메뉴 건너뛰기




Volumn 99, Issue , 2016, Pages 1-10

Animal models for diabetes: Understanding the pathogenesis and finding new treatments

Author keywords

Animal models; Type 1 diabetes; Type 2 diabetes

Indexed keywords

ALLOXAN; INSULIN; STREPTOZOCIN; ANTIDIABETIC AGENT;

EID: 84951819685     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.08.108     Document Type: Note
Times cited : (125)

References (186)
  • 1
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • J.A. Bluestone, K. Herold, and G. Eisenbarth Genetics, pathogenesis and clinical interventions in type 1 diabetes Nature 464 2010 1293 1300
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 2
    • 0031967886 scopus 로고    scopus 로고
    • Putative environmental factors in Type 1 diabetes
    • H.K. Akerblom, and M. Knip Putative environmental factors in Type 1 diabetes Diabetes Metab. Rev. 14 1998 31 68
    • (1998) Diabetes Metab. Rev. , vol.14 , pp. 31-68
    • Akerblom, H.K.1    Knip, M.2
  • 3
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • S.E. Kahn The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes Diabetologia 46 2003 3 19
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 4
    • 84894165853 scopus 로고    scopus 로고
    • Genetics of type 2 diabetes
    • O. Ali Genetics of type 2 diabetes World J. Diabetes 4 2013 114 123
    • (2013) World J. Diabetes , vol.4 , pp. 114-123
    • Ali, O.1
  • 5
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • J. Tuomilehto, J. Lindstrom, J.G. Eriksson, T.T. Valle, H. Hamalainen, P. Ilanne-Parikka, and et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance N. Engl. J. Med. 344 2001 1343 1350
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindstrom, J.2    Eriksson, J.G.3    Valle, T.T.4    Hamalainen, H.5    Ilanne-Parikka, P.6
  • 6
    • 78049325708 scopus 로고    scopus 로고
    • Quantitative analysis of cell composition and purity of human pancreatic islet preparations
    • A. Pisania, G.C. Weir, J.J. O'Neil, A. Omer, V. Tchipashvili, J. Lei, and et al. Quantitative analysis of cell composition and purity of human pancreatic islet preparations Lab. Invest. 90 2010 1661 1675
    • (2010) Lab. Invest. , vol.90 , pp. 1661-1675
    • Pisania, A.1    Weir, G.C.2    O'Neil, J.J.3    Omer, A.4    Tchipashvili, V.5    Lei, J.6
  • 10
    • 0017353944 scopus 로고
    • The spontaneously diabetic Wistar rat: Metabolic and morphologic studies
    • A.F. Nakhooda, A.A. Like, C.I. Chappel, F.T. Murray, and E.B. Marliss The spontaneously diabetic Wistar rat: metabolic and morphologic studies Diabetes 26 1977 100 112
    • (1977) Diabetes , vol.26 , pp. 100-112
    • Nakhooda, A.F.1    Like, A.A.2    Chappel, C.I.3    Murray, F.T.4    Marliss, E.B.5
  • 11
    • 0026052411 scopus 로고
    • New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia
    • K. Kawano, T. Hirashima, S. Mori, Y. Saitoh, M. Kurosumi, and T. Natori New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia Diabetes 40 1991 1375 1381
    • (1991) Diabetes , vol.40 , pp. 1375-1381
    • Kawano, K.1    Hirashima, T.2    Mori, S.3    Saitoh, Y.4    Kurosumi, M.5    Natori, T.6
  • 12
    • 17944372927 scopus 로고    scopus 로고
    • The LEW.1AR1/Ztm-iddm rat: A new model of spontaneous insulin-dependent diabetes mellitus
    • S. Lenzen, M. Tiedge, M. Elsner, S. Lortz, H. Weiss, A. Jorns, and et al. The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus Diabetologia 44 2001 1189 1196
    • (2001) Diabetologia , vol.44 , pp. 1189-1196
    • Lenzen, S.1    Tiedge, M.2    Elsner, M.3    Lortz, S.4    Weiss, H.5    Jorns, A.6
  • 13
    • 0037312881 scopus 로고    scopus 로고
    • Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse
    • T. Izumi, H. Yokota-Hashimoto, S. Zhao, J. Wang, P.A. Halban, and T. Takeuchi Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse Diabetes 52 2003 409 416
    • (2003) Diabetes , vol.52 , pp. 409-416
    • Izumi, T.1    Yokota-Hashimoto, H.2    Zhao, S.3    Wang, J.4    Halban, P.A.5    Takeuchi, T.6
  • 14
    • 0027166934 scopus 로고
    • NOD mouse colonies around the world - Recent facts and figures
    • P. Pozzilli, A. Signore, A.J. Williams, and P.E. Beales NOD mouse colonies around the world - recent facts and figures Immunol. Today 14 1993 193 196
    • (1993) Immunol. Today , vol.14 , pp. 193-196
    • Pozzilli, P.1    Signore, A.2    Williams, A.J.3    Beales, P.E.4
  • 16
    • 84885080249 scopus 로고    scopus 로고
    • Advances in our understanding of the pathophysiology of Type 1 diabetes: Lessons from the NOD mouse
    • A. Jayasimhan, K.P. Mansour, and R.M. Slattery Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse Clin. Sci. 126 2014 1 18
    • (2014) Clin. Sci. , vol.126 , pp. 1-18
    • Jayasimhan, A.1    Mansour, K.P.2    Slattery, R.M.3
  • 17
    • 78651275599 scopus 로고    scopus 로고
    • T1DBase: Update, organization and presentation of large-scale data sets for type 1 diabetes research
    • O.S. Burren, E.C. Adlem, P. Achuthan, M. Christensen, R.M. Coulson, and J.A. Todd T1DBase: update, organization and presentation of large-scale data sets for type 1 diabetes research Nucl. Acids Res. 39 2011 D997 D1001
    • (2011) Nucl. Acids Res. , vol.39 , pp. D997-D1001
    • Burren, O.S.1    Adlem, E.C.2    Achuthan, P.3    Christensen, M.4    Coulson, R.M.5    Todd, J.A.6
  • 18
    • 84879532718 scopus 로고    scopus 로고
    • Comparative genetics: Synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes
    • J.P. Driver, Y.G. Chen, and C.E. Mathews Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes Rev. Diabet. Stud. 9 2012 169 187
    • (2012) Rev. Diabet. Stud. , vol.9 , pp. 169-187
    • Driver, J.P.1    Chen, Y.G.2    Mathews, C.E.3
  • 19
    • 79251621206 scopus 로고    scopus 로고
    • Mouse models for the study of autoimmune type 1 diabetes: A NOD to similarities and differences to human disease
    • J.P. Driver, D.V. Serreze, and Y.G. Chen Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease Semin. Immunopathol. 33 2011 67 87
    • (2011) Semin. Immunopathol. , vol.33 , pp. 67-87
    • Driver, J.P.1    Serreze, D.V.2    Chen, Y.G.3
  • 20
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • H. Ueda, J.M. Howson, L. Esposito, J. Heward, H. Snook, G. Chamberlain, and et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease Nature 423 2003 506 511
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5    Chamberlain, G.6
  • 21
    • 84930791607 scopus 로고    scopus 로고
    • Insulitis in human type 1 diabetes: A comparison between patients and animal models
    • P. In't Veld Insulitis in human type 1 diabetes: a comparison between patients and animal models Semin. Immunopathol. 36 2014 569 579
    • (2014) Semin. Immunopathol. , vol.36 , pp. 569-579
    • In'T Veld, P.1
  • 22
    • 0022475906 scopus 로고
    • The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: A 25-year review of deaths in patients under 20 years of age in the United Kingdom
    • A.K. Foulis, C.N. Liddle, M.A. Farquharson, J.A. Richmond, and R.S. Weir The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom Diabetologia 29 1986 267 274
    • (1986) Diabetologia , vol.29 , pp. 267-274
    • Foulis, A.K.1    Liddle, C.N.2    Farquharson, M.A.3    Richmond, J.A.4    Weir, R.S.5
  • 23
    • 84929965930 scopus 로고    scopus 로고
    • Thinking bedside at the bench: The NOD mouse model of T1DM
    • J.C. Reed, and K.C. Herold Thinking bedside at the bench: the NOD mouse model of T1DM Nat. Rev. Endocrinol. 11 2015 308 314
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 308-314
    • Reed, J.C.1    Herold, K.C.2
  • 24
    • 0002758516 scopus 로고
