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension Am J Respir Crit Care Med 182 2010 1153 1160
31. W. Xu, T. Koeck, and A.R. Lara Alterations of cellular bioenergetics in pulmonary artery endothelial cells Proc Natl Acad Sci U S A 104 2007 1342 1347
32. S.L. Archer, G. Marsboom, and G.H. Kim Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target Circulation 121 2010 2661 2671
33. J.I. Aguirre, N.W. Morrell, and L. Long Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia Am J Physiol Lung Cell Mol Physiol 278 2000 L981 L987
34. E.K. Weir, A. Tucker, J.T. Reeves, D.H. Will, and R.F. Grover The genetic factor influencing pulmonary hypertension in cattle at high altitude Cardiovasc Res 8 1974 745 749
35. J.C. Cruz, J.T. Reeves, B.E. Russell, A.F. Alexander, and D.H. Will Embryo transplanted calves: the pulmonary hypertensive trait is genetically transmitted Proc Soc Exp Biol Med 164 1980 142 145
36. J.H. Newman, T.N. Holt, and L.K. Hedges High-altitude pulmonary hypertension in cattle (brisket disease): candidate genes and gene expression profiling of peripheral blood mononuclear cells Pulm Circ 1 2011 462 469
37. K.R. Stenmark, B. Meyrick, N. Galie, W.J. Mooi, and I.F. McMurtry Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure Am J Physiol Lung Cell Mol Physiol 297 2009 L1013 L1032
38. K.N. Cowan, A. Heilbut, T. Humpl, C. Lam, S. Ito, and M. Rabinovitch Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor Nat Med 6 2000 698 702
39. H.J. Bogaard, S. Mizuno, and C. Guignabert Copper-dependence of angioproliferation in pulmonary arterial hypertension in rats and humans Am J Respir Cell Mol Biol 46 2011 582 591
40. K. Abe, M. Toba, and A. Alzoubi Formation of plexiform lesions in experimental severe pulmonary arterial hypertension Circulation 121 2010 2747 2754
41. N.F. Voelkel, C.D. Cool, S.D. Lee, L. Wright, M.W. Geraci, and R.M. Tuder Primary pulmonary hypertension between inflammation and cancer Chest 114 1999 225S 230S
42. S.D. Lee, K.R. Shroyer, N.E. Markham, C.D. Cool, N.F. Voelkel, and R.M. Tuder Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension J Clin Invest 101 1998 927 934
43. I. Fijalkowska, W. Xu, and S.A. Comhair Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells Am J Pathol 176 2010 1130 1138
44. M.S. McMurtry, S.L. Archer, and D.C. Altieri Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension J Clin Invest 115 2005 1479 1491
45. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
46. S.L. Archer, M. Gomberg-Maitland, M.L. Maitland, S. Rich, J.G.N. Garcia, and E.K. Weir Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1a}-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer Am J Physiol Heart Circ Physiol 294 2008 H570 H578
47. R.M. Tuder, L.A. Davis, and B.B. Graham Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension Am J Respir Crit Care Med 185 2012 260 266
48. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
49. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
50. S.Y. Lunt, and M.G. Vander Heiden Aerobic glycolysis: meeting the metabolic requirements of cell proliferation Annu Rev Cell Dev Biol 27 2011 441 464
51. L.A. Shimoda, and G.L. Semenza HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease Am J Respir Crit Care Med 183 2011 152 156
52. N.S. Chandel, D.S. McClintock, and C.E. Feliciano Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing J Biol Chem 275 2000 25130 25138
53. K. Asosingh, M.A. Aldred, and A. Vasanji Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension Am J Pathol 172 2008 615 627
54. M. Toshner, R. Voswinckel, and M. Southwood Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension Am J Respir Crit Care Med 180 2009 780 787
55. S. Farha, K. Asosingh, and W. Xu Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities Blood 117 2011 3485 3493
56. F.A. Masri, W. Xu, and S.A. Comhair Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension Am J Physiol Lung Cell Mol Physiol 293 2007 L548 L554
57. G. Marsboom, P.T. Toth, and J.J. Ryan Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension Circ Res 110 2012 1484 1497
58. J.J. Ryan, G. Marsboom, and Y.H. Fang PGC1alpha-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension Am J Respir Crit Care Med 187 2013 865 878
59. P.B. Sehgal, and S. Mukhopadhyay Pulmonary arterial hypertension: a disease of tethers, SNAREs and SNAPs? Am J Physiol Heart Circ Physiol 293 2007 H77 H85
60. M.E. Yeager, M.B. Reddy, C.M. Nguyen, K.L. Colvin, D.D. Ivy, and K.R. Stenmark Activation of the unfolded protein response is associated with pulmonary hypertension Pulm Circ 2 2012 229 240
61. P. Dromparis, R. Paulin, T.H. Stenson, A. Haromy, G. Sutendra, and E.D. Michelakis Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension Circulation 127 2013 115 125
62. G. Sutendra, P. Dromparis, and P. Wright The role of nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension Sci Transl Med 3 2011 88ra55
63. E.L. Lundgrin, M.M. Park, and J. Sharp Fasting 2-deoxy-2-[18F]fluoro-D- glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year Ann Am Thorac Soc 10 2013 1 9
