Elevated serum bone morphogenetic protein 4 in patients with chronic kidney disease and coronary artery disease

Journal of Cardiovascular Translational Research

Volumn 6, Issue 2, 2013, Pages 232-238

  Stahls III, Paul F ^a   Lightell Jr , Daniel J ^a   Moss, Stephanie C ^a   Goldman, Corey K ^a   Woods, T Cooper ^a,b,c  

^a OCHSNER CLINIC FOUNDATION   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Institute of Translational Research   (United States)

Author keywords

Bone morphogenetic protein; Chronic kidney disease; Coronary artery disease; Vascular calcification

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; BIOLOGICAL MARKER; BMP4 PROTEIN, HUMAN;

ADULT; AGED; ANGIOGRAPHY; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CORONARY ARTERY CALCIFICATION; CORONARY ARTERY CALCIUM SCORE; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; ANGIOCARDIOGRAPHY; BLOOD; BLOOD VESSEL CALCIFICATION; CHI SQUARE DISTRIBUTION; CHRONIC KIDNEY FAILURE; ENZYME LINKED IMMUNOSORBENT ASSAY; METHODOLOGY; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; MULTIVARIATE ANALYSIS; PILOT STUDY; RADIOGRAPHY; RISK FACTOR; STATISTICAL MODEL; UPREGULATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN 4; CHI-SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; MULTIVARIATE ANALYSIS; PILOT PROJECTS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; UP-REGULATION; VASCULAR CALCIFICATION; YOUNG ADULT;

EID: 84883007268     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-012-9429-9     Document Type: Article

References (27)