    • The NOD mouse: A model for analyzing the interplay between heredity and environment in development of autoimmune disease
    • E.H. Leiter The NOD mouse: a model for analyzing the interplay between heredity and environment in development of autoimmune disease ILAR J. 35 1993 4 14
    • (1993) ILAR J. , vol.35 , pp. 4-14
    • Leiter, E.H.1
  • 25
    • 77951666052 scopus 로고    scopus 로고
    • Pathogenesis of type 1 diabetes mellitus: Interplay between enterovirus and host
    • D. Hober, and P. Sauter Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host Nat. Rev. Endocrinol. 6 2010 279 289
    • (2010) Nat. Rev. Endocrinol. , vol.6 , pp. 279-289
    • Hober, D.1    Sauter, P.2
  • 26
    • 84887052291 scopus 로고    scopus 로고
    • Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders
    • K.C. Herold, S.E. Gitelman, M.R. Ehlers, P.A. Gottlieb, C.J. Greenbaum, W. Hagopian, and et al. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders Diabetes 62 2013 3766 3774
    • (2013) Diabetes , vol.62 , pp. 3766-3774
    • Herold, K.C.1    Gitelman, S.E.2    Ehlers, M.R.3    Gottlieb, P.A.4    Greenbaum, C.J.5    Hagopian, W.6
  • 27
    • 24044513266 scopus 로고    scopus 로고
    • Utility of murine models for the study of spontaneous autoimmune type 1 diabetes
    • C.E. Mathews Utility of murine models for the study of spontaneous autoimmune type 1 diabetes Pediatr. Diabetes 6 2005 165 177
    • (2005) Pediatr. Diabetes , vol.6 , pp. 165-177
    • Mathews, C.E.1
  • 28
    • 84934442067 scopus 로고    scopus 로고
    • The BB rat as a model of human type 1 diabetes
    • R. Bortell, and C. Yang The BB rat as a model of human type 1 diabetes Methods Mol. Biol. 933 2012 31 44
    • (2012) Methods Mol. Biol. , vol.933 , pp. 31-44
    • Bortell, R.1    Yang, C.2
  • 30
    • 0020527178 scopus 로고
    • Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat
    • M.E. Elder, and N.K. Maclaren Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat J. Immunol. 130 1983 1723 1731
    • (1983) J. Immunol. , vol.130 , pp. 1723-1731
    • Elder, M.E.1    Maclaren, N.K.2
  • 31
    • 0020067836 scopus 로고
    • Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat
    • A.A. Like, E. Kislauskis, R.R. Williams, and A.A. Rossini Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat Science 216 1982 644 646
    • (1982) Science , vol.216 , pp. 644-646
    • Like, A.A.1    Kislauskis, E.2    Williams, R.R.3    Rossini, A.A.4
  • 32
    • 0018565284 scopus 로고
    • Spontaneous diabetes mellitus: Reversal and prevention in the BB/W rat with antiserum to rat lymphocytes
    • A.A. Like, A.A. Rossini, D.L. Guberski, M.C. Appel, and R.M. Williams Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes Science 206 1979 1421 1423
    • (1979) Science , vol.206 , pp. 1421-1423
    • Like, A.A.1    Rossini, A.A.2    Guberski, D.L.3    Appel, M.C.4    Williams, R.M.5
  • 33
    • 0347133294 scopus 로고    scopus 로고
    • Temporary, but essential requirement of CD8+ T cells early in the pathogenesis of diabetes in BB rats as revealed by thymectomy and CD8 depletion
    • H. Groen, F. Klatter, J. Pater, P. Nieuwenhuis, and J. Rozing Temporary, but essential requirement of CD8+ T cells early in the pathogenesis of diabetes in BB rats as revealed by thymectomy and CD8 depletion Clin. Dev. Immunol. 10 2003 141 151
    • (2003) Clin. Dev. Immunol. , vol.10 , pp. 141-151
    • Groen, H.1    Klatter, F.2    Pater, J.3    Nieuwenhuis, P.4    Rozing, J.5
  • 35
    • 0022414133 scopus 로고
    • Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals
    • C.F. Gotfredsen, K. Buschard, and E.K. Frandsen Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals Diabetologia 28 1985 933 935
    • (1985) Diabetologia , vol.28 , pp. 933-935
    • Gotfredsen, C.F.1    Buschard, K.2    Frandsen, E.K.3
  • 36
    • 0030895280 scopus 로고    scopus 로고
    • Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: Dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells
    • F.W. Scott, H.E. Cloutier, R. Kleemann, U. Woerz-Pagenstert, P. Rowsell, H.W. Modler, and et al. Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells Diabetes 46 1997 589 598
    • (1997) Diabetes , vol.46 , pp. 589-598
    • Scott, F.W.1    Cloutier, H.E.2    Kleemann, R.3    Woerz-Pagenstert, U.4    Rowsell, P.5    Modler, H.W.6
  • 37
    • 0025936380 scopus 로고
    • Intrathymic islet transplantation in the spontaneously diabetic BB rat
    • discussion 71-73
    • A.M. Posselt, A. Naji, J.H. Roark, J.F. Markmann, and C.F. Barker Intrathymic islet transplantation in the spontaneously diabetic BB rat Ann. Surg. 214 1991 363 371 discussion 71-73
    • (1991) Ann. Surg. , vol.214 , pp. 363-371
    • Posselt, A.M.1    Naji, A.2    Roark, J.H.3    Markmann, J.F.4    Barker, C.F.5
  • 38
    • 79551569614 scopus 로고    scopus 로고
    • Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats
    • A.J. Kruger, C. Yang, K.L. Lipson, S.C. Pino, J.H. Leif, C.M. Hogan, and et al. Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats Autoimmunity 44 2011 137 148
    • (2011) Autoimmunity , vol.44 , pp. 137-148
    • Kruger, A.J.1    Yang, C.2    Lipson, K.L.3    Pino, S.C.4    Leif, J.H.5    Hogan, C.M.6
  • 40
    • 21344471092 scopus 로고    scopus 로고
    • Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat
    • A. Jorns, A. Gunther, H.J. Hedrich, D. Wedekind, M. Tiedge, and S. Lenzen Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat Diabetes 54 2005 2041 2052
    • (2005) Diabetes , vol.54 , pp. 2041-2052
    • Jorns, A.1    Gunther, A.2    Hedrich, H.J.3    Wedekind, D.4    Tiedge, M.5    Lenzen, S.6
  • 41
    • 1542375195 scopus 로고    scopus 로고
    • Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm- iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus
    • A. Jorns, B. Kubat, M. Tiedge, D. Wedekind, H.J. Hedrich, G. Kloppel, and et al. Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm- iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus Virchows Arch. 444 2004 183 189
    • (2004) Virchows Arch. , vol.444 , pp. 183-189
    • Jorns, A.1    Kubat, B.2    Tiedge, M.3    Wedekind, D.4    Hedrich, H.J.5    Kloppel, G.6
  • 42
    • 77954898611 scopus 로고    scopus 로고
    • Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation
    • A. Jorns, K.J. Rath, T. Terbish, T. Arndt, A. Meyer Zu Vilsendorf, D. Wedekind, and et al. Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation Endocrinology 151 2010 3555 3565
    • (2010) Endocrinology , vol.151 , pp. 3555-3565
    • Jorns, A.1    Rath, K.J.2    Terbish, T.3    Arndt, T.4    Meyer Zu Vilsendorf, A.5    Wedekind, D.6
  • 43
    • 1842832870 scopus 로고    scopus 로고
    • The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat
    • J. Popovic, K.L. Kover, and W.V. Moore The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat Pediatr. Diabetes 5 2004 3 9
    • (2004) Pediatr. Diabetes , vol.5 , pp. 3-9
    • Popovic, J.1    Kover, K.L.2    Moore, W.V.3
  • 44
    • 0037184806 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice
    • T. Maki, R. Gottschalk, and A.P. Monaco Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice Transplantation 74 2002 1684 1686
    • (2002) Transplantation , vol.74 , pp. 1684-1686
    • Maki, T.1    Gottschalk, R.2    Monaco, A.P.3
  • 45
    • 0032469294 scopus 로고    scopus 로고
    • Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats
    • K. Komeda, M. Noda, K. Terao, N. Kuzuya, M. Kanazawa, and Y. Kanazawa Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats Endocr. J. 45 1998 737 744
    • (1998) Endocr. J. , vol.45 , pp. 737-744