64. G. Marsboom, C. Wietholt, and C.R. Haney Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension Am J Respir Crit Care Med 185 2012 670 679
65. G. Sutendra, P. Dromparis, and R. Paulin A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension J Mol Med (Berl) 91 2013 1315 1327
66. M.S. McMurtry, S. Bonnet, and X. Wu Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis Circ Res 95 2004 830 840
67. R.M. Tuder, and N.F. Voelkel Pulmonary hypertension and inflammation J Lab Clin Med 132 1998 16 24
68. C. Nathan Points of control in inflammation Nature 420 2002 846 852
69. M. Humbert, G. Monti, and F. Brenot Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension Am J Respir Crit Care Med 151 1995 1628 1631
70. E. Soon, A.M. Holmes, and C.M. Treacy Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension Circulation 122 2010 920 927
71. P. Dorfmuller, F. Perros, K. Balabanian, and M. Humbert Inflammation in pulmonary arterial hypertension Eur Respir J 22 2003 358 363
72. R.M. Tuder, B.M. Groves, D.B. Badesch, and N.F. Voelkel Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension Am J Pathol 144 1994 275 285
73. R. Savai, S.S. Pullamsetti, and J. Kolbe Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 186 2012 897 908
74. A. Huertas, L. Tu, and N. Gambaryan Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension Eur Respir J 40 2012 895 904
75. S. Ulrich, M.R. Nicolls, L. Taraseviciene, R. Speich, and N. Voelkel Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension Respiration 75 2008 272 280
76. M.L. Ormiston, C. Chang, and L.L. Long Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension Circulation 126 2012 1099 1109
77. K.N. Cowan, P.L. Jones, and M. Rabinovitch Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease J Clin Invest 105 2000 21 34
78. S.R. Walmsley, A.S. Cowburn, and M.R. Clatworthy Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis Blood 108 2006 3176 3178
79. E.M. Bauer, H. Zheng, S. Comhair, S. Erzurum, T.R. Billiar, and P.M. Bauer Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice PLoS ONE 6 2011 e28578
80. F. Perros, P. Dorfmuller, and D. Montani Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 185 2012 311 321
81. H. Dib, M.C. Tamby, and G. Bussone Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma Eur Resp J 39 2012 1405 1414
82. M.C. Tamby, Y. Chanseaud, and M. Humbert Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension Thorax 60 2005 765 772
83. B. Terrier, M.C. Tamby, and L. Camoin Identification of target antigens of antifibroblast antibodies in pulmonary arterial hypertension Am J Respir Crit Care Med 177 2008 1128 1134
84. B.B. Graham, A.P. Bandeira, N.W. Morrell, G. Butrous, and R.M. Tuder Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspective Chest 137 2010 20S 29S
85. S. Almodovar, R. Knight, and A.A. Allshouse Human Immunodeficiency Virus nef signature sequences are associated with pulmonary hypertension AIDS Res Hum Retroviruses 28 2012 607 618
86. M.G. Frid, J.A. Brunetti, and D.L. Burke Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage Am J Pathol 168 2006 659 669
87. M. Li, S.R. Riddle, and M.G. Frid Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension J Immunol 187 2011 2711 2722
88. R.M. Tuder, J.C. Marecki, A. Richter, I. Fijalkowska, and S. Flores Pathology of pulmonary hypertension Clin Chest Med 28 2007 23 42 vii
89. K.R. Stenmark, N. Davie, M. Frid, E. Gerasimovskaya, and M. Das Role of the adventitia in pulmonary vascular remodeling Physiology (Bethesda) 21 2006 134 145
90. M. Sahara, M. Sata, T. Morita, K. Nakamura, Y. Hirata, and R. Nagai Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation Circulation 115 2007 509 517
91. D. Lo, L. Feng, and L. Li Integrating innate and adaptive immunity in the whole animal Immunol Rev 169 1999 225 239
92. C.D. Buckley, D. Pilling, J.M. Lord, A.N. Akbar, D. Scheel-Toellner, and M. Salmon Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation Trends Immunol 22 2001 199 204
93. M.A. Cavasin, K. Demos-Davies, and T.R. Horn Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism Circ Res 110 2012 739 749
94. J.M. Daley, S.K. Brancato, A.A. Thomay, J.S. Reichner, and J.E. Albina The phenotype of murine wound macrophages J Leukoc Biol 87 2010 59 67
95. M. Ishii, H. Wen, and C.A. Corsa Epigenetic regulation of the alternatively activated macrophage phenotype Blood 114 2009 3244 3254
96. X. Liao, N. Sharma, and F. Kapadia Kruppel-like factor 4 regulates macrophage polarization J Clin Invest 121 2011 2736 2749
97. T. Satoh, O. Takeuchi, and A. Vandenbon The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection Nat Immunol 11 2010 936 944
98. T.A. Wynn, A. Chawla, and J.W. Pollard Macrophage biology in development, homeostasis and disease Nature 496 2013 445 455
99. R.A. Koeth, Z. Wang, and B.S. Levison Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis Nat Med 19 2013 576 585
100. C. Lee, S.A. Mitsialis, and M. Aslam Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension Circulation 126 2012 2601 2611