Food processing increases casein resistance to simulated infant digestion

Molecular Nutrition and Food Research

Volumn 54, Issue 11, 2010, Pages 1677-1689

  Dupont, Didier ^a   Mandalari, Giuseppina ^b,c   Mollé, Daniel ^a   Jardin, Julien ^a   Rolet Répécaud, Odile ^d   Duboz, Gabriel ^d   Léonil, Joëlle ^a   Mills, Clare E N ^b   Mackie, Alan R ^b  

^a UMR1253   (France)

^b NORWICH RESEARCH PARK   (United Kingdom)

^c UNIVERSITY OF MESSINA   (Italy)

^d Natl Inst of Agricultural Research   (France)

Author keywords

Food allergy; Heat treatment; Infant gut; Milk; Yogurt

Indexed keywords

CASEIN; PEPTIDE; YOGHURT;

AMINO ACID SEQUENCE; ARTICLE; DIGESTION; FOOD ALLERGY; FOOD HANDLING; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; INFANT; LACTOBACILLUS DELBRUECKII; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PROTEIN PROCESSING; STREPTOCOCCUS THERMOPHILUS;

AMINO ACID SEQUENCE; CASEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIGESTION; FOOD HANDLING; FOOD HYPERSENSITIVITY; HUMANS; HYDROLYSIS; INFANT; LACTOBACILLUS DELBRUECKII; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; STREPTOCOCCUS THERMOPHILUS; YOGURT;

EID: 78349246782     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200900582     Document Type: Article

References (32)