    • Komeda, K.1    Noda, M.2    Terao, K.3    Kuzuya, N.4    Kanazawa, M.5    Kanazawa, Y.6
  • 47
    • 84857785010 scopus 로고    scopus 로고
    • Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats
    • N. Yokoi, S. Hidaka, S. Tanabe, M. Ohya, M. Ishima, Y. Takagi, and et al. Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats Genes Immun. 13 2012 139 145
    • (2012) Genes Immun. , vol.13 , pp. 139-145
    • Yokoi, N.1    Hidaka, S.2    Tanabe, S.3    Ohya, M.4    Ishima, M.5    Takagi, Y.6
  • 48
    • 33847010931 scopus 로고    scopus 로고
    • Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat
    • N. Yokoi, C. Hayashi, Y. Fujiwara, H.Y. Wang, and S. Seino Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat Diabetes 56 2007 506 512
    • (2007) Diabetes , vol.56 , pp. 506-512
    • Yokoi, N.1    Hayashi, C.2    Fujiwara, Y.3    Wang, H.Y.4    Seino, S.5
  • 49
    • 0036699521 scopus 로고    scopus 로고
    • Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
    • N. Yokoi, K. Komeda, H.Y. Wang, H. Yano, K. Kitada, Y. Saitoh, and et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus Nat. Genet. 31 2002 391 394
    • (2002) Nat. Genet. , vol.31 , pp. 391-394
    • Yokoi, N.1    Komeda, K.2    Wang, H.Y.3    Yano, H.4    Kitada, K.5    Saitoh, Y.6
  • 52
    • 0037219387 scopus 로고    scopus 로고
    • A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice
    • T.C. Brodnicki, F. Quirk, and G. Morahan A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice Diabetes 52 2003 218 222
    • (2003) Diabetes , vol.52 , pp. 218-222
    • Brodnicki, T.C.1    Quirk, F.2    Morahan, G.3
  • 53
    • 84943390799 scopus 로고    scopus 로고
    • Bim deficiency protects NOD mice from diabetes by diverting thymocytes to regulatory T cells
    • B. Krishnamurthy, J. Chee, G. Jhala, P. Trivedi, T. Catterall, C. Selck, and et al. Bim deficiency protects NOD mice from diabetes by diverting thymocytes to regulatory T cells Diabetes 2015
    • (2015) Diabetes
    • Krishnamurthy, B.1    Chee, J.2    Jhala, G.3    Trivedi, P.4    Catterall, T.5    Selck, C.6
  • 54
    • 0036894358 scopus 로고    scopus 로고
    • Proinsulin 2 knockout NOD mice: A model for genetic variation of insulin gene expression in type 1 diabetes
    • D. Dubois-Lafforgue, L. Mogenet, K. Thebault, J. Jami, P. Krief, and C. Boitard Proinsulin 2 knockout NOD mice: a model for genetic variation of insulin gene expression in type 1 diabetes Diabetes 51 Suppl. 3 2002 S489 S493
    • (2002) Diabetes , vol.51 , pp. S489-S493
    • Dubois-Lafforgue, D.1    Mogenet, L.2    Thebault, K.3    Jami, J.4    Krief, P.5    Boitard, C.6
  • 55
    • 84926443680 scopus 로고    scopus 로고
    • Increased autoimmune diabetes in pIgR-deficient NOD mice is due to a hitchhiking interval that refines the genetic effect of Idd5.4
    • K.R. Simpfendorfer, R.A. Strugnell, T.C. Brodnicki, and O.L. Wijburg Increased autoimmune diabetes in pIgR-deficient NOD mice is due to a hitchhiking interval that refines the genetic effect of Idd5.4 PLoS One 10 2015 10.1371/journal.pone.0121979
    • (2015) PLoS One , vol.10
    • Simpfendorfer, K.R.1    Strugnell, R.A.2    Brodnicki, T.C.3    Wijburg, O.L.4
  • 56
    • 0031686176 scopus 로고    scopus 로고
    • Effector mechanisms in low-dose streptozotocin-induced diabetes
    • M.L. Lukic, S. Stosic-Grujicic, and A. Shahin Effector mechanisms in low-dose streptozotocin-induced diabetes Dev. Immunol. 6 1998 119 128
    • (1998) Dev. Immunol. , vol.6 , pp. 119-128
    • Lukic, M.L.1    Stosic-Grujicic, S.2    Shahin, A.3
  • 58
    • 0033041283 scopus 로고    scopus 로고
    • Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
    • M. Flodstrom, B. Tyrberg, D.L. Eizirik, and S. Sandler Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes Diabetes 48 1999 706 713
    • (1999) Diabetes , vol.48 , pp. 706-713
    • Flodstrom, M.1    Tyrberg, B.2    Eizirik, D.L.3    Sandler, S.4
  • 59
    • 84879376622 scopus 로고    scopus 로고
    • Murine animal models for preclinical islet transplantation: No model fits all (research purposes)
    • E. Cantarelli, A. Citro, S. Marzorati, R. Melzi, M. Scavini, and L. Piemonti Murine animal models for preclinical islet transplantation: no model fits all (research purposes) Islets 5 2013 79 86
    • (2013) Islets , vol.5 , pp. 79-86
    • Cantarelli, E.1    Citro, A.2    Marzorati, S.3    Melzi, R.4    Scavini, M.5    Piemonti, L.6
  • 60
    • 84943355943 scopus 로고    scopus 로고
    • TNF-alpha antibody therapy in combination with the T-cell specific antibody anti-TCR reverses the diabetic metabolic state in the LEW.1AR1-iddm rat
    • A. Jorns, U.G. Ertekin, T. Arndt, T. Terbish, D. Wedekind, and S. Lenzen TNF-alpha antibody therapy in combination with the T-cell specific antibody anti-TCR reverses the diabetic metabolic state in the LEW.1AR1-iddm rat Diabetes 60 2015 2880 2891
    • (2015) Diabetes , vol.60 , pp. 2880-2891
    • Jorns, A.1    Ertekin, U.G.2    Arndt, T.3    Terbish, T.4    Wedekind, D.5    Lenzen, S.6
  • 61
    • 84903309761 scopus 로고    scopus 로고
    • Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by beta cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes
    • A. Jorns, M. Akin, T. Arndt, T. Terbish, A.M. Zu Vilsendorf, D. Wedekind, and et al. Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by beta cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes J. Mol. Med. 92 2014 743 755
    • (2014) J. Mol. Med. , vol.92 , pp. 743-755
    • Jorns, A.1    Akin, M.2    Arndt, T.3    Terbish, T.4    Zu Vilsendorf, A.M.5    Wedekind, D.6
  • 62
    • 84928576994 scopus 로고    scopus 로고
    • HCELL expression on murine MSC licenses pancreatotropism and confers durable reversal of autoimmune diabetes in NOD mice
    • R. Abdi, R. Moore, S. Sakai, C.B. Donnelly, M. Mounayar, and R. Sackstein HCELL expression on murine MSC licenses pancreatotropism and confers durable reversal of autoimmune diabetes in NOD mice Stem Cells 33 2015 1523 1531
    • (2015) Stem Cells , vol.33 , pp. 1523-1531
    • Abdi, R.1    Moore, R.2    Sakai, S.3    Donnelly, C.B.4    Mounayar, M.5    Sackstein, R.6
  • 63
    • 67650685905 scopus 로고    scopus 로고
    • Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice
    • W.L. Suarez-Pinzon, G.S. Cembrowski, and A. Rabinovitch Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice Diabetologia 52 2009 1680 1682
    • (2009) Diabetologia , vol.52 , pp. 1680-1682
    • Suarez-Pinzon, W.L.1    Cembrowski, G.S.2    Rabinovitch, A.3
  • 64
    • 0037708577 scopus 로고    scopus 로고
    • Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody
    • R.D. Molano, A. Pileggi, T. Berney, R. Poggioli, E. Zahr, R. Oliver, and et al. Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody Transplantation 75 2003 1812 1819
    • (2003) Transplantation , vol.75 , pp. 1812-1819
    • Molano, R.D.1    Pileggi, A.2    Berney, T.3    Poggioli, R.4    Zahr, E.5    Oliver, R.6
  • 65
    • 0025300995 scopus 로고
    • Evidence that cyclosporine prevents rejection and recurrent diabetes in pancreatic transplants in the BB rat
    • W.E. Dugoni Jr., and S.T. Bartlett Evidence that cyclosporine prevents rejection and recurrent diabetes in pancreatic transplants in the BB rat Transplantation 49 1990 845 848
    • (1990) Transplantation , vol.49 , pp. 845-848
    • Dugoni, W.E.1    Bartlett, S.T.2
  • 66
    • 0033810263 scopus 로고    scopus 로고
    • Anti-CD154 (CD40L) prevents recurrence of diabetes in islet isografts in the DR-BB rat
    • K.L. Kover, Z. Geng, D.M. Hess, C.D. Benjamin, and W.V. Moore Anti-CD154 (CD40L) prevents recurrence of diabetes in islet isografts in the DR-BB rat Diabetes 49 2000 1666 1670
