Lactoferrin: A review

Veterinarni Medicina

Volumn 53, Issue 9, 2008, Pages 457-468

  Adlerova, L ^a   Bartoskova, A ^a   Faldyna, Martin ^a,b  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^b VETERINARY RESEARCH INSTITUTE   (Czech Republic)

Author keywords

Antimicrobial; Glycoprotein; Host defense; Leukocytes; Milk; Neutrophils; Protein; Transferrin

Indexed keywords

EID: 54349126915     PISSN: 03758427     EISSN: None     Source Type: Journal    
DOI: 10.17221/1978-VETMED     Document Type: Review

References (112)

1. Abrink M., Larsson E., Gobl A., Hellman L. (2000): Expression of lactoferrin in the kidney: implications for innate immunity and iron metabolism. Kidney International, 57, 2004-2010
2. Aisen P., Liebman A. (1972): Lactoferrin and transferrin: a comparative study. Biochimica et Biophysica Acta, 257, 314-323
3. Andersen J.H., Osbakk S.A., Vorland L.H., Traavik T., Gutteberg T.J. (2001): Lactoferrin and cyclic lactoferricin inhibit the entry of human fibroblasts. Antiviral Research, 51, 141-149
4. Antonsen S., Wiggers P., Dalhoj J., Blaabjerg o. (1993): An enzyme linked-immunosorbent assay for plasma-lactoferrin. Concentrations in 362 healthy, adult blood donors. Scandinavian Journal of Clinical and Laboratory Investigation, 53, 133-144
5. arnold r.r., cole m.f., mcghee j.r. (1977): A bactericidal effect for human lactoferrin. Science, 197, 263-265
6. arnold r.r., brewer m., gauthier j.j. (1980): Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms. Infection and Immunity, 28, 893-898
7. Ashorn R.G., Eskola J., Tuohimaa P.J., Krohn K.J. (1986): Effect of the progesterone-inducible proteins human lactoferrin and chicken avidin on lymphocyte proliferation. Human Reproduction, 1, 149-151
8. Baggiolini M., De Duve C., Masson P.L., heremans j.f. (1970): Association of lactoferrin with specific granules in rabbit heterophil leukocytes. The Journal of Experimental Medicine, 131, 559-570
9. baker e.n. (1994): Structure and reactivity of transferrins. Advances in Inorganic Chemistry, 41, 389-463
10. Baker E.N., Baker H.M. (2005): Molecular structure, binding properties and dynamics of lactoferrin. Cellular and Molecular Life Sciences, 62, 2531-2539
11. Barton M.H., Hurley D., Norton N., Heusner G., Costa L., Jones S., Byars D., Watanabe K. (2006): Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses. Journal of Veterinary Internal Medicine, 20, 1457-1462
12. Baynes R.D., Bezwoda W.R. (1994): Lactoferrin and the inflammatory response. Advances in Experimental Medicine and Biology, 357, 133-141
13. Baynes R., Bezwoda W., Bothwell T., Khan Q., Mansoor N. (1986): The non-immune inflammatory response: serial changes in plasma iron, iron-binding capacity, lactoferrin, ferritin and C reactive protein. Scandinavian Journal of Clinical and Laboratory Investigation, 46, 695-704
14. Bellamy W., Takase M., Yamauchi K., Wakabayashi H., Kawase K., Tomita M. (1992): Identification of the bactericidal domain of lactoferrin. Biochimica et Biophysica Acta, 1121, 130-136
15. Bennett r.m., mohla c. (1976): A solid-phase radio-immunoassay for the measurement of lactoferrin in human plasma: variations with age, sex and disease. The Journal of Laboratory and Clinical Medicine, 88, 156-166
16. Berlov M.N., Korableva E.S., Andreeva Y.V., Ovchinnikova T.V., Korkyakov V.N. (2007): Lactoferrin from canine neutrophils: isolation and physicochemical and antimicrobial properties. Biochemistry (Moscow), 72, 445-451
17. Bezault J., Bhimani R., Wiprovnick J., Furmanski P. (1994): Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Research, 54, 2310-2312
