Proinsulin 2 knockout NOD mice: A model for genetic variation of insulin gene expression in type 1 diabetes

Diabetes

Volumn 51, Issue SUPPL. 3, 2002, Pages

  Dubois Lafforgue, Danièle ^a   Mogenet, Laurent ^a   Thébault, Karine ^a   Jami, Jacques ^b   Krief, Patricia ^a   Boitard, Christian ^a  

^a HÔPITAL SAINT VINCENT DE PAUL   (France)

^b INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; ISOPROTEIN; PROINSULIN; PROINSULIN 1; PROINSULIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NULL ALLELE; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN LOCALIZATION; THYMUS; TISSUE DISTRIBUTION; WILD TYPE;

EID: 0036894358     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.2007.s489     Document Type: Conference Paper

References (23)

1. Lucassen AM, Julier C, Beressi JP, Boitard C, Froguel P, Lathrop M, Bell JI: Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat Genet 4:305-310, 1993
2. Pugliese A, Zeller M, Fernandez A Jr, Zalcberg M, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD: The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 15:293-297, 1997
3. Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C: Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 15:289-292, 1997
4. Kennedy GC, German MS, Rutter WJ: The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat Genet 9:293-298, 1995
5. McCarthy MI: Weighing in on diabetes risk. Nat Genet 19:209-210, 1998
6. Ong KK, Phillips DI, Poulton J, Bennett ST, Golding J, Todd JA, Dunger DB: The insulin gene VNTR, type 2 diabetes and birth weight. Nat Genet 21:262-263, 1999
7. Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI: Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number of tandem repeat alleles. Diabetes 49:126-130, 2000
8. Le Stunff C, Fallin D, Shork NJ, Bougnères P: The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Nat Genet 26:444-446, 2000
9. Nakamura Y, Leppert M, O'Connell P, Wolff R, Holm T, Culver M, Martin C, Fujimoto E, Hoff M, Kumlin E, et al.: Variable number of tandem repeat (VNTR) markers for human gene mapping. Science 235:1616-1622, 1987
10. Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, Bucchini D: Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc Natl Acad Sci U S A 90:527-531, 1993
11. Duvillie B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier JM, Monthioux E, Jami J, Joshi RL, Bucchini D: Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci U S A 94:5137-5140, 1997
12. Leroux L, Desbois P, Lamotte L, Duvillié B, Cordonnier N, Jackerott M, Jami J, Bucchini D, Joshi J: Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes 50:S150-S153, 2001
13. Serreze DV, Leiter EH: Genetic and pathogenic basis of autoimmune diabetes in NOD mice. Curr Opin Immunol 6:900-906, 1994
14. Chentoufi AA, Polychronakos C: Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51:1383-1390, 2002
15. Homo-Delarche F, Boitard C: Autoimmune diabetes: the role of the islets of Langerhans. Immunol Today 17:456-460, 1996
16. Chen W, Bergerot I, Elliott JF, Harrison LC, Abiru N, Eisenbarth GS, Delovitch TL: Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 167:4926-4935, 2001
17. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL: Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222:1337-1339, 1983
18. Wegmann DR, Norbury-Glaser M, Daniel D: Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 24:1853-1857, 1994
19. Yu L, Robles DT, Abiru N, Kaur P, Rewers M, Kelemen K, Eisenbarth GS: Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes. Proc Natl Acad Sci U S A 97:1701-1706, 2000
20. Dubois-Laforgue D, Carel JC, Bougneres PF, Guillet JG, Boitard C: T-cell response to proinsulin and insulin in type 1 and pretype 1 diabetes. J Clin Immunol 19:127-134, 1999
21. Larger E, Becourt C, Bach JF, Boitard C: Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model. J Exp Med 181:1635-1642, 1995
22. Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N: Insulin immunization of nonobese diabetic mice induces a protective insuhtis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest 95:628-634, 1995
23. Throsby M, Homo-Delarche F, Chevenne D, Goya R, Dardenne M, Pleau JM: Pancreatic hormone expression in the murine thymus: Localization in dendritic cells and macrophages. Endocrinology 139:2399-2406, 1998