    • (2000) Diabetes , vol.49 , pp. 1666-1670
    • Kover, K.L.1    Geng, Z.2    Hess, D.M.3    Benjamin, C.D.4    Moore, W.V.5
  • 67
    • 33644779799 scopus 로고    scopus 로고
    • Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse
    • S.A. Nanji, W.W. Hancock, B. Luo, C.D. Schur, R.L. Pawlick, L.F. Zhu, and et al. Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse Diabetes 55 2006 27 33
    • (2006) Diabetes , vol.55 , pp. 27-33
    • Nanji, S.A.1    Hancock, W.W.2    Luo, B.3    Schur, C.D.4    Pawlick, R.L.5    Zhu, L.F.6
  • 68
    • 55549137691 scopus 로고    scopus 로고
    • Islet alpha cell number is maintained in microencapsulated islet transplantation
    • S. Bohman, and A.J. King Islet alpha cell number is maintained in microencapsulated islet transplantation Biochem. Biophys. Res. Commun. 377 2008 729 733
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 729-733
    • Bohman, S.1    King, A.J.2
  • 69
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    • T. Szkudelski The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas Physiol. Res. 50 2001 537 546
    • (2001) Physiol. Res. , vol.50 , pp. 537-546
    • Szkudelski, T.1
  • 70
    • 0021092027 scopus 로고
    • Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro
    • S. Sandler, and I. Swenne Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro Diabetologia 25 1983 444 447
    • (1983) Diabetologia , vol.25 , pp. 444-447
    • Sandler, S.1    Swenne, I.2
  • 71
    • 34249279490 scopus 로고    scopus 로고
    • Animal models in type 2 diabetes research: An overview
    • K. Srinivasan, and P. Ramarao Animal models in type 2 diabetes research: an overview Indian J. Med. Res. 125 2007 451 472
    • (2007) Indian J. Med. Res. , vol.125 , pp. 451-472
    • Srinivasan, K.1    Ramarao, P.2
  • 72
    • 58849090031 scopus 로고    scopus 로고
    • Insights into modeling streptozotocin-induced diabetes in ICR mice
    • Y. Dekel, Y. Glucksam, I. Elron-Gross, and R. Margalit Insights into modeling streptozotocin-induced diabetes in ICR mice Lab. Anim. 38 2009 55 60
    • (2009) Lab. Anim. , vol.38 , pp. 55-60
    • Dekel, Y.1    Glucksam, Y.2    Elron-Gross, I.3    Margalit, R.4
  • 73
    • 33744944777 scopus 로고    scopus 로고
    • Strain differences in the diabetogenic activity of streptozotocin in mice
    • K. Hayashi, R. Kojima, and M. Ito Strain differences in the diabetogenic activity of streptozotocin in mice Biol. Pharm. Bull. 29 2006 1110 1119
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 1110-1119
    • Hayashi, K.1    Kojima, R.2    Ito, M.3
  • 75
    • 84875739195 scopus 로고    scopus 로고
    • Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is beneficial for transplantation outcome in diabetic mice
    • C.L. Rackham, P.K. Dhadda, P.C. Chagastelles, S.J. Simpson, A.A. Dattani, J.E. Bowe, and et al. Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is beneficial for transplantation outcome in diabetic mice Cytotherapy 15 2013 449 459
    • (2013) Cytotherapy , vol.15 , pp. 449-459
    • Rackham, C.L.1    Dhadda, P.K.2    Chagastelles, P.C.3    Simpson, S.J.4    Dattani, A.A.5    Bowe, J.E.6
  • 76
    • 84874352736 scopus 로고    scopus 로고
    • Maintenance of islet morphology is beneficial for transplantation outcome in diabetic mice
    • C.L. Rackham, P.M. Jones, and A.J. King Maintenance of islet morphology is beneficial for transplantation outcome in diabetic mice PLoS One 8 2013 e57844
    • (2013) PLoS One , vol.8 , pp. e57844
    • Rackham, C.L.1    Jones, P.M.2    King, A.J.3
  • 77
    • 0042519607 scopus 로고    scopus 로고
    • The effect of capsule composition in the reversal of hyperglycemia in diabetic mice transplanted with microencapsulated allogeneic islets
    • A. King, J. Lau, A. Nordin, S. Sandler, and A. Andersson The effect of capsule composition in the reversal of hyperglycemia in diabetic mice transplanted with microencapsulated allogeneic islets Diabetes Technol. Ther. 5 2003 653 663
    • (2003) Diabetes Technol. Ther. , vol.5 , pp. 653-663
    • King, A.1    Lau, J.2    Nordin, A.3    Sandler, S.4    Andersson, A.5
  • 78
    • 84930153840 scopus 로고    scopus 로고
    • Juvenile porcine islets can restore euglycemia in diabetic athymic nude mice after xenotransplantation
    • R. Krishnan, B. Buder, M. Alexander, C.E. Foster 3rd, and J.R. Lakey Juvenile porcine islets can restore euglycemia in diabetic athymic nude mice after xenotransplantation Transplantation 99 2015 710 716
    • (2015) Transplantation , vol.99 , pp. 710-716
    • Krishnan, R.1    Buder, B.2    Alexander, M.3    Foster, C.E.4    Lakey, J.R.5
  • 79
    • 77649309901 scopus 로고    scopus 로고
    • Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice
    • E.J. Grossman, D.D. Lee, J. Tao, R.A. Wilson, S.Y. Park, G.I. Bell, and et al. Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice PLoS One 5 2010 e8749
    • (2010) PLoS One , vol.5
    • Grossman, E.J.1    Lee, D.D.2    Tao, J.3    Wilson, R.A.4    Park, S.Y.5    Bell, G.I.6
  • 81
    • 84862559347 scopus 로고    scopus 로고
    • Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes
    • Z.L. Zhi, A. Kerby, A.J. King, P.M. Jones, and J.C. Pickup Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes Diabetologia 55 2012 1081 1090
    • (2012) Diabetologia , vol.55 , pp. 1081-1090
    • Zhi, Z.L.1    Kerby, A.2    King, A.J.3    Jones, P.M.4    Pickup, J.C.5
  • 82
    • 84951818606 scopus 로고    scopus 로고
    • Pre-culturing islets with adipose-derived Mesenchymal Stromal Cells is an effective strategy for improving transplantation efficiency at the clinically-preferred intraportal site
    • C.L. Rackham, P.K. Dhadda, A.M. Le Lay, A.J.F. King, and P.M. Jones Pre-culturing islets with adipose-derived Mesenchymal Stromal Cells is an effective strategy for improving transplantation efficiency at the clinically-preferred intraportal site Cell Med. 7 2014 37 47
    • (2014) Cell Med. , vol.7 , pp. 37-47
    • Rackham, C.L.1    Dhadda, P.K.2    Le Lay, A.M.3    King, A.J.F.4    Jones, P.M.5
  • 83
    • 33746885868 scopus 로고    scopus 로고
    • A novel drug delivery system for type 1 diabetes: Insulin-mimetic vanadyl-poly(gamma-glutamic acid) complex
    • S. Karmaker, T.K. Saha, Y. Yoshikawa, H. Yasui, and H. Sakurai A novel drug delivery system for type 1 diabetes: insulin-mimetic vanadyl-poly(gamma-glutamic acid) complex J. Inorg. Biochem. 100 2006 1535 1546
    • (2006) J. Inorg. Biochem. , vol.100 , pp. 1535-1546
    • Karmaker, S.1    Saha, T.K.2    Yoshikawa, Y.3    Yasui, H.4    Sakurai, H.5
  • 84
    • 84936942895 scopus 로고    scopus 로고
    • Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic beta cell glucotoxicity
    • J. Wu, and L.J. Yan Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic beta cell glucotoxicity Diabetes Metab. Syndr. Obes. 8 2015 181 188
    • (2015) Diabetes Metab. Syndr. Obes. , vol.8 , pp. 181-188
    • Wu, J.1    Yan, L.J.2
  • 85
    • 80052901759 scopus 로고    scopus 로고
    • Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells
    • Y.D. Muller, D. Golshayan, D. Ehirchiou, J.C. Wyss, L. Giovannoni, R. Meier, and et al. Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells Diabetes 60 2011 2331 2340
    • (2011) Diabetes , vol.60 , pp. 2331-2340
    • Muller, Y.D.1    Golshayan, D.2    Ehirchiou, D.3    Wyss, J.C.4    Giovannoni, L.5    Meier, R.6
  • 86
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • M. Yoshioka, T. Kayo, T. Ikeda, and A. Koizumi A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice Diabetes 46 1997 887 894