18. bezwoda w.r., baynes r.d., Khan Q., Manssor n. (1985): Enzyme linked immunosorbent assay for lactoferrin. Plasma and tissue measurements. Clinica Chimica Acta; International Journal of Clinical Chemistry, 151, 61-69
19. Birgens H.S. (1985): Lactoferrin in plasma measured by an ELISA technique: evidence that plasma lactoferrin is an indicator of neutrophil turnover and bone marrow activity in acute leukaemia. Scandinavian Journal of Haematology, 34, 326-331
20. Boxer L.A., Coates T.D., Haak R.A., Wolach J.B., Hoffstein S., Baehner R.L. (1982): Lactoferrin deficiency associated with altered granulocyte function. The New England Journal of Medicine, 307, 404-410
21. Brines R.D., Brock J.H. (1983): The effect of trypsin and chymotrypsin on the in vitro antibacterial and iron-binding proprieties of lactoferrin in human milk and bovine colostrum. Unusual resistance of human apolactoferrin to proteolytic digestion. Biochimica et Biophysica Acta, 759, 229-235
22. brock j.h. (1980): Lactoferrin in human milk: its role in iron absorption and protection against enteric infection in the newborn infant. Archives of Disease in Childhood, 55, 417-421
23. Brock j.h. (2002): The physiology of lactoferrin. Biochemistry and Cell Biology, 80, 1-6
24. Brock J.H., Arzabe F., Lampreave F., Pineiro A. (1976): The effect of trypsin on bovine transferrin and lactoferrin. Biochimica et Biophysica Acta, 446, 214-225
25. Brown R.D., Rickard K.A., Kronenberg H. (1983): Immunoradiometric assay of plasma lactoferrin. Pathology, 15, 27-31
26. Broxmeyer H.E., Gentile P., Bognacki J., Ralph P. (1983): Lactoferrin, transferrin and acidic isoferritins: regulatory molecules with potential therapeutic value in leukemia. Blood Cells, 9, 83-105
27. Cheng J.B., Wang J.Q., Bu D.P., Liu G.L., Zhang C.G., Wei H.Y., Zhou L.Y., Wang J.Z. (2008): Factors affecting the lactoferrin concentration in bovine milk. Journal of Dairy Science, 91, 970-976
28. Chung S., Hayward C., Brock D.J.H., Van Heyningen V. (1985): A monoclonal antibody-based immunoassay for human lactoferrin. Journal of Immunological Methods, 84, 135-141
29. Cirioni O., Giacometti A., Barchiesi F., Scalise G. (2000): Inhibition of growth of Pneumocystis carinii by lactoferrins alone and in combination with pyrimethamine, clarithromycin and minocycline. The Journal of Antimicrobial Chemotherapy, 46, 577-582
30. Cornish J., Callon K.E., Naot D., Palmano K.P., Banovic T., Bava U., Watson M., Lin J.M., Tong P.C., Chen Q., Chan V.A., Reid H.E., Fazzalari N., Baker H.M., Baker E.N., Haggararty N.W., Grey A.B., Reid I.R. (2004): Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology, 145, 4366-4374
31. crosa j.h. (1989): Genetics and molecular biology of siderophore-mediated iron transport in bacteria. Microbiological Reviews, 53, 517-530
32. Damiens E., Mazurier J., El Yazidi I., Masson M., Duthille I., Spik G., Boilly-Marer Y. (1998): Effects of human lactoferrin on NK cell cytotoxicity against haematopoetic and epithelial tumour cells. Biochimica et Biophysica Acta, 1402, 277-287
33. Damiens E., El Yazidi I., Mazurier J., Duthille I., Spik G., Boilly-Marer Y. (1999): Lactoferrrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells. Journal of Cellular Biochemistry, 74, 486-498
34. Davidsson L., Kastenmayer P., Yuen M., Lonnerdal B., Hurell R.F. (1994): Influence of lactoferrin on iron absorption from human milk in infants. Pediatric Research, 35, 117-124
