Specificity of Infant Digestive Conditions: Some Clues for Developing Relevant In Vitro Models

Critical Reviews in Food Science and Nutrition

Volumn 54, Issue 11, 2014, Pages 1427-1457

  Bourlieu, Claire ^a,b   Ménard, Olivia ^a,b   Bouzerzour, Karima ^a,b   Mandalari, Giuseppina ^c,d   Macierzanka, Adam ^c   Mackie, Alan R ^c   Dupont, Didier ^a,b  

^a UMR1253   (France)

^b AGROCAMPUS OUEST   (France)

^c NORWICH RESEARCH PARK   (United Kingdom)

^d UNIVERSITY OF MESSINA   (Italy)

Author keywords

Digestion; digestive fluids; gastrointestinal; in vitro model; infant nutrition; newborn infant

Indexed keywords

DRUG DELIVERY; SLUDGE DIGESTION;

ETHICAL CONSIDERATIONS; GASTROINTESTINAL; GROWTH AND DEVELOPMENT; IN-VITRO MODELS; INFANT NUTRITIONS; NEWBORN INFANT; ORAL DRUG DELIVERY; PRETERM INFANTS;

NUTRITION;

AMYLASE; BILE ACID; CHYMOTRYPSIN; PEPSIN A; TRIACYLGLYCEROL LIPASE; TRYPSIN;

ARTICLE; ARTIFICIAL MILK; BIOLOGICAL MODEL; BREAST MILK; CHEMISTRY; DIGESTION; DUODENUM; ENZYMOLOGY; GASTROINTESTINAL TRACT; HUMAN; INFANT; INFANT NUTRITION; METABOLISM; NEWBORN; PH; PHYSIOLOGY; PREMATURITY; STOMACH; STOMACH EMPTYING; STOMACH JUICE;

AMYLASES; BILE ACIDS AND SALTS; CHYMOTRYPSIN; DIGESTION; DUODENUM; GASTRIC EMPTYING; GASTRIC JUICE; GASTROINTESTINAL TRACT; HUMANS; HYDROGEN-ION CONCENTRATION; INFANT; INFANT FORMULA; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; INFANT, PREMATURE; LIPASE; MILK, HUMAN; MODELS, BIOLOGICAL; PEPSIN A; STOMACH; TRYPSIN;

EID: 84896835817     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2011.640757     Document Type: Article

References (177)

