A comprehensive review on in vitro digestion of infant formula

Food Research International

Volumn 76, Issue , 2015, Pages 373-386

  Nguyen, Thao T P ^a   Bhandari, Bhesh ^a   Cichero, Julie ^a   Prakash, Sangeeta ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Digestibility; Enzymes; Gastric; In vitro; Infant digestion; Infant formula; Intestine

Indexed keywords

ENZYMES; PHILOSOPHICAL ASPECTS;

DIGESTIBILITY; GASTRIC; IN-VITRO; INFANT FORMULA; INTESTINE;

TRANSPORTATION;

EID: 84952987648     PISSN: 09639969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodres.2015.07.016     Document Type: Review

References (220)

1. Abayomi J. Infant formula-Evaluating the safety of new ingredients. Journal of Human Nutrition and Dietetics 2005, 18(3). (226-226).
2. Abrahamse E., Minekus M., van Aken G.A., van de Heijning B., Knol J., Bartke N., et al. Development of the digestive system-Experimental challenges and approaches of infant lipid digestion. Food Digestion 2012, 3(1-3):63-77.
3. Adlerova L., Bartoskova A., Faldyna M. Lactoferrin: A review. Veterinární Medicína 2008, 53(9):457-468.
4. Aggett P.J., Agostini C., Goulet O., Hernell O., Koletzko B., Lafeber H.L., et al. The nutritional and safety assessment of breast milk substitutes and other dietary products for infants: A commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition 2001, 32(3):256-258.
5. Agostoni C., Axelsson I., Goulet O., Koletzko B., Michaelsen K.F., Puntis J., et al. Soy protein infant formulae and follow-on formulae: A commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition 2006, 42(4):352-361.
6. Agostoni C., Braegger C., Decsi T., Kolacek S., Koletzko B., Michaelsen K.F., et al. Breast-feeding: A commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition 2009, 49(1):112-125.
7. Agostoni C., Decsi T., Fewtrell M., Goulet O., Kolacek S., Koletzko B., et al. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition 2008, 46(1):99-110.
8. Agunod M., Yamaguchi N., Lopez R., Glass G.B.J. Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants. The American Journal of Digestive Diseases 1969, 14(6):400-414.
9. Alles M.S., Scholtens P.A., Bindels J.G. Current trends in the composition of infant milk formulas. Current Paediatrics 2004, 14(1):51-63.
10. Aly E., Ros G., Frontela C. Structure and functions of lactoferrin as ingredient in infant formulas. Journal of Food Research 2013, 2(4):25-36.
11. Amara S., Patin A., Giuffrida F., Wooster T.J., Thakkar S.K., Bénarouche A., et al. In vitro digestion of citric acid esters of mono- and diglycerides (CITREM) and CITREM-containing infant formula/emulsions. Food & Function 2014, 5(7):1409-1421.
12. Andersson E.-L., Hernell O., Bläckberg L., Fält H., Lindquist S. BSSL and PLRP2: Key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line. Journal of Lipid Research 2011, 52(11):1949-1956.
13. Andrea N.E., Nikoletta F. Oral drug absorption in paediatric population. Oral drug absorption: Prediction and assessment 2010, 108-123. B.D. Jennifer, R. Christos (Eds.).
14. Argyri K., Birba A., Miller D., Komaitis M., Kapsokefalou M. Predicting relative concentrations of bioavailable iron in foods using in vitro digestion: New developments. Food Chemistry 2009, 113(2):602-607.
15. Armand M., Hamosh M., DiPalma J.S., Gallagher J., Benjamin S.B., Philpott J.R., et al. Dietary fat modulates gastric lipase activity in healthy humans. The American Journal of Clinical Nutrition 1995, 62(1):74-80.
16. Armand M., Hamosh M., Mehta N.R., Angelus P.A., Philpott J.R., Henderson T.R., et al. Effect of human milk or formula on gastric function and fat digestion in the premature infant. Pediatric Research 1996, 40(3):429-437.
17. Arvedson J.C., Brodsky L. Pediatric swallowing and feeding: Assessment and management 2002, Cengage Learning.
18. Astwood J.D., Leach J.N., Fuchs R.L. Stability of food allergens to digestion in vitro. Nature Biotechnology 1996, 14(10):1269-1273.
19. Aunsholt L., Jeppesen P.B., Lund P., Sangild P.T., Ifaoui I.B.R., Qvist N., et al. Bovine colostrum to children with short bowel syndrome: A randomized, double-blind, crossover pilot study. Journal of Parenteral and Enteral Nutrition 2012, 38(1):99-106.
20. Auricchio S., Stellato A., De Vizia B. Development of brush border peptidases in human and rat small intestine during fetal and neonatal life. Pediatric Research 1981, 15(7):991-995.
21. Australia Government, Commonwealth Law Australia New Zealand Food Standards Code - Standard 2.9.1 - Infant formula products Retried from. http://www.comlaw.gov.au/Series/F2008B00658.
22. Badger T.M., Gilchrist J.M., Pivik R.T., Andres A., Shankar K., Chen J.-R., et al. The health implications of soy infant formula. The American Journal of Clinical Nutrition 2009, 89(5):1668S-1672S.
23. Ben X.-M. Nutritional management of newborn infants: Practical guidelines. World Journal of Gastroenterology 2008, 14(40):6133.
24. Benedé S., López-Expósito I., Giménez G., Grishina G., Bardina L., Sampson, et al. In vitro digestibility of bovine β-casein with simulated and human oral and gastrointestinal fluids. Identification and IgE-reactivity of the resultant peptides. Food Chemistry 2014, 143:514-521.