35. De Vet B.J., Van Gool J. (1974): Lactoferrin and iron absorption in the small intestine. Acta Medica Scandinavica, 196, 393-402
36. devi a.s., das m.r., pandit m.w. (1994): Lactoferrin contains structural motifs of ribonuclease. Biochimica et Biophysica Acta, 1205, 275-281
37. Ekins A., Khan a.g., shouldice s.r., schryvers a.b. (2004): Lactoferrin receptors in gram-negative bacteria: insights into the iron acquisition process. Biometals, 17, 235-243
38. Esaguy N., Aguas A.P., Vilanova M., Silva M.T. (1991): Activation of human neutrophils by phorbol ester decreases the cytoplasm compactness and the lactoferrin content of the granulocytes. Journal of Leukocyte Biology, 50, 444-452
39. Fairweather-tait s.j., balmer s.e., scott p.h., Minski m.j. (1987): Lactoferrin and iron absorption in newborn infants. Pediatric Research, 22, 651-654
40. Fujihara T., Hayashi K. (1995): Lactoferrin inhibits herpes simplex virus type-1 (HSV-1) infection to mouse cornea. Archives of Virology, 140, 1469-1472
41. Fujita K., Matsuda E., Sekine K., Iigo M., Tsuda H. (2004): Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. Carcinogenesis, 25, 1961-1966
42. furmanski p., li z.p., fortuna m.b., swamy c.v.b., das m.r. (1989): Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity. The Journal of Experimental Medicine, 170, 415-429
43. green m.r., pastewka j.v. (1978): Lactoferrin is a marker for prolactin response in mouse mammary explants. Endocrinology, 103, 1510-1513
44. Groves m.l. (1960): The isolation of a red protein from milk. Journal of the American Chemical Society, 82, 3345-3350
45. Hagiwara T., Shinoda I., Fukuwatari Y., Shimamura S. (1995): Effect of lactoferrin and its peptides on proliferation of rat intestinal epithelial cell line, IEC-18, in the presence of epidermal growth factor. Bioscience, Biotechnology, and Biochemistry, 59, 1875-1881
46. Hagiwara S., Kawai K., Anri A., Nagahata H. (2003): Lactoferrin concentrations in milk from normal and subclinical mastitic cows The Journal of Veterinary Medical Science, 65, 319-323
47. Hansen N.E., Malmquist J., Thorell J. (1975) Plasma myeloperoxidase and lactoferrin measured by radioimmunoassay: relations to neutrophil kinetics. Acta Medica Scandinavica, 198, 437-443
48. harmsen m.c., swart p.j., de bethune m.p., Pauwels R., De Clercq E., the t.h., meijer d.k.f. (1995): Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. The Journal of Infectious Diseases, 172, 380-388
49. Haversen L., Ohlsson B.G., Hahn-Zoric M., Hanson L.A., Mattsby-Baltzer I. (2002): Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cellular Immunology, 220, 83-95
50. He J., Furmanski p. (1995): Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA. Nature, 373, 721-724
51. Hutchens T.W., Henry J.F., Yip T.T., Hachey D.L., Schanler R.J., Motil K.J., Garza C. (1991): Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation by stable isotopic enrichment. Pediatric Research, 29, 243-250
52. Iyer S., Lonnerdal B. (1993): lactoferrin, lactoferrin receptors and iron metabolism. European Journal of Clinical Nutrition, 47, 232-241
53. jameson g.b., anderson b.f., norriss g.e., thomas d.h., baker e.n. (1998): Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change. Acta Crystallographica. Section D, Biological Crystallography, 54, 1319-1335
54. Johanson B. (1960): Isolation of an iron containing red protein from human milk. Acta Chemica Scandinavica, 14, 510-512
55. Kanyshkova t.g., buneva v.n., nevinsky g.a. (2001): Lactoferrin and its biological functions. Biochemistry (Moscow), 66, 1-7