1. Adamson, I., Esangbedo, A., Okolo, A. A. and Omene, J. A. 1988. Pepsin and its multiple forms in early life. Biol. Neonate., 53 (5): 267 - 273.
2. Aguilera, J. M. 2006. Food microstructure affects the bioavailability of several nutrients. J. Food Sci., 72 (2): R21 - R32.
3. Agunod, M., Yamaguchi, N., Lopez, R., Luhby, A. and Glass, G. 1969. Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants. Digest. Dis. Sci., 14 (6): 400 - 414.
4. Alemi, B., Hamosh, M., Scanlon, J. W., Salzman-Mann, C. and Hamosh, P. 1981. Fat digestion in very low-birth-weight infants: Effect of addition of human milk to low-birth-weight formula. Pediatrics, 68 (4): 484 - 489.
5. Allen, A. and Flemström, G. 2005. Gastroduodenal mucus bicarbonate barrier: Protection against acid and pepsin. Am. J. Physiol. Cell Physiol., 288 (1): C1 - C19.
6. Amara, S., Barouh, N., Lecomte, J., Lafont, D., Robert, S., Villeneuve, P. and Carrière, F. 2010. Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2. Biochim. Biophys. Acta., 1801 (4): 508 - 516.
7. Anderson, C. A. and Berseth, C. L. 1996. Neither motor responses nor gastric emptying vary in response to formula temperature in preterm infants. Biol. Neonate., 70 (5): 265 - 270.
8. Andersson, E., Lindquist, S., Blackberg, L. and Hernell, O. 2011. Bile salt-stimulated lipase and pancreatic lipase related protein 2 promote efficient lipid digestion and product absorption in the newborn. J. Pediatr. Gastroenterol. Nutr., 48: E87 - E88.
9. Andersson, L., Carrière, F., Lowe, M. E., Nilsson, A. and Verger, R. 1996. Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids. Biochim. Biophys. Acta. Lipids and Lipid Metabolism., 1302 (3): 236 - 240.
10. Anson, M. L. and Mirsky, A. E. 1932. The estimation of pepsin with hemoglobin. J. Gen. Physiol., 16: 59 - 63.
11. Antonowicz, I. and Lebenthal, E. 1977. Developmental pattern of small intestinal enterokinase and disaccharidase activities in the human fetus. Gastroenterology, 72 (6): 1299 - 1303.
12. Armand, M., Hamosh, M., DiPalma, J. S., Gallagher, J., Benjamin, S. B., Philpott, J. R., Lairon, D. and Hamosh, P. 1995. Dietary fats modulates gastric lipase activity in healthy humans. Am. J. Clin. Nutr., 62: 74 - 80.
13. Armand, M., Hamosh, M., Mehta, N. R. and Angelus, P. A. 1994. Fat digestion-Gastric lipolysis is higher in mothers own milk (Mom) than in formula (F) fed very-low-birth-weight (Vlbw) infants. Pediatr. Res., 35 (4): A124
14. Armand, M., Hamosh, M., Mehta, N. R., Angelus, P. A., Philpott, J. R., Henderson, T. R., Dwyer, N. K., Lairon, D. and Hamosh, P. 1996. Effect of human milk or formula on gastric function and fat digestion in the premature infant. Pediatr. Res., 40 (3): 429 - 437.
15. Armand, M., Pasquier, B., André, M., Borel, P., Senft, M., Peyrot, J., Salducci, J., Portugal, H., Jaussan, V. and Lairon, D. 1999. Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am. J. Clin. Nutr., 70 (6): 1096 - 1106.
16. Avery, G. B., Randolph, J. G. and Weaver, T. 1966. Gastric acidity in the first day of life. Pediatrics, 37 (6): 1005 - 1007.
17. Baba, T., Downs, D., Jackson, K. W., Tang, J. and Wang, C. S. 1991. Structure of human milk bile salt activated lipase. Biochemistry., 30 (2): 500 - 510.
18. Back, P. and Walter, K. 1980. Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium. Gastroenterology, 78 (4): 671 - 676.
19. Balistreri, W. F. 1991. Fetal and neonatal bile acid synthesis and metabolism-Clinical implications. J. Inheri Metab. Dis., 14 (4): 459 - 477.
20. Bernback, S., Blackberg, L. and Hernell, O. 1989. Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. Biochim. Biophys. Acta. Lipids and Lipid Metabolism., 1001 (3): 286 - 293.
21. Bernback, S., Blackberg, L. and Hernell, O. 1990. The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase and bile salt stimulated lipase. J. Clin. Invest., 85 (4): 1221 - 1226.
22. Berseth, C. L. 1989. Gestational evolution of small intestine motility in term or preterm infants. J. Pediatr., 115 (4): 646 - 651.
23. Berseth, C. L. 1990. Neonatal small intestinal motility: Motor responses to feeding in term and preterm infants. J. Pediatr., 117 (5): 777 - 782.
24. Berseth, C. L. 1996. Gastrointestinal motility in the neonate. Clin. Perinatol., 23 (3): 179 - 190.
25. Berton, A., Sebban-Kreuzer, C., Rouvellac, S., Lopez, C. and Crenon, I. 2009. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. Mol. Nutr. Food Res., 53 (12): 1592 - 1602.
26. Billeaud, C., Guillet, J. and Sandler, B. 1990. Gastric emptying in infants with or without gastro-oesophageal reflux according to the type of milk. Eur. J. Clin. Nutr., 44 (8): 577 - 583.
