메뉴 건너뛰기




Volumn 5, Issue 2, 2010, Pages 245-253

In vivo structure - Activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYTOKINE RECEPTOR ANTAGONIST; DORSOMORPHIN 1; DORSOMORPHIN 2; DORSOMORPHIN 3; DORSOMORPHIN 4; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR;

EID: 77449108244     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb9002865     Document Type: Article
Times cited : (316)

References (35)
  • 1
    • 1642294294 scopus 로고    scopus 로고
    • Organic chemistry in drug discovery
    • MacCoss, M., and Baillie, T. A. (2004) Organic chemistry in drug discovery, Science 303, 1810-1813.
    • (2004) Science , vol.303 , pp. 1810-1813
    • MacCoss, M.1    Baillie, T.A.2
  • 2
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • Zon, L. I., and Peterson, R. T. (2005) In vivo drug discovery in the zebrafish, Nat. Rev. Drug Discovery 4, 35-44.
    • (2005) Nat. Rev. Drug Discovery , vol.4 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2
  • 4
    • 0142167588 scopus 로고    scopus 로고
    • Zebrafish-based small molecule discovery
    • MacRae, C. A., and Peterson, R. T. (2003) Zebrafish-based small molecule discovery, Chem. Biol. 10, 901-908.
    • (2003) Chem. Biol. , vol.10 , pp. 901-908
    • MacRae, C.A.1    Peterson, R.T.2
  • 5
    • 66849140489 scopus 로고    scopus 로고
    • Large-scale small-molecule screen using zebrafish embryos
    • Hong, C. C. (2009) Large-scale small-molecule screen using zebrafish embryos, Methods Mol. Biol. (Clifton, N.J.) 486, 43-55.
    • (2009) Methods Mol. Biol. (Clifton, N.J.) , vol.486 , pp. 43-55
    • Hong, C.C.1
  • 6
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
    • Lipinski, C. A., Lombardo, F., Dominy, B. W., and Feeney, P. J. (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv. Drug Delivery Rev. 46, 3-26. (Pubitemid 33653411)
    • (2000) Advanced Drug Delivery Reviews , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 8
    • 51449091152 scopus 로고    scopus 로고
    • Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells
    • Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., Peterson, R. T., Hatzopoulos, A. K., and Hong, C. C. (2008) Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells, PLoS ONE 3, e2904.
    • (2008) PLoS ONE , vol.3
    • Hao, J.1    Daleo, M.A.2    Murphy, C.K.3    Yu, P.B.4    Ho, J.N.5    Hu, J.6    Peterson, R.T.7    Hatzopoulos, A.K.8    Hong, C.C.9
  • 10
    • 70449366408 scopus 로고    scopus 로고
    • The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization
    • Shen, Q., Little, S. C., Xu, M., Haupt, J., Ast, C., Katagiri, T., Mundlos, S., Seemann, P., Kaplan, F. S., Mullins, M. C., and Shore, E. M. (2009) The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization, J. Clin. Invest. 119, 3462-3472.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3462-3472
    • Shen, Q.1    Little, S.C.2    Xu, M.3    Haupt, J.4    Ast, C.5    Katagiri, T.6    Mundlos, S.7    Seemann, P.8    Kaplan, F.S.9    Mullins, M.C.10    Shore, E.M.11
  • 19
    • 33646228404 scopus 로고    scopus 로고
    • Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish
    • Covassin, L. D., Villefranc, J. A., Kacergis, M. C., Weinstein, B. M., and Lawson, N. D. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish, Proc. Natl. Acad. Sci. U.S.A. 103, 6554-6559.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 6554-6559
    • Covassin, L.D.1    Villefranc, J.A.2    Kacergis, M.C.3    Weinstein, B.M.4    Lawson, N.D.5
  • 20
    • 0037143447 scopus 로고    scopus 로고
    • Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis
    • Habeck, H., Odenthal, J., Walderich, B., Maischein, H., and Schulte- Merker, S. (2002) Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis, Curr. Biol. 12, 1405-1412.
    • (2002) Curr. Biol. , vol.12 , pp. 1405-1412
    • Habeck, H.1    Odenthal, J.2    Walderich, B.3    Maischein, H.4    Schulte- Merker, S.5
  • 24
    • 0036039827 scopus 로고    scopus 로고
    • In vivo imaging of embryonic vascular development using transgenic zebrafish
    • Lawson, N. D., and Weinstein, B. M. (2002) In vivo imaging of embryonic vascular development using transgenic zebrafish, Dev. Biol. 248, 307-318.
    • (2002) Dev. Biol. , vol.248 , pp. 307-318
    • Lawson, N.D.1    Weinstein, B.M.2
  • 25
    • 37048998913 scopus 로고    scopus 로고
    • Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines
    • Daniels, R. N., Kim, K., Lebois, E. P., Muchalski, H., Hughes, M., and Lindsley, C. W. (2008) Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines, Tetrahedron Lett. 49, 305-310.
    • (2008) Tetrahedron Lett. , vol.49 , pp. 305-310
    • Daniels, R.N.1    Kim, K.2    Lebois, E.P.3    Muchalski, H.4    Hughes, M.5    Lindsley, C.W.6
  • 28
    • 36549088668 scopus 로고    scopus 로고
    • A rapid and sensitive bioassay to measure bone morphogenetic protein activity
    • Zilberberg, L., ten Dijke, P., Sakai, L. Y., and Rifkin, D. B. (2007) A rapid and sensitive bioassay to measure bone morphogenetic protein activity, BMC Cell Biol. 8, 41.
    • (2007) BMC Cell Biol. , vol.8 , pp. 41
    • Zilberberg, L.1    Ten Dijke, P.2    Sakai, L.Y.3    Rifkin, D.B.4
  • 30
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong, T. A., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T. J., Kim, Y. H., Schreck, R., Wang, X., Risau, W., Ullrich, A., Hirth, K. P., and McMahon, G. (1999) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types, Cancer Res. 59, 99-106.
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, K.P.12    McMahon, G.13
  • 31
    • 37048998913 scopus 로고    scopus 로고
    • Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines
    • Daniels, R. N., Kim, K., Lebois, E. P., Muchalski, H., Hughes, M., and Lindsley, C. W. (2008) Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines, Tetrahedron Lett. 49, 305-310.
    • (2008) Tetrahedron Lett. , vol.49 , pp. 305-310
    • Daniels, R.N.1    Kim, K.2    Lebois, E.P.3    Muchalski, H.4    Hughes, M.5    Lindsley, C.W.6
  • 34
    • 2042507954 scopus 로고
    • Palladium-catalyzed crosscoupling reactions of organoboron compounds
    • Miyaura, N., and Suzuki, A. (1995) Palladium-catalyzed crosscoupling reactions of organoboron compounds, Chem. Rev. 95, 2457-2483.
    • (1995) Chem. Rev. , vol.95 , pp. 2457-2483
    • Miyaura, N.1    Suzuki, A.2
  • 35
    • 37049091909 scopus 로고
    • Highly general stereo-, regio-, and chemo-selective synthesis of terminal and internal conjugated enynes by the Pd-catalyzed reaction of alkynylzinc reagents with alkenyl halides
    • King, A. O., Okakadao, N., and E.-i, N. (1977) Highly general stereo-, regio-, and chemo-selective synthesis of terminal and internal conjugated enynes by the Pd-catalyzed reaction of alkynylzinc reagents with alkenyl halides, J. Chem. Soc., Chem. Comm. 683-684.
    • (1977) J. Chem. Soc., Chem. Comm. , pp. 683-684
    • King, A.O.1    Okakadao, N.2    E.-i, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.