56. kelver m.e., kaul a., nowicki b., findley w.e., hutchens t.w., nagamami m. (1996): Estrogen regulation of lactoferrin in human endometrium. American Journal of Reproductive Immunology, 36, 234-247
57. Kikuchi M., Mizoroki S., Kubo T., Ohiwa Y., Kubota M., Yamada N., Orino K., Ohnami Y., Watanabe K. (2003): Seminal plasma lactoferrin but not transferrin reflects gonadal function in dogs. The Journal of Veterinary Medical Science, 65, 679-684
58. kirkpatrick c.h., green i., rich r.r., schade a.l. (1971): Inhibition of growth of Candida albicans by iron-unsaturated lactoferrin: relation to host-defense mechanisms in chronic mucocutaneous candidiasis. The Journal of Infectious Diseases, 124, 539-544
59. Konuspayeva G., Faye B., Loiseau G., Levieux D. (2007): Lactoferrin and immunoglobulin contents in camel's milk (Camelus bactrianus, Camelus dromedarius, and hybrids) from Kazakhstan. Journal of Dairy Science, 90, 38-46
60. Legrand D., Elass E., Carpentier M., Mazurier J. (2005): Lactoferrin: a modulator of immune and inflammatory responses. Cellular and Molecular Life Sciences, 62, 2549-2559
61. leitch e.c., willcox m.d. (1998): Synergic antistaphylococcal properties of lactoferrin and lysozyme. Journal of Medical Microbiology, 47, 837-842
62. levay p.f., viljoen m. (1995): Lactoferrin: a general review. Haematologica, 80, 252-267
63. Lonnerdal B., Iyer S. (1995): Lactoferrin: molecular structure and biological function. Annual Review of Nutrition, 15, 93-110
64. Lorget F., Clough J., Oliveira M., Daury m.c., Sabokbar A., Offord E. (2002): Lactoferrin reduces in vitro osteoclast differentiation and resorbing activity. Biochemical and Biophysical Research Communications, 296, 261-266
65. Machnicki M., Zimecki M., Zagulski T. (1993): Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo. International Journal of Experimental Pathology, 74, 433-439
66. Marchetti M., Longhi C., Conte M.P., Pisani S., Valenti P., Seganti L. (1996): Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Research, 29, 221-231
67. Masson P.L., Heremans J.F. (1971): Lactoferrin in milk from different species. Comparative Biochemistry and Physiology. B, Comparative Biochemistry, 39, 119-129
68. Masson P.L., Heremans J.F., Dive C. (1966): An iron-binding protein common to many external secretions. Clinica Chimica Acta, 14, 735-739
69. Masson P.L., Heremans J.F., ferin j. (1968): Presence of an iron-binding protein (lactoferrin) in the genital tract of the human female. I. Its imunnohistochemical localization in the endometrium. Fertility and Sterility, 19, 679-689
70. Masson P.L., Heremans J.F., schonne e. (1969): Lactoferrin, an iron-binding protein in neutrophilic leukocytes. The Journal of Experimental Medicine, 130, 643-658
71. Mazurier J., Spik G. (1980): Comparative study of the iron-binding properties of human transferrins. I. Complete and sequential iron saturation and desaturation of the lactotransferrin. Biochimica et Biophysica Acta, 629, 399-408
72. Metz-Boutique M.H., Jolles J., Mazurier J., Schoentgen F., Legrand D., Spik G., Montreuil J., Jolles P. (1984): Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins. European Journal of Biochemistry, 145, 659-676
73. Montreuil J., Tonnelat J., Mullet S. (1960): Preparation and properties of lactosiderophilin (lactotransferrin) of human milk. Biochimica et Biophysica Acta, 45, 413-421
74. nelson k.g., Takahashi T., Bossert n.l., walmer d.k., mclachlan j.a. (1991): Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentation. Proceedings of the National Academy of Sciences of the United States of America, 88, 21-25
