Quantitative and qualitative study of gastric lipolysis in premature infants: Do MCT-enriched infant formulas improve fat digestion?

Pediatric Research

Volumn 61, Issue 1, 2007, Pages 83-88

  Roman, Céline ^a,b   Carriere, Frédéric ^b   Villeneuve, Pierre ^c   Pina, Michel ^c   Millet, Véronique ^a   Simeoni, Umberto ^a   Sarles, Jacques ^a,b  

^a TIMONE HOSPITAL   (France)

^b Centre National de la Recherche Scientifique   (France)

^c CIRAD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FATTY ACID ESTER; MEDIUM CHAIN TRIACYLGLYCEROL; OCTANOIC ACID; OLEIC ACID; PALMITIC ACID; TRIACYLGLYCEROL LIPASE; TRIACYLGLYCEROL;

ARTICLE; ARTIFICIAL MILK; ASPIRATION; BREAST MILK; CONFIDENCE INTERVAL; ENZYME ACTIVITY; FAT INTAKE; GAS CHROMATOGRAPHY; HUMAN; INFANT; INFANT FEEDING; LIPOLYSIS; PREMATURITY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; STOMACH CONTENT; STOMACH EMPTYING; STOMACH TUBE; THIN LAYER CHROMATOGRAPHY; METABOLISM; NEWBORN; PH; PHYSIOLOGY; SECRETION; STOMACH; STOMACH MUCOSA;

GASTRIC MUCOSA; HUMANS; HYDROGEN-ION CONCENTRATION; INFANT FORMULA; INFANT, NEWBORN; INFANT, PREMATURE; STOMACH; TRIGLYCERIDES;

EID: 33847001665     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000250199.24107.fb     Document Type: Article

References (30)