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 87
    • 0032918044 scopus 로고    scopus 로고
    • A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
    • J. Wang, T. Takeuchi, S. Tanaka, S.K. Kubo, T. Kayo, D. Lu, and et al. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse J. Clin. Invest. 103 1999 27 37
    • (1999) J. Clin. Invest. , vol.103 , pp. 27-37
    • Wang, J.1    Takeuchi, T.2    Tanaka, S.3    Kubo, S.K.4    Kayo, T.5    Lu, D.6
  • 88
    • 0036175125 scopus 로고    scopus 로고
    • Proteotoxicity in the endoplasmic reticulum: Lessons from the Akita diabetic mouse
    • D. Ron Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse J. Clin. Invest. 109 2002 443 445
    • (2002) J. Clin. Invest. , vol.109 , pp. 443-445
    • Ron, D.1
  • 89
    • 0037181624 scopus 로고    scopus 로고
    • New mouse model to study islet transplantation in insulin-dependent diabetes mellitus
    • C.E. Mathews, S.H. Langley, and E.H. Leiter New mouse model to study islet transplantation in insulin-dependent diabetes mellitus Transplantation 73 2002 1333 1336
    • (2002) Transplantation , vol.73 , pp. 1333-1336
    • Mathews, C.E.1    Langley, S.H.2    Leiter, E.H.3
  • 90
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • M. Prentki, and C.J. Nolan Islet beta cell failure in type 2 diabetes J. Clin. Invest. 116 2006 1802 1812
    • (2006) J. Clin. Invest. , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 91
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • B.B. Kahn, and J.S. Flier Obesity and insulin resistance J. Clin. Invest. 106 2000 473 481
    • (2000) J. Clin. Invest. , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 92
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: A key component of the obesity-diabetes link
    • G.S. Hotamisligil, and B.M. Spiegelman Tumor necrosis factor alpha: a key component of the obesity-diabetes link Diabetes 43 1994 1271 1278
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 93
    • 84929501597 scopus 로고    scopus 로고
    • The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models
    • H.G. Joost, and A. Schurmann The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models Mamm. Genome 25 2014 401 412
    • (2014) Mamm. Genome , vol.25 , pp. 401-412
    • Joost, H.G.1    Schurmann, A.2
  • 95
    • 84925228644 scopus 로고    scopus 로고
    • Leptin- and leptin receptor-deficient rodent models: Relevance for human type 2 diabetes
    • B. Wang, P.C. Chandrasekera, and J.J. Pippin Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes Curr. Diabetes Rev. 10 2014 131 145
    • (2014) Curr. Diabetes Rev. , vol.10 , pp. 131-145
    • Wang, B.1    Chandrasekera, P.C.2    Pippin, J.J.3
  • 96
    • 34249799917 scopus 로고    scopus 로고
    • The physiology of obese-hyperglycemic mice [ob/ob mice]
    • P. Lindstrom The physiology of obese-hyperglycemic mice [ob/ob mice] Sci. World J. 7 2007 666 685
    • (2007) Sci. World J. , vol.7 , pp. 666-685
    • Lindstrom, P.1
  • 97
    • 77953953486 scopus 로고    scopus 로고
    • Beta-cell function in obese-hyperglycemic mice [ob/ob Mice]
    • P. Lindstrom Beta-cell function in obese-hyperglycemic mice [ob/ob Mice] Adv. Exp. Med. Biol. 654 2010 463 477
    • (2010) Adv. Exp. Med. Biol. , vol.654 , pp. 463-477
    • Lindstrom, P.1
  • 98
    • 0015381515 scopus 로고
    • The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains
    • K.P. Hummel, D.L. Coleman, and P.W. Lane The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains Biochem. Genet. 7 1972 1 13
    • (1972) Biochem. Genet. , vol.7 , pp. 1-13
    • Hummel, K.P.1    Coleman, D.L.2    Lane, P.W.3
  • 100
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat
    • A. Pick, J. Clark, C. Kubstrup, M. Levisetti, W. Pugh, S. Bonner-Weir, and et al. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat Diabetes 47 1998 358 364
    • (1998) Diabetes , vol.47 , pp. 358-364
    • Pick, A.1    Clark, J.2    Kubstrup, C.3    Levisetti, M.4    Pugh, W.5    Bonner-Weir, S.6
  • 101
    • 70350302229 scopus 로고    scopus 로고
    • Age dependence of glucose tolerance in adult KK-Ay mice, a model of non-insulin dependent diabetes mellitus
    • G. Chakraborty, S. Thumpayil, D.E. Lafontant, W. Woubneh, and J.H. Toney Age dependence of glucose tolerance in adult KK-Ay mice, a model of non-insulin dependent diabetes mellitus Lab. Anim. 38 2009 364 368
    • (2009) Lab. Anim. , vol.38 , pp. 364-368
    • Chakraborty, G.1    Thumpayil, S.2    Lafontant, D.E.3    Woubneh, W.4    Toney, J.H.5
  • 102
    • 3042732491 scopus 로고    scopus 로고
    • Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity
    • R.A. Koza, K. Flurkey, D.M. Graunke, C. Braun, H.J. Pan, P.C. Reifsnyder, and et al. Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity Metabolism 53 2004 799 808
    • (2004) Metabolism , vol.53 , pp. 799-808
    • Koza, R.A.1    Flurkey, K.2    Graunke, D.M.3    Braun, C.4    Pan, H.J.5    Reifsnyder, P.C.6
  • 103
    • 0842263993 scopus 로고    scopus 로고
    • Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes
    • E.H. Leiter, and P.C. Reifsnyder Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes Diabetes 53 Suppl. 1 2004 S4 11
    • (2004) Diabetes , vol.53 , pp. S4-S11
    • Leiter, E.H.1    Reifsnyder, P.C.2
  • 104
    • 84934444357 scopus 로고    scopus 로고
    • The TALLYHO mouse as a model of human type 2 diabetes
    • J.H. Kim, and A.M. Saxton The TALLYHO mouse as a model of human type 2 diabetes Methods Mol. Biol. 933 2012 75 87
    • (2012) Methods Mol. Biol. , vol.933 , pp. 75-87
    • Kim, J.H.1    Saxton, A.M.2
  • 105
    • 84879406550 scopus 로고    scopus 로고
    • Comparison of two new mouse models of polygenic type 2 diabetes at the jackson laboratory, NONcNZO10Lt/J and TALLYHO/JngJ
    • 165327
    • E.H. Leiter, M. Strobel, A. O'Neill, D. Schultz, A. Schile, and P.C. Reifsnyder Comparison of two new mouse models of polygenic type 2 diabetes at the jackson laboratory, NONcNZO10Lt/J and TALLYHO/JngJ J. Diabetes Res. 2013 2013 165327
    • (2013) J. Diabetes Res. , vol.2013
    • Leiter, E.H.1    Strobel, M.2    O'Neill, A.3    Schultz, D.4    Schile, A.5    Reifsnyder, P.C.6
  • 106
    • 0028112936 scopus 로고
    • OLETF (Otsuka Long-Evans Tokushima Fatty) rat: A new NIDDM rat strain
    • K. Kawano, T. Hirashima, S. Mori, and T. Natori OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain Diabetes Res. Clin. Pract. 24 Suppl 1994 S317 S320
    • (1994) Diabetes Res. Clin. Pract. , vol.24 , pp. S317-S320
    • Kawano, K.1    Hirashima, T.2    Mori, S.3    Natori, T.4
  • 107
    • 41849107486 scopus 로고    scopus 로고
    • Unraveling the obesity of OLETF rats
    • T.H. Moran Unraveling the obesity of OLETF rats Physiol. Behav. 94 2008 71 78
    • (2008) Physiol. Behav. , vol.94 , pp. 71-78
    • Moran, T.H.1
  • 109
    • 3543009434 scopus 로고    scopus 로고
    • The high-fat diet-fed mouse: A model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes
    • M.S. Winzell, and B. Ahren The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes Diabetes 53 Suppl. 3 2004 S215 S219
    • (2004) Diabetes , vol.53 , pp. S215-S219
    • Winzell, M.S.1    Ahren, B.2
  • 110
    • 0029065480 scopus 로고
    • Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice
    • R.S. Surwit, M.N. Feinglos, J. Rodin, A. Sutherland, A.E. Petro, E.C. Opara, and et al. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice Metabolism 44 1995 645 651
    • (1995) Metabolism , vol.44 , pp. 645-651
    • Surwit, R.S.1    Feinglos, M.N.2    Rodin, J.3    Sutherland, A.4    Petro, A.E.5    Opara, E.C.6
