Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat

Diabetes

Volumn 55, Issue 6, 2006, Pages 1625-1633

  Homo Delarche, Françoise ^a   Calderari, Sophie ^a   Irminger, Jean Claude ^b   Gangnerau, Marie Noëlle ^a   Coulaud, Josiane ^a   Rickenbach, Katharina ^b   Dolz, Manuel ^a   Halban, Philippe ^b   Portha, Bernard ^a   Serradas, Patricia ^a  

^a CNRS   (France)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

ECM, extracellular matrix; MHC, major histocompatibility complex; vWF, von Willebrand factor

Indexed keywords

ANNEXIN; CD53 ANTIGEN; CD8 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DECORIN; FIBRONECTIN; HLA ANTIGEN CLASS 2; LIPOCALIN; MATRIX METALLOPROTEINASE 14; OSTEOPONTIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GRANULOCYTE; HYPERGLYCEMIA; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICROANGIOPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULARIZATION;

ANIMALS; CELL ADHESION; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION PROFILING; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; ISLETS OF LANGERHANS; MACROPHAGES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33748306069     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1526     Document Type: Article

References (59)

1. Kakizaki M, Fujiya H, Goto Y: The pancreatic islets of the spontaneous diabetic rats. Diabetes 7:23-25, 1979
2. Movassat J, Saulnier C, Serradas P, Portha B: Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia 40:916-925, 1997
3. Hoog A, Hu W, Abdel-Halim SM, Falkmer S, Qing L, Grimelius L: Ultrastructural localization of insulin-like growth factor-2 (IGF-2) to the secretory granules of insulin cells: a study in normal and diabetic (GK) rats. Ultrastruct Pathol 21:457-466, 1997
4. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS: Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat. Diabetes 47:358-364, 1998
5. Ko SH, Kwon HS, Kim SR, Moon SD, Ahn YB, Song KH, Son HS, Cha BY, Lee KW, Son HY, Kang SK, Park CG, Lee IK, Yoon KH: Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochem Biophys Res Commun 316:114-122, 2004
6. Masuyama T, Komeda K, Hara A, Noda M, Shinohara M, Oikawa T, Kanazawa Y, Taniguchi K: Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats. Biochem Biophys Res Commun 314:870-877, 2004
7. Like AA, Chick WL: Studies in the diabetic mutant mouse: II. Electron microscopy of pancreatic islets. Diabetologia 6:216-242, 1970
8. Clark A, Nilsson MR: Islet amyloid: a complication of islet dysfunction or an aetiological factor in type 2 diabetes? Diabetologia 47:157-169, 2004
9. Donath MY, Storling J, Maedler K, Mandrup-Poulsen T: Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81:455-470, 2003
10. Kolb H, Mandrup-Poulsen T: An immune origin of type 2 diabetes? Diabetologia 48:1038-1050, 2005
11. Atef N, Portha B, Penicaud L: Changes in islet blood flow in rats with NIDDM. Diabetologia 37:677-680, 1994
12. Portha B, Giroix MH, Serradas P, Gangnerau MN, Movassat J, Rajas F, Bailbe D, Plachot C, Mithieux G, Marie JC: β-Cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony. Diabetes 50 (Suppl. 1):S89-S93, 2001
13. Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC: Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines. Endocrinology 144:1368-1379, 2003
14. Homo-Delarche F, Calderari S, Irminger J, Coulaud J, Rickenbach K, Gangnerau M, Portha B, Serradas P: Chronic hyperglycemia is associated with an inflammatory islet reaction in a spontaneous model of type 2 diabetes (T2D) (Abstract). Diabetologia 48 (Suppl. 1):A180, 2005