25. Berfenstam R., Jagenburg R., Mellander O. Protein hydrolysis in the stomachs of premature and full-term infants. Acta Paediatrica 1955, 44(4):348-354.
26. Bernbäck S., Bläckberg L., Hernell O. Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. Biochimica et Biophysica Acta, Lipids and Lipid Metabolism 1989, 1001(3):286-293.
27. Bernbäck S., Bläckberg L., Hernell O. The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase. Journal of Clinical Investigation 1990, 85(4):1221.
28. Berton A., Sebban-Kreuzer C., Rouvellac S., Lopez C., Crenon I. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. Molecular Nutrition & Food Research 2009, 53(12):1592-1602.
29. Bindels J.G. Artificial feeds for infants - Human milk substitutes: Current composition and future trends. Current Paediatrics 1992, 2(3):163-167.
30. Blanquet S., Zeijdner E., Beyssac E., Meunier J.-P., Denis S., Havenaar R., et al. A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Pharmaceutical Research 2004, 21(4):585-591.
31. Bode L. Human milk oligosaccharides: Every baby needs a sugar mama. Glycobiology 2012, 22(9):1147-1162.
32. Boisen S., Eggum B. Critical evaluation of in vitro methods for estimating digestibility in simple-stomach animals. Nutrition Research Reviews 1991, 4:141-162.
33. Borgstrom B., Lindquist B., Lundh G. Enzyme concentration and absorption of protein and glucose in duodenum of premature infants. Archives of Pediatrics and Adolescent Medicine 1960, 99(3):338.
34. Bosscher D., Van Caillie-Bertrand M., Van Dyck K., Robberecht H., Van Cauwenbergh R., Deelstra H. Thickening infant formula with digestible and indigestible carbohydrate: Availability of calcium, iron, and zinc in vitro. Journal of Pediatric Gastroenterology and Nutrition 2000, 30(4):373-378.
35. Böttger F.H., Etzel M.R., Lucey J.A. In vitro infant digestion of whey protein-dextran glycates. Food Digestion 2013, 4(2-3):76-84.
36. Bourlieu C., Ménard O., Bouzerzour K., Mandalari G., Macierzanka A., Mackie A.R., et al. Specificity of infant digestive conditions: Some clues for developing relevant in vitro models. Critical Reviews in Food Science and Nutrition 2014, 54(11):1427-1457.
37. Bourlieu C., Ménard O., De La Chevasnerie A., Sams L., Rousseau F., Madec M.N., et al. The structure of infant formulas impacts their lipolysis, proteolysis and disintegration during in vitro gastric digestion. Food Chemistry 2015, 182:224-235.
38. Bracco U. Effect of triglyceride structure on fat absorption. The American Journal of Clinical Nutrition 1994, 60(6):1002S-1009S.
39. Carbonaro M., Maselli P., Nucara A. Relationship between digestibility and secondary structure of raw and thermally treated legume proteins: a Fourier transform infrared (FT-IR) spectroscopic study. Amino Acids 2012, 43(2):911-921.
40. Carbonaro M., Maselli P., Nucara A. Structural aspects of legume proteins and nutraceutical properties. Food Research International 2015, 76(Part 1):19-30.
41. Capolino P., Guérin C., Paume J., Giallo J., Ballester J.M., Cavalier J.F., et al. In vitro gastrointestinal lipolysis: replacement of human digestive lipases by a combination of rabbit gastric and porcine pancreatic extracts. Food Digestion 2011, 2(1-3):43-51.
42. Carey M.C., Small D., Bliss C. Lipid digestion and absorption. Annual Review of Physiology 1983, 45(1):651-677.
43. Carrière F., Barrowman J.A., Verger R., Laugier R. Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. Gastroenterology 1993, 105(3):876-888.
44. Carrière F., Renou C., Lopez V., De Caro J., Ferrato F., Lengsfeld H., et al. The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals. Gastroenterology 2000, 119(4):949-960.
45. Carrière F., Renou C., Ransac S., Lopez V., De Caro J., Ferrato F., et al. Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers. American Journal of Physiology. Gastrointestinal and Liver Physiology 2001, 281(1):G16-G28.
46. Cavell B. Postprandial gastric acid secretion in infants. Acta Paediatrica 1983, 72(6):857-860.
47. Charman W.N., Porter C.J., Mithani S., Dressman J.B. Physicochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH. Journal of Pharmaceutical Sciences 1997, 86(3):269-282.
48. Chatterton D., Rasmussen J., Heegaard C., Sørensen E., Petersen T. In vitro digestion of novel milk protein ingredients for use in infant formulas: Research on biological functions. Trends in Food Science and Technology 2004, 15(7):373-383.
49. Chierici R., Vigi V. Lactoferrin in infant formulae. Acta Peadiatrica 1994, 83:83-88.
50. Cichero J.A., Nicholson T.M., September C. Thickened milk for the management of feeding and swallowing issues in infants: A call for interdisciplinary professional guidelines. Journal of Human Lactation 2013, 29(2):132-135.
51. Cohen M., Morgan R.G., Hofmann A.F. Lipolytic activity of human gastric and duodenal juice against medium and long chain triglycerides. Gastroenterology 1971, 60(1):1-15.
52. Coles L., Moughan P., Darragh A. In vitro digestion and fermentation methods, including gas production techniques, as applied to nutritive evaluation of foods in the hindgut of humans and other simple-stomached animals. Animal Feed Science and Technology 2005, 123:421-444.