1. Shulman, N. B.; Ford, C. E.; Hall, W. D.; Blaufox, M. D.; Simon, D.; Langford, H. G.; et al. (1989). Prognostic value of serum creatinine and effect of treatment of hypertension on renal function. Results from the hypertension detection and follow-up program. The Hypertension Detection and Follow-up Program Cooperative Group. Hypertension, 13, I80-I93.
2. Lloyd-Jones, D.; Adams, R.; Carnethon, M.; De Simone, G.; Ferguson, T. B.; Flegal, K.; et al. (2009). Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 119, e21-e181.
3. Chonchol, M.; Whittle, J.; Desbien, A.; Orner, M. B.; Petersen, L. A.; Kressin, N. R. (2008). Chronic kidney disease is associated with angiographic coronary artery disease. American Journal of Nephrology, 28, 354-360.
4. Weiner, D. E.; Tighiouart, H.; Elsayed, E. F.; Griffith, J. L.; Salem, D. N.; Levey, A. S.; et al. (2007). The Framingham predictive instrument in chronic kidney disease. Journal of the American College of Cardiology, 50, 217-224.
5. Kestenbaum, B. R.; Adeney, K. L.; de Boer, I. H.; Ix, J. H.; Shlipak, M. G.; Siscovick, D. S. (2009). Incidence and progression of coronary calcification in chronic kidney disease: the multi-ethnic study of atherosclerosis. Kidney International, 76, 991-998.
6. Nakano, T.; Ninomiya, T.; Sumiyoshi, S.; Fujii, H.; Doi, Y.; Hirakata, H.; et al. (2010). Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. American Journal of Kidney Diseases, 55, 21-30.
7. Russo, D.; Palmiero, G.; De Blasio, A. P.; Balletta, M. M.; Andreucci, V. E. (2004). Coronary artery calcification in patients with CRF not undergoing dialysis. American Journal of Kidney Diseases, 44, 1024-1030.
8. Mesquita, M.; Demulder, A.; Damry, N.; Melot, C.; Wittersheim, E.; Willems, D.; et al. (2009). Plasma osteoprotegerin is an independent risk factor for mortality and an early biomarker of coronary vascular calcification in chronic kidney disease. Clinical Chemistry and Laboratory Medicine, 47, 339-346.
9. Kiyono, M.; Shibuya, M. (2003). Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression. Molecular and Cellular Biology, 23, 4627-4636.
10. Graff, J. M. (1997). Embryonic patterning: to BMP or not to BMP, that is the question. Cell, 89, 171-174.
11. Dhore, C. R.; Cleutjens, J. P.; Lutgens, E.; Cleutjens, K. B.; Geusens, P. P.; Kitslaar, P. J.; et al. (2001). Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arteriosclerosis, Thrombosis, and Vascular Biology, 21, 1998-2003.
12. Schluesener, H. J.; Meyermann, R. (1995). Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells. Atherosclerosis, 113, 153-156.
13. Bostrom, K.; Watson, K. E.; Horn, S.; Wortham, C.; Herman, I. M.; Demer, L. L. (1993). Bone morphogenetic protein expression in human atherosclerotic lesions. The Journal of Clinical Investigation, 91, 1800-1809.
14. Yao, Y.; Bennett, B. J.; Wang, X.; Rosenfeld, M. E.; Giachelli, C.; Lusis, A. J.; et al. (2010). Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circulation Research, 107, 485-494.
15. Panizo, S.; Cardus, A.; Encinas, M.; Parisi, E.; Valcheva, P.; Lopez-Ongil, S.; et al. (2009). RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway. Circulation Research, 104, 1041-1048.
16. Sorescu, G. P.; Sykes, M.; Weiss, D.; Platt, M. O.; Saha, A.; Hwang, J.; et al. (2003). Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. Journal of Biological Chemistry, 278, 31128-31135.
17. Miriyala, S.; Gongora Nieto, M. C.; Mingone, C.; Smith, D.; Dikalov, S.; Harrison, D. G.; et al. (2006). Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation, 113, 2818-2825.
18. Wong, W. T.; Tian, X. Y.; Chen, Y.; Leung, F. P.; Liu, L.; Lee, H. K.; et al. (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circulation Research, 107, 984-991.
19. National Kidney Foundation. (2002). K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. American Journal of Kidney Diseases, 39, S1-S266.
20. Oh, J.; Wunsch, R.; Turzer, M.; Bahner, M.; Raggi, P.; Querfeld, U.; et al. (2002). Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation, 106, 100-105.
21. Goodman, W. G.; Goldin, J.; Kuizon, B. D.; Yoon, C.; Gales, B.; Sider, D.; et al. (2000). Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. The New England Journal of Medicine, 342, 1478-1483.
22. Braun, J.; Oldendorf, M.; Moshage, W.; Heidler, R.; Zeitler, E.; Luft, F. C. (1996). Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients. American Journal of Kidney Diseases, 27, 394-401.
23. Schwarz, U.; Buzello, M.; Ritz, E.; Stein, G.; Raabe, G.; Wiest, G.; et al. (2000). Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure. Nephrology, Dialysis, Transplantation, 15, 218-223.
24. Moe, S. M.; Chen, N. X. (2004). Pathophysiology of vascular calcification in chronic kidney disease. Circulation Research, 95, 560-567.
25. Nitta, K.; Akiba, T.; Uchida, K.; Kawashima, A.; Yumura, W.; Kabaya, T.; et al. (2003). The progression of vascular calcification and serum osteoprotegerin levels in patients on long-term hemodialysis. American Journal of Kidney Diseases, 42, 303-309.
26. Morena, M.; Terrier, N.; Jaussent, I.; Leray-Moragues, H.; Chalabi, L.; Rivory, J. P.; et al. (2006). Plasma osteoprotegerin is associated with mortality in hemodialysis patients. Journal of the American Society of Nephrology, 17, 262-270.
27. Gonnelli, S.; Montagnani, A.; Caffarelli, C.; Cadirni, A.; Campagna, M. S.; Franci, M. B.; et al. (2005). Osteoprotegerin (OPG) and receptor activator of NF-kB ligand (RANK-L) serum levels in patients on chronic hemodialysis. Journal of Endocrinological Investigation, 28, 534-539.