27. Boehm, G., Bierbach, U., DelSanto, A., Moro, G. and Minoli, I. 1995a. Activities of trypsin and lipase in duodenal aspirates of healthy preterm infants. Effects of gestational and postnatal age. Biol. Neonate., 67 (4): 248 - 253.
28. Boehm, G., Borte, M., Muller, H., Moro, G. and Minoli, I. 1995b. Activities of trypsin and lipase in duodenal aspirates of preterm infants: Influence of dietary protein and fat composition. Am. J. Clin. Nutr., 61 (3): 524 - 527.
29. Boisen, S. and Eggum, B. O. 1991. Critical evaluation of in vitro methods for estimating digestibility in simple-stomach animals. Nutr. Res. Rev., 4: 141 - 162.
30. Borgström, B., Erlanson-Albertsson, C. and Borgström, A. 1993. Human pancreatic proenzymes are activated at different rates in vitro. Scand. J. Gastroenterol, 28: 455 - 459.
31. Borgström, B., Erlanson-Albertsson, C. and Wieloch, T. 1979. Pancreatic colipase: Chemistry and physiology. J. Lipid Res., 20 (7): 805 - 816.
32. Borgström, B., Lindquist, S. and Lundh, G. 1960. Enzyme concentration and absorption of protein and glucose in duodenum of premature infants. Am. J. Dis. Child., 99 (3): 338 - 343.
33. Borgström, B., Lindquist, S. and Lundh, G. 1961. Digestive studies in children: Studies under normal and pathological conditions. Am. J. Dis. Child., 101 (4): 454 - 466.
34. Borgström, B. and Patton, J. S. 2010. " Luminal events in gastrointestinal lipid digestion ". In Supplement 19: Handbook of Physiology, The Gastrointestinal System, Intestinal Absorption and Secretion. Comprehensive Physiology, Edited by: Terjung, R. 475 - 504. New-York: John Wiley & Sons.
35. Borulf, S., Lindberg, T. and Hansson, L. 2011. Agarose gel electrophoresis of duodenal juice in normal condition and in children with malabsorption. Scand. J. Gastroenterol, 14 (2): 151 - 160.
36. Britton, J. and Koldovsky, O. 1989. Development of luminal protein digestion: Implications for biologically active dietary polypeptides. J. Pediatr. Gastroenterol. Nutr., 9: 144 - 162.
37. Brockerhoff, H. 1970. Substrate specificity of pancreatic lipase. Influence of the structure of fatty acids on the reactivity of esters. Biochim. Biophys. Acta., 212 (1): 92 - 101.
38. Brown, G. A., Sule, D., Williams, J., Puntis, J. W., Booth, I. W. and McNeish, A. S. 1988. Faecal chymotrypsin: A reliable index of exocrine pancreatic function. Arch. Dis. Child., 63 (7): 785 - 789.
39. Brueton, M. J., Berger, H. M., Brown, G. A., Ablitt, L., Iyngkaran, N. and Wharton, B. A. 1978. Duodenal bile acid conjugation patterns and dietary sulphur amino acids in the newborn. Gut, 19: 95 - 98.
40. Carey, M. C., Small, D. M. and Bliss, C. M. 1983. Lipid digestion and absorption. Am. Rev. Physiol., 45: 651 - 677.
41. Carrière, F., Barrowman, J. A., Verger, R. and Laugier, R. 1993. Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. Gastroenterology, 105 (3): 876 - 888.
42. Cavell, B. 1979. Gastric emptying in preterm infants. Acta Paediatr. Scand., 68 (5): 725 - 730.
43. Cavell, B. 1981. Gastric emptying in infants fed human milk or infant formula. Acta Paediatr. Scand., 70 (5): 639 - 641.
44. Cavell, B. 1983. Posprandial gastric acid secretion in infants. Acta Paediatr. Scand., 72 (6): 857 - 860.
45. Chen, Q., Blackberg, L., Nilsson, A., Sternby, B. and Hernell, O. 1994. Digestion of triacylglycerols containing long chain polyenoic fatty acids in vitro by colipase-dependent pancreatic lipase and human milk bile-salt stimulated lipase. Biochim. Biophys. Acta., 1210 (2): 239 - 243.
46. Chen, Q., Sternby, B. and Nilsson, A. 1989. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. Biochim. Biophys. Acta., 1004 (3): 372 - 385.
47. Commare, C. E. and Tappenden, K. A. 2007. Development of the infant intestine: Implications for nutrition support. Nutr. Clin. Practice., 22 (2): 159 - 173.
48. Cowen, A. E. and Campbell, C. B. 1977. Bile salt metabolism. I. The physiology of bile salts. Austr. New-Zealand J. Med., 7 (6): 579 - 586.
49. Davidson, L., Donovan, S., Lönnerdal, B. and Atkinson, S. A. 1989. " Excretion of human milk proteins by term and preterm infants ". In Protein and Non-protein Nitrogen in Human Milk, Edited by: Atkinson, S. A. and Lönnerdal, B. 161 - 172. Boca Raton: CRC Press.
50. De Belle, R. C., Vaupshas, V., Vitullo, B. B., Haber, L. R., Shaffer, E., Mackie, G. G., Owen, H., Little, J. M. and Lester, R. 1979. Intestinal absorption of bile salts: Immature development in the neonate. J. Pediatr., 94 (3): 472 - 476.
