Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules

Molecular Nutrition and Food Research

Volumn 53, Issue 12, 2009, Pages 1592-1602

  Berton, Amélie ^a   Sebban Kreuzer, Corinne ^b   Rouvellac, Stéphanie ^a   Lopez, Christelle ^c   Crenon, Isabelle ^a  

^a INSERM   (France)

^b CNRS and Aix Marseille University   (France)

^c UMR1253   (France)

Author keywords

Colipase; Digestion; Milk fat globules; Pancreatic lipase related protein 1; Pancreatic lipase related protein 2

Indexed keywords

BILE ACID; COLIPASE; FATTY ACID; GLYCOLIPID; GLYCOPROTEIN; MILK FAT GLOBULE; PANCREATIC LIPASE RELATED PROTEIN 1; PANCREATIC LIPASE RELATED PROTEIN 2; PANCREATIC LIPASE-RELATED PROTEIN 1; PNLIP PROTEIN, HUMAN; RECOMBINANT PROTEIN; TRIACYLGLYCEROL LIPASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; FAT INTAKE; FOOD HANDLING; HUMAN; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; METHODOLOGY; MILK;

ANIMALS; BILE ACIDS AND SALTS; COLIPASES; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; FOOD HANDLING; GLYCOLIPIDS; GLYCOPROTEINS; HUMANS; KINETICS; LIPASE; MILK; RECOMBINANT PROTEINS;

EID: 71149115500     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200800563     Document Type: Article

References (45)

