Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice

Diabetologia

Volumn 52, Issue 8, 2009, Pages 1680-1682

  Suarez Pinzon, W L ^a   Cembrowski, G S ^a   Rabinovitch, A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Dipeptidyl peptidase 4; Gastrin Glucagon like peptide 1; NOD mice Proton pump inhibitor; Type 1 diabetes

Indexed keywords

1 [[(3 HYDROXY 1 ADAMANTYL)AMINO]ACETYL] 2 CYANOPYRROLIDINE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; PANTOPRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; GASTRIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; LETTER; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; FEMALE; GASTRINS; MICE; MICE, INBRED NOD;

EID: 67650685905     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1390-z     Document Type: Letter

References (11)

1. TJ Kieffer CH McIntosh RA Pederson 1995 Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV Endocrinology 136 3585 3596
2. DJ Drucker MA Nauck 2006 The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes Lancet 368 1696 1705 (Pubitemid 46048557)
3. J Mu J Woods Y-P Zhou 2006 Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic β-cell mass and function in a rodent model of type 2 diabetes Diabetes 55 1695 1704 (Pubitemid 44324122)
4. JA Pospisilik J Martin T Doty 2003 Dipeptidyl peptidase IV inhibitor treatment stimulates beta cell survival and islet neogenesis in streptozotocin induced diabetic rats Diabetes 52 741 750 (Pubitemid 36323582)
5. N Ogawa JF List JF Habener T Maki 2004 Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4 Diabetes 53 1700 1705 (Pubitemid 38857027)
6. WL Suarez-Pinzon RF Power Y Yan C Wasserfall M Atkinson A Rabinovitch 2008 Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice Diabetes 57 3281 3288
7. S-J Kim C Nian DJ Doudet CHS McIntosh 2009 Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T cell modulation Diabetes 58 641 651
8. T Hansotia LL Baggio D Delmeire 2004 Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors Diabetes 53 1326 1335 (Pubitemid 38569020)
9. A Maida Y Seino DJ Drucker 2008 Differential importance of GIP vs. GLP-1 receptor signaling vs. DPP-4 inhibition for beta cell survival and function in mice Diabetologia 51 Suppl 1 S363
10. G Xu S Sumi M Koike K Tanigawa Y Nio K Tamura 1996 Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy Dig Dis Sci 41 2433 2439 (Pubitemid 27041799)
11. J-Y Jang S-W Kim J-K Han 2003 Randomized prospective trial of the effect of induced hypergastrinemia on the prevention of pancreatic atrophy after pancreatoduodenectomy in humans Ann Surg 237 522 529 (Pubitemid 38176433)