75. Niemela A., Kulomaa M., Vija P., Tuohimaa P., Saarikoski S. (1989): Lactoferrin in human amniotic fluid. Human Reproduction, 4, 99-101
76. Oberg G., Lindmark G., Moberg L., Venge P. (1983): The peroxidase activity and cellular content of granule proteins in PMN during pregnancy. British Journal of Haematology, 55, 701-708
77. Olofsson T., Olsson I., Venge P., Elgefors B. (1977): Serum myeloperoxidase and lactoferrin in neutropenia. Scandinavian Journal of Haematology, 18, 73-80
78. Omata Y., Satake M., Maeda R., Saito A., Shimazaki K., Yamauchi K., Uzuka Y., Tanabe S., Sarashina T., Mikami T. (2001): Reduction of the infectivity of Toxoplasma gondii and Eimeria stiedai sporozoites by treatment with bovine laktoferricin. The Journal of Veterinary Medical Science, 63, 187-190
79. Orsi N. (2004): The antimicrobial activity of lactofer-rin: current status and perspectives. Biometals, 17, 189-196
80. Otnaess A.B.K., Meberg A., Sande H.A. (1983): Plasma lactoferrin measured by an enzyme-linked immunosorbent-assay (ELISA). Measurements on adult and infant plasma. Scandinavian Journal of Haematology, 31, 235-240
81. pentecost b.t., teng c.t. (1987): Lactotransferrin is the major estrogen inducible protein in mouse uterine secretions. The Journal of Biological Chemistry, 262, 10134-10139
82. Petschow b.w., talbott r.d., batema r.p. (1999): Ability of lactoferrin to promote the growth of Bifidobacterium spp. in vitro is independent of receptor binding capacity and iron saturation level. Journal of Medical Microbiology, 48, 541-549
83. Ratledge C., Dover l.g. (2000): Iron metabolism in pathogenic bacteria. Annual Review of Microbiology, 54, 881-941
84. Richie E.R., Hilliard J.K., Gilmore R., Gillespie D.J. (1987): Human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. Journal of Reproductive Immunology, 12, 137-148
85. Rossi P., Giansanti F., Boffi A., Ajello M., Valenti P., Chiancone E., Antonini G. (2002): Ca2+ binding to bovine lactoferrin enhances protein stability and influences the release of bacterial lipopolysaccharide. Biochemistry and Cell Biology, 80, 41-48
86. Rumke P., Visser D., Kwa H.G., Hart A.A. (1971): Radio-immuno assay of lactoferrin in blood plasma of breast cancer patients, lactating and normal women; prevention of false high levels caused by leakage from neutrophile leucocytes in vitro. Folia Medica Neerlandica, 14, 156-168
87. Saito N., Takemori N., Hirai K., Onodera R., Watanabe S., Namiki M. (1993): Ultrastructural localization of lactoferrin in the granules other than typical secondary granules of human neutrophils. Human Cell, 6, 42-48
88. Sanchez L., Calvo M., Brock j.h. (1992): Biological role of lactoferrin. Archives of Disease in Childhood, 67, 657-661
89. schryvers a.b., bonnah r., yu r.h., Wong H., Retzer M. (1998): Bacterial lactoferrin receptors. Advances in Experimental Medicine and Biology, 443, 123-133
90. Scott P.H. (1989): Enzyme immunoassay of lactoferrin in newborn term infants: reference values and influence of diet. Annals of Clinical Biochemistry, 26, 407-411
91. Sherman m.p., bennett s.h., Hwang f.f., yu c. (2004): Neonatal small bowel epithelia: enhancing anti-bacterial defense with lactoferrin and Lactobacillus GG. Biometals, 17, 285-289
92. singh p.k., parsek m.r., greenberg e.p., welsh m.j. (2002): A component of innate immunity prevents bacterial biofilm development. Nature, 417, 552-555