51. DiPalma, J., Kirk, C., Hamosh, M., Colon, A. R. and Hamosh, P. 1991. Lipase and pepsin activities in the gastric mucosa of infants, children and adults. Gastroenterology, 101 (1): 116 - 120.
52. Dubois, A., Eerdewegh, P. V. and Gardner, J. D. 1977. Gastric emptying and secretion in zollinger-ellison syndrome. J. Clin. Invest., 59: 255 - 263.
53. Dumont, R. C. and Rudolph, C. D. 1994. Development of gastrointestinal motility in the infant and child. Gastroenterol. Clin. North Am., 23: 655 - 671.
54. Dupont, D., Mandalari, G., Mollé, D., Jardin, J., Rolet-Répécaud, O., Duboz, G., Léonil, J., Mills, C.E.N. and Mackie, A. R. 2010. Food processing increases casein resistance to simulated infant digestion. Mol. Nutr. Food. Res., 54 (11): 677 - 1689.
55. Elashoff, J. D., Reedy, T. J. and Meyer, J. H. 1982. Analysis of gastric emptying data. Gastroenterology, 83: 1306 - 1312.
56. Engberg, S., Mansson, M., Andersson, Y., Jakobsson, I. and Lindberg, T. 1999. Trypsin and elastase activity in duodenal juice from preterm infants before and after a test meal of human milk. Prenat. Neonat. Med., 4: 466 - 471.
57. Ewer, A. K., Durbin, G. M., Morgan, M. E. I. and Booth, I. W. 1994. Gastric emptying in preterm infants. Arch. Dis. Child., 71: F24 - F27.
58. Ewer, A. K., Morgan, M. E. I. and Booth, I. W. 1996. Gastric emptying and gastro-oesophageal reflux in preterm infants. Arch. Dis. Child, 75: F117 - F121.
59. Faure, C. and Navarro, J. 2000. " Chapter 8. Maturation de la motricité digestive ". In Gastro-Entérologie Pédiatrique, 97 - 109. Paris: Flammarion.
60. Foltz, M., Maljaars, J., Schuring, E. A. H., Van Der Wal, R. J. P., Boer, T., Duchateau, G. S. M., Peters, H. P. F., Stellaard, F. and Masclee, A. A. 2009. Intragastric layering of lipids delays lipid absorption and increases plasma CCK but has minor effects on gastric emptying and appetite. Am. J. Physiol-Gastr. L., 296 (5): G982 - G991.
61. Forsyth, J. S., Ross, P. E. and Bouchier, I. A. D. 1983. Bile salts in breast milk. Eur. J. Pediatr., 140 (2): 126 - 127.
62. Fredrikzon, B. and Hernell, O. 1977. Role of feeding on lipase activity in gastric contents. Acta Paediatr, 66 (4): 479 - 484.
63. Fredrikzon, B. and Olivecrona, T. 1978. Decrease of lipase and esterase activities in intestinal contents of newborn infants during test meals. Pediatr. Res., 12 (5): 631 - 634.
64. Freeman, H. J. and Kim, Y. S. 1978. Digestion and absorption of protein. Annu. Rev. Med., 29 (1): 99 - 116.
65. Garzi, A., Messina, M., Frati, F., Carfagna, L., Zagordo, L., Belcastro, M., Parmiani, S., Sensi, L. and Marcucci, F. 2002. An extensively hydrolysed cow's milk formula improves clinical symptoms of gastroesophageal reflux and reduced the gastric emptying time in infants. Allergol. Immunopathol., 30 (1): 36 - 41.
66. Gaskin, K. J., Durie, P. R., Lee, L. and Forstner, G. G. 1984. Colipase and lipase secretion in childhood-onset pancreatic insufficiency: Delineation of patients with steatorrhea secondary to relative colipase deficiency. Gastroenterology, 86 (1): 1 - 7.
67. Geigy, J. R. 1973. " Gastric juice ". In Scientific Tables, Edited by: Geigy, J. R. 123 - 133. Basel: Documenta Geigy.
68. Gellis, S. S., White, P. and Pfeffer, W. 1949. Gastric suction; a proposed additional technic for the prevention of asphyxia in infants delivered by cesarean section; a preliminary report. New Engl. J. Med., 240 (14): 533 - 537.
69. Giller, T., Buchwald, P., Blum-Kaelin, D. and Hunziker, W. 1992. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. J. Biol. Chem., 267: 16509 - 16516.
70. Golding, M. and Wooster, T. J. 2010. The influence of emulsion structure and stability on lipid digestion. Curr. Opin. Colloid Int., 15 (1-2): 90 - 101.
71. Halpern, Z., Vinograd, Z., Laufer, H., Gilat, T., Moskowitz, M. and Bujanover, Y. 1996. Characteristics of gallbladder bile of infants and children. J. Pediatr. Gastroenterol. Nutr., 23 (2): 147 - 50.
72. Hamosh, M. 1983. Lingual lipase and fat digestion in the neonatal period. J. Pediatr. Gastroenterol. Nutr., 2: S236 - S241.
73. Hamosh, M. 1996. Digestion in the newborn. Clin Perinatol., 23: 191 - 209. Jun;(2)
74. Hamosh, M., Scanlon, J. W., Ganot, D., Likel, M., Scanlon, K. B. and Hamosh, P. 1981. Fat digestion in the newborn. Characterization of lipase in gastric aspirates of premature and term infants. J. Clin. Invest., 67 (3): 838 - 846.
75. Hamosh, M., Sivasubramanian, K. N., Salzman-Mann, C. and Hamosh, P. 1978. Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity. J. Pediatr., 93 (4): 674 - 679.