53. Commare C.E., Tappenden K.A. Development of the infant intestine: Implications for nutrition support. Nutrition in Clinical Practice 2007, 22(2):159-173.
54. Coppa G.V., Gabrielli O., Pierani P., Catassi C., Carlucci A., Giorgi P.L. Changes in carbohydrate composition in human milk over 4months of lactation. Pediatrics 1993, 91(3):637-641.
55. Dallas D.C., Underwood M.A., Zivkovic A.M., German J.B. Digestion of protein in premature and term infants. Journal of Nutritional Disorders & Therapy 2012, 2(3):1-9.
56. Daly T., Ryan E., Aisling Aherne S., O'Grady M.N., Hayes J., Allen P., et al. Bioactivity of ellagic acid, lutein or sesamol enriched meat patties assessed using an in vitro digestion and Caco-2 cell model system. Food Research International 2010, 43(3):753-760.
57. Davidson G., Daniels E., Nunan H., Moore A., Whyte P., Franklin K., et al. Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. The Lancet 1989, 334(8665):709-712.
58. Davidson L.A., Lönnerdal B. Persistence of human milk proteins in the breast-fed infant. Acta Paediatrica 1987, 76(5):733-740.
59. Davis A.M., Harris B.J., Lien E.L., Pramuk K., Trabulsi J. α-Lactalbumin-rich infant formula fed to healthy term infants in a multicenter study: Plasma essential amino acids and gastrointestinal tolerance. European Journal of Clinical Nutrition 2008, 62(11):1294-1301.
60. de Maria P.D., Fernández-Álvaro E., ten Kate A., Bargeman G. Role of apparent pK a of carboxylic acids in lipase-catalyzed esterifications in biphasic systems. Journal of Molecular Catalysis B: Enzymatic 2009, 59(1):220-224.
61. Dewit O., Dibba B., Prentice A. Breast-milk amylase activity in English and Gambian mothers: Effects of prolonged lactation, maternal parity, and individual variations. Pediatric Research 1990, 28(5):502-506.
62. DiPalma J., Kirk C.L., Hamosh M., Colon A.R., Benjamin S.B., Hamosh P. Lipase and pepsin activity in the gastric mucosa of infants, children, and adults. Gastroenterology 1991, 101(1):116-121.
63. Donovan S.M., Atkinson S.A., Whyte R.K., Lönnerdal B. Partition of nitrogen intake and excretion in low-birth-weight infants. American Journal of Diseases of Children 1989, 143(12):1485-1491.
64. Dressman J.B., Berardi R.R., Dermentzoglou L.C., Russell T.L., Schmaltz S.P., Barnett J.L., et al. Upper gastrointestinal (GI) pH in young, healthy men and women. Pharmaceutical Research 1990, 7(7):756-761.
65. Dupont D., Boutrou R., Menard O., Jardin J., Tanguy G., Schuck P., et al. Heat treatment of milk during powder manufacture increases casein resistance to simulated infant digestion. Food Digestion 2010, 1(1-2):28-39.
66. Dupont D., Mandalari G., Molle D., Jardin J., Léonil J., Faulks R.M., et al. Comparative resistance of food proteins to adult and infant in vitro digestion models. Molecular Nutrition & Food Research 2010, 54(6):767-780.
67. Dupont D., Mandalari G., Mollé D., Jardin J., Rolet-Répécaud O., Duboz G., et al. Food processing increases casein resistance to simulated infant digestion. Molecular Nutrition & Food Research 2010, 54(11):1677-1689.
68. Ebina T., Sato A., Umezu K., Ishida N., Ohyama S., Oizumi A., et al. Prevention of rotavirus infection by oral administration of cow colostrum containing antihumanrotavirus antibody. Medical Microbiology and Immunology 1985, 174(4):177-185.
69. Eidelman A., Feldman-Winter L. From the American Academy of Pediatrics: Policy statement: Breastfeeding and the use of human milk. Pediatrics 2005, 115(2):496-506.
70. El-Agamy E. The challenge of cow milk protein allergy. Small Ruminant Research 2007, 68(1):64-72.
71. Engfer M.B., Stahl B., Finke B., Sawatzki G., Daniel H. Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper gastrointestinal tract. The American Journal of Clinical Nutrition 2000, 71(6):1589-1596.
72. Eugenia Lucena M., Alvarez S., Menéndez C., Riera F.A., Alvarez R. Beta-lactoglobulin removal from whey protein concentrates: Production of milk derivatives as a base for infant formulas. Separation and Purification Technology 2006, 52(2):310-316.
73. European Commission, Health and Consumers Protectorate-General Report of the scientific committee on food on the revision of essential requirements of infant formulae and follow-on formulae 2003, (Retried from http://ec.europa.eu/food/fs/sc/scf/out199_en.pdf).
74. European Union Commission Directive 2006/141/EC of 22nd December 2006 on infant formulae and follow-on formulae, amending Directive 1999/21/EC. Official Journal of the European Union 2006, L 401/1. (Retried from http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32006L0141&from=EN).
75. Fabek H., Messerschmidt S., Brulport V., Goff H.D. The effect of in vitro digestive processes on the viscosity of dietary fibres and their influence on glucose diffusion. Food Hydrocolloids 2014, 35:718-726.
76. Fanaro S., Vigi V. Feeding the term infant: Human milk and formulas. Neonatology 2012, 290-297. (Springer).
77. Fernandez S., Jannin V., Chevrier S., Chavant Y., Demarne F., Carrière F. In vitro digestion of the self-emulsifying lipid excipient Labrasol® by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate. Pharmaceutical Research 2013, 30(12):3077-3087.