  • 111
    • 9644260361 scopus 로고    scopus 로고
    • Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice
    • K. Almind, and C.R. Kahn Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice Diabetes 53 2004 3274 3285
    • (2004) Diabetes , vol.53 , pp. 3274-3285
    • Almind, K.1    Kahn, C.R.2
  • 112
    • 33644833635 scopus 로고    scopus 로고
    • Animal models of type 2 diabetes with reduced pancreatic beta-cell mass
    • P. Masiello Animal models of type 2 diabetes with reduced pancreatic beta-cell mass Int. J. Biochem. Cell Biol. 38 2006 873 893
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 873-893
    • Masiello, P.1
  • 113
    • 35148863543 scopus 로고    scopus 로고
    • Islet gene expression and function in type 2 diabetes; Studies in the Goto-Kakizaki rat and humans
    • C.G. Ostenson, and S. Efendic Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and humans Diabetes Obes. Metab. 9 Suppl. 2 2007 180 186
    • (2007) Diabetes Obes. Metab. , vol.9 , pp. 180-186
    • Ostenson, C.G.1    Efendic, S.2
  • 114
    • 0035129014 scopus 로고    scopus 로고
    • Beta-cell function and viability in the spontaneously diabetic GK rat: Information from the GK/Par colony
    • B. Portha, M.H. Giroix, P. Serradas, M.N. Gangnerau, J. Movassat, F. Rajas, and et al. Beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony Diabetes 50 Suppl. 1 2001 S89 S93
    • (2001) Diabetes , vol.50 , pp. S89-S93
    • Portha, B.1    Giroix, M.H.2    Serradas, P.3    Gangnerau, M.N.4    Movassat, J.5    Rajas, F.6
  • 117
    • 0019450010 scopus 로고
    • Responses of neonatal rat islets to streptozotocin: Limited B-cell regeneration and hyperglycemia
    • S. Bonner-Weir, D.F. Trent, R.N. Honey, and G.C. Weir Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia Diabetes 30 1981 64 69
    • (1981) Diabetes , vol.30 , pp. 64-69
    • Bonner-Weir, S.1    Trent, D.F.2    Honey, R.N.3    Weir, G.C.4
  • 118
    • 0016270910 scopus 로고
    • Diabetogenic effect of streptozotocin in the rat during the perinatal period
    • B. Portha, C. Levacher, L. Picon, and G. Rosselin Diabetogenic effect of streptozotocin in the rat during the perinatal period Diabetes 23 1974 889 895
    • (1974) Diabetes , vol.23 , pp. 889-895
    • Portha, B.1    Levacher, C.2    Picon, L.3    Rosselin, G.4
  • 119
    • 33646534187 scopus 로고    scopus 로고
    • Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats
    • T. Irako, T. Akamizu, H. Hosoda, H. Iwakura, H. Ariyasu, K. Tojo, and et al. Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats Diabetologia 49 2006 1264 1273
    • (2006) Diabetologia , vol.49 , pp. 1264-1273
    • Irako, T.1    Akamizu, T.2    Hosoda, H.3    Iwakura, H.4    Ariyasu, H.5    Tojo, K.6
  • 120
    • 70349967847 scopus 로고    scopus 로고
    • Administration of conophylline and betacellulin-delta4 increases the beta-cell mass in neonatal streptozotocin-treated rats
    • T. Kodera, S. Yamada, Y. Yamamoto, A. Hara, Y. Tanaka, M. Seno, and et al. Administration of conophylline and betacellulin-delta4 increases the beta-cell mass in neonatal streptozotocin-treated rats Endocr. J. 56 2009 799 806
    • (2009) Endocr. J. , vol.56 , pp. 799-806
    • Kodera, T.1    Yamada, S.2    Yamamoto, Y.3    Hara, A.4    Tanaka, Y.5    Seno, M.6
  • 121
    • 0032798195 scopus 로고    scopus 로고
    • Effect of partial pancreatectomy on diabetic status in BALB/c mice
    • A.A. Hardikar, M.S. Karandikar, and R.R. Bhonde Effect of partial pancreatectomy on diabetic status in BALB/c mice J. Endocrinol. 162 1999 189 195
    • (1999) J. Endocrinol. , vol.162 , pp. 189-195
    • Hardikar, A.A.1    Karandikar, M.S.2    Bhonde, R.R.3
  • 122
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • S. Bonner-Weir, D.F. Trent, and G.C. Weir Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release J. Clin. Invest. 71 1983 1544 1553
    • (1983) J. Clin. Invest. , vol.71 , pp. 1544-1553
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 123
    • 0032836724 scopus 로고    scopus 로고
    • Mechanisms of glucose hypersensitivity in beta-cells from normoglycemic, partially pancreatectomized mice
    • F. Martin, E. Andreu, J.M. Rovira, J.A. Pertusa, M. Raurell, C. Ripoll, and et al. Mechanisms of glucose hypersensitivity in beta-cells from normoglycemic, partially pancreatectomized mice Diabetes 48 1999 1954 1961
    • (1999) Diabetes , vol.48 , pp. 1954-1961
    • Martin, F.1    Andreu, E.2    Rovira, J.M.3    Pertusa, J.A.4    Raurell, M.5    Ripoll, C.6
  • 124
    • 0033553462 scopus 로고    scopus 로고
    • Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
    • J.C. Jonas, A. Sharma, W. Hasenkamp, H. Ilkova, G. Patane, R. Laybutt, and et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes J. Biol. Chem. 274 1999 14112 14121
    • (1999) J. Biol. Chem. , vol.274 , pp. 14112-14121
    • Jonas, J.C.1    Sharma, A.2    Hasenkamp, W.3    Ilkova, H.4    Patane, G.5    Laybutt, R.6
  • 125
    • 0033045376 scopus 로고    scopus 로고
    • Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats
    • D.T. Finegood, G.C. Weir, and S. Bonner-Weir Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats Am. J. Physiol. 276 1999 E822 7
    • (1999) Am. J. Physiol. , vol.276 , pp. E822-E827
    • Finegood, D.T.1    Weir, G.C.2    Bonner-Weir, S.3
  • 127
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • E. Araki, M.A. Lipes, M.E. Patti, J.C. Bruning, B. Haag 3rd, R.S. Johnson, and et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene Nature 372 1994 186 190
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3    Bruning, J.C.4    Haag, B.5    Johnson, R.S.6
  • 128
    • 0028810236 scopus 로고
    • 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice
    • M.E. Patti, X.J. Sun, J.C. Bruening, E. Araki, M.A. Lipes, M.F. White, and et al. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice J. Biol. Chem. 270 1995 24670 24673
    • (1995) J. Biol. Chem. , vol.270 , pp. 24670-24673
    • Patti, M.E.1    Sun, X.J.2    Bruening, J.C.3    Araki, E.4    Lipes, M.A.5    White, M.F.6
  • 130
    • 0034671645 scopus 로고    scopus 로고
    • Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo
    • S.F. Previs, D.J. Withers, J.M. Ren, M.F. White, and G.I. Shulman Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo J. Biol. Chem. 275 2000 38990 38994
    • (2000) J. Biol. Chem. , vol.275 , pp. 38990-38994
    • Previs, S.F.1    Withers, D.J.2    Ren, J.M.3    White, M.F.4    Shulman, G.I.5
  • 131
    • 0033966768 scopus 로고    scopus 로고
    • Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    • Y. Kido, D.J. Burks, D. Withers, J.C. Bruning, C.R. Kahn, M.F. White, and et al. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2 J. Clin. Invest. 105 2000 199 205
    • (2000) J. Clin. Invest. , vol.105 , pp. 199-205
    • Kido, Y.1    Burks, D.J.2    Withers, D.3    Bruning, J.C.4    Kahn, C.R.5    White, M.F.6
  • 132
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • R.N. Kulkarni, J.C. Bruning, J.N. Winnay, C. Postic, M.A. Magnuson, and C.R. Kahn Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes Cell 96 1999 329 339
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 133
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • M.D. Michael, R.N. Kulkarni, C. Postic, S.F. Previs, G.I. Shulman, M.A. Magnuson, and et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Mol. Cell 6 2000 87 97
    • (2000) Mol. Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6
  • 134
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • M. Bluher, M.D. Michael, O.D. Peroni, K. Ueki, N. Carter, B.B. Kahn, and et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance Dev. Cell 3 2002 25 38