93. Sinkora J., Samankova P., Kummer V., Leva L., Maskova J., Rehakova Z., Faldyna M. (2007): Commercially available rabbit anti-human polyclonal antisera as a useful tool for immune system studies in veterinary species. Veterinary Immunology and Immunopathology, 119, 156-162
94. Sorensen M., Sorensen S.P.L. (1939): The proteins in whey. Comptes-rendus des Travaux du Laboratoire Carlsberg, 23, 55-99
95. Suzuki y.a., lonnerdal b. (2002): Characterization of mammalian receptors for lactoferrin. Biochemistry and Cell Biology, 80, 75-80
96. Suzuki y.a., Lopez V., Lonnerdal b. (2005): Mammalian lactoferrin receptors: structure and function. Cellular and Molecular Life Sciences, 62, 2560-2575
97. sykes j.a., thomas m.j., goldie d.j., turner g.m. (1982): Plasma lactoferrin levels in pregnancy and cystic fibrosis. Clinica Chimica Acta, 122, 385-393
98. Tachezy J., Kulda J., Bahnikova I., Suchan P., Razga J., Schrevel J. (1996): Tritrichomonas foetus: iron acquisition from lactoferrin and transferrin. Experimental Parasitology, 83, 216-228
99. teng c.t., Beard C., Gladwell w. (2002): Differential expression and estrogen response of lactoferrin gene in the female reproductive tract of mouse, rat and hamster. Biology of Reproduction, 67, 1439-1449
100. Valenti P., Antonini G. (2005): Lactoferrin: an important host defense against microbial and viral attack. Cellular and Molecular Life Sciences, 62, 2576-2587
101. Van Snick j.l., masson p.l., heremans j.f. (1974): The involvement of lactoferrin in the hyposideremia of acute inflammation. The Journal of Experimental Medicine, 140, 1068-1084
102. Van Vugt h., Van Gool J., Ladiges n.c., boers w. (1975): Lactoferrin in rabbit bile: its relation to iron metabolism. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 60, 79-88
103. walmer d.k., wrona m.a., hughes c.l., nelson k.g. (1992): Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: Correlation with circulating estradiol and progesterone. Endocrinology, 131, 1458-1466
104. Wang w.p., Iigo m., Sato J., Sekine K., Adachi I., Tsuda H. (2000): Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Japanese Journal of Cancer Research, 91, 1022-1027
105. Ward p.p., Zhou X., Conneely o.m. (1996): Cooperative interactions between the amino-a carboxyl-terminal lobes contribute to the unique iron-binding stability of lactoferrin. The Journal of Biological Chemistry, 271, 12790-12794
106. Ward p.p., Mendoza-Meneses M., Mulac-Jericevic b., cunningham g.a., Saucedo-Cardenas O., Teng c.t., conneely o.m. (1999): Restricted spatiotemporal expression of lactoferrin during murine embryonic development. Endocrinology, 140, 1852-1860
107. ward p.p., Paz E., Conneely o.m. (2005): Multifunctional roles of lactoferrin: a critical overview. Cellular and Molecular Life Sciences, 62, 2540-2548
108. Welty F.K., Smith K.L., Schanbacher F.L. (1976): Lactoferrin concentration during involution of the bovine mammary gland. Journal of Dairy Science, 59, 224-231
109. wolf j.s., Li D., Taylor r.j., o'malley b.w. jr. (2003): Lactoferrin inhibits growth of malignant tumors of the head and neck. ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties, 65, 245-249
110. Yamauchi K., Tomita M., Giehl T.J., Ellison r.t. 3rd (1993): Antibacterial activity of lactoferrin and pepsin-derived lactoferrin peptide fragment. Infection and Immunity, 61, 719-728
111. Yanaihara A., Toma Y., Saito H., Yanaihara T. (2000): Cell proliferation effect of lactoferrin in human endometrial stroma cells. Molecular Human Reproduction, 6, 469-473
112. Yi M., Kaneko S., Yu d.y., Murakami S. (1997): Hepatitis C virus envelope proteins bind lactoferrin. Journal of Virology, 71, 5997-6002