78. Filer L.J. Modified food starches for use in infant foods. Nutrition Reviews 1971, 29(3):55-59.
79. Flack S., Shaw V. Infants-Breast and bottle feeding. Encyclopedia of food sciences and nutrition 2003, 3288-3293. Academic Press, Oxford. Second Edition. C. Benjamin (Ed.).
80. Floris R., Lambers T., Alting A., Kiers J. Trends in infant formulas: A dairy perspective. Volume 2: Improving quality in milk products 2010, 454-474. M.W. Griffiths (Ed.).
81. Fomon S.J. Nutrition of normal infants 1993, Mosby-Year Book, Inc.
82. Formon S.J., Ziegler E.E., Thomas L.N., Jensen R.L., Filer L. Excretion of fat by normal full-term infants fed various milks and formulas. The American Journal of Clinical Nutrition 1970, 23(10):1299-1313.
83. Foundation B.N. Unsaturated fatty acids: Nutritional and physiological significance: The report of the British Nutrition Foundation's task force 1992, Chapman and Hall.
84. Fox P.F., McSweeney P.L. Dairy chemistry and biochemistry 1998, Springer.
85. Friedt M., Welsch S. An update on pediatric endoscopy. European Journal of Medical Research 2013, 18(1):24.
86. Fu T.-J., Abbott U.R., Hatzos C. Digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated intestinal fluid: A comparative study. Journal of Agricultural and Food Chemistry 2002, 50(24):7154-7160.
87. Gallier S., Tate H., Singh H. In vitro gastric and intestinal digestion of a walnut oil body dispersion. Journal of Agricultural and Food Chemistry 2012, 61(2):410-417.
88. Gallier S., Zhu X.Q., Rutherfurd S.M., Ye A., Moughan P.J., Singh H. In vivo digestion of bovine milk fat globules: Effect of processing and interfacial structural changes. II. Upper digestive tract digestion. Food Chemistry 2013, 141(3):3215-3223.
89. Gnoth M.J., Kunz C., Kinne-Saffran E., Rudloff S. Human milk oligosaccharides are minimally digested in vitro. The Journal of Nutrition 2000, 130(12):3014-3020.
90. Goedhart A.C., Bindels J.G. The composition of human milk as a model for the design of infant formulas: Recent findings and possible applications. Nutrition Research Reviews 1994, 7:1-24.
91. Goldman A., Goldblum R., Atkinson S., Lönnerdal B. Immunoglobulins in human milk. Protein and non-protein nitrogen in human milk 1989, 43-51.
92. Guerra A., Etienne-Mesmin L., Livrelli V., Denis S., Blanquet-Diot S., Alric M. Relevance and challenges in modeling human gastric and small intestinal digestion. Trends in Biotechnology 2012, 30(11):591-600.
93. Gurr M.I. Review of the progress of dairy science: Human and artificial milks for infant feeding. Journal of Dairy Research 1981, 48:519-554.
94. Hamosh M. Lingual and gastric lipases: Their role in fat digestion 1990, CRC Press, Inc.
95. Hamosh M. Gastric and lingual lipases. Physiology of the Gastrointestinal Tract 1994, 3:1239-1253.
96. Hamosh M. Digestion in the newborn. Clinics in Perinatology 1996, 23(2):191-209.
97. Hamosh M. Enteral lipid digestion and absorption. Neonatal nutrition and metabolism 2006, 350-368. Cambridge University Press, Cambridge. W.H. William (Ed.).
98. Hamosh M., Iverson S.J., Kirk C.L., Hamosh P. Milk lipids and neonatal fat digestion: Relationship between fatty acid composition, endogenous and exogenous digestive enzymes and digestion of milk fat. World Review of Nutrition and Dietetics 1994, 75:86-91.
99. Hamosh M., Scanlon J.W., Ganot D., Likel M., Scanlon K.B., Hamosh P. Fat digestion in the newborn: Characterization of lipase in gastric aspirates of premature and term infants. Journal of Clinical Investigation 1981, 67(3):838.
100. Hamosh M., Sivasubramanian K., Salzman-Mann C., Hamosh P. Fat digestion in the stomach of premature infants: I. Characteristics of lipase activity. The Journal of Pediatrics 1978, 93(4):674-679.
101. Harzer G., Bindels J. Changes in human milk immunoglobulin A and lactoferrin during early lactation. Compositional and physiological properties of human milk 1985, 171-177. Elsevier, Amsterdam.
102. Haug A., Hostmark A.T., Harstad O.M. Bovine milk in human nutrition-A review. Journal of Lipids in Health and Disease 2007, 6(25):1-16.
103. Heine W.E., Klein P.D., Reeds P.J. The importance of alpha-lactalbumin in infant nutrition. Journal of Nutrition 1991, 121(3):277-283.
104. Heine W., Radke M., Wutzke K.D., Peters E., Kundt G. a-Lactalbumin-enriched low-protein infant formulas: a comparison to breast milk feeding. Acta Paediatrica 1996, 85(9):1024-1028.
105. Henschel M.J., Newport M.J., Parmar V. Gastric proteases in the human infant. Neonatology 1987, 52(5):268-272.
106. Hermoso M., Tabacchi G., Iglesia-Altaba I., Bel-Serrat S., Moreno-Aznar L.A., García-Santos Y., et al. The nutritional requirements of infants. Towards EU alignment of reference values: The EURRECA network. Maternal & Child Nutrition 2010, 6:55-83.