76. Harries, J. T. and Fraser, A. F. 1968. The acidity of the gastric contents of premature babies during the first fourteen days of life. Biol. Neonate., 12 (3): 186 - 193.
77. Henderson, T. R., Hamosh, M., Armand, M., Mehta, N. R. and Hamosh, P. 1998. Gastric proteolysis in the preterm infant: Protein digestion is limited and is not affected by diet, human milk or formula + 580. Pediatr. Res., 43 (4): 101
78. Henderson, T. R., Hamosh, M., Armand, M., Mehta, N. R. and Hamosh, P. 2001. " Chapter 43. Gastric Proteolysis in Preterm Infants fed mother's milk or formula ". In Bioactive Components in Human Milk, Edited by: Newburg, D. S. 403 - 408. New-York: Kluwer Academic/Plenum Publishers.
79. Hernell, O. and Blackberg, L. 1994. Human milk bile salt-stimulated lipase: Functional and molecular aspects. J. Pediatr., 125 (5): S56 - S61.
80. Hernell, O., Blackberg, L., Chen, Q., Sternby, B. and Nilsson, A. 1993. Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids. J. Pediatr. Gastr. Nutr., 16 (4): 426 - 431.
81. Howles, P. N., Stemmerman, G. N., Fenoglio-Preiser, C. M. and Huy, D. Y. 1999. Cholesterol ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice. Am. J. Physiol. Gastr. L., 40 (3): G653 - G661.
82. Hui, D. Y. and Howles, P. N. 2002. Carboxyl ester lipase. J. Lipid Res., 43 (12): 2017 - 2030.
83. Humphrey, S. P. and Williamson, R. T. 2001. A review of saliva: Normal composition, flow, and function. J. Prosth. Dent., 85 (2): 162 - 169.
84. Hunt, J. N. and Knox, M. T. 1968. A relation between the chain length of fatty acids and the slowing of gastric emtying. J. Physiol., 194 (2): 327 - 336.
85. Hur, S. J., Lim, B. O., Decker, E. A. and McClements, D. J. 2011. In vitro digestion models for food applications. Food Chem, 125: 1 - 12.
86. Hyde, G. A. 1968. Gastric secretions following neonatal surgery. J. Pediatr. Surg., 3 (6): 691 - 695.
87. Jenness, R. 1979. The composition of human milk. Semin. Perinatol., 3 (3): 225 - 239.
88. Kalantzi, L., Goumas, K., Kalioras, V., Abrahamsson, B., Dressman, J. B. and Reppas, C. 2006. Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies. Pharm. Res., 23 (1): 165 - 175.
89. Kauffman, R. E. 2011. " Chapter 3. Drug action and therapy in the infant and child ". In Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice, Edited by: Summer, Y. J. and Aranda, J. V. 20 - 30. Philadelphia: Lippincott Williams and Wilkins.
90. Keene, M. L. F. and Hewer, E. E. 1929. Digestive enzymes of the human foetus. Lancet, 1: 767 - 769.
91. Kelly, D. and Coutts, A. G. P. 2000. Development of digestive and immunological function in neonates: Role of early nutrition. Livest. Prod. Sci., 66 (2): 161 - 167.
92. Kelly, D. G., Sternby, B. and DiMagno, E. P. 1991. How to protect human pancratic enzyme activities in frozen duodenal juice. Gastroenterology, 100 (1): 189 - 195.
93. Kelly, E. J. and Newell, S. J. 1994. Gastric ontogeny: Clinical implications. Arch. Dis. Child. Fetal and Neonat. Ed., 71 (2): F136 - F141.
94. Layer, P., Go, V. L. W. and DiMagno, E. P. 1986. Fate of pancreatic enzymes during small intestinal aboral transit in humans. Am. J. Physiol., 251 (4): G475 - G480.
95. Lebenthal, E. and Lee, P. C. 1980. Development of functional response in human exocrine pancreas. Pediatr, 66 (4): 556 - 560.
96. Lengsfeld, H., Beaumier-Gallon, G., Chahinian, H., De Caro, A., Verger, R., Laugier, R. and Carrière, F. 2003. " Physiology of gastrointestinal lipolysis and therapeutical use of lipase and digestive lipase inhibitors ". In Lipases and Phospholipases in Drug Development, Edited by: Muller, G. and Petry, S. 195 - 229. Weihem: Wiley-CH.
97. Lehtonen, L., Svedström, E., Kero, P. and Korvenranta, H. 1993. Gall bladder contractility in preterm infants. Arch Dis Child., 68 (1): 43 - 45.
98. Lehtonen, L., Svedström, E. and Korvenranta, H. 1992. The size and contractility of the gallbladder in infants. Pediatr. Radiol., 22: 515 - 518.
99. Li, X., Lindquist, S., Lowe, M., Noppa, L. and Hernell, O. 2007. Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats. Pediatr. Res., 62 (5): 537 - 541.
100. Liddle, R. A., Morita, E. T., Conrad, C. K. and Williams, J. A. 1986. Regulation of gastric emptying in humans by cholecystokinin. J. Clin. Invest., 77 (3): 992 - 996.
101. Lindquist, S. and Hernell, O. 2010. Lipid digestion and absorption in early life: An update. Curr. Opin. Clin. Nutr. Metab. Care., 13 (3): 314 - 320.
102. Lowe, M. E. 2002. The triglyceride lipases of the pancreas. J. Lipid Res., 43 (12): 2007 - 2016.
