메뉴 건너뛰기




Volumn 55, Issue 10, 2012, Pages 2667-2676

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

Author keywords

Beta cell mass; GLP 1; Glucose tolerance; GWAS; Insulin; Knockout mouse; Pancreas

Indexed keywords

CRE RECOMBINASE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INCRETIN; INSULIN; PROINSULIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR PDX 1;

EID: 84866107559     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2600-7     Document Type: Article
Times cited : (89)

References (53)
  • 1
    • 0028813310 scopus 로고
    • Risk of diabetes in offspring of parents with non-insulin-dependent diabetes
    • 7712706 10.1111/j.1464-5491.1995.tb02054.x 1:STN:280:DyaK2M3ivVaqsw%3D%3D
    • Pierce M, Keen H, Bradley C (1995) Risk of diabetes in offspring of parents with non-insulin-dependent diabetes. Diabet Med 12:6-13
    • (1995) Diabet Med , vol.12 , pp. 6-13
    • Pierce, M.1    Keen, H.2    Bradley, C.3
  • 2
    • 0023201498 scopus 로고
    • Concordance for Type 2 (non-insulin-dependent) diabetes mellitus in male twins
    • Newman B, Selby JV, King MC, Slemenda C, Fabsitz R, Friedman GD (1987) Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 30:763-768 (Pubitemid 17163001)
    • (1987) Diabetologia , vol.30 , Issue.10 , pp. 763-768
    • Newman, B.1    Selby, J.V.2    King, M.-C.3    Slemenda, C.4    Fabsitz, R.5    Friedman, G.D.6
  • 3
    • 17844373857 scopus 로고    scopus 로고
    • Genetics of Type 2 diabetes
    • DOI 10.1111/j.1464-5491.2005.01550.x
    • Barroso I (2005) Genetics of type 2 diabetes. Diabet Med 22:517-535 (Pubitemid 40593126)
    • (2005) Diabetic Medicine , vol.22 , Issue.5 , pp. 517-535
    • Barroso, I.1
  • 5
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • 17293876 10.1038/nature05616 1:CAS:528:DC%2BD2sXhvFGiurw%3D
    • Sladek R, Rocheleau G, Rung J et al (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 9
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • 21142536 10.1056/NEJMra0906948 1:CAS:528:DC%2BC3cXhsFGkt7zO
    • McCarthy MI (2010) Genomics, type 2 diabetes, and obesity. N Engl J Med 363:2339-2350
    • (2010) N Engl J Med , vol.363 , pp. 2339-2350
    • McCarthy, M.I.1
  • 10
    • 79960016921 scopus 로고    scopus 로고
    • Type 2 diabetes and obesity: Genomics and the clinic
    • 21647602 10.1007/s00439-011-1023-8 1:CAS:528:DC%2BC3MXotlyrtbk%3D
    • Travers ME, McCarthy MI (2011) Type 2 diabetes and obesity: genomics and the clinic. Hum Genet 130:41-58
    • (2011) Hum Genet , vol.130 , pp. 41-58
    • Travers, M.E.1    McCarthy, M.I.2
  • 11
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • 20581827 10.1038/ng.609 1:CAS:528:DC%2BC3cXnvFykt70%3D
    • Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579-589
    • (2010) Nat Genet , vol.42 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3
  • 12
    • 79952342793 scopus 로고    scopus 로고
    • Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity
    • 21324932 10.1242/dmm.000414 1:CAS:528:DC%2BC3MXktFehsr8%3D
    • Cox RD, Church CD (2011) Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity. Dis Model Mech 4:155-164
    • (2011) Dis Model Mech , vol.4 , pp. 155-164
    • Cox, R.D.1    Church, C.D.2
  • 14
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • 16415884 10.1038/ng1732 1:CAS:528:DC%2BD28XhslCjtrw%3D
    • Grant SF, Thorleifsson G, Reynisdottir I et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
    • (2006) Nat Genet , vol.38 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 15
    • 55049106032 scopus 로고    scopus 로고
    • The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus
    • 18599616 10.1210/me.2008-0135 1:CAS:528:DC%2BD1cXhtleitbjE
    • Jin T, Liu L (2008) The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol 22:2383-2392
    • (2008) Mol Endocrinol , vol.22 , pp. 2383-2392
    • Jin, T.1    Liu, L.2
  • 16
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • DOI 10.1038/nature03319
    • Reya T, Clevers H (2005) Wnt signalling in stem cells and cancer. Nature 434:843-850 (Pubitemid 40558990)