15. Raines EW: The extracellular matrix can regulate vascular cell migration, proliferation, and survival: relationships to vascular disease. Int J Exp Pathol 81:173-182, 2000
16. Xin X, Khan ZA, Chen S, Chakrabarti S: Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis. Lab Invest 84:1451-1459, 2004
17. Grabowska A, Lampson LA: MHC expression in nonlymphoid tissues of the developing embryo: strongest class I or class II expression in separate populations of potential antigen-presenting cells in the skin, lung, gut, and interorgan connective tissue. Dev Comp Immunol 19:425-450, 1995
18. Voorbij HA, Jeucken PH, Kabel PJ, De Haan M, Drexhage HA: Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats. Diabetes 38:1623-1629, 1989
19. Tomlinson MG, Williams AF, Wright MD: Epitope mapping of anti-rat CD53 monoclonal antibodies. Implications for the membrane orientation of the transmembrane 4 superfamily. Eur J Immunol 23:136-140, 1993
20. Finegood DT, McArthur MD, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE: β-Cell mass dynamics in Zucker diabetic fatty rats: rosiglitazone prevents the rise in net cell death. Diabetes 50:1021-1029, 2001
21. Schalkwijk CG, Stehouwer CD: Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin Sci (Lond ) 109:143-159, 2005
22. Kampf C, Bodin B, Kallskog O, Carlsson C, Jansson L: Marked increase in white adipose tissue blood perfusion in the type 2 diabetic GK rat. Diabetes 54:2620-2627, 2005
23. Svensson AM, Ostenson CG, Jansson L: Age-induced changes in pancreatic islet blood flow: evidence for an impaired regulation in diabetic GK rats. Am J Physiol Endocrinol Metab 279:E1139-E1144, 2000
24. Carlsson PO, Jansson L, Ostenson CG, Kallskog O: Islet capillary blood pressure increase mediated by hyperglycemia in NIDDM GK rats. Diabetes 46:947-952, 1997
25. Mizuno A, Noma Y, Kuwajima M, Murakami T, Zhu M, Shima K: Changes in islet capillary angioarchitecture coincide with impaired B-cell function but not with insulin resistance in male Otsuka-Long-Evans-Tokushima fatty rats: dimorphism of the diabetic phenotype at an advanced age. Metabolism 48:477-483, 1999
26. Iwase M, Uchizono Y, Tashiro K, Goto D, Iida M: Islet hyperperfusion during prediabetic phase in OLETF rats, a model of type 2 diabetes. Diabetes 51:2530-2535, 2002
27. Seki N, Hashimoto N, Sano H, Horiuchi S, Yagui K, Makino H, Saito Y: Mechanisms involved in the stimulatory effect of advanced glycation end products on growth of rat aortic smooth muscle cells. Metabolism 52:1558-1563, 2003
28. Schonherr E, Sunderkotter C, Schaefer L, Thanos S, Grassel S, Oldberg A, Iozzo RV, Young MF, Kresse H: Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J Vasc Res 41:499-508, 2004
29. Strom A, Ahlqvist E, Franzen A, Heinegard D, Hultgardh-Nilsson A: Extracellular matrix components in atherosclerotic arteries of Apo E/LDL receptor deficient mice: an immunohistochemical study. Histol Histopathol 19:337-347, 2004
30. Haas TL: Endothelial cell regulation of matrix metalloproteinases. Can J Physiol Pharmacol 83:1-7, 2005
31. Takemoto M, Yokote K, Nishimura M, Shigematsu T, Hasegawa T, Kon S, Uede T, Matsumoto T, Saito Y, Mori S: Enhanced expression of osteopontin in human diabetic artery and analysis of its functional role in accelerated atherogenesis. Arterioscler Thromb Vasc Biol 20:624-628, 2000
32. Akahane T, Akahane M, Shah A, Thorgeirsson UP: TIMP-1 stimulates proliferation of human aortic smooth muscle cells and Ras effector pathways. Biochem Biophys Res Commun 324:440-445, 2004
33. Calles-Escandon J, Cipolla M: Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 22:36-52, 2001
34. Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820, 2001