1. Asero, R., Ballmer-Weber, B. K., Beyer, K., Conti, A. et al., IgE-mediated food allergy diagnosis: current status and new perspectives. Mol. Nutr. Food Res. 2007, 51, 135-147.
2. Jarvinen, K. M., Chatchatee, P., Bardina, L., Beyer, K. et al., IgE and IgG binding epitopes on α-lactalbumin and β-lactoglobulin in cow's milk allergy. Int. Arch. Allergy Immunol. 2001, 126, 111-118.
3. Docena, G. H., Fernandez, R., Chiro, F. G., Fossati, C. A., Identification of casein as the major allergenic and antigenic protein in cow's milk. Allergy 1996, 51, 306-312.
4. Guo, M. R., Fox, P. F., Flynn, A., Kindstedt, P. S., Susceptibility of β-lactoglobulin and sodium caseinate to proteolysis by pepsin and trypsin. J. Dairy Sci. 1995, 78, 2336-2344.
5. Macierzanka, A., Sancho, A. I., Mills, E. N. C., Rigby, N. M. et al., Emulsification alters simulated gastrointestinal proteolysis of β-casein and β-lactoglobulin. Soft Matter 2009, 5, 538-550.
6. Mandalari, G., Adel-Patient, K., Barkholt, V., Baro, C. et al., In vitro digestibility of β-casein and β-lactoglobulin under simulated human gastric and duodenal conditions: a multi-laboratory evaluation. Regul. Toxicol. Pharmacol. 2009, DOI:10.1016/j.yrtph.2009.08.010.
7. Dupont, D., Mandalari, G., Molle, D., Jardin, J. et al., Comparative resistance of food proteins to adult and infant in vitro digestion models. Mol. Nutr. Food Res. 2009, 53, 1-14.
8. Bernard, H., Meisel, H., Creminon, C., Wal, J.-M., Post-translational phosphorylation affects the IgE binding capacity of caseins. FEBS Lett. 2000, 467, 239-244.
9. Roth-Walter, F., Berin, M. C., Arnaboldi, P., Escalante, C. R. et al., Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches. Allergy 2008, 63, 882-890.
10. Guyomarc'h, F., Law, A. J., Dalgleish, D. G., Formation of soluble and micelle-bound protein aggregates in heated milk. J. Agric. Food Chem. 2003, 51, 4652-4660.
11. Patel, H. A., Singh, H., Anema, S. G., Creamer, L. K., Effects of heat and high hydrostatic pressure treatments on disulfide bonding interchanges among the proteins in skim milk. J. Agric. Food Chem. 2006, 54, 3409-3420.
12. Senocq, D., Dupont, D., Rolet-Répécaud, O., Levieux, D., Monoclonal antibodies against bovine β-casein: production and epitope characterization. Food Agric. Immunol. 2001, 13, 213-224.
13. Mandalari, G., Mackie, A. R., Rigby, N. M., Wickham, M. S. J. et al., Physiological phosphatidylcholine protects bovine β-lactoglobulin from simulated gastrointestinal proteolysis. Mol. Nutr. Food Res. 2009, 53, S131-S139.
14. Johansson, A., Lugand, D., Rolet-Repecaud, O., Molle, D. et al., Epitope characterization of a supramolecular protein assembly with a collection of monoclonal antibodies: the case of casein micelle. Mol. Immunol. 2009, 46, 1058-1066.
15. Senocq, D., Dupont, D., Rolet-Répécaud, O., Faurie, F. et al., Antipeptide antibodies recognizing plasmin sensitive sites in bovine β-casein sequence. J. Agric. Food Chem. 2001, 49, 1571-1577.
16. R Development Core Team, R: a Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria 2008. ISBN 3-900051-07-0
17. Sweet, R. M., Eisenberg, D., Correlation of sequence hydrophobicities measures similarity in 3-dimensional protein-structure. J. Mol. Biol. 1983, 171, 479-488.
18. Dupont, D., Rolet-Répécaud, O., Senocq, D., A new approach for monitoring proteolysis phenomena using antibodies specifically directed against the enzyme cleavage site on its substrate. Anal. Biochem. 2003, 317, 240-246.
19. Chatterton, D. E. W., Rasmussen, J. T., Heegaard, C. W., Sørensen, E. S. et al., In vitro digestion of novel milk protein ingredients for use in infant formulas: research on biological functions. Trends Food Sci. Technol. 2004, 15, 373-383.
20. Almaas, H., Cases, A.-L., Devold, T. G., Holm, H. et al., In vitro digestion of bovine and caprine milk by human gastric and duodenal enzymes. Int. Dairy J. 2006, 16, 961-968.
21. Lowe, E. K., Anema, S. G., Bienvenue, A., Boland, M. J. et al., Heat-induced redistribution of disulfide bonds in milk proteins. 2. Disulfide bonding patterns between bovine beta-lactoglobulin and kappa-casein. J Agric. Food Chem. 2004, 52, 7669-7680.
22. Meisel, H., Bernard, H., Fairweather-Tait, S., Fitzgerald, R. J. et al., Detection of caseinophosphopeptides in the distal ileostomy fluid of human subjects. Br. J. Nutr. 2003, 89, 351-358.
23. Ledoux, N., Mahé, S., Duarry, M., Bourras, M. et al., Intraluminal immunoreactive caseinomacropeptide after milk protein ingestion in human. Nahrung 1999, 43, 196-200.
24. Chabance, B., Marteau, P., Rambaud, J. C., Migliore-Samour, D. et al., Casein peptide release and passage to the blood in humans during digestion of milk or yogurt. Biochimie 1998, 80, 155-165.
25. Vila, L., Beyer, K., Järvinen, K. M., Chatchatee, P. et al., Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy. Clin. Exp. Allergy 2001, 31, 1599-1606.
26. Chatchatee, P., Jarvinen, K. M., Bardina, L., Vila, L. et al., Identification of IgE and IgG binding epitopes on beta- and kappa-casein in cow's milk allergic patients. Clin. Exp. Allergy 2001, 31, 1256-1262.
27. 1-casein recognized by human IgE and IgG. Allergy 1996, 51, 306-312.
28. 1-casein-specific B cells and T cells characteristic in cow's-milk allergy. J. Allergy Clin. Immunol. 1998, 101, 660-671.
29. Jarvinen, K. M., Beyer, K., Vila, L., Chatchatee, P. et al., B-cell epitopes as a screening instrument for persistent cow's milk allergy. J. Allergy Clin. Immunol. 2002, 110, 293-297.
30. 1-casein, a major cow's milk allergen. J. Allergy Clin. Immunol. 2003, 112, 433-437.
31. 1-casein using extensively purified synthetic peptides. Scan. J. Immunol. 2004, 60, 486-493.
32. Albrecht, M., Kühne, Y., Ballmer-Weber, B. K., Becker, W.-M. et al., Relevance of IgE binding to short peptides for the allergenic activity of food allergens. J. Allergy Clin. Immunol. 2009, 124, 328-336.