Following the digestion of milk proteins from mother to baby

Journal of Proteome Research

Volumn 13, Issue 12, 2014, Pages 5777-5783

  Holton, Thérèse A ^a   Vijayakumar, Vaishnavi ^a   Dallas, David C ^b   Guerrero, Andrés ^b   Borghese, Robyn A ^c   Lebrilla, Carlito B ^b   German, J Bruce ^b   Barile, Daniela ^b   Underwood, Mark A ^b,c   Shields, Denis C ^a   Khaldi, Nora ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

digestive enzymes; enzyme activity; human milk; indigenous enzymes; infant digestion; milk enzymes; proteolytic enzymes

Indexed keywords

CATHEPSIN D; CHYMOTRYPSIN; ELASTASE; MILK PROTEIN; PEPSIN A; PLASMIN; PROLYL ENDOPEPTIDASE; TRYPSIN; PANCREATIC ELASTASE; PEPTIDE; PROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; BREAST MILK; CASE REPORT; ENZYME ACTIVITY; FEMALE; GASTRIC SUCTION; HUMAN; INFANT; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PROTEIN DEGRADATION; PUERPERIUM; STOMACH FUNCTION; DIGESTION; DIGESTIVE TRACT INTUBATION; ENZYMOLOGY; METABOLISM; MOTHER; NEWBORN; PROCEDURES; PROTEOMICS; STOMACH;

CATHEPSIN D; CHYMOTRYPSIN; DIGESTION; ENDOPEPTIDASES; FEMALE; FIBRINOLYSIN; HUMANS; INFANT, NEWBORN; INTUBATION, GASTROINTESTINAL; MASS SPECTROMETRY; MILK PROTEINS; MILK, HUMAN; MOTHERS; PANCREATIC ELASTASE; PEPSIN A; PEPTIDES; PROTEOLYSIS; PROTEOMICS; STOMACH; TRYPSIN;

EID: 84915746084     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5006907     Document Type: Article

References (27)