107. Hernell O. Human milk vs. cow's milk and the evolution of infant formulas. Milk and Milk Products in Human Nutrition 2011, Vol. 67:17-28. R.A. Clemens, O. Hernell, K.M. Michaelsen (Eds.).
108. Hernell O., Blackberg L., Bernback S. Digestion and absorption of human milk lipids. Perinatal Nutrition, Bristol-Myers Nutrition Symposia 1988, 6:259-272. Academic Press, San Diego. Herausgegeben von, B.S. Lindblad (Eds.).
109. Hirata Y., Matsuo T., Kokubu H. Digestion and absorption of milk protein in infants' intestine. Kobe Journal of Medical Sciences 1965, 11:103.
110. Hoffman D.R., Birch E.E., Birch D.G., Uauy R., Castañeda Y.S., Lapus M.G., et al. Impact of early dietary intake and blood lipid composition of long chain polyunsaturated fatty acids on later visual development. Journal of Pediatric Gastroenterology and Nutrition 2000, 31(5):540-553.
111. Holton T.A., Vijayakumar V., Dallas D.C., Guerrero A., Borghese R.A., Lebrilla C.B., et al. Following the digestion of milk proteins from mother to baby. Journal of Proteome Research 2014, 13(12):5777-5783.
112. Hur S.J., Lim B.O., Decker E.A., McClements D.J. In vitro human digestion models for food applications. Food Chemistry 2011, 125(1):1-12.
113. International Union of Pure and Applied Chemistry, International Union of Biochemistry Abbreviated terminology of oligosaccharide chains. Journal of Pure and Applied Chemistry 1982, 54(8):1517-1522.
114. Iyer S., Lönnerdal B. Lactoferrin, lactoferrin receptors and iron metabolism. European Journal of Clinical Nutrition 1993, 47(4):232.
115. Jakobsson I., Lindberg T., Benediktsson B. In vitro digestion of cow's milk proteins by duodenal juice from infants with various gastrointestinal disorders. Journal of Pediatric Gastroenterology and Nutrition 1982, 1(2):183-192.
116. Jensen R.G. Handbook of milk composition 1995, Academic Press.
117. Jensen R.G. Lipids in human milk. Lipids 1999, 34(12):1243-1271.
118. Jensen R.G., Ferris A.M., Lammi-Keefe C.J., Henderson R.A. Lipids of bovine and human milks: A comparison. Journal of Dairy Science 1990, 73(2):223-240.
119. Jensen M.L., Sangild P.T., Lykke M., Schmidt M., Boye M., Jensen B.B., et al. Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2013, 305(1):R4-R12.
120. Joeckel R.J., Phillips S.K. Overview of infant and pediatric formulas. Nutrition in Clinical Practice 2009, 24(3):356-362.
121. Jovani M., Barbera R., Farré R. Lactoferrin and its possible role in iron enrichment of infant formulas. Food Science and Technology International 2001, 7(2):97-103.
122. Jovaní M., Barberá R., Farré R. Effect of lactoferrin addition on the dialysability of iron from infant formulas. Journal of Trace Elements in Medicine and Biology 2003, 17(2):139-142.
123. Kaur M., Sandhu K.S., Lim S.T. Microstructure, physicochemical properties and in vitro digestibility of starches from different Indian lentil (Lens culinaris) cultivars. Carbohydrate Polymers 2010, 79(2):349-355.
124. Kitabatake N., Kinekawa Y.I. Digestibility of bovine milk whey protein and β-lactoglobulin in vitro and in vivo. Journal of Agricultural and Food Chemistry 1998, 46(12):4917-4923.
125. Klein K.O. Isoflavones, soy-based infant formulas, and relevance to endocrine function. Nutrition Reviews 1998, 56(7):193-204.
126. Koletzko B., Agostoni C., Carlson S., Clandinin T., Hornstra G., Neuringer M., et al. Long chain polyunsaturated fatty acids (LC-PUFA) and perinatal development. Acta Paediatrica 2001, 90(4):460-464.
127. Koletzko B., Baker S., Cleghorn G., Neto U.F., Gopalan S., Hernell O., et al. Global standard for the composition of infant formula: Recommendations of an ESPGHAN Coordinated International Expert Group. Journal of Pediatric Gastroenterology and Nutrition 2005, 41(5):584-599.
128. Koletzko B., Thiel I., Abiodun P.O. The fatty acid composition of human milk in Europe and Africa. The Journal of Pediatrics 1992, 120(4):S62-S70.
129. Kunz C., Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatrica 1992, 81(2):107-112.
130. Kunz C., Rudloff S. Biological functions of oligosaccharides in human milk. Acta Paediatrica 1993, 82(12):903-912.
131. Kunz C., Rudloff S., Baier W., Klein N., Strobel S. Oligosaccharides in human milk: Structural, functional, and metabolic aspects. Annual Review of Nutrition 2000, 20(1):699-722.
132. Landers S., Hartmann B.T. Donor human milk banking and the emergence of milk sharing. Pediatric Clinics of North America 2013, 60(1):247-260.
133. Lapillonne A., Groh-Wargo S., Lozano Gonzalez C.H., Uauy R. Lipid needs of preterm infants: Updated recommendations. The Journal of Pediatrics 2013, 162(3):S37-S47.
134. Larsen A.T., Sassene P., Müllertz A. In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems. International Journal of Pharmaceutics 2011, 417(1):245-255.
135. Lauritzen L., Hansen H.S., Jorgensen M., Michaelsen K. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Progress in Lipid Research 2001, 40(1):1-94.