103. Lowe, M. E., Rosenblum, J. and Strauss, A. 1989. Cloning and characterization of human pancreatic lipase cDNA. J. Biol. Chem., 264: 20042 - 20048.
104. Maldonado-Valderrama, J., Wilde, P., Macierzanka, A. and Mackie, A. 2011. The role of bile salts in digestion. Adv. Colloid Interfac., 165 (1): 36 - 46.
105. Manson, W. G. and Weaver, L. T. 1997. Fat digestion in the neonate. Arch. Dis. Child., 76: F206 - F211.
106. Marciani, L., Faulks, R., Wicham, M., Bush, D., Pick, B., Wright, J., Cox, E., Fillery-travis, A., Gowland, P. A. and Spiller, R. 2009. Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety. British J. Nutr., 101 (6): 918 - 928.
107. Marino, L. R., Bacon, B. R., Hines, J. D. and Halpin, T. C. 1984. Parietal cell function of full-term and premature infants: Unstimulated gastric acid and intrinsic factor secretion. J. Pediatr. Gastroenterol. Nutr., 3 (1): 23 - 27.
108. Martin, C., Edwards, C. and Weaver, L. T. 1999. Starch digestion in infancy. J. Pediatr. Gastroenterol. Nutr., 29 (2): 116 - 124.
109. Mas, E., Abouakil, N., Roudani, S., Miralles, F., Guy-Crotte, O., Figarella, C., Escribano, M. J. and Lombardo, D. 1993. Human fetoacinar pancreatic protein: An oncofetal glycoform of the normally secreted pancreatic bile-salt-dependent lipase. Biochem. J., 289: 609 - 615.
110. Mason, S. 1962. Some aspects of gastric function in the newborn. Arch. Dis. Child., 37: 387 - 391.
111. McClure, R. J. and Newell, S. J. 1996. Effect of fortifying breast milk on gastric emptying. Arch. Dis. Child., 74: F60 - F62.
112. McClean, P. and Weaver, L. T. 1993. Ontogeny of human pancreatic exocrine function. Arch. Dis. Child., 68: 62 - 65.
113. McClements, D. J. and Li, Y. 2009. Controlling lipid bioavailability through physicochemical and structural approaches. Crit. Rev. Food Sci., 49 (1): 48 - 67.
114. McClements, D. J. and Li, Y. 2010. Review of in vitro digestion models for rapid screening of emulsion-based systems. Food Funct., 1 (1): 32 - 59.
115. McConnell, E., Fadda, H. M. and Basit, A. W. 2008. Gut instincts: Explorations in intestinal physiology and drug delivery. International J. Pharm., 364: 213 - 226.
116. Ménard, D., Monfils, S. and Tremblay, E. 1995. Ontogeny of human gastric lipase and pepsin activities. Gastroenterology, 108: 1650 - 1656.
117. Miclat, N. N., Hodgkinson, R. and Marx, G. F. 1978. Neonatal gastric pH. Anesthesia & Analgesia., 57 (1): 98 - 101.
118. Mitchell, D. J., McClure, B. G. and Tubman, T. R. J. 2001. Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants. Arch. Dis. Child., 84: 273 - 276.
119. Moran, T. H. and Kimberly, P. K. 2004. Gastrointestinal satiety signals. II. Cholecystokinin. Am. J. Physiol. Gastrointest. Liver Physiol., 286: G183 - G188.
120. Mu, H. and Hoy, C. E. 2004. The digestion of dietary triacylglycerols. Prog. Lipid Res., 43: 105 - 133.
121. Murray, R. D., Kerzner, B., Sloan, H. R., McClung, H. J., Gilbert, M. and Ailabouni, A. 1986. The contribution of salivary amylase to glucose polymer hydrolysis in premature infants. Pediatr. Res., 20 (2): 186 - 191.
122. Neu, J. 2007. Gastrointestinal maturation and implications for infant feeding. Early Hum. Dev., 83 (12): 767 - 775.
123. Newell, S. J., Chapman, S. and Booth, I. W. 1993. Ultrasonic assessment of gastric emptying in the preterm infant. Arch. Dis. Child., 69: 32 - 36.
124. Norman, A., Strandvik, B. and Ojamae, O. 1972. Bile acids and pancreatic enzymes during absorption in the newborn. Acta Paediatr. Scand., 61 (5): 571 - 576.
125. Nouri-Sorkhabi, M. H., Chapman, B. E., Kuchel, P. W., Gruca, A. M. and Gaskin, K. J. 2000. Parallel secretion of pancreatic phospholipase A2, phospholipase A1, lipase, and colipase in children with exocrine pancreatic dysfunction. Pediatr. Res., 48 (6): 735 - 740.
126. O'Keefe, S. J. D., Lee, R. B., Li, J., Stevens, S., bou-Assi, S. and Zhou, W. 2005. Trypsin secretion and turnover in patients with acute pancreatitis. Am. J. Physiol Gastr. L., 289 (2): G181 - G187.
127. Omari, T. I. and Davidson, G. P. 2003. Multipoint measurement of intragastric pH in healthy preterm infants. Arch. Dis. Child. Fetal and Neonat Ed., 88 (6): F517 - F520.
128. Oomen, A. G., Rompelberg, C. J. M., Bruil, M. A., Dobbe, C. J. G., Pereboom, D. P. K. and Sips, A. 2003. Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants. Arch. Environ. Con. Tox., 44: 281 - 287.
129. Pafumi, Y., Lairon, D., Lechene, P., Juhel, C., Storch, J., Hamosh, M. and Armand, M. 2002. Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase. J. Biol. Chem., 277 (31): 28070 - 28079.