1. Armand, M., Lipases and lipolysis in the human digestivetract: where do we stand? Curr. Opin. Clin. Nutr. Metab. Care. 2007, 10, 156-164
2. Borgstrom, B., On the interactions between pancreaticlipase and colipase and the substrate, and the importance ofbile salts. J. Lipid Res. 1975, 16, 411-417
3. Brockman, H. L., Kinetic behavior of the pancreatic lipase-colipase-lipid system. Biochimie 2000, 82, 987-995.
4. van Tilbeurgh, H., Egloff, M. P., Martinez, C., Rugani, N. et al., Interfacial activation of the lipase-procolipasecomplex by mixed micelles revealed by X-ray crystal-lography. Nature 1993, 362, 814-820
5. Winkler, F. K., D'Arcy, A., Hunziker, W., Structure of humanpancreatic lipase. Nature 1990, 343, 771-774
6. Giller, T., Buchwald, P., Blum-Kaelin, D., Hunziker, W., Twonovel human pancreatic lipase related proteins, hPLRP1 andhPLRP2. Differences in colipase dependence and in lipaseactivity. J. Biol. Chem. 1992, 267, 16509-16516
7. Lowe, M. E., The triglyceride lipases of the pancreas. J. Lipid Res. 2002, 43, 2007-2016
8. Crenon, I., Jayne, S., Kerfelec, B., Hermoso, J. et al., Pancreatic lipase-related protein type 1: a double mutationrestores a significant lipase activity. Biochem. Biophys. Res. Commun. 1998, 246, 513-517
9. Sias, B., Ferrato, F., Grandval, P., Lafont, D. et al., Humanpancreatic lipase-related protein 2 is a galactolipase. Biochemistry 2004, 43, 10138-10148
10. Jayne, S., Kerfelec, B., Foglizzo, E., Chapus, C., Crenon, I., High expression in adult horse of PLRP2 displaying a lowphospholipase activity. Biochim. Biophys. Acta 2002, 1594,255-265
11. Li, X., Lindquist, S., Lowe, M., Noppa, L., Hernell, O., Bilesalt-stimulated lipase and pancreatic lipase-related protein2 are the dominating lipases in neonatal fat digestion inmice and rats. Pediatr. Res. 2007, 62, 537-541
12. Payne, R. M., Sims, H. F., Jennens, M. L., Lowe, M. E., Ratpancreatic lipase and two related proteins: enzymaticproperties and mRNA expression during development. Am. J. Physiol. 1994, 266, G914-G921
13. Yang, Y., Sanchez, D., Figarella, C., Lowe, M. E., Discoor-dinate expression of pancreatic lipase and two relatedproteins in the human fetal pancreas. Pediatr. Res. 2000, 47,184-188
14. Lowe, M. E., Kaplan, M. H., Jackson-Grusby, L., D'Agostino, D., Grusby, M. J., Decreased neonatal dietary fat absorptionand T cell cytotoxicity in pancreatic lipase-relatedprotein 2-deficient mice. J. Biol. Chem. 1998, 273,31215-31221
15. Armand, M., Borel, P., Ythier, P., Dutot, G., Effects of dropletsize, triacylglycerol composition, and calcium on thehydrolysis of complex emulsions by pancreatic lipase - anin vitro study. J. Nutr. Biochem. 1992, 3, 333-341
16. Borel, P., Armand, M., Ythier, P., Dutot, G. et al., Hydrolysisof emulsions with different triglycerides and droplet sizesby gastric lipase in-vitro - effect on pancreatic lipase activ-ity. J. Nutr. Biochem. 1994, 5, 124-133
17. Jensen, R. G., Ferris, A. M., Lammi-Keefe, C. J., Henderson, R. A., Lipids of bovine and human milks: a comparison. J. Dairy Sci. 1990, 73, 223-240
18. Jensen, R. G., The composition of bovine milk lipids:January 1995 to December 2000. J. Dairy Sci. 2002, 85,295-350
19. Heid, H. W., Keenan, T. W., Intracellular origin and secretionof milk fat globules. Eur. J. Cell Biol. 2005, 84, 245-258.
20. Keenan, T. W., Patton, S., The Milk Lipid Globules Membrane, in: Jensen, R. G. (Ed.), Handbook of Milk Composition, Academic Press, San Diego 1995.
21. Lopez, C., Briard-Bion, V., Menard, O., Rousseau, F. et al., Phospholipid, sphingolipid, and fatty acid compositions ofthe milk fat globule membrane are modified by diet. J. Agric. Food Chem. 2008, 56, 5226-5236
22. Bernback, S., Blackberg, L., Hernell, O., Fatty acids gener-ated by gastric lipase promote human milk triacylglyceroldigestion by pancreatic colipase-dependent lipase. Biochim. Biophys. Acta 1989, 1001, 286-293
23. Bernback, S., Blackberg, L., Hernell, O., The completedigestion of human milk triacylglycerol in vitro requiresgastric lipase, pancreatic colipase-dependent lipase, andbile salt-stimulated lipase. J. Clin. Invest. 1990, 85,1221-1226
24. Blackberg, L., Hernell, O., Olivecrona, T., Hydrolysis ofhuman milk fat globules by pancreatic lipase: role of coli-pase, phospholipase A2, and bile salts. J. Clin. Invest. 1981,67,1748-1752
25. Borgstrom, B., Erlanson-Albertsson, C., Hydrolysis ofmilk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts. J. Clin. Invest. 1982, 70,30-32
26. Iverson, S. J., Kirk, C. L., Hamosh, M., Newsome, J., Milklipid digestion in the neonatal dog: the combined actions ofgastric and bile salt stimulated lipases. Biochim. Biophys. Acta 1991, 1083, 109-119
27. Lopez, C., Focus on the supramolecular structure of milk fatin dairy products. Reprod. Nutr. Dev. 2005, 45, 497-511.
28. Michalski, M. C., Januel, C., Does homogenization affect thehuman health properties of cow's milk? Trends Food Sci. Technol. 2006, 17, 423-437
29. Colin, D. Y., Deprez-Beauclair, P., Allouche, M., Brasseur, R., Kerfelec, B., Exploring the active site cavity of humanpancreatic lipase. Biochem. Biophys. Res. Commun. 2008,370,394-398
30. Sebban-Kreuzer, C., Deprez-Beauclair, P., Berton, A., Crenon, I., High-level expression of nonglycosylated humanpancreatic lipase-related protein 2 in Pichia pastoris. ProteinExpr. Purif. 2006, 49, 284-291
31. Laemmli, U. K., Cleavage of structural proteins during theassembly of the head of bacteriophage T4. Nature 1970,227,680-685
32. Burnette, W. N., ''Western blotting'': electrophoretic transfer of proteins from sodium dodecyl sulfate--poly-acrylamide gels to unmodified nitrocellulose andradiographic detection with antibody and radioiodinatedprotein A. Anal. Biochem. 1981, 112, 195-203.
33. Bligh, E. G., Dyer, W. J., A rapid method of total lipidextraction and purification. Can. J. Biochem. Physiol. 1959,37,911-917
34. Eydoux, C., De Caro, J., Ferrato, F., Boullanger, P. et al., Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells. J. Lipid Res. 2007, 48, 1539-1549
35. De Caro, J., Eydoux, C., Cherif, S., Lebrun, R. et al., Occur-rence of pancreatic lipase-related protein-2 in variousspecies and its relationship with herbivore diet. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2008, 150, 1-9.
36. d'Agostino, D., Lowe, M. E., Pancreatic lipase-relatedprotein 2 is the major colipase-dependent pancreatic lipasein suckling mice. J. Nutr. 2004, 134, 132-134
37. Borgstrom, B., Importance of phospholipids, pancreatic phospholipase A2, and fatty acid for the digestion of dietaryfat: in vitro experiments with the porcine enzymes. Gastroenterology 1980, 78, 954-962
38. Momsen, M. M., Dahim, M., Brockman, H. L., Lateral pack-ing of the pancreatic lipase cofactor, colipase, with phos-phatidylcholine and substrates. Biochemistry 1997, 36,10073-10081
39. Berton, A., Sebban-Kreuzer, C., Crenon, I., Role of thestructural domains in the functional properties of pancreaticlipase-related protein 2. FEBS J. 2007, 274, 6011-6023.
40. Miller, R., Lowe, M. E., Carboxyl ester lipase from eithermother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice. J. Nutr. 2008, 138, 927-930.
41. Jayne, S., Kerfelec, B., Foglizzo, E., Granon, S. et al., Activation of horse PLRP2 by bile salts does not require colipase. Biochemistry 2002, 41, 8422-8428.
42. Miled, N., Berti-Dupuis, L., Riviere, M., Carriere, F., Verger, R., In vitro lipolysis by human pancreatic lipase is specifically abolished by its inactive forms. Biochim. Biophys. Acta 2003, 1645, 241-246.
43. Crenon, I., Foglizzo, E., Kerfelec, B., Verine, A. et al., Pancreatic lipase-related protein type I: a specialized lipase or an inactive enzyme. Protein Eng. 1998, 11, 135-142.
44. Reboul, E., Berton, A., Moussa, M., Kreuzer, C. et al., Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions. Biochim. Biophys. Acta 2006, 1761, 4-10.
45. Birk, R. Z., Regan, K. S., Boyle-Roden, E., Brannon, P. M., Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats. Pediatr. Res. 2004, 56, 256-262.