    • (2005) Nature , vol.434 , Issue.7035 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 17
    • 0032830931 scopus 로고    scopus 로고
    • TCF transcription factors: Molecular switches in carcinogenesis
    • 10528152 1:CAS:528:DyaK1MXntVGksr0%3D
    • Roose J, Clevers H (1999) TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta 1424:M23-M37
    • (1999) Biochim Biophys Acta , vol.1424
    • Roose, J.1    Clevers, H.2
  • 18
    • 69449101810 scopus 로고    scopus 로고
    • The links between transcription, beta-catenin/JNK signaling, and carcinogenesis
    • 19671687 10.1158/1541-7786.MCR-09-0027 1:CAS:528:DC%2BD1MXhtVWrsL7K
    • Saadeddin A, Babaei-Jadidi R, Spencer-Dene B, Nateri AS (2009) The links between transcription, beta-catenin/JNK signaling, and carcinogenesis. Mol Cancer Res 7:1189-1196
    • (2009) Mol Cancer Res , vol.7 , pp. 1189-1196
    • Saadeddin, A.1    Babaei-Jadidi, R.2    Spencer-Dene, B.3    Nateri, A.S.4
  • 19
    • 25844530871 scopus 로고    scopus 로고
    • Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function
    • DOI 10.2337/diabetes.54.10.2844
    • Papadopoulou S, Edlund H (2005) Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54:2844-2851 (Pubitemid 41401078)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2844-2851
    • Papadopoulou, S.1    Edlund, H.2
  • 22
    • 33745084564 scopus 로고    scopus 로고
    • Stabilization of β-catenin impacts pancreas growth
    • DOI 10.1242/dev.02366
    • Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M (2006) Stabilization of beta-catenin impacts pancreas growth. Development 133:2023-2032 (Pubitemid 43881267)
    • (2006) Development , vol.133 , Issue.10 , pp. 2023-2032
    • Heiser, P.W.1    Lau, J.2    Taketo, M.M.3    Herrera, P.L.4    Hebrok, M.5
  • 25
    • 77449099615 scopus 로고    scopus 로고
    • TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action
    • 19934000 10.2337/db09-1169 1:CAS:528:DC%2BC3cXhvVyru7Y%3D
    • Villareal DT, Robertson H, Bell GI et al (2010) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes 59:479-485
    • (2010) Diabetes , vol.59 , pp. 479-485
    • Villareal, D.T.1    Robertson, H.2    Bell, G.I.3
  • 26
    • 67349102328 scopus 로고    scopus 로고
    • The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
    • 19288077 10.1007/s00125-009-1307-x 1:CAS:528:DC%2BD1MXms1yhs70%3D
    • Pilgaard K, Jensen CB, Schou JH et al (2009) The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men. Diabetologia 52:1298-1307
    • (2009) Diabetologia , vol.52 , pp. 1298-1307
    • Pilgaard, K.1    Jensen, C.B.2    Schou, J.H.3
  • 27
    • 67249096093 scopus 로고    scopus 로고
    • Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
    • 19386626 10.1093/hmg/ddp178 1:CAS:528:DC%2BD1MXnt1ehtL0%3D
    • Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet 18:2388-2399
    • (2009) Hum Mol Genet , vol.18 , pp. 2388-2399
    • Shu, L.1    Matveyenko, A.V.2    Kerr-Conte, J.3    Cho, J.H.4    McIntosh, C.H.5    Maedler, K.6
  • 28
    • 75749091912 scopus 로고    scopus 로고
    • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • 20081857 10.1038/ng.521 1:CAS:528:DC%2BC3cXntVCksw%3D%3D
    • Saxena R, Hivert MF, Langenberg C et al (2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 42:142-148
    • (2010) Nat Genet , vol.42 , pp. 142-148
    • Saxena, R.1    Hivert, M.F.2    Langenberg, C.3
  • 29
    • 64649105053 scopus 로고    scopus 로고
    • TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
    • 10.2337/db09-0166
    • da Silva XG, Loder MK, McDonald A et al (2009) TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes 58:894-905
    • (2009) Diabetes , vol.58 , pp. 894-905
    • Da Silva, X.G.1    Loder, M.K.2    McDonald, A.3
  • 30
    • 40949141938 scopus 로고    scopus 로고
    • Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
    • 18071026 10.2337/db07-0847 1:CAS:528:DC%2BD1cXjt1Chtbo%3D
    • Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K (2008) Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57:645-653