136. Lebenthal E., Lee P. Development of functional response in human exocrine pancreas. Pediatrics 1980, 66(4):556-560.
137. Lebenthal E., Lee P. Glucoamylase and disaccharidase activities in normal subjects and in patients with mucosal injury of the small intestine. The Journal of Pediatrics 1980, 97(3):389-393.
138. Lebenthal E., Lee P., Heitlinger L.A. Impact of development of the gastrointestinal tract on infant feeding. The Journal of Pediatrics 1983, 102(1):1-9.
139. Lee P., Werlin S., Trost B., Struve M. Glucoamylase activity in infants and children: Normal values and relationship to symptoms and histological findings. Journal of Pediatric Gastroenterology and Nutrition 2004, 39(2):161-165.
140. Li H.J., Zhu K.X., Zhou H.M., Peng W., Guo X.N. Comparative study about some physical properties, in vitro digestibility and immunoreactivity of soybean protein isolate for infant formula. Plant Foods for Human Nutrition 2013, 68(2):124-130.
141. Li-Chan E., Nakai S. Enzymic dephosphorylation of bovine casein to improve acid clotting properties and digestibility for infant formula. The Journal of Dairy Research 1989, 56(3):381-390.
142. Lien E.L. Infant formulas with increased concentrations of alpha-lactalbumin. American Journal of Clinical Nutrition 2003, 77(6):1555S-1558S.
143. Lien E.L., Yuhas R.J., Boyle F.G. Corandomization of fats improves absorption in rats. Journal of Nutrition 1993, 123:1859-1867.
144. Lindquist S., Hernell O. Lipid digestion and absorption in early life: An update. Current Opinion in Clinical Nutrition and Metabolic Care 2010, 13(3):314-320.
145. Löhr J.M., Hummel F.M., Pirilis K.T., Steinkamp G., Körner A., Henniges F. Properties of different pancreatin preparations used in pancreatic exocrine insufficiency. European Journal of Gastroenterology & Hepatology 2009, 21(9):1024-1031.
146. Lönnerdal B. Nutritional aspects of soy formula. Acta Paediatrica 1994, 83(402):105-108.
147. Lönnerdal B. Nutritional and physiologic significance of human milk proteins. The American Journal of Clinical Nutrition 2003, 77(6):1537S-1543S.
148. Lönnerdal B. Bioactive proteins in breast milk. Journal of Paediatrics and Child Health 2013, 49:1-7.
149. Lönnerdal B. Infant formula and infant nutrition: Bioactive proteins of human milk and implications for composition of infant formulas. The American Journal of Clinical Nutrition 2014, 99(3):712S-717S.
150. Lönnerdal B., Darragh Human milk. Encyclopedia of dairy sciences 2011, 581-590. Academic Press. J.W. Fuquay (Ed.).
151. López A.M. Proteins in human milk. Breastfeeding review: professional publication of the Nursing Mothers' Association of Australia 2007, 15(1):5-16.
152. Lucas A., Stafford M., Morley R., Abbott R., Stephenson T., MacFadyen U., et al. Efficacy and safety of long chain polyunsaturated fatty acid supplementation of infant formula milk: A randomised trial. The Lancet 1999, 354(9194):1948-1954.
153. Mandalari G., Faulks R.M., Rich G.T., Lo Turco V., Picout D.R., Lo Curto R.B., et al. Release of protein, lipid, and vitamin E from almond seeds during digestion. Journal of Agricultural and Food Chemistry 2008, 56(9):3409-3416.
154. Mason S. Some aspects of gastric function in the newborn. Archives of Disease in Childhood 1962, 37(194):387-391.
155. Matsumoto T. Mitigation of the allergenic activity of beta-lactoglobulin by electrolysis. Pediatric Allergy and Immunology 2011, 22(2):235-242.
156. McClements D.J., Li Y. Review of in vitro digestion models for rapid screening of emulsion-based systems. Food & Function 2010, 1(1):32-59.
157. Ménard O., Cattenoz T., Guillemin H., Souchon I., Deglaire A., Dupont D., et al. Validation of a new in vitro dynamic system to simulate infant digestion. Food Chemistry 2014, 145:1039-1045.
158. Merritt R.J., Jenks B.H. Safety of soy-based infant formulas containing isoflavones: The clinical evidence. The Journal of Nutrition 2004, 134(5):1220S-1224S.
159. Michalski M.C., Briard V., Michel F., Tasson F., Poulain P. Size distribution of fat globules in human colostrum, breast milk, and infant formula. Journal of Dairy Science 2005, 88(6):1927-1940.
160. Miller R. Gastric acidity during the first year of life. Archives of Disease in Childhood 1942, 17(92):198-209.
161. Minekus M., Alminger M., Alvito P., Ballance S., Bohn T., Bourlieu C., et al. A standardised static in vitro digestion method suitable for food-An international consensus. Food & Function 2014, 5(6):1113-1124.
162. Minekus M., Marteau P., Havenaar R. Multicompartmental dynamic computer-controlled model simulating the stomach and small intestine. Alternatives to Laboratory Animals 1995, 23:197-209.
163. Mitchell D., McClure B., Tubman T. Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants. Archives of Disease in Childhood 2001, 84(3):273-276.
164. Mock D.M., Perman J.A., Thaler M.M., Morris R.C. Chronic fructose intoxication after infancy in children with hereditary fructose intolerance: A cause of growth retardation. New England Journal of Medicine 1983, 309(13):764-770.
165. Moller H.K., Thymann T., Fink L.N., Frokiaer H., Kvistgaard A.S., Sangild P.T. Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs. British Journal of Nutrition 2011, 105(01):44-53.