1. Dallas, D. C.; Guerrero, A.; Khaldi, N.; Castillo, P. A.; Martin, W. F.; Smilowitz, J. T.; Bevins, C. L.; Barile, D.; German, J. B.; Lebrilla, C. B. Extensive in vivo human milk peptidomics reveals specific proteolysis yielding protective antimicrobial peptides J. Proteome Res. 2013, 12 (5) 2295-2304
2. Khaldi, N.; Vijayakumar, V.; Dallas, D. C.; Guerrero, A.; Wickramasinghe, S.; Smilowitz, J. T.; Medrano, J. F.; Lebrilla, C. B.; Shields, D. C.; German, J. B. Predicting the important enzyme players in human breast milk digestion J. Agric. Food Chem. 2014, 62 (29) 7225-7232
3. Keene, M.; Hewer, E. Digestive enzymes of the human foetus Lancet 1929, 213 (5511) 767-769
4. Defize, J.; Meuwissen, S. Pepsinogens: An update of biochemical, physiological, and clinical aspects J. Pediatr. Gastroenterol. Nutr. 1987, 6 (4) 493-508
5. Mason, S. Some aspects of gastric function in the newborn Arch. Dis. Child. 1962, 37 (194) 387-390
6. Armand, M.; Hamosh, M.; Mehta, N. R.; Angelus, P. A.; Philpott, J. R.; Henderson, T. R.; Dwyer, N. K.; Lairon, D.; Hamosh, P. Effect of human milk or formula on gastric function and fat digestion in the premature infant Pediatr. Res. 1996, 40 (3) 429-437
7. Dallas, D. C.; Underwood, M. A.; Zivkovic, A. M.; German, J. B. Digestion of protein in premature and term infants J. Nutr. Disord. Ther. 2012, 2 (112) 1-9
8. Silanikove, N.; Merin, U.; Leitner, G. Physiological role of indigenous milk enzymes: An overview of an evolving picture Int. Dairy J. 2006, 16 (6) 533-545
9. Jensen, R. G. Handbook of Milk Composition; Academic Press: San Diego, CA, 1995; access online at http://www.sciencedirect.com/science/book/9780123844309.
10. Shahani, K.; Kwan, A.; Friend, B. A. Role and significance of enzymes in human milk Am. J. Clin. Nutr. 1980, 33 (8) 1861-1868
11. Dallas, D. C.; Guerrero, A.; Khaldi, N.; Borghese, R.; Bhandari, A.; Underwood, M. A.; Lebrilla, C. B.; German, J. B.; Barile, D. A peptidomic analysis of human milk digestion in the infant stomach reveals protein-specific degradation patterns J. Nutr. 2014, 144 (6) 815-820
12. Dallas, D. C.; Martin, W. F.; Strum, J. S.; Zivkovic, A. M.; Smilowitz, J. T.; Underwood, M. A.; Affolter, M.; Lebrilla, C. B.; German, J. B. N-Linked glycan profiling of mature human milk by high-performance microfluidic chip liquid chromatography time-of-flight tandem mass spectrometry J. Agric. Food Chem. 2011, 59 (8) 4255-4263
13. Ferranti, P.; Traisci, M. V.; Picariello, G.; Nasi, A.; Boschi, V.; Siervo, M.; Falconi, C.; Chianese, L.; Addeo, F. Casein proteolysis in human milk: Tracing the pattern of casein breakdown and the formation of potential bioactive peptides J. Dairy Res. 2004, 71 (01) 74-87
14. Craig, R.; Beavis, R. C. TANDEM: Matching proteins with tandem mass spectra Bioinformatics 2004, 20 (9) 1466-1467
15. Molinari, C. E.; Casadio, Y. S.; Hartmann, B. T.; Livk, A.; Bringans, S.; Arthur, P. G.; Hartmann, P. E. Proteome mapping of human skim milk proteins in term and preterm milk J. Proteome Res. 2012, 11 (3) 1696-1714
16. Mangé, A.; Bellet, V.; Tuaillon, E.; Van de Perre, P.; Solassol, J. Comprehensive proteomic analysis of the human milk proteome: Contribution of protein fractionation J. Chromatogr., B 2008, 876 (2) 252-256
17. Liao, Y.; Alvarado, R.; Phinney, B.; Lönnerdal, B. Proteomic characterization of human milk fat globule membrane proteins during a 12 month lactation period J. Proteome Res. 2011, 10 (8) 3530-3541
18. Vijayakumar, V.; Guerrero, A.; Davey, N.; Lebrilla, C. B.; Shields, D. C.; Khaldi, N. EnzymePredictor: A tool for predicting and visualizing enzymatic cleavages of digested proteins J. Proteome Res. 2012, 11 (12) 6056-6065
19. Considine, T.; Healy, á.; Kelly, A. L.; McSweeney, P. L. H. Hydrolysis of bovine caseins by cathepsin B, a cysteine proteinase indigenous to milk Int. Dairy J. 2004, 14 (2) 117-124
20. Considine, T.; Geary, S.; Kelly, A. L.; McSweeney, P. L. H. Proteolytic specificity of cathepsin G on bovine αs1- and β-caseins Food Chem. 2002, 76 (1) 59-67
21. Kelly, A. L.; O'Flaherty, F.; Fox, P. F. Indigenous proteolytic enzymes in milk: A brief overview of the present state of knowledge Int. Dairy J. 2006, 16 (6) 563-572
22. Raymond, W. W.; Trivedi, N. N.; Makarova, A.; Ray, M.; Craik, C. S.; Caughey, G. H. How immune peptidases change specificity: Cathepsin G gained tryptic function but lost efficiency during primate evolution J. Immunol. 2010, 185 (9) 5360-5368
23. Korycha-Dahl, M.; Dumas, B. R.; Chene, N.; Martal, J. Plasmin activity in milk J. Dairy Sci. 1983, 66 (4) 704-711
24. Piper, D.; Fenton, B. pH stability and activity curves of pepsin with special reference to their clinical importance Gut 1965, 6 (5) 506-508
25. Roszkowska-Jakimiec, W.; Dabrowska, E.; Gacko, M.; Karwowska, A.; Chlabicz, M. The choice of conditions for cathepsin D activity determination in human saliva Adv. Med. Sci. 2006, 51 (S1) 179-181
26. Schwert, G. W.; Takenaka, Y. A spectrophotometric determination of trypsin and chymotrypsin Biochim. Biophys. Acta 1955, 16, 570-575
27. Ohlsson, K.; Odsson, I. The neutral proteases of human granulocytes Eur. J. Biochem. 1974, 42 (2) 519-527