130. Roman, C., Carrière, F., Villeneuve, P., Pina, M., Millet, V., Simeoni, U. and Sarles, J. 2007. Quantitative and qualitative study of gastric lipolysis in premature infants: Do MCT-enriched infant formulas improve fat digestion?. Pediatr. Res., 61 (1): 83 - 88.
131. Roudani, S., Miralles, F., Margotat, A., Escribano, M.-J. and Lombardo, D. 1995. Bile salt-dependent lipase transcripts in human fetal tissues. Biochim. Biophys. Acta., 1264 (1): 141 - 150.
132. Roy, C. C., Weber, A. M., Lepage, G., Smith, L. and Levy, E. 1988. Digestive and absorptive phase anomalies associated with the exocrine pancreatic insufficiency of cystic fibrosis. J. Pediatr. Gastroenterol. Nutr., 7: S1 - S7.
133. Roy, R. N., Pollinitz, R. P., Hamilton, J. R. and Chance, G. W. 1977. Impaired assimilation of nasojejunal feeds in healthy low-birth weight newborn infants. J. Pediatr., 90 (3): 431 - 434.
134. Rubio, S., Lacaze-Masmonteil, T., Bourbon, J. and Ducroc, R. 1995. Les surfactants dans le tube digestif. Archives de Pédiatrie, 2 (1): 79 - 84.
135. Rudloff, S. and Lonnerdal, B. 1992. Solubility and digestibility of milk proteins in infant formulas exposed to different heat treatments. J. Pediatr. Gastroenterol. Nutr., 15 (1): 25 - 33.
136. Sakai, K., Yoshino, K., Satter, M. A., Ota, F., Nil, Y., Fukuta, K., Ueda, N., Shimizu, Y. and Yamamoto, S. 2000. Effects of pH variation and NaCl on in vitro digestibility of cow's milk proteins in commercially available infant formulas. J. Nutr. Sci. Vitaminol., 46 (6): 325 - 328.
137. Saliba, E., Hamamah, S., Gold, F. and Benhamed, M. 2001. " Développement anatomique ". In Médecine et biologie du développement. Du gène au nouveau-né, 293 - 305. Paris: Masson.
138. Savary, P. 1971. The action of pure pig pancreatic lipase upon esters of long chain fatty acids and short chain primary alcohols. Biochim. Biophys. Acta., 248 (2): 149 - 155.
139. Sbarra, V., Mas, E., Henderson, T. R., Hamosh, M., Lombardo, D. and Hamosh, P. 1996. Digestive lipases of the newborn ferret: Compensatory role of milk bile salt-dependent lipase. Pediatr. Res., 40 (2): 263 - 268.
140. Scanff, P., Yvon, M., Pelissier, J. P., Guilloteau, P. and Toullec, R. 1992. Effect of some technological treatments of milk on in vivo gastric emptying of immunoreactive whey proteins. Le Lait, 72 (1): 43 - 51.
141. Schanler, R. J., Goldblum, R.M, Garza, C. and Goldman, A. S. 1986. Enhanced fecal excretion of selected immune factors in very low birth weight infants fed fortified human milk. Pediatr. Res., 20: 711 - 715.
142. Schipper, R. G., Silletti, E. and Vingerhoeds, M. H. 2007. Saliva as research material: Biochemical, physicochemical and practical aspects. Arch. Oral Biol., 52 (12): 1114 - 1135.
143. Schlamowitz, M. and Petersen, L. V. 1959. Studies on the optimum pH for the action of pepsin on 'native' and denaturated bovin serum albumin and bovine hemoglobin. J. Biol. Chem., 234 (12): 3137 - 3145.
144. Seidel, B. M., Schubert, S., Schulze, B. and Borte, M. 2001. Secretory IgA, free secretory component and IgD in saliva of newborn infants. Early Hum. Dev., 62 (2): 159 - 164.
145. Setchell, K. D., Dumaswala, R., Colombo, C. and Ronchi, M. 1988. Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile. J. Biol. Chem., 263 (32): 16637 - 16644.
146. Sevenhuysen, G. P., Holodinsky, C. and Dawes, C. 1990. Development of salivary alpha-amylase in infants from birth to 5 months. Am. J. Clin. Nutr., 39 (4): 584 - 588.
147. Shub, M. D., Pang, K. Y., Swann, D. A. and Walker, W. A. 1983. Age-related changes in chemical composition and physical properties of mucus glycoproteins from rat small intestine. Biochem. J., 215: 405 - 411.
148. Sias, B., Ferrato, F., Grandval, P., Boulanger, P., De Caro, A., Leboeuf, B., Verger, R. and Carrière, F. 2004. Human pancreatic lipase-related 2 is a galactolipase. Biochem., 43 (31): 10138 - 10148.
149. Siegel, M., Krantz, B. and Lebenthal, E. 1985. Effect of fat and carbohydrate composition on the gastric emptying of isocaloric feeding in premature infants. Gastroenterology, 89 (4): 785 - 790.
150. Siegel, M., Lebenthal, E. and Krantz, B. S. B. 1984. Effect of caloric density on gastric emptying in premature infants. J. Pediatr., 104 (1): 118 - 122.
151. Siegel, M., Lebenthal, E., Topper, W., Krantz, B. and Li, P. K. 1982. Gastric emptying in prematures of isocaloric feedings with differing osmolalities. Pediatr. Res., 16 (2): 141 - 147.
152. Signer, E. and Fridrich, R. 1975. Gastric emptying in newborns and young infants. Acta Paediatr. Scand., 64 (3): 525 - 530.