    • (2002) Dev. Cell , vol.3 , pp. 25-38
    • Bluher, M.1    Michael, M.D.2    Peroni, O.D.3    Ueki, K.4    Carter, N.5    Kahn, B.B.6
  • 135
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • J.C. Bruning, M.D. Michael, J.N. Winnay, T. Hayashi, D. Horsch, D. Accili, and et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance Mol. Cell 2 1998 559 569
    • (1998) Mol. Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1    Michael, M.D.2    Winnay, J.N.3    Hayashi, T.4    Horsch, D.5    Accili, D.6
  • 136
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • D. Cai, M. Yuan, D.F. Frantz, P.A. Melendez, L. Hansen, J. Lee, and et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat. Med. 11 2005 183 190
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6
  • 137
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
    • S.E. Shoelson, J. Lee, and M. Yuan Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance Int. J. Obes. Relat. Metab. Disord. 27 Suppl. 3 2003 S49 52
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , pp. S49-S52
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 138
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • M. Yuan, N. Konstantopoulos, J. Lee, L. Hansen, Z.W. Li, M. Karin, and et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta Science 293 2001 1673 1677
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6
  • 139
    • 77955514154 scopus 로고    scopus 로고
    • Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
    • N. Wijesekara, F.F. Dai, A.B. Hardy, P.R. Giglou, A. Bhattacharjee, V. Koshkin, and et al. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion Diabetologia 53 2010 1656 1668
    • (2010) Diabetologia , vol.53 , pp. 1656-1668
    • Wijesekara, N.1    Dai, F.F.2    Hardy, A.B.3    Giglou, P.R.4    Bhattacharjee, A.5    Koshkin, V.6
  • 140
    • 18344382724 scopus 로고    scopus 로고
    • Targeted deletion of the PRL receptor: Effects on islet development, insulin production, and glucose tolerance
    • M. Freemark, I. Avril, D. Fleenor, P. Driscoll, A. Petro, E. Opara, and et al. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance Endocrinology 143 2002 1378 1385
    • (2002) Endocrinology , vol.143 , pp. 1378-1385
    • Freemark, M.1    Avril, I.2    Fleenor, D.3    Driscoll, P.4    Petro, A.5    Opara, E.6
  • 142
    • 4344571667 scopus 로고    scopus 로고
    • Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase
    • P.E. MacDonald, J.W. Joseph, D. Yau, J. Diao, Z. Asghar, F. Dai, and et al. Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase Endocrinology 145 2004 4078 4083
    • (2004) Endocrinology , vol.145 , pp. 4078-4083
    • MacDonald, P.E.1    Joseph, J.W.2    Yau, D.3    Diao, J.4    Asghar, Z.5    Dai, F.6
  • 143
    • 84921697003 scopus 로고    scopus 로고
    • Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state
    • K. Kim, C.M. Oh, M. Ohara-Imaizumi, S. Park, J. Namkung, V.K. Yadav, and et al. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state Endocrinology 156 2015 444 452
    • (2015) Endocrinology , vol.156 , pp. 444-452
    • Kim, K.1    Oh, C.M.2    Ohara-Imaizumi, M.3    Park, S.4    Namkung, J.5    Yadav, V.K.6
  • 145
    • 84938602095 scopus 로고    scopus 로고
    • Dual actions of a novel bifunctional compound to lower glucose in mice with diet-induced insulin resistance
    • K. Chen, A. Jih, S. Kavaler, W.S. Lagakos, D. Oh, S. Watkins, and et al. Dual actions of a novel bifunctional compound to lower glucose in mice with diet-induced insulin resistance Am. J. Physiol. Endocrinol. Metab. 309 2015 E293 E301
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.309 , pp. E293-E301
    • Chen, K.1    Jih, A.2    Kavaler, S.3    Lagakos, W.S.4    Oh, D.5    Watkins, S.6
  • 146
    • 84859540710 scopus 로고    scopus 로고
    • Salicylate downregulates 11beta-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization
    • M. Nixon, D.J. Wake, D.E. Livingstone, R.H. Stimson, C.L. Esteves, J.R. Seckl, and et al. Salicylate downregulates 11beta-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization Diabetes 61 2012 790 796
    • (2012) Diabetes , vol.61 , pp. 790-796
    • Nixon, M.1    Wake, D.J.2    Livingstone, D.E.3    Stimson, R.H.4    Esteves, C.L.5    Seckl, J.R.6
  • 147
    • 84879956920 scopus 로고    scopus 로고
    • A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro
    • A. Al-Romaiyan, A.J. King, S.J. Persaud, and P.M. Jones A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro Phytother. Res. 27 2013 1006 1011
    • (2013) Phytother. Res. , vol.27 , pp. 1006-1011
    • Al-Romaiyan, A.1    King, A.J.2    Persaud, S.J.3    Jones, P.M.4
  • 148
    • 84885832858 scopus 로고    scopus 로고
    • The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis
    • B. Liu, Z. Hassan, S. Amisten, A.J. King, J.E. Bowe, G.C. Huang, and et al. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis Diabetologia 56 2013 2467 2476
    • (2013) Diabetologia , vol.56 , pp. 2467-2476
    • Liu, B.1    Hassan, Z.2    Amisten, S.3    King, A.J.4    Bowe, J.E.5    Huang, G.C.6
  • 149
    • 0034060985 scopus 로고    scopus 로고
    • Inhibition of progressive reduction of islet beta-cell mass in spontaneously diabetic Goto-Kakizaki rats by alpha-glucosidase inhibitor
    • M. Koyama, R. Wada, H. Mizukami, H. Sakuraba, H. Odaka, H. Ikeda, and et al. Inhibition of progressive reduction of islet beta-cell mass in spontaneously diabetic Goto-Kakizaki rats by alpha-glucosidase inhibitor Metabolism 49 2000 347 352
    • (2000) Metabolism , vol.49 , pp. 347-352
    • Koyama, M.1    Wada, R.2    Mizukami, H.3    Sakuraba, H.4    Odaka, H.5    Ikeda, H.6
  • 150
    • 0342617615 scopus 로고    scopus 로고
    • Repaglinide, glibenclamide and glimepiride administration to normal and hereditarily diabetic rats
    • L. Ladriere, F. Malaisse-Lagae, J. Fuhlendorff, and W.J. Malaisse Repaglinide, glibenclamide and glimepiride administration to normal and hereditarily diabetic rats Eur. J. Pharmacol. 335 1997 227 234
    • (1997) Eur. J. Pharmacol. , vol.335 , pp. 227-234
    • Ladriere, L.1    Malaisse-Lagae, F.2    Fuhlendorff, J.3    Malaisse, W.J.4
  • 151
    • 0032932825 scopus 로고    scopus 로고
    • Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
    • N.H. Greig, H.W. Holloway, K.A. De Ore, D. Jani, Y. Wang, J. Zhou, and et al. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations Diabetologia 42 1999 45 50
    • (1999) Diabetologia , vol.42 , pp. 45-50
    • Greig, N.H.1    Holloway, H.W.2    De Ore, K.A.3    Jani, D.4    Wang, Y.5    Zhou, J.6
  • 152
  • 153
    • 10744230106 scopus 로고    scopus 로고
    • GLP-1 derivative liraglutide in rats with beta-cell deficiencies: Influence of metabolic state on beta-cell mass dynamics
    • J. Sturis, C.F. Gotfredsen, J. Romer, B. Rolin, U. Ribel, C.L. Brand, and et al. GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics Br. J. Pharm. 140 2003 123 132
    • (2003) Br. J. Pharm. , vol.140 , pp. 123-132
    • Sturis, J.1    Gotfredsen, C.F.2    Romer, J.3    Rolin, B.4    Ribel, U.5    Brand, C.L.6
  • 154
    • 84939958366 scopus 로고    scopus 로고
    • Emerging new therapies for the treatment of type 2 diabetes mellitus: Glucagon-like peptide-1 receptor agonists
    • C.A. Lindamood, and J.R. Taylor Emerging new therapies for the treatment of type 2 diabetes mellitus: glucagon-like peptide-1 receptor agonists Clin. Ther. 37 2015 483 493
    • (2015) Clin. Ther. , vol.37 , pp. 483-493
    • Lindamood, C.A.1    Taylor, J.R.2
  • 155