1. Zoppi G, Andreotti G, Pajno-Ferrara F, Njai DM, Gaburro D 1972 Exocrine pancreas function in premature and full term neonates. Pediatr Res 6:880-886
2. Fredrikzon B, Olivecrona T 1978 Decrease of lipase and esterase activities in intestinal contents of newborn infants during test meals. Pediatr Res 12:631-634
3. Watkins JB, Ingall D, Szczepanik P, Klein PD, Lester R 1973 Bile-salt metabolism in the newborn. Measurement of pool size and synthesis by stable isotope technic. N Engl J Med 288:431-434
4. Murphy GM, Signer E 1974 Bile acid metabolism in infants and children. Gut 15:151-163
5. Bernback S, Blackberg L, Hernell O 1990 The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase. J Clin Invest 85:1221-1226
6. Sarles J, Moreau H, Verger R 1992 Human gastric lipase: ontogeny and variations in children. Acta Paediatr 81:511-513
7. Bernbäck S, Bläckberg L, Hernell O 1989 Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. Biochim Biophys Acta 1001:286-291
8. Armand M, Hamosh M, Mehta NR, Angelus PA, Philpott JR, Henderson TR, Dwyer NK, Lairon D, Hamosh P 1996 Effect of human milk or formula on gastric function and fat digestion in the premature infant. Pediatr Res 40:429-437
9. Armand M, Hamosh M, Dipalma JS, Gallagher J, Benjamin SB, Philpott JR, Lairon D, Hamosh P 1995 Dietary fat modulates gastric lipase activity in healthy humans. Am J Clin Nutr 62:74-80
10. Carrière F, Barrowman JA, Verger R, Laugier R 1993 Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. Gastroenterology 105:876-888
11. Lengsfeld H, Beaumier-Gallon G, Chahinian H, De Caro A, Verger R, Laugier R Carrière F 2004 Physiology of gastrointestinal lipolysis and therapeutical use of lipases and digestive lipase inhibitors. In: Müller G, Petry S (eds) Lipases and Phospholipases in Drug Development. Wiley, Weinheim, pp 195-229
12. Ville E, Carriere F, Renou C, Laugier R 2002 Physiological study of pH stability and sensitivity to pepsin of human gastric lipase. Digestion 65:73-81
13. Roulet M, Weber AM, Paradis Y, Roy CC, Chartraud L, Lasalle R, Morin CL 1980 Gastric emptying and lingual lipase activity in cystic fibrosis. Pediatr Res 14:1360-1362
14. Moreau J, Bouisson M, Balas D, Ravaud A, Stupnik S, Buscail L, Vaysse N, Ribet A 1990 Gastric lipase in alcoholic pancreatitis. Comparison of secretive profiles following pentagastrin stimulation in normal adults and patients with pancreatic insufficiency. Gastroenterology 99:175-180
15. Carrière F, Grandval P, Renou C, Palomba A, Priéri F, Giallo J, Henniges F, Sander-Struckmeier S, Laugier R 2005 Quantitative study of digestive enzyme secretion and gastrointestinal lipolysis in chronic pancreatitis. Clin Gastroenterol Hepatol 3:28-38
16. Schanler RJ, Shulman RJ, Lau C 1999 Feeding strategies for premature infants: beneficial outcomes of feeding fortified human milk versus preterm formula. Pediatrics 103:1150-1157
17. Hamosh M, Bitman J, Liao TH, Mehta NR, Buczek RJ, Wood DL, Grylack LJ, Hamosh P 1989 Gastric lipolysis and fat absorption in preterm infants: effect of medium-chain triglyceride or long-chain triglyceride-containing formulas. Pediatrics 83:86-92
18. Villeneuve P, Pina M, Montet D, Graille J 1995 Determination of lipase specificities through the use of chiral triglycerides and their racemics. Chem Phys Lipids 76:109-113
19. Fredrikzon B, Hernell O 1977 Role of feeding on lipase activity in gastric contents. Acta Paediatr Scand 66:479-484
20. Siegel M, Lebenthal E, Topper W, Krantz B, Li PK 1982 Gastric emptying in prematures of isocaloric feedings with differing osmolalities. Pediatr Res 16:141-147
21. Carriere F, Renou C, Ransac S, Lopez V, De Caro J, Ferrato F, De Caro A, Fleury A, Sanwald-Ducray P, Lengsfeld H, Beglinger C, Hadvary P, Verger R, Laugier R 2001 Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers. Am J Physiol Gastrointest Liver Physiol 281:G16-G28
22. Carrière F, Rogalska E, Cudrey C, Ferrato F, Laugier R, Verger R 1997 In vivo and in vitro studies on the stereoselective hydrolysis of tri- and diglycerides by gastric and pancreatic lipases. Bioorg Med Chem 5:429-435
23. Straarup EM, Lauritzen L, Faerk J, Hoy Deceased CE, Michaelsen KF 2006 The stereospecific triacylglycerol structures and fatty acid profiles of human milk and infant formulas. J Pediatr Gastroenterol Nutr 42:293-299
24. Patton JS, Rigler MW, Liao H, Hamosh P, Hamosh M 1982 Hydrolysis of triacylglycerol emulsions by lingual lipase. A microscopic study. Biochim Biophys Acta 712:400-407
25. Hamosh M, Bitman J, Liao T, Mehta NR, Buczek RJ, Wood DL, Grylack LJ, Hamosh P 1989 Gastric lipolysis and fat absorption in preterm infants: effect of medium chain triglyceride or long chain triglyceride containing formulas. Pediatrics 83:86-92
26. Myher JJ, Kuksis A, Steiner G 1984 Milk fat structure of a patient with type 1 hyperlipidemia. Lipids 19:673-682
27. Winter CH, Hoving EB, Muskiet FA 1993 Fatty acid composition of human milk triglyceride species. Possible consequences for optimal structures of infant formula triglycerides. J Chromatogr 616:9-24
28. Staggers JE, Fernando-Warnakulasuriya GJ, Wells MA 1981 Studies on fat digestion, absorption, and transport in the suckling rat. II. Triacylglycerols: molecular species, stereospecific analysis, and specificity of hydrolysis by lingual lipase. J Lipid Res 22:675-679
29. Fernando-Warnakulasuriya GJ, Staggers JE, Frost SC, Wells MA 1981 Studies on fat digestion, absorption, and transport in the suckling rat. I. Fatty acid composition and concentrations of major lipid components. J Lipid Res 22:668-674
30. Hildebrand P, Petrig C, Burckhardt B, Ketterer S, Lengsfeld H, Fleury A, Hadvary P, Beglinger C 1998 Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release. Gastroenterology 114:123-129