153. Signer, E., Murphy, G. M., Edkins, S. and Anderson, C. M. 1974. Role of bile salts in fat malabsorption of premature infants. Arch. Dis. Child., 49 (3): 174 - 180.
154. Singh, M., Monterio, C. and Ghai, O. P. 1970. Gastric juice pH and blood glucose in the newborn. Indian J. Pediatr., 37 (1): 1 - 3.
155. Singh, H., Ye, A. and Horne, D. 2009. Structuring food emulsions in the gastrointestinal tract to modify lipid digestion. Prog. Lipid Res., 48 (2): 92 - 100.
156. Smith, L. J., Kaminsky, S. and D'souza, S. W. 1986. Neonatal fat digestion and lingual lipase. Acta Paediatr, 75 (6): 913 - 918.
157. Staelens, S., Van Den Driessche, M., Barclay, D., Carrié-Faessler, A. L., Haschke, F., Verbeke, K., Vandebroek, H., Allegaert, K., Van Overmeire, B., Van Damme, M. and Veereman-Wauters, G. 2008. Gastric emptying in healthy newborns fed an intact protein formula, a partially and an extensively hydrolysed formula. Clin. Nutr., 27 (2): 264 - 268.
158. Sternby, B., Nilsson, A., Melin, T. and Borgström, B. 1991. Pancreatic lipolytic enzymes in human duodenal contents. Scand. J. Gastroenterol., 26: 859 - 866.
159. Stromqvist, M., Tornell, J., Edlund, M., Edlund, A., Johansson, T., Lindgren, K., Lundberg, L. and Hansson, L. 1996. Recombinant human bile salt-stimulated lipase: An example of defective O-glycosylation of a protein produced in milk of transgenic mice. Transgenic Res, 5 (6): 475 - 485.
160. Thompson, J. 1951. The volume and gastric contents in the unfed newborn infant. Arch. Dis. Child., 26: 558 - 565.
161. Tribl, B., Sibbald, W. J., Vogelsang, H., Spitzauer, S., Gangl, A. and Madl, C. 2003. Exocrine pancreatic dysfunction in sepsis. Eur. J. Clin. Inv., 33 (3): 239 - 243.
162. Driessche, M., Peeters, K., Marien, P., Ghoos, Y., Devlieger, H. and Veereman-Wauters, G. 1999. Gastric emptying in formula-fed and breast-fed infants measured with the 13C-octanoic acid breath test. J. Pediatr. Gastroenterol. Nutr., 29 (1): 46 - 51. Van Den
163. Tilbeurgh, H., Sarda, L., Verger, R. and Cambillau, C. 1992. Structure of the pancreatic lipase-procolipase complex. Nature., 359: 159 - 162.
164. Ville, E., Carrière, F., Renou, C. and Laugier, R. 2002. Physiological study of pH stability and sensitivity to pepsin of human gastric lipase. Digestion, 65 (2): 73 - 81.
165. Wang, C. S., Martindale, M. E., King, M. M. and Tang, J. 1989. Bile-salt-activated lipase: Effect on kitten growth rate. Am. J. Clin.Nutr., 49 (3): 457 - 463.
166. Watkins, J. B., Ingall, D., Szczepanik, P., Klein, P. D. and Lester, R. 1973. Bile-salt metabolism in the newborn. New England J. Medicine., 288 (9): 431 - 434.
167. Weisselberg, B., Yahav, J., Reichman, B. and Jonas, A. 1992. Basal and meal-stimulated pepsinogen secretion in preterm infants: A longitudinal study. J. Pediatr. Gastroenterol. Nutr., 15 (1): 58 - 62.
168. Whitcomb, D. C. and Lowe, M. E. 2007. Human pancreatic digestive enzymes. Digestive Dis. Sci., 52: 1 - 17.
169. Wickham, M., Faulks, R. and Mills, C. 2009. In vitro digestion methods for assessing the effect of food structure on allergen breakdown. Mol. Nutr. Food Res., 53: 952 - 958.
170. Winkler, F., D'Arcy, A. and Hunziker, W. 1990. Structure of human pancreatic lipase. Nature, 343: 771 - 774.
171. Wolman, I. J. 1946. Gastric phase of milk digestion in childhood: A study of the fasting secretions and of the physiologic responses to "hard curd" (pasteurized) and "soft curd" (homogenized) milks. Am. J. Dis. Child., 71 (4): 394 - 422.
172. Yahav, J., Carrion, V., Lee, P. C. and Lebenthal, E. 1987. Meal-stimulated pepsinogen secretion in premature infants. J. Pediatr., 110: 949 - 951.
173. Yang, L.-Y., Kuksis, A. and Myher, J. J. 1990. Lipolysis of menhaden oil triacylglycerols and the corresponding fatty acid alkyl esters by pancreatic lipase in vitro: A reexamination. J. Lipid Res., 31: 137 - 148.
174. Yang, Y., Sanchez, D., Figarella, C. and Lowe, M. E. 2000. Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas. Pediatr. Res., 47: 184 - 188.
175. Yoo, J. Y. and Chen, X. D. 2006. GIT physicochemical modeling-A critical review. Int. J. Food Eng., 2 (4): 1 - 7.
176. Zoppi, G., Andreotti, G., Pajno-Ferrara, F., Bellini, P. and Gaburro, D. 1973. The development of specific responses of the exocrine pancreas to pancreozymin and secretin stimulation in newborn infants. Pediatr. Res., 7 (4): 198 - 203.
177. Zoppi, G., Andreotti, G., Pajno-Ferrara, F., Njai, D. M. and Gaburro, D. 1972. Exocrine pancreas function in premature and full term neonates. Pediatr. Res., 6 (12): 880 - 886.