166. Moreau H., Laugier R., Gargouri Y., Ferrato F., Verger R. Human preduodenal lipase is entirely of gastric fundic origin. Gastroenterology 1988, 95(5):1221-1226.
167. Murphy G., Signer E. Bile acid metabolism in infants and children. Gut 1974, 15(2):151-163.
168. Nagita A., Amemoto K., Yoden A., Aoki S., Sakaguchi M., Ashida K., et al. Diurnal variation in intragastric pH in children with and without peptic ulcers. Pediatric Research 1996, 40(4):528-532.
169. Neumann M.A., Simmer K., Gibson R.A. A critical appraisal of the role of dietary long-chain polyunsaturated fatty acids on neural indices of term infants: A randomized, controlled trial. Pediatrics 2000, 105(1):32-38.
170. N'Goma J.C.B., Amara S., Dridi K., Jannin V., Carrière F. Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems. Therapeutic Delivery 2012, 3(1):105-124.
171. Nik A.M., Corredig M., Wright A.J. Changes in WPI-stabilized emulsion interfacial properties in relation to lipolysis and β-carotene transfer during exposure to simulated gastric-duodenal fluids of variable composition. Food Digestion 2010, 1(1-2):14-27.
172. Nobigrot T., Chasalow F., Lifshitz F. Carbohydrate absorption from one serving of fruit juice in young children: Age and carbohydrate composition effects. Journal of the American College of Nutrition 1997, 16(2):152-158.
173. O'Callaghan D.M., O'Mahony J.A., Ramanujam K.S., Burgher A.M. Dehydrated dairy products/infant formulae. Encyclopedia of dairy sciences 2011, 135-145. Academic Press. Second Edition. W.F. John (Ed.).
174. Oomen A., Rompelberg C., Bruil M., Dobbe C., Pereboom D., Sips A. Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants. Archives of Environmental Contamination and Toxicology 2003, 44(3):281-287.
175. Oosting A., van Vlies N., Kegler D., Schipper L., Abrahamse-Berkeveld M., Ringler S., et al. Effect of dietary lipid structure in early postnatal life on mouse adipose tissue development and function in adulthood. British Journal of Nutrition 2014, 111(02):215-226.
176. Patole S. Developmental physiology of the gastrointestinal tract and feed intolerance in preterm neonates. Nutrition for the preterm neonate 2013, 3-23. Springer, Netherlands. S. Patole (Ed.).
177. Perry D.L., Spedick J.M., McCoy T.P., Adams M.R., Franke A.A., Cline J.M. Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). The Journal of Nutrition 2007, 137(6):1390-1394.
178. Picciano M.F. Nutrient composition of human milk. Pediatric Clinics of North America 2001, 48(1):53-67.
179. Pinto M.S., Léonil J., Henry G., Cauty C., Carvalho A.F., Bouhallab S. Heating and glycation of β-lactoglobulin and β-casein: Aggregation and in vitro digestion. Food Research International 2014, 55:70-76.
180. Plucinski T.M., Hamosh M., Hamosh P. Fat digestion in rat: Role of lingual lipase. American Journal of Physiology 1979, 237(6):G541-G547.
181. Renneberg R., Skåra B. Essential fatty acids in human colostrum. Acta Paediatrica 1992, 81(10):779-783.
182. Roman C., Carriere F., Villeneuve P., Pina M., Millet V., Simeoni U., et al. Quantitative and qualitative study of gastric lipolysis in premature infants: Do MCT-enriched infant formulas improve fat digestion?. Pediatric Research 2007, 61(1):83-88.
183. Roussel A., de Caro J., Bezzine S., Gastinel L., de Caro A., Carrière F., et al. Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations. Proteins: Structure, Function, and Bioinformatics 1998, 32(4):523-531.
184. Rudloff S., Kunz C. Protein and nonprotein nitrogen components in human milk, bovine milk, and infant formula: Quantitative and qualitative aspects in infant nutrition. Journal of Pediatric Gastroenterology and Nutrition 1997, 24(3):328-344.
185. Ruegg M., Blanc B. Structure and properties of the particulate constituents of human milk, A review. Food Microstructure 1982, 1:25-40.
186. Sakai K., Yoshino K., Satter M.A., Ota F., Nil Y., Fututa K., et al. Effects of pH variation and NaCl on in vitro digestibility of cow's milk proteins in commercially available infant formulas. Journal of Nutritional Science and Vitaminology 2000, 46(6):325-328.
187. Sandström O., Lönnerdal B., Graverholt G., Hernell O. Effects of α-lactalbumin enriched formula containing different concentrations of glycomacropeptide on infant nutrition. The American Journal of Clinical Nutrition 2008, 87(4):921-928.
188. SanGiovanni J.P., Berkey C.S., Dwyer J.T., Colditz G.A. Dietary essential fatty acids, long-chain polyunsaturated fatty acids, and visual resolution acuity in healthy fullterm infants: A systematic review. Early Human Development 2000, 57(3):165-188.
189. Sarles J., Moreau H., Verger R. Human gastric lipase: ontogeny and variations in children. Acta Paediatrica 1992, 81(6-7):511-513.
190. Sato R., Noguchi T., Naito H. Casein phosphopeptide (CPP) enhances calcium absorption from the ligated segment of rat small intestine. Journal of Nutritional Science and Vitaminology 1986, 32(1):67-76.
191. Shah N.P. Effects of milk-derived bioactives: An overview. British Journal of Nutrition 2000, 84(S1):3-10.
192. Shani-Levi C., Levi-Tal S., Lesmes U. Comparative performance of milk proteins and their emulsions under dynamic in vitro adult and infant gastric digestion. Food Hydrocolloids 2013, 32(2):349-357.