    • (2008) Diabetes , vol.57 , pp. 645-653
    • Shu, L.1    Sauter, N.S.2    Schulthess, F.T.3    Matveyenko, A.V.4    Oberholzer, J.5    Maedler, K.6
  • 31
    • 80052527283 scopus 로고    scopus 로고
    • Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism
    • 21673050 10.1101/gr.123745.111 1:CAS:528:DC%2BC3MXhtFGisLjM
    • Savic D, Ye H, Aneas I, Park SY, Bell GI, Nobrega MA (2011) Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res 21:1417-1425
    • (2011) Genome Res , vol.21 , pp. 1417-1425
    • Savic, D.1    Ye, H.2    Aneas, I.3    Park, S.Y.4    Bell, G.I.5    Nobrega, M.A.6
  • 32
    • 43749120731 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
    • 18216022 10.1074/jbc.M706105200 1:CAS:528:DC%2BD1cXjsFCgt7o%3D
    • Liu Z, Habener JF (2008) Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 283:8723-8735
    • (2008) J Biol Chem , vol.283 , pp. 8723-8735
    • Liu, Z.1    Habener, J.F.2
  • 34
    • 12544254474 scopus 로고    scopus 로고
    • TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
    • 15525634 10.1074/jbc.M411487200 1:CAS:528:DC%2BD2MXitFCktw%3D%3D
    • Yi F, Brubaker PL, Jin T (2005) TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 280:1457-1464
    • (2005) J Biol Chem , vol.280 , pp. 1457-1464
    • Yi, F.1    Brubaker, P.L.2    Jin, T.3
  • 35
    • 79953840839 scopus 로고    scopus 로고
    • Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6)
    • 21335550 10.1074/jbc.M110.204248 1:CAS:528:DC%2BC3MXksVKmu7k%3D
    • Meur G, Qian Q, da Silva XG et al (2011) Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol Chem 286:13647-13656
    • (2011) J Biol Chem , vol.286 , pp. 13647-13656
    • Meur, G.1    Qian, Q.2    Da Silva, X.G.3
  • 36
    • 0033919717 scopus 로고    scopus 로고
    • Acute overexpression of lactate dehydrogenase-A perturbs β-cell mitochondrial metasbolism and insulin secretion
    • Ainscow EK, Zhao C, Rutter GA (2000) Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion. Diabetes 49:1149-1155 (Pubitemid 30439089)
    • (2000) Diabetes , vol.49 , Issue.7 , pp. 1149-1155
    • Ainscow, E.K.1    Zhao, C.2    Rutter, G.A.3
  • 37
    • 0038584871 scopus 로고    scopus 로고
    • Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
    • DOI 10.1042/BJ20021812
    • da Silva XG, Leclerc I, Varadi A, Tsuboi T, Moule SK, Rutter GA (2003) Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J 371:761-774 (Pubitemid 36578875)
    • (2003) Biochemical Journal , vol.371 , Issue.3 , pp. 761-774
    • Da Silva Xavier, G.1    Leclerc, I.2    Varadi, A.3    Tsuboi, T.4    Moule, S.K.5    Rutter, G.A.6
  • 39
    • 77952095690 scopus 로고    scopus 로고
    • Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
    • 20221584 10.1007/s00125-010-1692-1 1:CAS:528:DC%2BC3cXktlGgtLc%3D
    • Sun G, Tarasov AI, McGinty J et al (2010) Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia 53:924-936
    • (2010) Diabetologia , vol.53 , pp. 924-936
    • Sun, G.1    Tarasov, A.I.2    McGinty, J.3
  • 40
    • 84858994452 scopus 로고    scopus 로고
    • MUC1-C oncoprotein induces TCF7L2 activation and promotes cyclin D1 expression in human breast cancer cells
    • 22318732 10.1074/jbc.M111.323311 1:CAS:528:DC%2BC38XktlKrtrc%3D
    • Rajabi H, Ahmad R, Jin C et al (2012) MUC1-C oncoprotein induces TCF7L2 activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem 287:10703-10713
    • (2012) J Biol Chem , vol.287 , pp. 10703-10713
    • Rajabi, H.1    Ahmad, R.2    Jin, C.3
  • 42
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457 (Pubitemid 34863851)
    • (2002) Development , vol.129 , Issue.10 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 43
    • 78049446505 scopus 로고    scopus 로고
    • Conditional gene targeting in mouse pancreatic ss-cells: Analysis of ectopic Cre transgene expression in the brain
    • 20802254 10.2337/db10-0624 1:CAS:528:DC%2BC3MXlsVamuw%3D%3D
    • Wicksteed B, Brissova M, Yan W et al (2010) Conditional gene targeting in mouse pancreatic ss-cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59:3090-3098