35. Morigi M, Angioletti S, Imberti B, Donadelli R, Micheletti G, Figliuzzi M, Remuzzi A, Zoja C, Remuzzi G: Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. J Clin Invest 101:1905-1915, 1998
36. Booth G, Stalker TJ, Lefer AM, Scalia R: Elevated ambient glucose induces acute inflammatory events in the microvasculature: effects of insulin. Am J Physiol Endocrinol Metab 280:E848-E856, 2001
37. Biedermann BC: Vascular endothelium: checkpoint for inflammation and immunity. News Physiol Sci 16:84-88, 2001
38. Takaishi H, Taniguchi T, Takahashi A, Ishikawa Y, Yokoyama M: High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells. Biochem Biophys Res Commun 305:122-128, 2003
39. Kobayashi S, Kimura I, Kimura M: Diabetic state-modified macrophages in GK rat release platelet-derived growth factor-BB for tube formation of endothelial cells in rat aorta. Immunopharmacology 35:171-180, 1996
40. Bitar MS, Wahid S, Mustafa S, Al-Saleh E, Dhaunsi GS, Al-Mulla F: Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes. Eur J Pharmacol 511:53-64, 2005
41. Nagashima R, Maeda K, Imai Y, Takahashi T: Lamina propria macrophages in the human gastrointestinal mucosa: their distribution, immunohistological phenotype, and function. J Histochem Cytochem 44:721-731, 1996
42. Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R: MIF signal transduction initiated by binding to CD74. J Exp Med 197:1467-1476, 2003
43. Nathan CF: Secretory products of macrophages. J Clin Invest 79:319-326, 1987
44. Homo-Delarche F, Drexhage HA: Immune cells, pancreas development, regeneration and type 1 diabetes. Trends Immunol 25:222-229, 2004
45. Shanmugam N, Reddy MA, Guha M, Natarajan R: High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 52:1256-1264, 2003
46. Devaraj S, Venugopal SK, Singh U, Jialal I: Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-α and -β. Diabetes 54:85-91, 2005
47. Bolcato-Bellemin A, Mattei M, Fenton M, Amar S: Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. J Endotoxin Res 10:15-23, 2004
48. Almkvist J, Karlsson A: Galectins as inflammatory mediators. Glycoconj J 19:575-581, 2004
49. Larkin L, Khachigian LM, Jessup W: Regulation of apolipoprotein E production in macrophages (Review). Int J Mol Med 6:253-258, 2000
50. Perretti M: Endogenous mediators that inhibit the leukocyte-endothelium interaction. Trends Pharmacol Sci 18:418-425, 1997
51. Gomme PT, McCann KB, Bertolini J: Transferrin: structure, function and potential therapeutic actions. Drug Discov Today 10:267-273, 2005
52. Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Maeda N, Falk RJ, Jennette JC: The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol 167:39-45, 2005
53. Xu S, Venge P: Lipocalins as biochemical markers of disease. Biochim Biophys Acta 1482:298-307, 2000
54. Perretti M, Flower RJ: Annexin 1 and the biology of the neutrophil. J Leukoc Biol 76:25-29, 2004
55. Kim SY, Johnson MA, McLeod DS, Alexander T, Hansen BC, Lutty GA: Neutrophils are associated with capillary closure in spontaneously diabetic monkey retinas. Diabetes 54:1534-1542, 2005
56. Langheinrich AC, Bohle RM: Atherosclerosis: humoral and cellular factors of inflammation. Virchows Arch 446:101-111, 2005
57. Diani AR, Sawada G, Wyse B, Murray FT, Khan M: Pioglitazone preserves pancreatic islet structure and insulin secretory function in three murine models of type 2 diabetes. Am J Physiol Endocrinol Metab 286:E116-E122, 2004
58. Jia D, Taguchi M, Otsuki M: Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats. Metabolism 54:619-627, 2005
59. Sjoholm A, Nystrom T: Endothelial inflammation in insulin resistance. Lancet 365:610-612, 2005