193. Sibley E. Carbohydrate digestion and absorption. Encyclopedia of gastroenterology 2004, 275-278. Elsevier, New York. L.R. Johnson (Ed.).
194. Sidnell A., Greenstreet E. Infant nutrition-Review of lipid innovation in infant formula. Nutrition Bulletin 2011, 36(3):373-380.
195. Sopade P.A., Gidley M.J. A rapid in vitro digestibility assay based on glucometry for investigating kinetics of starch digestion. Starch-Starke 2009, 61(5):245-255.
196. Stephen A., Alles M., De Graaf C., Fleith M., Hadjilucas E., Isaacs E., et al. The role and requirements of digestible dietary carbohydrates in infants and toddlers. European Journal of Clinical Nutrition 2012, 66(7):765-779.
197. Strom B.L., Schinnar R., Ziegler E.E., Barnhart K.T., Sammel M.D., Macones G.A., et al. Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood. JAMA, the Journal of the American Medical Association 2001, 286(7):807-814.
198. Stromqvist M., Falk P., Bergstrom S., Hansson L., Lönnerdal B., Normark S., et al. Human milk kappa-casein and inhibition of Helicobacter pylori adhesion to human gastric mucosa. Journal of Pediatric Gastroenterology and Nutrition 1995, 21(3):288-296.
199. Terracciano L., Isoardi P., Arrigoni S., Zoja A., Martelli A. Use of hydrolysates in the treatment of cow's milk allergy. Annals of Allergy, Asthma, and Immunology 2002, 89(6):86-90.
200. Tetens I. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on bovine lactoferrin: EFSA-Q-2010-01269 2012, European Food Safety Authority.
201. Thompkinson D., Kharb S. Aspects of infant food formulation. Comprehensive Reviews in Food Science and Food Safety 2007, 6(4):79-102.
202. Tomarelli R., Meyer B., Weaber J., Bernhart F. Effect of positional distribution on the absorption of the fatty acids of human milk and infant formulas. The Journal of Nutrition 1968, 95(4):583-590.
203. Tomita M., Wakabayashi H., Yamauchi K., Teraguchi S., Hayasawa H. Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochemistry and Cell Biology 2002, 80(1):109-112.
204. Turner R.B., Kelsey D.K. Passive immunization for prevention of rotavirus illness in healthy infants. The Pediatric Infectious Disease Journal 1993, 12(9):718-721.
205. Uauy R., Mena P., Wegher B., Nieto S., Salem N. Long chain polyunsaturated fatty acid formation in neonates: Effect of gestational age and intrauterine growth. Pediatric Research 2000, 47(1). (127-127).
206. Uruakpa F.O., Ismond M.A.H., Akobundu E.N.T. Colostrum and its benefits: A review. Nutrition Research 2002, 22(6):755-767.
207. Vandenplas Y., De Greef E., Devreker T., Hauser B. Soy infant formula: Is it that bad?. Acta Paediatrica 2011, 100(2):162-166.
208. Ville E., Carrière F., Renou C., Laugier R.E. Physiological study of pH stability and sensitivity to pepsin of human gastric lipase. Digestion 2002, 65(2):73-81.
209. Vors C., Capolino P., Guérin C., Meugnier E., Pesenti S., Chauvin M.A., et al. Coupling in vitro gastrointestinal lipolysis and Caco-2 cell cultures for testing the absorption of different food emulsions. Food & Function 2012, 3(5):537-546.
210. Wada Y., Lönnerdal B. Effects of different industrial heating processes of milk on site-specific protein modifications and their relationship to in vitro and in vivo digestibility. Journal of Agricultural and Food Chemistry 2014, 62(18):4175-4185.
211. Wal J.M. Bovine milk allergenicity. Annals of Allergy, Asthma, and Immunology 2004, 93(5):S2-S11.
212. Whitnah C.H. Indications of glucose in milk. Journal of the American Chemical Society 1931, 53(1):300-304.
213. Wickham M., Faulks R., Mills C. In vitro digestion methods for assessing the effect of food structure on allergen breakdown. Molecular Nutrition & Food Research 2009, 53(8):952-958.
214. Willatts P., Forsyth J.S., DiModugno M.K., Varma S., Colvin M. Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10months of age. The Lancet 1998, 352(9129):688-691.
215. Wolter A., Hager A.S., Zannini E., Arendt E.K. In vitro starch digestibility and predicted glycaemic indexes of buckwheat, oat, quinoa, sorghum, teff and commercial gluten-free bread. Journal of Cereal Science 2013, 58(3):431-436.
216. Wong J.H., Lau T., Cai N., Singh J., Pedersen J.F., Vensel W.H., et al. Digestibility of protein and starch from sorghum (Sorghum bicolor) is linked to biochemical and structural features of grain endosperm. Journal of Cereal Science 2009, 49(1):73-82.
217. World Health Organization, UNICEF Global strategy for infant and young child feeding Retried from. http://www.who.int/nutrition/publications/infantfeeding/9241562218/en/.
218. Xu R. Development of the newborn GI tract and its relation to colostrum/milk intake: A review. Reproduction, Fertility and Development 1996, 8(1):35-48.
219. Yoo J.Y., Chen X.D. GIT physicochemical modeling-A critical review. International Journal of Food Engineering 2006, 2(4).
220. Zhang Q., Carpenter C.J. Proteomics in milk and milk processing. Proteomics in foods 2013, 223-245. Springer, US.