    • (2010) Diabetes , vol.59 , pp. 3090-3098
    • Wicksteed, B.1    Brissova, M.2    Yan, W.3
  • 45
    • 0031898957 scopus 로고    scopus 로고
    • Mouse pancreatic β-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene
    • DOI 10.2337/diabetes.47.4.646
    • Flamez D, van Breusegem A, Scrocchi LA et al (1998) Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene. Diabetes 47:646-652 (Pubitemid 28160457)
    • (1998) Diabetes , vol.47 , Issue.4 , pp. 646-652
    • Flamez, D.1    Van Breusegem, A.2    Scrocchi, L.A.3    Quartier, E.4    Pipeleers, D.5    Drucker, D.J.6    Schuit, F.7
  • 46
    • 84866097706 scopus 로고    scopus 로고
    • TCF7L2 plays a role in the beta cell regeneration
    • (Abstract)
    • Maedler K, Kerr-Conte J, Shu L (2011) TCF7L2 plays a role in the beta cell regeneration. Diabetologia S 1:407 (Abstract)
    • (2011) Diabetologia S , vol.1 , pp. 407
    • Maedler, K.1    Kerr-Conte, J.2    Shu, L.3
  • 47
    • 77649086970 scopus 로고    scopus 로고
    • A map of open chromatin in human pancreatic islets
    • 20118932 10.1038/ng.530 1:CAS:528:DC%2BC3cXht1yntrg%3D
    • Gaulton KJ, Nammo T, Pasquali L et al (2010) A map of open chromatin in human pancreatic islets. Nat Genet 42:255-259
    • (2010) Nat Genet , vol.42 , pp. 255-259
    • Gaulton, K.J.1    Nammo, T.2    Pasquali, L.3
  • 48
    • 0034660872 scopus 로고    scopus 로고
    • The human T-cell transcription factor-4 gene: Structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines
    • Duval A, Rolland S, Tubacher E, Bui H, Thomas G, Hamelin R (2000) The human T cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res 60:3872-3879 (Pubitemid 32204580)
    • (2000) Cancer Research , vol.60 , Issue.14 , pp. 3872-3879
    • Duval, A.1    Rolland, S.2    Tubacher, E.3    Bui, H.4    Thomas, G.5    Hamelin, R.6
  • 49
    • 77749239722 scopus 로고    scopus 로고
    • Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans
    • 20097709 10.1210/jc.2009-2064 1:CAS:528:DC%2BC3cXjs1Kqur4%3D
    • Mondal AK, Das SK, Baldini G et al (2010) Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. J Clin Endocrinol Metab 95:1450-1457
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1450-1457
    • Mondal, A.K.1    Das, S.K.2    Baldini, G.3
  • 50
    • 64149124055 scopus 로고    scopus 로고
    • Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
    • 19247628 10.1007/s00125-009-1293-z 1:CAS:528:DC%2BD1MXktVOktLc%3D
    • Osmark P, Hansson O, Jonsson A, Ronn T, Groop L, Renstrom E (2009) Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. Diabetologia 52:850-854
    • (2009) Diabetologia , vol.52 , pp. 850-854
    • Osmark, P.1    Hansson, O.2    Jonsson, A.3    Ronn, T.4    Groop, L.5    Renstrom, E.6
  • 51
    • 82455212279 scopus 로고    scopus 로고
    • An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes
    • 21913056 10.1007/s00125-011-2290-6 1:CAS:528:DC%2BC3MXhsVGgu7rM
    • Locke JM, da Silva XG, Rutter GA, Harries LW (2011) An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia 54:3078-3082
    • (2011) Diabetologia , vol.54 , pp. 3078-3082
    • Locke, J.M.1    Da Silva, X.G.2    Rutter, G.A.3    Harries, L.W.4
  • 52
    • 70349569023 scopus 로고    scopus 로고
    • Tissue-specific alternative splicing of TCF7L2
    • 19602480 10.1093/hmg/ddp321 1:CAS:528:DC%2BD1MXhtFyhurfI
    • Prokunina-Olsson L, Welch C, Hansson O et al (2009) Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet 18:3795-3804
    • (2009) Hum Mol Genet , vol.18 , pp. 3795-3804
    • Prokunina-Olsson, L.1    Welch, C.2    Hansson, O.3
  • 53
    • 79955444467 scopus 로고    scopus 로고
    • TCF7L2 splice variants have distinct effects on beta-cell turnover and function
    • 21357677 10.1093/hmg/ddr072
    • Le Bacquer O, Shu L, Marchand M et al (2011) TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Hum Mol Genet 20:1906-1915
    • (2011) Hum Mol Genet , vol.20 , pp. 1906-1915
    • Le Bacquer, O.1    Shu, L.2    Marchand, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.