    • 0036312680 scopus 로고    scopus 로고
    • Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4
    • C. Tourrel, D. Bailbe, M. Lacorne, M.J. Meile, M. Kergoat, and B. Portha Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4 Diabetes 51 2002 1443 1452
    • (2002) Diabetes , vol.51 , pp. 1443-1452
    • Tourrel, C.1    Bailbe, D.2    Lacorne, M.3    Meile, M.J.4    Kergoat, M.5    Portha, B.6
  • 156
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • A.A. Young, B.R. Gedulin, S. Bhavsar, N. Bodkin, C. Jodka, B. Hansen, and et al. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta) Diabetes 48 1999 1026 1034
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6
  • 157
    • 3042737844 scopus 로고    scopus 로고
    • Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4
    • N. Ogawa, J.F. List, J.F. Habener, and T. Maki Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4 Diabetes 53 2004 1700 1705
    • (2004) Diabetes , vol.53 , pp. 1700-1705
    • Ogawa, N.1    List, J.F.2    Habener, J.F.3    Maki, T.4
  • 158
    • 0035405821 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
    • C. Tourrel, D. Bailbe, M.J. Meile, M. Kergoat, and B. Portha Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age Diabetes 50 2001 1562 1570
    • (2001) Diabetes , vol.50 , pp. 1562-1570
    • Tourrel, C.1    Bailbe, D.2    Meile, M.J.3    Kergoat, M.4    Portha, B.5
  • 159
    • 84889066890 scopus 로고    scopus 로고
    • Animal models of diabetic retinopathy: Summary and comparison
    • 106594
    • A.K. Lai, and A.C. Lo Animal models of diabetic retinopathy: summary and comparison J. Diabetes Res. 2013 2013 106594
    • (2013) J. Diabetes Res. , vol.2013
    • Lai, A.K.1    Lo, A.C.2
  • 160
    • 84904272582 scopus 로고    scopus 로고
    • Recent advances in animal models of diabetic nephropathy
    • B. Betz, and B.R. Conway Recent advances in animal models of diabetic nephropathy Nephron Exp. Nephrol. 126 2014 191 195
    • (2014) Nephron Exp. Nephrol. , vol.126 , pp. 191-195
    • Betz, B.1    Conway, B.R.2
  • 163
    • 34250816918 scopus 로고    scopus 로고
    • Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice
    • Y. Kanetsuna, K. Takahashi, M. Nagata, M.A. Gannon, M.D. Breyer, R.C. Harris, and et al. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice Am. J. Pathol. 170 2007 1473 1484
    • (2007) Am. J. Pathol. , vol.170 , pp. 1473-1484
    • Kanetsuna, Y.1    Takahashi, K.2    Nagata, M.3    Gannon, M.A.4    Breyer, M.D.5    Harris, R.C.6
  • 165
    • 84894423492 scopus 로고    scopus 로고
    • Animal models of diabetic neuropathic pain
    • F. Gao, and Z.M. Zheng Animal models of diabetic neuropathic pain Exp. Clin. Endocrinol. Diabetes 122 2014 100 106
    • (2014) Exp. Clin. Endocrinol. Diabetes , vol.122 , pp. 100-106
    • Gao, F.1    Zheng, Z.M.2
  • 167
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • R. Sladek, G. Rocheleau, J. Rung, C. Dina, L. Shen, D. Serre, and et al. A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 2007 881 885
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3    Dina, C.4    Shen, L.5    Serre, D.6
  • 168
    • 79952342793 scopus 로고    scopus 로고
    • Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity
    • R.D. Cox, and C.D. Church Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity Dis. Models Mech. 4 2011 155 164
    • (2011) Dis. Models Mech. , vol.4 , pp. 155-164
    • Cox, R.D.1    Church, C.D.2
  • 171
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • L.J. Scott, K.L. Mohlke, L.L. Bonnycastle, C.J. Willer, Y. Li, W.L. Duren, and et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 2007 1341 1345
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3    Willer, C.J.4    Li, Y.5    Duren, W.L.6
  • 172
    • 84866107559 scopus 로고    scopus 로고
    • Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice
    • G. da Silva Xavier, A. Mondragon, G. Sun, L. Chen, J.A. McGinty, P.M. French, and et al. Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice Diabetologia 55 2012 2667 2676
    • (2012) Diabetologia , vol.55 , pp. 2667-2676
    • Da Silva Xavier, G.1    Mondragon, A.2    Sun, G.3    Chen, L.4    McGinty, J.A.5    French, P.M.6
  • 173
    • 84871596296 scopus 로고    scopus 로고
    • Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand
    • S.F. Boj, J.H. van Es, M. Huch, V.S. Li, A. Jose, P. Hatzis, and et al. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand Cell 151 2012 1595 1607
    • (2012) Cell , vol.151 , pp. 1595-1607
    • Boj, S.F.1    Van Es, J.H.2    Huch, M.3    Li, V.S.4    Jose, A.5    Hatzis, P.6
  • 174
    • 70349113136 scopus 로고    scopus 로고
    • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    • T.J. Nicolson, E.A. Bellomo, N. Wijesekara, M.K. Loder, J.M. Baldwin, A.V. Gyulkhandanyan, and et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants Diabetes 58 2009 2070 2083
    • (2009) Diabetes , vol.58 , pp. 2070-2083
    • Nicolson, T.J.1    Bellomo, E.A.2    Wijesekara, N.3    Loder, M.K.4    Baldwin, J.M.5    Gyulkhandanyan, A.V.6
  • 176
    • 75249099675 scopus 로고    scopus 로고
    • What can bariatric surgery teach us about the pathophysiology of type 2 diabetes?
    • F. Andreelli, C. Amouyal, C. Magnan, and G. Mithieux What can bariatric surgery teach us about the pathophysiology of type 2 diabetes? Diabetes Metab. 35 2009 499 507
    • (2009) Diabetes Metab. , vol.35 , pp. 499-507
    • Andreelli, F.1    Amouyal, C.2    Magnan, C.3    Mithieux, G.4
  • 179
    • 61549094077 scopus 로고    scopus 로고
    • Weight and type 2 diabetes after bariatric surgery: Systematic review and meta-analysis
    • e5
    • H. Buchwald, R. Estok, K. Fahrbach, D. Banel, M.D. Jensen, W.J. Pories, and et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis Am. J. Med. 122 2009 248 256 e5
    • (2009) Am. J. Med. , vol.122 , pp. 248-256
    • Buchwald, H.1    Estok, R.2    Fahrbach, K.3    Banel, D.4    Jensen, M.D.5    Pories, W.J.6
  • 182
    • 0842283988 scopus 로고    scopus 로고
    • Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: A new perspective for an old disease
    • F. Rubino, and J. Marescaux Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease Ann. Surg. 239 2004 1 11
    • (2004) Ann. Surg. , vol.239 , pp. 1-11
    • Rubino, F.1    Marescaux, J.2
  • 184
    • 79956092573 scopus 로고    scopus 로고
    • Lessons learned from gastric bypass operations in rats
    • F. Seyfried, R. le, C.W. oux, and M. Bueter Lessons learned from gastric bypass operations in rats Obes. Facts 4 Suppl. 1 2011 3 12
    • (2011) Obes. Facts , vol.4 , pp. 3-12
    • Seyfried, F.1    Le, R.2    Oux, C.W.3    Bueter, M.4
  • 185
    • 84899126845 scopus 로고    scopus 로고
    • Gastric bypass improves beta-cell function and increases beta-cell mass in a porcine model
    • A. Lindqvist, P. Spegel, M. Ekelund, E. Garcia Vaz, S. Pierzynowski, M.F. Gomez, and et al. Gastric bypass improves beta-cell function and increases beta-cell mass in a porcine model Diabetes 63 2014 1665 1671
    • (2014) Diabetes , vol.63 , pp. 1665-1671
    • Lindqvist, A.1    Spegel, P.2    Ekelund, M.3    Garcia Vaz, E.4    Pierzynowski, S.5    Gomez, M.F.6
  • 186
    • 84874244844 scopus 로고    scopus 로고
    • Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance
    • S. Salinari, C. Debard, A. Bertuzzi, C. Durand, P. Zimmet, H. Vidal, and et al. Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance PLoS One 8 2013 e56258
    • (2013) PLoS One , vol.8
    • Salinari, S.1    Debard, C.2    Bertuzzi, A.3    Durand, C.4    Zimmet, P.5    Vidal, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.